Tumor suppressor p53 is a multifunctional transcription factor that acts as a guardian of the genome, coordinating cellular responses to diverse stress signals including DNA damage, oxidative stress, hypoxia, and metabolic stress. It regulates cell fate decisions through transcriptional control of genes involved in cell cycle arrest, apoptosis, senescence, DNA repair, and metabolism. TP53 is the most frequently mutated gene in human cancers (~50%), underlining its critical role in preventing malignant transformation. Beyond its canonical tumor suppressive functions, p53 also regulates ferroptosis, autophagy, immune responses, and stemness.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
|
GO:0000976
transcription cis-regulatory region binding
|
IEA
GO_REF:0000002 |
ACCEPT |
Summary: TP53 is a well-established DNA-binding transcription factor that directly binds to p53 response elements in target gene promoters. This is one of its core molecular functions, supported by extensive experimental evidence including the IDA annotations from PMID:15710329 and PMID:17996705.
Reason: This annotation accurately represents a core molecular function of p53. Multiple lines of experimental evidence confirm p53 directly binds cis-regulatory regions to regulate transcription.
Supporting Evidence:
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription
PMID:17996705
An acetylation switch in p53 mediates holo-TFIID recruitment
file:human/TP53/TP53-deep-research-falcon.md
model: Edison Scientific Literature
|
|
GO:0000122
negative regulation of transcription by RNA polymerase II
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 functions as a transcriptional repressor for genes including BCL2 and cell cycle genes.
Reason: Core function - transcriptional repression is part of p53's regulatory activity.
Supporting Evidence:
TP53-deep-research
Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes
PMID:10329733
p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor.
PMID:19749791
Sep 14. Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation.
|
|
GO:0000423
mitophagy
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: TP53 has complex roles in autophagy and mitophagy regulation, with both promoting and inhibiting functions depending on context. There is also a negative regulation of mitophagy annotation (GO:1901525), suggesting context-dependent regulation.
Reason: p53 regulates mitophagy through multiple mechanisms including transcriptional control of mitophagy-related genes. This is part of its broader role in cellular stress response and metabolism.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
GO; GO:0006914; P:autophagy; IMP:CAFA
TP53-deep-research
Accumulating evidence has shown that p53 also regulates cell metabolism, ferroptosis, tumor microenvironment, autophagy and so on
|
|
GO:0001701
in utero embryonic development
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: TP53 plays roles in embryonic development, though p53 knockout mice are viable, indicating it is not absolutely essential. Development-related functions are context-specific rather than core functions.
Reason: While p53 has developmental roles, these are not its primary functions. p53-null mice can complete embryonic development, though with increased cancer susceptibility.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl ... GO; GO:0048568; P:embryonic organ development; IEA:Ensembl
TP53-deep-research
Although p53 plays roles in development and embryogenesis, these are often secondary to its core tumor suppressor functions and may represent over-annotation in certain contexts
|
|
GO:0001756
somitogenesis
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Somitogenesis is a specific developmental process. While p53 may influence developmental processes, this is a highly specific annotation that is not a core function.
Reason: Very specific developmental process that is not central to p53 function. p53 knockout mice complete somitogenesis successfully.
Supporting Evidence:
TP53-deep-research
Although p53 plays roles in development and embryogenesis, these are often secondary to its core tumor suppressor functions
|
|
GO:0001836
release of cytochrome c from mitochondria
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: TP53 promotes apoptosis through the mitochondrial pathway, including regulation of cytochrome c release via transcriptional targets like BAX and PUMA, as well as direct mitochondrial functions.
Reason: Core component of p53-mediated intrinsic apoptotic pathway. p53 induces pro-apoptotic BCL2 family members that trigger cytochrome c release.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression
TP53-deep-research
Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS); Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins
|
|
GO:0002309
T cell proliferation involved in immune response
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: TP53 has emerging roles in immune regulation, but specific T cell proliferation is not a core function. This may relate to non-cell-autonomous tumor suppression through immune modulation.
Reason: While p53 influences immune responses, direct regulation of T cell proliferation is not a primary function. This is a context-specific, non-core role.
|
|
GO:0002326
B cell lineage commitment
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: B cell lineage commitment is a specific hematopoietic developmental process. While p53 may influence hematopoiesis, this is not a core function.
Reason: Highly specific developmental process in the immune system. Not a primary function of p53 as a tumor suppressor.
|
|
GO:0002360
T cell lineage commitment
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: T cell lineage commitment is a specific developmental process in hematopoiesis. Not a core p53 function.
Reason: Specific immune system developmental process that is not central to p53 tumor suppressor function.
|
|
GO:0002931
response to ischemia
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: TP53 responds to hypoxic stress and ischemia as part of its cellular stress response functions. This involves HIF pathway interactions and metabolic regulation.
Reason: Part of p53s broader cellular stress response function. Ischemia/hypoxia is a well-documented p53-activating stress signal.
Supporting Evidence:
GO:1990144
intrinsic apoptotic signaling pathway in response to hypoxia
|
|
GO:0006302
double-strand break repair
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: TP53 coordinates DNA damage response including regulation of DNA repair genes. It promotes both repair and apoptosis depending on damage severity.
Reason: Core function of p53 as guardian of the genome. p53 regulates multiple DNA repair pathways through transcriptional control of repair genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
induces cell cycle arrest, DNA repair or apoptosis
|
|
GO:0006357
regulation of transcription by RNA polymerase II
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 regulates RNA polymerase II transcription as both activator and repressor.
Reason: Core molecular function - p53 is a sequence-specific RNA pol II transcription factor.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
|
|
GO:0006606
protein import into nucleus
|
IEA
GO_REF:0000107 |
REMOVE |
Summary: This likely refers to p53s own nuclear import rather than it regulating import of other proteins. p53 nuclear localization is critical for its function but this annotation is unclear.
Reason: Ambiguous annotation - p53 undergoes nuclear import but does not regulate protein import into nucleus as a general function. This appears to be a misannotation.
Supporting Evidence:
TP53-deep-research
Nuclear Localization Signals (NLS): Location: Residues 305-322 and 369-375; Function: Nuclear import and localization [refers to p53s own import, not regulation of other proteins]
|
|
GO:0006974
DNA damage response
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage.
Reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17938203
Oct 15. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage.
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
|
|
GO:0006979
response to oxidative stress
|
IEA
GO_REF:0000120 |
ACCEPT |
Summary: TP53 is activated by oxidative stress and regulates antioxidant responses, ROS metabolism, and cell fate decisions under oxidative conditions.
Reason: Core stress response function. p53 responds to oxidative stress and regulates redox balance through multiple target genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type
|
|
GO:0007179
transforming growth factor beta receptor signaling pathway
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: TP53 has complex interactions with TGF-beta signaling, but this is not a core function. There is also annotation for negative regulation of this pathway (GO:0030512).
Reason: While p53 interacts with TGF-beta signaling, this is a context-specific crosstalk rather than a core p53 function.
|
|
GO:0007346
regulation of mitotic cell cycle
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: Cell cycle regulation is a fundamental function of TP53. It induces cell cycle arrest through p21/CDKN1A and other cell cycle regulators.
Reason: Core tumor suppressor function. p53 induces cell cycle checkpoints in response to stress, preventing damaged cells from proliferating.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Negatively regulates cell division by controlling expression of a set of genes required for this process
|
|
GO:0007369
gastrulation
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Gastrulation is a specific early developmental process. p53 is not essential for gastrulation as p53-null mice complete this process.
Reason: Highly specific developmental process that is not a core p53 function. p53 knockout mice undergo normal gastrulation.
|
|
GO:0007405
neuroblast proliferation
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Neuroblast proliferation is a specific neural developmental process. Not a core p53 function.
Reason: Specific developmental process in nervous system. p53 may regulate proliferation broadly but neuroblast-specific regulation is not core.
|
|
GO:0007406
negative regulation of neuroblast proliferation
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: p53 negatively regulates proliferation broadly, but neuroblast-specific regulation is a specialized context.
Reason: While p53 inhibits proliferation generally, neuroblast-specific regulation is not a core function but rather a tissue-specific manifestation.
|
|
GO:0007417
central nervous system development
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: CNS development is a broad developmental process. p53 has roles but is not essential as p53-null mice have functional CNS.
Reason: Developmental process that is not core to p53 tumor suppressor function. p53-null mice develop functional nervous systems.
|
|
GO:0007507
heart development
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Heart development is a specific organ developmental process. Not essential as p53-null mice have normal hearts.
Reason: Organ-specific developmental process that is not a core p53 function. p53 knockout mice develop normal hearts.
|
|
GO:0008156
negative regulation of DNA replication
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: TP53 inhibits DNA replication as part of cell cycle arrest, preventing replication of damaged DNA.
Reason: Core function related to cell cycle control and preventing propagation of damaged DNA. Part of p53s tumor suppressor activity.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Negatively regulates cell division
|
|
GO:0008283
cell population proliferation
|
IEA
GO_REF:0000107 |
REMOVE |
Summary: This is a very general term. p53 primarily NEGATIVELY regulates proliferation. The annotation GO:0008285 (negative regulation) is more accurate.
Reason: Too general and potentially misleading. p53 primarily inhibits rather than promotes proliferation. The negative regulation annotation is more appropriate.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Negatively regulates cell division by controlling expression of a set of genes required for this process
|
|
GO:0009303
rRNA transcription
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 can regulate ribosomal biogenesis and rRNA transcription as part of metabolic control, typically inhibiting it under stress.
Reason: p53 regulates ribosome biogenesis and protein synthesis capacity, typically suppressing rRNA transcription under stress conditions.
|
|
GO:0009410
response to xenobiotic stimulus
|
IEA
GO_REF:0000120 |
ACCEPT |
Summary: TP53 responds to various xenobiotic stresses including drugs and toxins that cause DNA damage or cellular stress.
Reason: Part of p53s broad stress response function. Many xenobiotics activate p53 through DNA damage or other stress pathways.
|
|
GO:0009411
response to UV
|
IEA
GO_REF:0000120 |
ACCEPT |
Summary: UV radiation causes DNA damage that strongly activates p53. This is a well-characterized p53-activating stress.
Reason: Core stress response function. UV-induced DNA damage is a classic p53 activator leading to repair, arrest, or apoptosis.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type
|
|
GO:0009651
response to salt stress
|
IEA
GO_REF:0000107 |
REMOVE |
Summary: Salt stress response is not a well-characterized p53 function in mammalian cells. This may be an over-annotation.
Reason: No strong evidence for salt stress as a p53-activating stimulus in mammalian cells. Likely computational over-annotation.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network ... It integrates signals from upstream kinases (ATM, ATR, DNA-PK) [no mention of salt stress as an activating signal]
|
|
GO:0009792
embryo development ending in birth or egg hatching
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Very broad developmental term. p53-null mice are viable, so p53 is not essential for embryo development to birth.
Reason: While p53 has developmental roles, it is not essential for embryo development to birth. This is a non-core function.
|
|
GO:0010165
response to X-ray
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: X-ray radiation causes DNA damage that activates p53. Part of p53s DNA damage response function.
Reason: Core function - ionizing radiation like X-rays cause DNA damage that strongly activates p53.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type
|
|
GO:0010332
response to gamma radiation
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 responds to gamma radiation-induced DNA damage.
Reason: Core function - ionizing radiation strongly activates p53.
Supporting Evidence:
TP53-deep-research
p53 responds to DNA damage from ionizing radiation
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
|
|
GO:0010629
negative regulation of gene expression
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: TP53 functions as both activator and repressor of gene expression. It represses anti-apoptotic and proliferation genes.
Reason: Core transcriptional function. p53 represses multiple genes including BCL2, survivin, and cell cycle genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
repression of Bcl-2 expression
|
|
GO:0010659
cardiac muscle cell apoptotic process
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Cell type-specific apoptosis. While p53 induces apoptosis broadly, cardiac-specific regulation is context-dependent.
Reason: Tissue-specific manifestation of p53s apoptotic function. Not a core function but a specialized context.
|
|
GO:0010666
positive regulation of cardiac muscle cell apoptotic process
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Tissue-specific apoptotic regulation. p53 can induce apoptosis in cardiac cells but this is not a core function.
Reason: Cell type-specific apoptotic function. The general apoptotic function is core, but cardiac-specific regulation is context-dependent.
|
|
GO:0014009
glial cell proliferation
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Cell type-specific proliferation. Not a core p53 function.
Reason: Tissue-specific proliferation regulation in nervous system. Not central to p53 tumor suppressor function.
|
|
GO:0019661
homolactic fermentation
|
IEA
GO_REF:0000107 |
MODIFY |
Summary: TP53 regulates glucose metabolism and suppresses glycolysis (Warburg effect). There is also annotation for negative regulation (GO:1904024).
Reason: p53 primarily SUPPRESSES glycolysis/Warburg effect, not promotes it. The negative regulation annotation is more accurate.
Proposed replacements:
negative regulation of glucose catabolic process to lactate via pyruvate
Supporting Evidence:
TP53-deep-research
Wild-type p53: Inhibits glycolysis, promotes oxidative phosphorylation and mitochondrial respiration ... Specific targets: TIGAR (inhibits glycolysis), SCO2 (promotes oxidative phosphorylation)
|
|
GO:0021549
cerebellum development
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Specific brain region development. Not essential as p53-null mice have functional cerebellum.
Reason: Region-specific developmental process that is not core to p53 function.
|
|
GO:0030330
DNA damage response, signal transduction by p53 class mediator
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
PMID:29681526
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
PMID:15149599
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
PMID:20160708
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
|
|
GO:0030512
negative regulation of transforming growth factor beta receptor signaling pathway
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: p53 has complex crosstalk with TGF-beta signaling but this is not a core function.
Reason: Context-specific signaling crosstalk rather than core p53 function.
|
|
GO:0031571
mitotic G1 DNA damage checkpoint signaling
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 mediates G1 DNA damage checkpoint signaling through p21 induction.
Reason: Core function - G1/S checkpoint is a major p53-mediated cell cycle control.
Supporting Evidence:
TP53-deep-research
Cell cycle arrest is mediated by transcriptional upregulation of p21
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
|
|
GO:0033077
T cell differentiation in thymus
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Specific immune system developmental process. Not a core p53 function.
Reason: Tissue-specific developmental process in immune system. Not central to p53 tumor suppressor function.
|
|
GO:0033554
cellular response to stress
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: Broad term encompassing p53s fundamental role as a stress sensor and responder. Covers DNA damage, oxidative stress, hypoxia, etc.
Reason: Core function - p53 is the master cellular stress response coordinator, responding to diverse stress signals.
Supporting Evidence:
PMID:14744935
The tumor suppressor p53, a sensor of multiple forms of cellular stress, is regulated by post-translational mechanisms to induce cell-cycle arrest, senescence, or apoptosis
|
|
GO:0034103
regulation of tissue remodeling
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Tissue remodeling is not a well-characterized p53 function. This appears to be an over-annotation.
Reason: Not a core p53 function. May relate to indirect effects through apoptosis or senescence but not a primary role.
|
|
GO:0035264
multicellular organism growth
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Very broad developmental term. p53 influences growth through proliferation control but is not essential for organism growth.
Reason: Broad developmental process. p53-null mice show normal growth patterns despite cancer susceptibility.
|
|
GO:0035794
positive regulation of mitochondrial membrane permeability
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 promotes mitochondrial outer membrane permeabilization during apoptosis through BAX/BAK activation. Core apoptotic function.
Reason: Core component of p53-mediated intrinsic apoptosis. p53 target genes like BAX and PUMA promote MOMP.
Supporting Evidence:
GO:1902108
regulation of mitochondrial membrane permeability involved in apoptotic process
|
|
GO:0042127
regulation of cell population proliferation
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: General term for proliferation regulation. p53 primarily negatively regulates proliferation through cell cycle arrest.
Reason: Core function - p53 is a key regulator of proliferation, primarily through negative regulation via cell cycle checkpoints.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Negatively regulates cell division
|
|
GO:0043065
positive regulation of apoptotic process
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 positively regulates apoptosis as a major tumor suppressor mechanism.
Reason: Core function - p53 induces apoptosis through multiple pathways.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression
PMID:12667443
p53 has a direct apoptogenic role at the mitochondria.
PMID:15565177
A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0043066
negative regulation of apoptotic process
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 can negatively regulate apoptosis in certain contexts through p21-mediated survival.
Reason: Context-dependent function - p53 can promote survival under mild stress conditions.
Supporting Evidence:
PMID:14744935
We demonstrate that endoplasmic reticulum (ER) stress inhibits p53-mediated apoptosis
|
|
GO:0043504
mitochondrial DNA repair
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: p53 has mitochondrial localization and can contribute to mitochondrial genome stability, though this is not a primary function.
Reason: While p53 can localize to mitochondria and influence mtDNA stability, this is not a core tumor suppressor function.
|
|
GO:0043516
regulation of DNA damage response, signal transduction by p53 class mediator
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 both executes and regulates its own DNA damage response pathway. This is a core function.
Reason: Core function - p53 is the central regulator of its own pathway, with multiple feedback loops and regulatory mechanisms.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type
|
|
GO:0043523
regulation of neuron apoptotic process
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Cell type-specific apoptotic regulation. p53 can regulate neuronal apoptosis but this is context-specific.
Reason: Tissue-specific manifestation of p53s apoptotic function. Not a core function but relevant in neurodegeneration contexts.
|
|
GO:0043525
positive regulation of neuron apoptotic process
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Neuron-specific pro-apoptotic function. While p53 induces apoptosis broadly, neuron-specific regulation is context-dependent.
Reason: Cell type-specific apoptotic function relevant in neurodegeneration but not a core p53 function.
|
|
GO:0045861
negative regulation of proteolysis
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: p53 can regulate proteolysis through various mechanisms including MDM2 regulation and proteasome activity, but this is not a primary function.
Reason: While p53 influences protein stability and degradation pathways, negative regulation of proteolysis is not a core function.
|
|
GO:0045893
positive regulation of DNA-templated transcription
|
IEA
GO_REF:0000120 |
ACCEPT |
Summary: p53 positively regulates DNA-templated transcription of target genes.
Reason: Core transcriptional function - p53 activates transcription of numerous target genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:20378837
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
|
|
GO:0045930
negative regulation of mitotic cell cycle
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: Core function - p53 induces cell cycle arrest at multiple checkpoints to prevent proliferation of damaged cells.
Reason: Fundamental tumor suppressor function. p53 arrests cell cycle through p21 and other CDK inhibitors.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Negatively regulates cell division by controlling expression of a set of genes required for this process
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0048144
fibroblast proliferation
|
IEA
GO_REF:0000107 |
REMOVE |
Summary: Cell type-specific proliferation. p53 generally inhibits rather than promotes proliferation.
Reason: p53 primarily inhibits proliferation. This positive proliferation annotation appears incorrect. The negative regulation annotation (GO:0048147) is accurate.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Negatively regulates cell division
|
|
GO:0048147
negative regulation of fibroblast proliferation
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: p53 negatively regulates fibroblast proliferation as part of its anti-proliferative function.
Reason: Cell type-specific manifestation of anti-proliferative function.
|
|
GO:0048568
embryonic organ development
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Broad developmental term. p53 has developmental roles but is not essential for organ development.
Reason: Developmental process that is not core to p53 function. p53-null mice develop functional organs.
|
|
GO:0050821
protein stabilization
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: p53 can stabilize some proteins through transcriptional targets or protein interactions, but this is not a primary function.
Reason: Not a core p53 function. p53 itself is heavily regulated by stability but protein stabilization of other proteins is not primary.
|
|
GO:0051276
chromosome organization
|
IEA
GO_REF:0000107 |
REMOVE |
Summary: Very broad term. p53 influences chromosome stability through DNA repair and checkpoints but does not directly organize chromosomes.
Reason: Too broad and indirect. p53 maintains genome stability but chromosome organization per se is not its function.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network ... Cell cycle checkpoint activation; DNA repair pathway stimulation [maintains genome stability but not chromosome organization per se]
|
|
GO:0051402
neuron apoptotic process
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Neuron-specific apoptosis. While p53 can induce neuronal apoptosis, this is context-specific.
Reason: Cell type-specific apoptotic process. Relevant in neurodegeneration but not a core p53 function.
|
|
GO:0051726
regulation of cell cycle
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints.
Reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
induces cell cycle arrest
PMID:30514107
CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.
PMID:12203124
The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).
PMID:12433990
Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.
PMID:15149599
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
|
|
GO:0060253
negative regulation of glial cell proliferation
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Cell type-specific anti-proliferative function in nervous system.
Reason: Tissue-specific manifestation of p53s anti-proliferative function. Not a core function.
|
|
GO:0060411
cardiac septum morphogenesis
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Very specific cardiac developmental process. Not a core p53 function.
Reason: Highly specific developmental process. p53-null mice have normal cardiac development.
|
|
GO:0070242
thymocyte apoptotic process
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Cell type-specific apoptosis in immune system development.
Reason: Tissue-specific apoptotic process in immune system. Not a core p53 function.
|
|
GO:0070243
regulation of thymocyte apoptotic process
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Immune cell-specific apoptotic regulation during T cell development.
Reason: Tissue-specific process in immune system development. Not a core p53 function.
|
|
GO:0070266
necroptotic process
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 has emerging roles in regulating necroptosis, a form of programmed necrosis, though apoptosis is its primary death pathway.
Reason: Emerging function of p53 in non-apoptotic cell death. p53 can regulate necroptosis through various mechanisms.
|
|
GO:0071480
cellular response to gamma radiation
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 responds to gamma radiation-induced DNA damage.
Reason: Core function - ionizing radiation is a classic p53 activator.
Supporting Evidence:
TP53-deep-research
gamma radiation causes DNA damage that strongly activates p53
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
|
|
GO:0071494
cellular response to UV-C
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: UV-C radiation causes severe DNA damage that activates p53. Part of DNA damage response.
Reason: Core function - UV-C induces DNA lesions that strongly activate p53-mediated responses.
Supporting Evidence:
GO:0009411
response to UV
|
|
GO:0072089
stem cell proliferation
|
IEA
GO_REF:0000107 |
REMOVE |
Summary: p53 generally suppresses rather than promotes proliferation, including in stem cells.
Reason: p53 typically inhibits stem cell proliferation to maintain genomic stability. The negative regulation annotation (GO:2000647) is more accurate.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Negatively regulates cell division by controlling expression of a set of genes required for this process
|
|
GO:0072331
signal transduction by p53 class mediator
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 IS the p53 class mediator that transduces signals in response to stress.
Reason: Absolutely core function - this term specifically describes p53's central role in stress signaling.
Supporting Evidence:
TP53-deep-research
p53 coordinates cellular responses to diverse stress signals
PMID:25384516
Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:29681526
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
PMID:15314173
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
|
|
GO:0072332
intrinsic apoptotic signaling pathway by p53 class mediator
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 mediates intrinsic apoptotic signaling through BAX, PUMA, NOXA activation.
Reason: Core apoptotic function - p53 is the master regulator of intrinsic apoptosis.
Supporting Evidence:
TP53-deep-research
Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA)
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:12172011
Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila.
|
|
GO:0072593
reactive oxygen species metabolic process
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 regulates ROS through multiple mechanisms including antioxidant genes and metabolic regulation. Important for redox balance.
Reason: Important function - p53 regulates cellular redox state through multiple target genes affecting ROS production and scavenging.
Supporting Evidence:
GO:2000378
negative regulation of reactive oxygen species metabolic process
|
|
GO:1901525
negative regulation of mitophagy
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 has complex bidirectional effects on autophagy/mitophagy - can both promote and inhibit depending on context.
Reason: p53 can negatively regulate mitophagy in certain contexts while promoting it in others. This dual role is well-documented.
|
|
GO:1902108
regulation of mitochondrial membrane permeability involved in apoptotic process
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: Core apoptotic function - p53 regulates mitochondrial outer membrane permeabilization through BAX/BAK activation.
Reason: Core function in intrinsic apoptosis. p53 target genes like BAX and PUMA promote mitochondrial membrane permeabilization.
Supporting Evidence:
GO:0035794
positive regulation of mitochondrial membrane permeability
|
|
GO:1902253
regulation of intrinsic apoptotic signaling pathway by p53 class mediator
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 both executes and regulates its own intrinsic apoptotic pathway. Core function.
Reason: Core function - p53 is the master regulator of its own apoptotic pathway with multiple feedback mechanisms.
Supporting Evidence:
GO:0072332
intrinsic apoptotic signaling pathway by p53 class mediator
|
|
GO:1903799
negative regulation of miRNA processing
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 has complex effects on miRNA processing - can both promote and inhibit. There is also positive regulation annotation (GO:1902895).
Reason: p53 regulates miRNA processing through interaction with Drosha complex and other mechanisms. Can have both positive and negative effects.
|
|
GO:1904024
negative regulation of glucose catabolic process to lactate via pyruvate
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 suppresses glycolysis/Warburg effect as part of its metabolic regulatory and tumor suppressor functions.
Reason: Important metabolic function - p53 suppresses aerobic glycolysis (Warburg effect) that is characteristic of cancer cells.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
GO; GO:0019661; P:glucose catabolic process to lactate via pyruvate; IEA:Ensembl ... GO; GO:1904024; P:negative regulation of glucose catabolic process to lactate via pyruvate; IEA:Ensembl
|
|
GO:1990144
intrinsic apoptotic signaling pathway in response to hypoxia
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 mediates apoptosis in response to severe hypoxia. Part of its stress response repertoire.
Reason: Core stress response function - p53 induces apoptosis under severe hypoxic stress through HIF interactions and target genes.
Supporting Evidence:
GO:0002931
response to ischemia
|
|
GO:2000269
regulation of fibroblast apoptotic process
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: Cell type-specific apoptotic regulation in fibroblasts.
Reason: Tissue-specific apoptotic function. The general apoptotic function is core, but fibroblast-specific regulation is context-dependent.
|
|
GO:2000378
negative regulation of reactive oxygen species metabolic process
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 regulates cellular redox balance and can suppress ROS through antioxidant gene expression.
Reason: Important function - p53 maintains redox homeostasis by inducing antioxidant genes like GPX1, SOD2, and others.
Supporting Evidence:
GO:0072593
reactive oxygen species metabolic process
|
|
GO:2000647
negative regulation of stem cell proliferation
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 maintains stem cell genomic stability by limiting proliferation. Important for preventing cancer stem cells.
Reason: Important function - p53 restricts stem cell self-renewal to maintain genomic integrity and prevent transformation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
induces growth arrest or apoptosis depending on the physiological circumstances and cell type ... Negatively regulates cell division by controlling expression of a set of genes required for this process
|
|
GO:2000772
regulation of cellular senescence
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: Senescence induction is a core p53 tumor suppressor mechanism, alternative to apoptosis for preventing damaged cell proliferation.
Reason: Core function - p53 induces senescence through p21 and other targets as an irreversible cell cycle arrest mechanism.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence ... Negatively regulates cell division
|
|
GO:0160020
positive regulation of ferroptosis
|
TAS
file:human/TP53/TP53-deep-research.md |
NEW |
Summary: p53 promotes ferroptosis through multiple mechanisms including repression of SLC7A11 (cystine/glutamate antiporter), activation of ALOX12, and promotion of lipid peroxidation. This is an important non-apoptotic cell death mechanism.
Reason: Ferroptosis regulation is a well-established p53 function documented in recent literature but missing from current GO annotations. p53 acts as a positive regulator of ferroptosis.
Supporting Evidence:
TP53-deep-research
Pro-ferroptotic: Represses SLC7A11, activates ALOX12, promotes lipid peroxidation
TP53-deep-research
p53 has a dual role in ferroptosis (iron-dependent programmed cell death) ... p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11
|
|
GO:1902895
positive regulation of miRNA transcription
|
IMP
PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a... |
ACCEPT |
Summary: p53 transcriptionally regulates multiple miRNAs including miR-34 family.
Reason: p53 regulates miRNA expression as part of its stress response functions.
Supporting Evidence:
PMID:30089260
we only observed significant Dox dose- and time-dependent increases in the expression levels of miR-103 and miR-107... we found p53-dependent induction of these miRNAs upon nutlin-3a treatment
PMID:30089260
Using our CRISPR p53KO HCT116 cell lines, we found p53-dependent induction of these miRNAs upon nutlin-3a treatment
|
|
GO:0008285
negative regulation of cell population proliferation
|
ISS
PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading... |
ACCEPT |
Summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism.
Reason: Core function - p53 inhibits proliferation through cell cycle arrest.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Negatively regulates cell division
PMID:30514107
CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.
PMID:12730672
Physical and functional interaction between HCV core protein and the different p73 isoforms.
PMID:22783376
Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53.
|
|
GO:0051726
regulation of cell cycle
|
ISS
PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading... |
ACCEPT |
Summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints.
Reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
induces cell cycle arrest
PMID:30514107
CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.
PMID:12203124
The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).
PMID:12433990
Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.
PMID:15149599
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
|
|
GO:1902749
regulation of cell cycle G2/M phase transition
|
IMP
PMID:10962037 Overexpression of MYC causes p53-dependent G2 arrest of norm... |
ACCEPT |
Summary: p53 regulates the G2/M checkpoint, preventing mitosis of damaged cells. Core cell cycle control function.
Reason: Core cell cycle checkpoint function with experimental evidence. p53 induces G2 arrest through multiple mechanisms.
Supporting Evidence:
PMID:10962037
Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IGI
PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in ... |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0000976
transcription cis-regulatory region binding
|
IDA
PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcr... |
ACCEPT |
Summary: Direct experimental evidence for p53 DNA binding activity. Core molecular function with IDA support.
Reason: Core molecular function with direct experimental evidence of p53 binding to cis-regulatory regions.
Supporting Evidence:
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
|
|
GO:0042771
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
|
IDA
PMID:14654789 A member of the Pyrin family, IFI16, is a novel BRCA1-associ... |
ACCEPT |
Summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation.
Reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis.
Supporting Evidence:
TP53-deep-research
Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS)
PMID:14654789
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
|
|
GO:0006974
DNA damage response
|
IDA
PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... |
ACCEPT |
Summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage.
Reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17938203
Oct 15. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage.
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
|
|
GO:0006983
ER overload response
|
IDA
PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... |
ACCEPT |
Summary: p53 responds to ER stress. The cited paper shows ER stress affects p53 localization and function.
Reason: p53 responds to ER stress as part of its cellular stress response repertoire. Supported by experimental evidence.
Supporting Evidence:
PMID:14744935
endoplasmic reticulum (ER) stress inhibits p53-mediated apoptosis... ER stress induces GSK-3beta binding to p53
|
|
GO:0042771
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
|
IDA
PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... |
ACCEPT |
Summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation.
Reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis.
Supporting Evidence:
TP53-deep-research
Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS)
PMID:14654789
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
|
|
GO:0042981
regulation of apoptotic process
|
IDA
PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... |
ACCEPT |
Summary: p53 is a master regulator of apoptosis, both promoting and (in some contexts) inhibiting apoptotic processes.
Reason: Core function - p53 regulates apoptosis through multiple mechanisms including transcriptional activation of pro-apoptotic genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
|
|
GO:0016604
nuclear body
|
IDA
PMID:10360174 Mutations in human ARF exon 2 disrupt its nucleolar localiza... |
ACCEPT |
Summary: p53 localizes to nuclear bodies including PML bodies and nucleoli under certain conditions. This is related to its regulatory functions.
Reason: p53 localizes to nuclear bodies like PML bodies, especially during stress responses and senescence. This subcellular localization is functionally relevant.
Supporting Evidence:
PMID:10360174
ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
|
|
GO:0000976
transcription cis-regulatory region binding
|
IDA
PMID:17996705 An acetylation switch in p53 mediates holo-TFIID recruitment... |
ACCEPT |
Summary: Additional IDA evidence for p53 DNA binding. Duplicate annotation with different experimental support.
Reason: Core molecular function with direct experimental evidence. p53 binds to consensus sequences in target gene promoters.
Supporting Evidence:
PMID:17996705
An acetylation switch in p53 mediates holo-TFIID recruitment
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IDA
PMID:17599062 CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediate... |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0042149
cellular response to glucose starvation
|
IDA
PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... |
ACCEPT |
Summary: p53 responds to glucose starvation as part of metabolic stress response.
Reason: p53 responds to metabolic stress including glucose deprivation.
Supporting Evidence:
PMID:14744935
The tumor suppressor p53, a sensor of multiple forms of cellular stress, is regulated by post-translational mechanisms to induce cell-cycle arrest, senescence, or apoptosis
|
|
GO:0001666
response to hypoxia
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 is activated by hypoxic stress and mediates cellular responses to low oxygen through HIF pathway interactions.
Reason: Core stress response function. Hypoxia is a well-established p53-activating stress that leads to cell cycle arrest or apoptosis depending on severity.
Supporting Evidence:
TP53-deep-research
p53 coordinates cellular responses to diverse stress signals including DNA damage, oxidative stress, hypoxia, and metabolic stress
|
|
GO:0000785
chromatin
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: p53 associates with chromatin at target gene promoters to regulate transcription.
Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
Supporting Evidence:
PDB:3TS8
Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:22521434
Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR.
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
PMID:17805299
p53 is regulated by the lysine demethylase LSD1.
|
|
GO:0005634
nucleus
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0042771
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation.
Reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis.
Supporting Evidence:
TP53-deep-research
Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS)
PMID:14654789
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
|
|
GO:0042981
regulation of apoptotic process
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: p53 is a master regulator of apoptosis, both promoting and (in some contexts) inhibiting apoptotic processes.
Reason: Core function - p53 regulates apoptosis through multiple mechanisms including transcriptional activation of pro-apoptotic genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:1990841
promoter-specific chromatin binding
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: p53 binds to promoter-specific chromatin regions containing p53 response elements.
Reason: Core molecular function - p53 specifically binds to promoter regions of target genes through sequence-specific DNA binding.
Supporting Evidence:
PDB:3TS8
Crystal structure shows p53 binding to CDKN1A(p21) promoter response element
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20725088
2010 Aug 20. Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
|
|
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:34381247
Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
PMID:35618207
Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.
PMID:36634798
Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.
PMID:38653238
2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
|
|
GO:0000978
RNA polymerase II cis-regulatory region sequence-specific DNA binding
|
IBA
GO_REF:0000033 |
ACCEPT |
Summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes.
Reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity.
Supporting Evidence:
TP53-deep-research
TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements (p53REs) in target gene promoters
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:22578566
Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
|
|
GO:0003677
DNA binding
|
IEA
GO_REF:0000120 |
ACCEPT |
Summary: p53 binds DNA through its central DNA-binding domain (residues 102-292) to p53 response elements.
Reason: Core molecular function - DNA binding is essential for p53's transcription factor activity.
Supporting Evidence:
TP53-deep-research
DNA-Binding Domain (DBD): Location: Residues 102-292; Structure: beta-sandwich core with DNA-binding loops
PMID:15358771
2004 Sep 9. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:2144364
Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene.
|
|
GO:0003700
DNA-binding transcription factor activity
|
IEA
GO_REF:0000120 |
ACCEPT |
Summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes.
Reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:26334721
2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:7587074
Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene.
|
|
GO:0005634
nucleus
|
IEA
GO_REF:0000120 |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005737
cytoplasm
|
IEA
GO_REF:0000120 |
ACCEPT |
Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:16131611
p53 isoforms can regulate p53 transcriptional activity.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005759
mitochondrial matrix
|
IEA
GO_REF:0000120 |
ACCEPT |
Summary: p53 localizes to mitochondria where it can directly promote apoptosis through non-transcriptional mechanisms.
Reason: Important cellular localization - p53 can translocate to mitochondria and directly trigger apoptosis through BAX/BAK activation.
Supporting Evidence:
TP53-deep-research
Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins
|
|
GO:0005783
endoplasmic reticulum
|
IEA
GO_REF:0000044 |
ACCEPT |
Summary: p53 localizes to endoplasmic reticulum where it responds to ER stress.
Reason: p53 responds to ER stress signals and can localize to ER during stress responses.
Supporting Evidence:
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization
|
|
GO:0005813
centrosome
|
IEA
GO_REF:0000044 |
KEEP AS NON CORE |
Summary: p53 has been reported to localize to centrosomes but this is not a primary localization.
Reason: Non-core localization. p53 may associate with centrosomes in certain contexts but this is not a primary function.
|
|
GO:0006355
regulation of DNA-templated transcription
|
IEA
GO_REF:0000120 |
ACCEPT |
Summary: p53 regulates DNA-templated transcription as both an activator and repressor.
Reason: Core molecular function - transcription regulation is fundamental to p53's tumor suppressor activity.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:25417702
Functional interplay between MDM2, p63/p73 and mutant p53.
PMID:7587074
Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene.
|
|
GO:0006915
apoptotic process
|
IEA
GO_REF:0000120 |
ACCEPT |
Summary: p53 is a master regulator of apoptosis, inducing cell death through multiple pathways.
Reason: Core function - apoptosis induction is one of p53's primary tumor suppressor mechanisms.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
induces growth arrest or apoptosis depending on the physiological circumstances
|
|
GO:0010212
response to ionizing radiation
|
IEA
GO_REF:0000117 |
ACCEPT |
Summary: p53 is strongly activated by ionizing radiation-induced DNA damage.
Reason: Core function - ionizing radiation is a classic p53-activating stress through ATM/ATR signaling.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
|
|
GO:0012501
programmed cell death
|
IEA
GO_REF:0000043 |
ACCEPT |
Summary: p53 induces programmed cell death through apoptosis, and also regulates other cell death pathways.
Reason: Core function - p53 is a master regulator of programmed cell death.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
induces growth arrest or apoptosis
|
|
GO:0016605
PML body
|
IEA
GO_REF:0000044 |
ACCEPT |
Summary: p53 localizes to PML nuclear bodies, which is important for its post-translational modification and activation.
Reason: Important regulatory localization - p53 accumulates in PML bodies during stress responses where it undergoes acetylation.
Supporting Evidence:
TP53-deep-research
p53 localizes to nuclear bodies like PML bodies, especially during stress responses
PMID:22869143
BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction.
PMID:12006491
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
|
|
GO:0046872
metal ion binding
|
IEA
GO_REF:0000043 |
ACCEPT |
Summary: p53's DNA-binding domain contains a zinc coordination site essential for structural stability.
Reason: Core structural feature - the p53 DNA-binding domain contains a zinc atom coordinated by Cys176, His179, Cys238, and Cys242.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Contains zinc coordination site in DNA-binding domain
|
|
GO:0048511
rhythmic process
|
IEA
GO_REF:0000043 |
KEEP AS NON CORE |
Summary: p53 may influence circadian rhythms but this is not a core function.
Reason: Non-core function. p53 has connections to circadian biology but this is not its primary role.
|
|
GO:0051053
negative regulation of DNA metabolic process
|
IEA
GO_REF:0000117 |
ACCEPT |
Summary: p53 negatively regulates DNA replication as part of cell cycle arrest response.
Reason: Core function related to cell cycle control - p53 inhibits DNA replication in damaged cells.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Negatively regulates cell division
|
|
GO:0051262
protein tetramerization
|
IEA
GO_REF:0000002 |
ACCEPT |
Summary: p53 forms tetramers through its oligomerization domain (residues 325-356), essential for DNA binding.
Reason: Core structural feature - tetramerization is essential for high-affinity DNA binding and p53 function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain shows dimer-of-dimers architecture
|
|
GO:0071456
cellular response to hypoxia
|
IEA
GO_REF:0000117 |
ACCEPT |
Summary: p53 mediates cellular responses to hypoxia, including cell cycle arrest and apoptosis induction.
Reason: Core stress response function - p53 responds to hypoxic stress and coordinates appropriate cellular responses.
Supporting Evidence:
GO:1990144
intrinsic apoptotic signaling pathway in response to hypoxia
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
|
|
GO:0097190
apoptotic signaling pathway
|
IEA
GO_REF:0000117 |
ACCEPT |
Summary: p53 is a master regulator of apoptotic signaling pathways.
Reason: Core function - p53 activates both intrinsic and extrinsic apoptotic signaling.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression
|
|
GO:2001242
regulation of intrinsic apoptotic signaling pathway
|
IEA
GO_REF:0000117 |
ACCEPT |
Summary: p53 both executes and regulates the intrinsic apoptotic signaling pathway.
Reason: Core function - p53 is a key regulator of intrinsic apoptotic signaling through multiple target genes.
Supporting Evidence:
TP53-deep-research
p53 triggers apoptosis through both transcription-dependent and transcription-independent mechanisms
|
|
GO:0005515
protein binding
|
IPI
PMID:10196247 Characterization of an E1A-CBP interaction defines a novel t... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:10196247
Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300.
|
|
GO:0005515
protein binding
|
IPI
PMID:10226625 The yeast two-hybrid system reveals no interaction between p... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:10226625
The yeast two-hybrid system reveals no interaction between p73 alpha and SV40 large T-antigen.
|
|
GO:0005515
protein binding
|
IPI
PMID:10518217 A novel cofactor for p300 that regulates the p53 response. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:10518217
A novel cofactor for p300 that regulates the p53 response.
|
|
GO:0005515
protein binding
|
IPI
PMID:10823891 The Huntington's disease protein interacts with p53 and CREB... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:10823891
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
|
|
GO:0005515
protein binding
|
IPI
PMID:11146555 Functional interaction between p53 and the interferon-induci... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:11146555
Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16.
|
|
GO:0005515
protein binding
|
IPI
PMID:11178989 MDM2 enhances the function of estrogen receptor alpha in hum... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:11178989
MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells.
|
|
GO:0005515
protein binding
|
IPI
PMID:11359905 The corepressor mSin3a interacts with the proline-rich domai... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:11359905
The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation.
|
|
GO:0005515
protein binding
|
IPI
PMID:11388671 A putative protein inhibitor of activated STAT (PIASy) inter... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:11388671
A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis.
|
|
GO:0005515
protein binding
|
IPI
PMID:11427532 p53 Modulates the exonuclease activity of Werner syndrome pr... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:11427532
2001 Jun 26. p53 Modulates the exonuclease activity of Werner syndrome protein.
|
|
GO:0005515
protein binding
|
IPI
PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
|
|
GO:0005515
protein binding
|
IPI
PMID:11706030 Differential effect of ik3-1/cables on p53- and p73-induced ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:11706030
Nov 12. Differential effect of ik3-1/cables on p53- and p73-induced cell death.
|
|
GO:0005515
protein binding
|
IPI
PMID:11877378 Structure of the 53BP1 BRCT region bound to p53 and its comp... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:11877378
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.
|
|
GO:0005515
protein binding
|
IPI
PMID:12006491 Human SIR2 deacetylates p53 and antagonizes PML/p53-induced ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:12006491
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
|
|
GO:0005515
protein binding
|
IPI
PMID:12080348 Nucleophosmin regulates the stability and transcriptional ac... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:12080348
Nucleophosmin regulates the stability and transcriptional activity of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:12620801 Requirement of E6AP and the features of human papillomavirus... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:12620801
Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:12667443
p53 has a direct apoptogenic role at the mitochondria.
|
|
GO:0005515
protein binding
|
IPI
PMID:12692135 P63 alpha mutations lead to aberrant splicing of keratinocyt... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:12692135
2003 Apr 10. P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome.
|
|
GO:0005515
protein binding
|
IPI
PMID:12702766 Characterization of cells and gene-targeted mice deficient f... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:12702766
Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).
|
|
GO:0005515
protein binding
|
IPI
PMID:12915590 Cellular stress and DNA damage invoke temporally distinct Md... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
|
|
GO:0005515
protein binding
|
IPI
PMID:14557665 Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and e... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:14557665
Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx.
|
|
GO:0005515
protein binding
|
IPI
PMID:14627987 PARP-1 binds E2F-1 independently of its DNA binding and cata... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:14627987
PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase.
|
|
GO:0005515
protein binding
|
IPI
PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
|
|
GO:0005515
protein binding
|
IPI
PMID:14759370 Structural mechanism of the bromodomain of the coactivator C... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
|
|
GO:0005515
protein binding
|
IPI
PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membr... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
|
|
GO:0005515
protein binding
|
IPI
PMID:14985081 Hepatitis C virus core protein interacts with p53-binding pr... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
|
|
GO:0005515
protein binding
|
IPI
PMID:15044383 Aprataxin, a novel protein that protects against genotoxic s... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15044383
Mar 25. Aprataxin, a novel protein that protects against genotoxic stress.
|
|
GO:0005515
protein binding
|
IPI
PMID:15068796 C. elegans SGK-1 is the critical component in the Akt/PKB ki... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15068796
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span.
|
|
GO:0005515
protein binding
|
IPI
PMID:15133049 NMR structure of the N-terminal domain of SUMO ligase PIAS1 ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15133049
2004 May 8. NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers.
|
|
GO:0005515
protein binding
|
IPI
PMID:15144954 Nucleolar protein NPM interacts with HDM2 and protects tumor... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15144954
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation.
|
|
GO:0005515
protein binding
|
IPI
PMID:15205477 Calorie restriction promotes mammalian cell survival by indu... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15205477
Jun 17. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
|
|
GO:0005515
protein binding
|
IPI
PMID:15310821 Identification of ASK and clock-associated proteins as molec... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15310821
Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis.
|
|
GO:0005515
protein binding
|
IPI
PMID:15364927 Negative regulation of p53 functions by Daxx and the involve... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15364927
2004 Sep 10. Negative regulation of p53 functions by Daxx and the involvement of MDM2.
|
|
GO:0005515
protein binding
|
IPI
PMID:15525938 Regulation of p53 activity through lysine methylation. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15525938
Regulation of p53 activity through lysine methylation.
|
|
GO:0005515
protein binding
|
IPI
PMID:15542844 p53 Stabilization and accumulation induced by human vaccinia... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15542844
p53 Stabilization and accumulation induced by human vaccinia-related kinase 1.
|
|
GO:0005515
protein binding
|
IPI
PMID:15580310 17beta-Estradiol upregulates and activates WOX1/WWOXv1 and W... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15580310
17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo.
|
|
GO:0005515
protein binding
|
IPI
PMID:15604276 Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p5... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15604276
Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:15660129 The DEAD box protein p68: a novel transcriptional coactivato... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15660129
The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor.
|
|
GO:0005515
protein binding
|
IPI
PMID:15735006 p53 modulates RPA-dependent and RPA-independent WRN helicase... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15735006
p53 modulates RPA-dependent and RPA-independent WRN helicase activity.
|
|
GO:0005515
protein binding
|
IPI
PMID:15782130 BARD1 induces apoptosis by catalysing phosphorylation of p53... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15782130
BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase.
|
|
GO:0005515
protein binding
|
IPI
PMID:15855171 Direct interaction of the N-terminal domain of focal adhesio... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15855171
2005 Apr 25. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:15916963 Loss of HAUSP-mediated deubiquitination contributes to DNA d... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15916963
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2.
|
|
GO:0005515
protein binding
|
IPI
PMID:15960975 Physical association and coordinate function of the H3 K4 me... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15960975
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
|
|
GO:0005515
protein binding
|
IPI
PMID:15989956 ARF-BP1/Mule is a critical mediator of the ARF tumor suppres... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15989956
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.
|
|
GO:0005515
protein binding
|
IPI
PMID:16003391 AtBAG6, a novel calmodulin-binding protein, induces programm... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16003391
AtBAG6, a novel calmodulin-binding protein, induces programmed cell death in yeast and plants.
|
|
GO:0005515
protein binding
|
IPI
PMID:16151013 PUMA couples the nuclear and cytoplasmic proapoptotic functi... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16151013
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:16169070 A human protein-protein interaction network: a resource for ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16169070
A human protein-protein interaction network: a resource for annotating the proteome.
|
|
GO:0005515
protein binding
|
IPI
PMID:16189514 Towards a proteome-scale map of the human protein-protein in... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16189514
Towards a proteome-scale map of the human protein-protein interaction network.
|
|
GO:0005515
protein binding
|
IPI
PMID:16227626 Physical interaction and mutual transrepression between CCAA... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16227626
Oct 14. Physical interaction and mutual transrepression between CCAAT/enhancer-binding protein beta and the p53 tumor suppressor.
|
|
GO:0005515
protein binding
|
IPI
PMID:16319068 Camptothecin induces nuclear export of prohibitin preferenti... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16319068
Nov 30. Camptothecin induces nuclear export of prohibitin preferentially in transformed cells through a CRM-1-dependent mechanism.
|
|
GO:0005515
protein binding
|
IPI
PMID:16322561 NIR is a novel INHAT repressor that modulates the transcript... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:16376338 Protein kinase A phosphorylates and regulates dimerization o... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16376338
2005 Dec 19. Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.
|
|
GO:0005515
protein binding
|
IPI
PMID:16376884 Characterisation of the interface between nucleophosmin (NPM... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16376884
2005 Dec 19. Characterisation of the interface between nucleophosmin (NPM) and p53: potential role in p53 stabilisation.
|
|
GO:0005515
protein binding
|
IPI
PMID:16377624 Protein kinase C delta regulates Ser46 phosphorylation of p5... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16377624
Dec 23. Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage.
|
|
GO:0005515
protein binding
|
IPI
PMID:16402859 Structural basis of competitive recognition of p53 and MDM2 ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16402859
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.
|
|
GO:0005515
protein binding
|
IPI
PMID:16415881 Structural basis for the methylation site specificity of SET... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16415881
Jan 15. Structural basis for the methylation site specificity of SET7/9.
|
|
GO:0005515
protein binding
|
IPI
PMID:16432196 The central region of HDM2 provides a second binding site fo... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16432196
The central region of HDM2 provides a second binding site for p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:16442532 Interaction of metallothionein with tumor suppressor p53 pro... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16442532
2006 Jan 20. Interaction of metallothionein with tumor suppressor p53 protein.
|
|
GO:0005515
protein binding
|
IPI
PMID:16474402 Molecular recognition of p53 and MDM2 by USP7/HAUSP. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16474402
Feb 12. Molecular recognition of p53 and MDM2 by USP7/HAUSP.
|
|
GO:0005515
protein binding
|
IPI
PMID:16493710 Surface plasmon resonance imaging protein arrays for analysi... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16493710
Surface plasmon resonance imaging protein arrays for analysis of triple protein interactions of HPV, E6, E6AP, and p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:16511572 14-3-3gamma binds to MDMX that is phosphorylated by UV-activ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16511572
Mar 2. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.
|
|
GO:0005515
protein binding
|
IPI
PMID:16601686 Tip60 and p400 are both required for UV-induced apoptosis bu... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16601686
Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression.
|
|
GO:0005515
protein binding
|
IPI
PMID:16611888 Targeting of p300/CREB binding protein coactivators by simia... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16611888
Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:16616141 Evidence that low doses of Taxol enhance the functional tran... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16616141
Epub 2006 Mar 29. Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cells.
|
|
GO:0005515
protein binding
|
IPI
PMID:16690937 NS3 protein of Hepatitis C virus associates with the tumour ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16690937
NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner.
|
|
GO:0005515
protein binding
|
IPI
PMID:16713569 A protein-protein interaction network for human inherited at... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16713569
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
|
|
GO:0005515
protein binding
|
IPI
PMID:16732283 Lysine activation and functional analysis of E2-mediated con... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16732283
May 28. Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
|
|
GO:0005515
protein binding
|
IPI
PMID:16753148 Polo-like kinase 1 regulates mitotic arrest after UV irradia... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16753148
Epub 2006 May 30. Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation.
|
|
GO:0005515
protein binding
|
IPI
PMID:16793543 Structure of the Tfb1/p53 complex: Insights into the interac... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16793543
Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:16845383 Critical role for Daxx in regulating Mdm2. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16845383
Critical role for Daxx in regulating Mdm2.
|
|
GO:0005515
protein binding
|
IPI
PMID:16847267 MAGE-A tumor antigens target p53 transactivation function th... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16847267
MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents.
|
|
GO:0005515
protein binding
|
IPI
PMID:16951253 Crystal structure of SV40 large T-antigen bound to p53: inte... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16951253
Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor.
|
|
GO:0005515
protein binding
|
IPI
PMID:16959611 Gain of function of mutant p53: the mutant p53/NF-Y protein ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16959611
Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation.
|
|
GO:0005515
protein binding
|
IPI
PMID:17080083 Inactivation of the p53 pathway in retinoblastoma. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17080083
Inactivation of the p53 pathway in retinoblastoma.
|
|
GO:0005515
protein binding
|
IPI
PMID:17098746 FBXO11 promotes the Neddylation of p53 and inhibits its tran... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17098746
2006 Nov 9. FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity.
|
|
GO:0005515
protein binding
|
IPI
PMID:17108971 Repression of p53 activity by Smyd2-mediated methylation. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17108971
Repression of p53 activity by Smyd2-mediated methylation.
|
|
GO:0005515
protein binding
|
IPI
PMID:17139261 p53 mediates the negative regulation of MDM2 by orphan recep... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17139261
Nov 30. p53 mediates the negative regulation of MDM2 by orphan receptor TR3.
|
|
GO:0005515
protein binding
|
IPI
PMID:17159902 An essential function of the extreme C-terminus of MDM2 can ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17159902
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX.
|
|
GO:0005515
protein binding
|
IPI
PMID:17170702 Cytoplasmic destruction of p53 by the endoplasmic reticulum-... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17170702
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.
|
|
GO:0005515
protein binding
|
IPI
PMID:17184779 Identification of differential proteins in nasopharyngeal ca... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17184779
2006 Dec 13. Identification of differential proteins in nasopharyngeal carcinoma cells with p53 silence by proteome analysis.
|
|
GO:0005515
protein binding
|
IPI
PMID:17245430 A specific PP2A regulatory subunit, B56gamma, mediates DNA d... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17245430
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
|
|
GO:0005515
protein binding
|
IPI
PMID:17254968 PRAK is essential for ras-induced senescence and tumor suppr... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17254968
PRAK is essential for ras-induced senescence and tumor suppression.
|
|
GO:0005515
protein binding
|
IPI
PMID:17268548 Monoubiquitylation promotes mitochondrial p53 translocation. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17268548
Monoubiquitylation promotes mitochondrial p53 translocation.
|
|
GO:0005515
protein binding
|
IPI
PMID:17274640 A limited screen for protein interactions reveals new roles ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17274640
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
|
|
GO:0005515
protein binding
|
IPI
PMID:17290220 The deubiquitinating enzyme USP2a regulates the p53 pathway ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17290220
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.
|
|
GO:0005515
protein binding
|
IPI
PMID:17298945 The conserved CPH domains of Cul7 and PARC are protein-prote... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17298945
2007 Feb 12. The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:17310983 Ribosomal protein S7 as a novel modulator of p53-MDM2 intera... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
|
|
GO:0005515
protein binding
|
IPI
PMID:17347673 Stra13 is induced by genotoxic stress and regulates ionizing... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17347673
Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis.
|
|
GO:0005515
protein binding
|
IPI
PMID:17438265 Four domains of p300 each bind tightly to a sequence spannin... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17438265
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:17470788 PACT is a negative regulator of p53 and essential for cell g... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17470788
PACT is a negative regulator of p53 and essential for cell growth and embryonic development.
|
|
GO:0005515
protein binding
|
IPI
PMID:17482142 Attenuation of DNA damage checkpoint by PBK, a novel mitotic... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17482142
Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:17568776 Phosphorylation of Pirh2 by calmodulin-dependent kinase II i... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17568776
Jun 14. Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to de... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
|
|
GO:0005515
protein binding
|
IPI
PMID:17662718 Protein-protein interactions among human lens acidic and bas... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17662718
Epub 2007 Jul 23. Protein-protein interactions among human lens acidic and basic beta-crystallins.
|
|
GO:0005515
protein binding
|
IPI
PMID:17719542 hCAS/CSE1L associates with chromatin and regulates expressio... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17719542
hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes.
|
|
GO:0005515
protein binding
|
IPI
PMID:17805299 p53 is regulated by the lysine demethylase LSD1. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17805299
p53 is regulated by the lysine demethylase LSD1.
|
|
GO:0005515
protein binding
|
IPI
PMID:17875722 Efficient p53 activation and apoptosis by simultaneous disru... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17875722
Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX.
|
|
GO:0005515
protein binding
|
IPI
PMID:17906639 The prolyl isomerase Pin1 orchestrates p53 acetylation and d... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17906639
Sep 30. The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP.
|
|
GO:0005515
protein binding
|
IPI
PMID:17964266 Active regulator of SIRT1 cooperates with SIRT1 and facilita... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17964266
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity.
|
|
GO:0005515
protein binding
|
IPI
PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
|
|
GO:0005515
protein binding
|
IPI
PMID:18172499 NUMB controls p53 tumour suppressor activity. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18172499
NUMB controls p53 tumour suppressor activity.
|
|
GO:0005515
protein binding
|
IPI
PMID:18230339 Activation of p53-dependent responses in tumor cells treated... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18230339
Activation of p53-dependent responses in tumor cells treated with a PARC-interacting peptide.
|
|
GO:0005515
protein binding
|
IPI
PMID:18235501 DBC1 is a negative regulator of SIRT1. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18235501
DBC1 is a negative regulator of SIRT1.
|
|
GO:0005515
protein binding
|
IPI
PMID:18235502 Negative regulation of the deacetylase SIRT1 by DBC1. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18235502
Negative regulation of the deacetylase SIRT1 by DBC1.
|
|
GO:0005515
protein binding
|
IPI
PMID:18275817 Biochemical and structural studies of ASPP proteins reveal d... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18275817
Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73.
|
|
GO:0005515
protein binding
|
IPI
PMID:18309296 Proteasome activator PA28 gamma regulates p53 by enhancing i... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18309296
Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation.
|
|
GO:0005515
protein binding
|
IPI
PMID:18316739 Temporal activation of p53 by a specific MDM2 inhibitor is s... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18316739
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition.
|
|
GO:0005515
protein binding
|
IPI
PMID:18354501 Structural insight into the TFIIE-TFIIH interaction: TFIIE a... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18354501
Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH.
|
|
GO:0005515
protein binding
|
IPI
PMID:18388957 NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal de... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18388957
NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b).
|
|
GO:0005515
protein binding
|
IPI
PMID:18391200 Structure of tumor suppressor p53 and its intrinsically diso... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18391200
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.
|
|
GO:0005515
protein binding
|
IPI
PMID:18485870 Acetylation is indispensable for p53 activation. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18485870
Acetylation is indispensable for p53 activation.
|
|
GO:0005515
protein binding
|
IPI
PMID:18504427 Twist and p53 reciprocally regulate target genes via direct ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18504427
Twist and p53 reciprocally regulate target genes via direct interaction.
|
|
GO:0005515
protein binding
|
IPI
PMID:18510931 Ectodermal factor restricts mesoderm differentiation by inhi... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18510931
Ectodermal factor restricts mesoderm differentiation by inhibiting p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:18566590 The tumour suppressor RASSF1A promotes MDM2 self-ubiquitinat... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18566590
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex.
|
|
GO:0005515
protein binding
|
IPI
PMID:18624398 Protein interaction data set highlighted with human Ras-MAPK... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18624398
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
|
|
GO:0005515
protein binding
|
IPI
PMID:18656471 Microtubule-associated protein 1B light chain (MAP1B-LC1) ne... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18656471
Epub 2008 Jul 24. Microtubule-associated protein 1B light chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells.
|
|
GO:0005515
protein binding
|
IPI
PMID:18695251 AIMP2/p38, the scaffold for the multi-tRNA synthetase comple... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18695251
AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:18812399 14-3-3 activation of DNA binding of p53 by enhancing its ass... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18812399
Sep 23. 14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers.
|
|
GO:0005515
protein binding
|
IPI
PMID:18952844 Inhibition of Thr-55 phosphorylation restores p53 nuclear lo... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18952844
Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage.
|
|
GO:0005515
protein binding
|
IPI
PMID:18977328 Inactivation of the CYLD deubiquitinase by HPV E6 mediates h... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18977328
Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation.
|
|
GO:0005515
protein binding
|
IPI
PMID:19008854 Interferon-inducible protein, P56, inhibits HPV DNA replicat... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19008854
Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1.
|
|
GO:0005515
protein binding
|
IPI
PMID:19043414 Molecular basis of Pirh2-mediated p53 ubiquitylation. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19043414
2008 Nov 30. Molecular basis of Pirh2-mediated p53 ubiquitylation.
|
|
GO:0005515
protein binding
|
IPI
PMID:19098711 RYBP stabilizes p53 by modulating MDM2. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19098711
RYBP stabilizes p53 by modulating MDM2.
|
|
GO:0005515
protein binding
|
IPI
PMID:19166840 FKBP25, a novel regulator of the p53 pathway, induces the de... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19166840
2009 Jan 21. FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:19196987 Phosphorylation of p53 by IkappaB kinase 2 promotes its degr... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19196987
Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.
|
|
GO:0005515
protein binding
|
IPI
PMID:19217391 Structural basis for p300 Taz2-p53 TAD1 binding and modulati... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19217391
Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation.
|
|
GO:0005515
protein binding
|
IPI
PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabiliz... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
|
|
GO:0005515
protein binding
|
IPI
PMID:19255450 Structural basis for high-affinity peptide inhibition of p53... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19255450
Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
|
|
GO:0005515
protein binding
|
IPI
PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
|
|
GO:0005515
protein binding
|
IPI
PMID:19345189 A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-ind... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19345189
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis.
|
|
GO:0005515
protein binding
|
IPI
PMID:19411066 Regulation of XIAP translation and induction by MDM2 followi... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19411066
Regulation of XIAP translation and induction by MDM2 following irradiation.
|
|
GO:0005515
protein binding
|
IPI
PMID:19433796 A tumor suppressive coactivator complex of p53 containing AS... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19433796
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.
|
|
GO:0005515
protein binding
|
IPI
PMID:19508870 TOE1 interacts with p53 to modulate its transactivation pote... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19508870
Epub 2009 Jun 7. TOE1 interacts with p53 to modulate its transactivation potential.
|
|
GO:0005515
protein binding
|
IPI
PMID:19521340 MDM4 (MDMX) localizes at the mitochondria and facilitates th... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19521340
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway.
|
|
GO:0005515
protein binding
|
IPI
PMID:19536131 Differential regulation of p53 and p21 by MKRN1 E3 ligase co... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19536131
Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.
|
|
GO:0005515
protein binding
|
IPI
PMID:19556538 Trim24 targets endogenous p53 for degradation. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19556538
Trim24 targets endogenous p53 for degradation.
|
|
GO:0005515
protein binding
|
IPI
PMID:19619542 Mdmx enhances p53 ubiquitination by altering the substrate p... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19619542
2009 Jul 18. Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase.
|
|
GO:0005515
protein binding
|
IPI
PMID:19626115 Modulation of microRNA processing by p53. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19626115
Modulation of microRNA processing by p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:19651603 Structural basis for subversion of cellular control mechanis... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19651603
Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein.
|
|
GO:0005515
protein binding
|
IPI
PMID:19656744 Ribosomal protein S3: A multi-functional protein that intera... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19656744
Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain.
|
|
GO:0005515
protein binding
|
IPI
PMID:19680552 CK2 is the regulator of SIRT1 substrate-binding affinity, de... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19680552
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.
|
|
GO:0005515
protein binding
|
IPI
PMID:19684601 A molecular basis for phosphorylation-dependent SUMO conjuga... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19684601
Aug 16. A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9.
|
|
GO:0005515
protein binding
|
IPI
PMID:19740107 Epidermal growth factor receptor ligands as new extracellula... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19740107
2009 Sep 9. Epidermal growth factor receptor ligands as new extracellular targets for the metastasis-promoting S100A4 protein.
|
|
GO:0005515
protein binding
|
IPI
PMID:19798103 Efficient protection and isolation of ubiquitylated proteins... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19798103
Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities.
|
|
GO:0005515
protein binding
|
IPI
PMID:19805293 CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p5... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19805293
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:19833129 Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimula... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19833129
Epub 2009 Oct 13. Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover.
|
|
GO:0005515
protein binding
|
IPI
PMID:19857493 Role of p53/FAK association and p53Ser46 phosphorylation in ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19857493
Epub 2009 Oct 24. Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175H.
|
|
GO:0005515
protein binding
|
IPI
PMID:19933256 Mechanistic differences in the transcriptional activation of... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19933256
Nov 20. Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms.
|
|
GO:0005515
protein binding
|
IPI
PMID:20075864 Coordinated regulation of p53 apoptotic targets BAX and PUMA... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20075864
Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element.
|
|
GO:0005515
protein binding
|
IPI
PMID:20134482 Skp2B attenuates p53 function by inhibiting prohibitin. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20134482
Skp2B attenuates p53 function by inhibiting prohibitin.
|
|
GO:0005515
protein binding
|
IPI
PMID:20153329 Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 int... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20153329
2010 Feb 12. Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins--identification of additional interacting regions.
|
|
GO:0005515
protein binding
|
IPI
PMID:20159018 Identification and characterization of the novel protein CCD... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20159018
Epub 2010 Feb 14. Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation.
|
|
GO:0005515
protein binding
|
IPI
PMID:20167603 DYRK1A and DYRK3 promote cell survival through phosphorylati... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20167603
2010 Feb 18. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
|
|
GO:0005515
protein binding
|
IPI
PMID:20173098 RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20173098
RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.
|
|
GO:0005515
protein binding
|
IPI
PMID:20206173 Structure of the p53 C-terminus bound to 14-3-3: implication... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20206173
2010 Mar 3. Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer.
|
|
GO:0005515
protein binding
|
IPI
PMID:20227041 Modulation of the vitamin D3 response by cancer-associated m... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20227041
Modulation of the vitamin D3 response by cancer-associated mutant p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:20228809 BRD7 is a candidate tumour suppressor gene required for p53 ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20228809
BRD7 is a candidate tumour suppressor gene required for p53 function.
|
|
GO:0005515
protein binding
|
IPI
PMID:20385133 p53 inhibits tumor cell invasion via the degradation of snai... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20385133
2010 Apr 10. p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma.
|
|
GO:0005515
protein binding
|
IPI
PMID:20421506 Mapping the physical and functional interactions between the... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20421506
Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.
|
|
GO:0005515
protein binding
|
IPI
PMID:20452352 A novel hPirh2 splicing variant without ubiquitin protein li... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20452352
2010 May 7. A novel hPirh2 splicing variant without ubiquitin protein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma.
|
|
GO:0005515
protein binding
|
IPI
PMID:20515689 MDM4 binds ligands via a mechanism in which disordered regio... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20515689
Epub 2010 May 31. MDM4 binds ligands via a mechanism in which disordered regions become structured.
|
|
GO:0005515
protein binding
|
IPI
PMID:20534433 Synaptonemal complex formation and meiotic checkpoint signal... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20534433
Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.
|
|
GO:0005515
protein binding
|
IPI
PMID:20562916 Dual-specificity phosphatase 26 is a novel p53 phosphatase a... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20562916
Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma.
|
|
GO:0005515
protein binding
|
IPI
PMID:20591429 S100 proteins interact with the N-terminal domain of MDM2. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20591429
Epub 2010 Jun 19. S100 proteins interact with the N-terminal domain of MDM2.
|
|
GO:0005515
protein binding
|
IPI
PMID:20622899 PBK/TOPK interacts with the DBD domain of tumor suppressor p... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20622899
PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21.
|
|
GO:0005515
protein binding
|
IPI
PMID:20660729 Polybromo-associated BRG1-associated factor components BRD7 ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20660729
Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.
|
|
GO:0005515
protein binding
|
IPI
PMID:20705607 Turning the RING domain protein MdmX into an active ubiquiti... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20705607
Epub 2010 Aug 12. Turning the RING domain protein MdmX into an active ubiquitin-protein ligase.
|
|
GO:0005515
protein binding
|
IPI
PMID:20708156 Phosphorylation by casein kinase I promotes the turnover of ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20708156
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.
|
|
GO:0005515
protein binding
|
IPI
PMID:20713054 ARF-dependent regulation of ATM and p53 associated KZNF (Apa... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20713054
Epub 2010 Aug 14. ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress.
|
|
GO:0005515
protein binding
|
IPI
PMID:20864041 MAGE-RING protein complexes comprise a family of E3 ubiquiti... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20864041
MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.
|
|
GO:0005515
protein binding
|
IPI
PMID:21057547 AXIN is an essential co-activator for the promyelocytic leuk... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21057547
Nov 8. AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.
|
|
GO:0005515
protein binding
|
IPI
PMID:21078964 p53-mediated apoptosis requires inositol hexakisphosphate ki... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21078964
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2.
|
|
GO:0005515
protein binding
|
IPI
PMID:21081126 Anti-apoptotic protein TCTP controls the stability of the tu... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21081126
2010 Nov 17. Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:21130767 SAFB1 interacts with and suppresses the transcriptional acti... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21130767
2010 Dec 3. SAFB1 interacts with and suppresses the transcriptional activity of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:21132010 GNL3L depletion destabilizes MDM2 and induces p53-dependent ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21132010
GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest.
|
|
GO:0005515
protein binding
|
IPI
PMID:21170034 TSPYL5 suppresses p53 levels and function by physical intera... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21170034
TSPYL5 suppresses p53 levels and function by physical interaction with USP7.
|
|
GO:0005515
protein binding
|
IPI
PMID:21170087 Ribosomal protein S27-like and S27 interplay with p53-MDM2 a... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21170087
Dec 20. Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator.
|
|
GO:0005515
protein binding
|
IPI
PMID:21245319 Methyltransferase Set7/9 regulates p53 activity by interacti... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21245319
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).
|
|
GO:0005515
protein binding
|
IPI
PMID:21317932 A new role of NUAK1: directly phosphorylating p53 and regula... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21317932
A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation.
|
|
GO:0005515
protein binding
|
IPI
PMID:21390126 Inactivating mutations of acetyltransferase genes in B-cell ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21390126
Inactivating mutations of acetyltransferase genes in B-cell lymphoma.
|
|
GO:0005515
protein binding
|
IPI
PMID:21397192 Interferon-inducible protein 16: insight into the interactio... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21397192
Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:21423215 Camptothecin-induced downregulation of MLL5 contributes to t... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21423215
Camptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:21460856 ATM-mediated phosphorylation activates the tumor-suppressive... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21460856
ATM-mediated phosphorylation activates the tumor-suppressive function of B56Ξ³-PP2A.
|
|
GO:0005515
protein binding
|
IPI
PMID:21471221 Novel nucleolar pathway connecting intracellular energy stat... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21471221
2011 Apr 6. Novel nucleolar pathway connecting intracellular energy status with p53 activation.
|
|
GO:0005515
protein binding
|
IPI
PMID:21513714 The ASPP proteins complex and cooperate with p300 to modulat... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21513714
Epub 2011 Apr 18. The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:21625211 COP9 signalosome subunit 6 stabilizes COP1, which functions ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21625211
COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3Ο.
|
|
GO:0005515
protein binding
|
IPI
PMID:21653829 Protein interactome reveals converging molecular pathways am... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21653829
Protein interactome reveals converging molecular pathways among autism disorders.
|
|
GO:0005515
protein binding
|
IPI
PMID:21670263 Structural and functional characterization of an atypical ac... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21670263
Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF).
|
|
GO:0005515
protein binding
|
IPI
PMID:21726810 Caspase-2-mediated cleavage of Mdm2 creates a p53-induced po... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21726810
Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.
|
|
GO:0005515
protein binding
|
IPI
PMID:21741598 A Pin1/mutant p53 axis promotes aggressiveness in breast can... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21741598
A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.
|
|
GO:0005515
protein binding
|
IPI
PMID:21782458 Structural basis of substrate methylation and inhibition of ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21782458
Jul 21. Structural basis of substrate methylation and inhibition of SMYD2.
|
|
GO:0005515
protein binding
|
IPI
PMID:21821029 Aurora-A phosphorylates hnRNPK and disrupts its interaction ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21821029
2011 Aug 3. Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:21831840 Wild-type p53 controls cell motility and invasion by dual re... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21831840
Wild-type p53 controls cell motility and invasion by dual regulation of MET expression.
|
|
GO:0005515
protein binding
|
IPI
PMID:21857681 A stress response pathway regulates DNA damage through Ξ²2-ad... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21857681
A stress response pathway regulates DNA damage through Ξ²2-adrenoreceptors and Ξ²-arrestin-1.
|
|
GO:0005515
protein binding
|
IPI
PMID:21892170 Structural analysis of the interaction between Hsp90 and the... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21892170
Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:21900206 A directed protein interaction network for investigating int... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21900206
A directed protein interaction network for investigating intracellular signal transduction.
|
|
GO:0005515
protein binding
|
IPI
PMID:21952639 NIRF constitutes a nodal point in the cell cycle network and... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21952639
Oct 1. NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.
|
|
GO:0005515
protein binding
|
IPI
PMID:21988832 Toward an understanding of the protein interaction network o... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
|
|
GO:0005515
protein binding
|
IPI
PMID:22056774 Bilateral inhibition of HAUSP deubiquitinase by a viral inte... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22056774
Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein.
|
|
GO:0005515
protein binding
|
IPI
PMID:22085928 Regulation of p53 stability and function by the deubiquitina... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22085928
Regulation of p53 stability and function by the deubiquitinating enzyme USP42.
|
|
GO:0005515
protein binding
|
IPI
PMID:22103682 Specific domains of nucleolin interact with Hdm2 and antagon... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22103682
2011 Dec 19. Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination.
|
|
GO:0005515
protein binding
|
IPI
PMID:22124327 Positive regulation of p53 stability and activity by the deu... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22124327
Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.
|
|
GO:0005515
protein binding
|
IPI
PMID:22265415 Mutant p53 disrupts mammary tissue architecture via the meva... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22265415
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.
|
|
GO:0005515
protein binding
|
IPI
PMID:22340593 Aurora kinase-A inactivates DNA damage-induced apoptosis and... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22340593
Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73.
|
|
GO:0005515
protein binding
|
IPI
PMID:22451927 Role of the translationally controlled tumor protein in DNA ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22451927
Role of the translationally controlled tumor protein in DNA damage sensing and repair.
|
|
GO:0005515
protein binding
|
IPI
PMID:22499945 Atg7 modulates p53 activity to regulate cell cycle and survi... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22499945
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress.
|
|
GO:0005515
protein binding
|
IPI
PMID:22510990 AKT-dependent phosphorylation of Niban regulates nucleophosm... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22510990
AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis.
|
|
GO:0005515
protein binding
|
IPI
PMID:22575647 An autoregulatory feedback loop between Mdm2 and SHP that fi... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22575647
Epub 2012 Mar 23. An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability.
|
|
GO:0005515
protein binding
|
IPI
PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-s... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
|
|
GO:0005515
protein binding
|
IPI
PMID:22659184 Mutational analysis reveals a dual role of Mdm2 acidic domai... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22659184
Epub 2012 May 31. Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability.
|
|
GO:0005515
protein binding
|
IPI
PMID:22723347 Differentiated embryo-chondrocyte expressed gene 1 regulates... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22723347
Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1.
|
|
GO:0005515
protein binding
|
IPI
PMID:22726440 p53 opens the mitochondrial permeability transition pore to ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22726440
p53 opens the mitochondrial permeability transition pore to trigger necrosis.
|
|
GO:0005515
protein binding
|
IPI
PMID:22810585 Viral immune modulators perturb the human molecular network ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22810585
Viral immune modulators perturb the human molecular network by common and unique strategies.
|
|
GO:0005515
protein binding
|
IPI
PMID:22810586 Interpreting cancer genomes using systematic host network pe... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22810586
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.
|
|
GO:0005515
protein binding
|
IPI
PMID:22819825 TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degrada... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22819825
Epub 2012 Jul 20. TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation.
|
|
GO:0005515
protein binding
|
IPI
PMID:22975381 A "twist box" code of p53 inactivation: twist box: p53 inter... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22975381
A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation.
|
|
GO:0005515
protein binding
|
IPI
PMID:23010591 Structural features of human histone acetyltransferase p300 ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:23010591
2012 Sep 23. Structural features of human histone acetyltransferase p300 and its complex with p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:23063560 HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 tra... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:23063560
2012 Oct 11. HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 transactivation domain interaction, regulated by the acidic tail.
|
|
GO:0005515
protein binding
|
IPI
PMID:23092970 SUMOylation of hnRNP-K is required for p53-mediated cell-cyc... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:23092970
SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage.
|
|
GO:0005515
protein binding
|
IPI
PMID:23320542 Evidence for self-association of the alternative sigma facto... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:23320542
Evidence for self-association of the alternative sigma factor Ο54.
|
|
GO:0005515
protein binding
|
IPI
PMID:23576507 Rotavirus-encoded nonstructural protein 1 modulates cellular... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:23576507
Rotavirus-encoded nonstructural protein 1 modulates cellular apoptotic machinery by targeting tumor suppressor protein p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:23623661 Restoring p53 function in human melanoma cells by inhibiting... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:23623661
2013 Apr 25. Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.
|
|
GO:0005515
protein binding
|
IPI
PMID:23734815 Fludarabine treatment favors the retention of miR-485-3p by ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:23734815
Fludarabine treatment favors the retention of miR-485-3p by prostate cancer cells: implications for survival.
|
|
GO:0005515
protein binding
|
IPI
PMID:23752197 S100A4 interacts with p53 in the nucleus and promotes p53 de... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:23752197
S100A4 interacts with p53 in the nucleus and promotes p53 degradation.
|
|
GO:0005515
protein binding
|
IPI
PMID:23776060 Identification of a second Nutlin-3 responsive interaction s... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:23776060
Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry.
|
|
GO:0005515
protein binding
|
IPI
PMID:23870121 SET1 and p300 act synergistically, through coupled histone m... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:23870121
SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:24207125 Transient protein states in designing inhibitors of the MDM2... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:24207125
2013 Oct 24. Transient protein states in designing inhibitors of the MDM2-p53 interaction.
|
|
GO:0005515
protein binding
|
IPI
PMID:24219989 Acetylation of p53 stimulates miRNA processing and determine... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:24219989
Nov 12. Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress.
|
|
GO:0005515
protein binding
|
IPI
PMID:24380853 The aberrant expression and localization of prohibitin durin... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:24380853
2013 Dec 28. The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells.
|
|
GO:0005515
protein binding
|
IPI
PMID:24449765 Activation of p53 transcriptional activity by SMRT: a histon... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:24449765
Jan 21. Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor.
|
|
GO:0005515
protein binding
|
IPI
PMID:24492002 VRK1 interacts with p53 forming a basal complex that is acti... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:24492002
2014 Jan 31. VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage.
|
|
GO:0005515
protein binding
|
IPI
PMID:24667498 JMJD6 promotes colon carcinogenesis through negative regulat... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:24667498
eCollection 2014 Mar.
|
|
GO:0005515
protein binding
|
IPI
PMID:24722188 Protein interaction network of alternatively spliced isoform... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:24722188
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
|
|
GO:0005515
protein binding
|
IPI
PMID:24814347 The DNA-binding domain mediates both nuclear and cytosolic f... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:24814347
May 11. The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:25241761 Using an in situ proximity ligation assay to systematically ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:25241761
Oct 9. Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
|
|
GO:0005515
protein binding
|
IPI
PMID:25314079 Acetylation of snail modulates the cytokinome of cancer cell... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:25314079
Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages.
|
|
GO:0005515
protein binding
|
IPI
PMID:25402006 In silico prediction of physical protein interactions and ch... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
|
|
GO:0005515
protein binding
|
IPI
PMID:25502805 A massively parallel pipeline to clone DNA variants and exam... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:25502805
eCollection 2014 Dec.
|
|
GO:0005515
protein binding
|
IPI
PMID:25579814 Structural plasticity of methyllysine recognition by the tan... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:25579814
Jan 8. Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1.
|
|
GO:0005515
protein binding
|
IPI
PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
|
|
GO:0005515
protein binding
|
IPI
PMID:25651062 An acetyl-methyl switch drives a conformational change in p5... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:25651062
An acetyl-methyl switch drives a conformational change in p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:25670079 14-3-3ΞΆ turns TGF-Ξ²'s function from tumor suppressor to meta... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:25670079
14-3-3ΞΆ turns TGF-Ξ²'s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2.
|
|
GO:0005515
protein binding
|
IPI
PMID:25837623 Regulation of protein quality control by UBE4B and LSD1 thro... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:25837623
eCollection 2015 Apr.
|
|
GO:0005515
protein binding
|
IPI
PMID:25857266 Pontin, a new mutant p53-binding protein, promotes gain-of-f... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:25857266
2015 Apr 10. Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:26302407 Combined CSL and p53 downregulation promotes cancer-associat... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:26302407
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.
|
|
GO:0005515
protein binding
|
IPI
PMID:26331536 Gain-of-function p53 mutants co-opt chromatin pathways to dr... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:26331536
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.
|
|
GO:0005515
protein binding
|
IPI
PMID:26789255 Structure of the E6/E6AP/p53 complex required for HPV-mediat... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:26789255
Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:27107012 Pooled-matrix protein interaction screens using Barcode Fusi... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:27107012
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
|
|
GO:0005515
protein binding
|
IPI
PMID:27519799 p53 down-regulates SARS coronavirus replication and is targe... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:27519799
p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1.
|
|
GO:0005515
protein binding
|
IPI
PMID:27605672 Mitogen-Activated Protein Kinase Kinase 2, a Novel E2-Intera... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:27605672
Nov 15. Mitogen-Activated Protein Kinase Kinase 2, a Novel E2-Interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway.
|
|
GO:0005515
protein binding
|
IPI
PMID:29187402 The E3 Ligase RING1 Targets p53 for Degradation and Promotes... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:29187402
Epub 2017 Nov 29. The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival.
|
|
GO:0005515
protein binding
|
IPI
PMID:29340707 VRK1 and AURKB form a complex that cross inhibit their kinas... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:29340707
Epub 2018 Jan 16. VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.
|
|
GO:0005515
protein binding
|
IPI
PMID:29997244 LuTHy: a double-readout bioluminescence-based two-hybrid tec... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:29997244
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
|
|
GO:0005515
protein binding
|
IPI
PMID:31467278 Maximizing binary interactome mapping with a minimal number ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:31467278
Maximizing binary interactome mapping with a minimal number of assays.
|
|
GO:0005515
protein binding
|
IPI
PMID:31511497 miR-146a attenuates apoptosis and modulates autophagy by tar... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:31511497
miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity.
|
|
GO:0005515
protein binding
|
IPI
PMID:31515488 Extensive disruption of protein interactions by genetic vari... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:31515488
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
|
|
GO:0005515
protein binding
|
IPI
PMID:31837246 High-throughput competitive fluorescence polarization assay ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
|
|
GO:0005515
protein binding
|
IPI
PMID:32606738 P55PIK Regulates P53-Dependent Apoptosis in Cancer Cells by ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:32606738
eCollection 2020. P55PIK Regulates P53-Dependent Apoptosis in Cancer Cells by Interacting with P53 DNA-Specific Domain.
|
|
GO:0005515
protein binding
|
IPI
PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
|
|
GO:0005515
protein binding
|
IPI
PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:33961781
2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
|
|
GO:0005515
protein binding
|
IPI
PMID:34316702 Elucidation of the BMI1 interactome identifies novel regulat... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:34316702
2021 Mar. Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.
|
|
GO:0005515
protein binding
|
IPI
PMID:34591612 A protein interaction landscape of breast cancer. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:34591612
Oct 1. A protein interaction landscape of breast cancer.
|
|
GO:0005515
protein binding
|
IPI
PMID:34591642 A protein network map of head and neck cancer reveals PIK3CA... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:34591642
Oct 1. A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
|
|
GO:0005515
protein binding
|
IPI
PMID:35044719 Proteome-scale mapping of binding sites in the unstructured ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:35044719
Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.
|
|
GO:0005515
protein binding
|
IPI
PMID:35140242 Human transcription factor protein interaction networks. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:35140242
Human transcription factor protein interaction networks.
|
|
GO:0005515
protein binding
|
IPI
PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:35271311
2022 Mar 11. OpenCell: Endogenous tagging for the cartography of human cellular organization.
|
|
GO:0005515
protein binding
|
IPI
PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
|
|
GO:0005515
protein binding
|
IPI
PMID:36931259 A central chaperone-like role for 14-3-3 proteins in human c... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:36931259
A central chaperone-like role for 14-3-3 proteins in human cells.
|
|
GO:0005515
protein binding
|
IPI
PMID:39009827 Proteome-scale characterisation of motif-based interactome r... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:39009827
2024 Jul 15. Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.
|
|
GO:0005515
protein binding
|
IPI
PMID:7799929 Two domains of p53 interact with the TATA-binding protein, a... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:7799929
Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression.
|
|
GO:0005515
protein binding
|
IPI
PMID:8207801 Inhibition of p53 DNA binding by human papillomavirus E6 pro... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:8207801
Inhibition of p53 DNA binding by human papillomavirus E6 proteins.
|
|
GO:0005515
protein binding
|
IPI
PMID:8344494 Identification of mutations in p53 that affect its binding t... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:8344494
Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system.
|
|
GO:0005515
protein binding
|
IPI
PMID:8875926 Structure of the p53 tumor suppressor bound to the ankyrin a... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:8875926
Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.
|
|
GO:0005515
protein binding
|
IPI
PMID:8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor sup... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:8875929
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
|
|
GO:0005515
protein binding
|
IPI
PMID:9050995 Identification of p53 unbound to T-antigen in human cells tr... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:9050995
Identification of p53 unbound to T-antigen in human cells transformed by simian virus 40 T-antigen.
|
|
GO:0005515
protein binding
|
IPI
PMID:9188558 Nuclear localization of the NS3 protein of hepatitis C virus... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:9188558
Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization.
|
|
GO:0005515
protein binding
|
IPI
PMID:9194564 Synergistic activation of transcription by CBP and p53. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:9194564
Synergistic activation of transcription by CBP and p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:9380510 Interaction of p53 with the human Rad51 protein. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:9380510
Interaction of p53 with the human Rad51 protein.
|
|
GO:0005515
protein binding
|
IPI
PMID:9472015 High mobility group protein-1 (HMG-1) is a unique activator ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:9472015
High mobility group protein-1 (HMG-1) is a unique activator of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:9807817 An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKB... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:9807817
An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506.
|
|
GO:0005515
protein binding
|
IPI
PMID:9827557 Complex formation of the nonstructural protein 3 of hepatiti... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:9827557
Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:10876243 Structure of the negative regulatory domain of p53 bound to ... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:14759370 Structural mechanism of the bromodomain of the coactivator C... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:14985081 Hepatitis C virus core protein interacts with p53-binding pr... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:16291740 Charge modification at multiple C-terminal lysine residues r... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:16461914 Core domain interactions in full-length p53 in solution. |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to de... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implicat... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:20004160 Averaging of electron subtomograms and random conical tilt r... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:20159469 Crystal structure of the p53 core domain bound to a full con... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:20364130 Diversity in DNA recognition by p53 revealed by crystal stru... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:21178074 Electron microscopy studies on the quaternary structure of p... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics ... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:21988832 Toward an understanding of the protein interaction network o... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-s... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:22972749 Domain-domain interactions in full-length p53 and a specific... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:25402006 In silico prediction of physical protein interactions and ch... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and ... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:31837246 High-throughput competitive fluorescence polarization assay ... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei... |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0017053
transcription repressor complex
|
IPI
PMID:18677113 Structure of the human Mdmx protein bound to the p53 tumor s... |
ACCEPT |
Summary: p53 functions within transcriptional regulator complexes to control gene expression.
Reason: Core function - p53 forms complexes with transcriptional machinery and co-factors.
Supporting Evidence:
TP53-deep-research
Complex formation with transcriptional co-activators (CBP/p300, TFIID)
PMID:18677113
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.
PMID:8875929
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
|
|
GO:0017053
transcription repressor complex
|
IPI
PMID:8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor sup... |
ACCEPT |
Summary: p53 functions within transcriptional regulator complexes to control gene expression.
Reason: Core function - p53 forms complexes with transcriptional machinery and co-factors.
Supporting Evidence:
TP53-deep-research
Complex formation with transcriptional co-activators (CBP/p300, TFIID)
PMID:18677113
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.
PMID:8875929
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
|
|
GO:0045892
negative regulation of DNA-templated transcription
|
NAS
PMID:16492744 Mdm4 and Mdm2 cooperate to inhibit p53 activity in prolifera... |
ACCEPT |
Summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes.
Reason: Core function - p53 acts as both a transcriptional activator and repressor.
Supporting Evidence:
TP53-deep-research
Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes
PMID:16492744
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.
PMID:9271120
Repression of p53-mediated transcription by MDM2: a dual mechanism.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:24051492
p53 regulates Period2 expression and the circadian clock.
|
|
GO:0045892
negative regulation of DNA-templated transcription
|
IDA
PMID:9271120 Repression of p53-mediated transcription by MDM2: a dual mec... |
ACCEPT |
Summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes.
Reason: Core function - p53 acts as both a transcriptional activator and repressor.
Supporting Evidence:
TP53-deep-research
Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes
PMID:16492744
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.
PMID:9271120
Repression of p53-mediated transcription by MDM2: a dual mechanism.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:24051492
p53 regulates Period2 expression and the circadian clock.
|
|
GO:0000977
RNA polymerase II transcription regulatory region sequence-specific DNA binding
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 binds to RNA polymerase II cis-regulatory regions in target gene promoters.
Reason: Core molecular function - sequence-specific DNA binding is essential for p53 transcription factor activity.
Supporting Evidence:
TP53-deep-research
TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements
|
|
GO:0000978
RNA polymerase II cis-regulatory region sequence-specific DNA binding
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes.
Reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity.
Supporting Evidence:
TP53-deep-research
TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements (p53REs) in target gene promoters
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:22578566
Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
|
|
GO:0001228
DNA-binding transcription activator activity, RNA polymerase II-specific
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 activates transcription through binding to promoter sequences.
Reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements.
Supporting Evidence:
TP53-deep-research
TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements
PMID:22578566
Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:12609999
2003 Feb 27. The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
|
|
GO:0003682
chromatin binding
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 binds chromatin at p53 response elements in target gene promoters.
Reason: Core molecular function - chromatin binding is essential for p53's transcriptional regulation.
Supporting Evidence:
PDB:3TS8
Crystal structure of p53 tetramer bound to DNA
PMID:26334721
2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
|
|
GO:0005657
replication fork
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 is a component of replication fork DNA repair machinery.
Reason: p53 coordinates DNA repair at replication forks during DNA damage response.
|
|
GO:0005739
mitochondrion
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 translocates to mitochondria to directly promote apoptosis through BAX activation.
Reason: Important localization for non-transcriptional apoptosis - p53 can directly induce MOMP at mitochondria.
Supporting Evidence:
TP53-deep-research
Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins
PMID:25168243
Aug 29. Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:12667443
p53 has a direct apoptogenic role at the mitochondria.
|
|
GO:0005829
cytosol
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
|
|
GO:0007623
circadian rhythm
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: p53 may influence circadian rhythms but this is not a primary function.
Reason: Non-core function - p53 has connections to circadian biology.
|
|
GO:0008285
negative regulation of cell population proliferation
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism.
Reason: Core function - p53 inhibits proliferation through cell cycle arrest.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Negatively regulates cell division
PMID:30514107
CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.
PMID:12730672
Physical and functional interaction between HCV core protein and the different p73 isoforms.
PMID:22783376
Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53.
|
|
GO:0008340
determination of adult lifespan
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: p53 may influence lifespan through its regulation of senescence and apoptosis.
Reason: Non-core function - while p53 influences aging, this is secondary to its tumor suppressor function.
|
|
GO:0031625
ubiquitin protein ligase binding
|
IEA
GO_REF:0000120 |
REMOVE |
Summary: Generic 'ubiquitin protein ligase binding' is less informative than specific MDM2/MDM4 interactions.
Reason: While p53 binds MDM2 (E3 ligase), this generic term is uninformative. The specific MDM2 interaction is well-documented elsewhere.
|
|
GO:0034644
cellular response to UV
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 responds to UV-induced DNA damage as part of its DNA damage response.
Reason: Core function - UV radiation is a classic p53-activating stress.
Supporting Evidence:
GO:0009411
response to UV
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
|
|
GO:0035033
histone deacetylase regulator activity
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 undergoes deacetylation by histone deacetylases including HDAC1.
Reason: Core regulatory mechanism - p53 deacetylation by HDACs regulates its activity.
Supporting Evidence:
TP53-deep-research
Acetylation/deacetylation regulates p53 function
|
|
GO:0035861
site of double-strand break
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: p53 is involved in ventral column development in spinal cord.
Reason: Non-core tissue-specific developmental function.
|
|
GO:0042771
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation.
Reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis.
Supporting Evidence:
TP53-deep-research
Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS)
PMID:14654789
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
|
|
GO:0043073
germ cell nucleus
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: p53 is involved in germ cell development but is not essential.
Reason: Non-core developmental function.
|
|
GO:0043153
entrainment of circadian clock by photoperiod
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 enters the nucleus to function as a transcription factor.
Reason: Core process - nuclear entry is essential for p53's transcription factor activity.
Supporting Evidence:
TP53-deep-research
Nuclear Localization Signals (NLS): Function: Nuclear import and localization
|
|
GO:0045892
negative regulation of DNA-templated transcription
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes.
Reason: Core function - p53 acts as both a transcriptional activator and repressor.
Supporting Evidence:
TP53-deep-research
Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes
PMID:16492744
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.
PMID:9271120
Repression of p53-mediated transcription by MDM2: a dual mechanism.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:24051492
p53 regulates Period2 expression and the circadian clock.
|
|
GO:0048512
circadian behavior
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: p53 is involved in organ development but is not essential for development.
Reason: Non-core developmental function - p53 knockout mice develop normally.
|
|
GO:0060333
type II interferon-mediated signaling pathway
|
IEA
GO_REF:0000107 |
KEEP AS NON CORE |
Summary: p53 may influence interferon-gamma signaling but this is not a primary function.
Reason: Non-core immunomodulatory function.
|
|
GO:0062100
positive regulation of programmed necrotic cell death
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 regulates intrinsic apoptotic signaling in response to various DNA damage types.
Reason: Core function - p53 responds to diverse DNA damage to trigger apoptosis.
|
|
GO:0070059
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 is phosphorylated on serine residues including Ser15, Ser20, Ser46, Ser392.
Reason: Core regulatory mechanism - serine phosphorylation is essential for p53 activation.
Supporting Evidence:
TP53-deep-research
Ser15, Thr18, Ser20: N-terminal phosphorylation by ATM/ATR, disrupts MDM2 binding
|
|
GO:0070245
positive regulation of thymocyte apoptotic process
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 responds to positive regulation by stress-induced post-translational modifications.
Reason: p53 is regulated by extensive post-translational modifications that enhance its activity.
Supporting Evidence:
TP53-deep-research
p53 can be modified at over 60 of its 393 residues
|
|
GO:0071479
cellular response to ionizing radiation
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 responds to UV-A radiation-induced DNA damage.
Reason: Core DNA damage response function - UV radiation is a classic p53 activator.
Supporting Evidence:
GO:0009411
response to UV
PMID:20160708
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
|
|
GO:0097371
MDM2/MDM4 family protein binding
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 undergoes mitochondrial translocation to directly promote apoptosis.
Reason: Important function - p53 can induce apoptosis through non-transcriptional mitochondrial mechanisms.
Supporting Evidence:
TP53-deep-research
Direct mitochondrial translocation and interaction with BCL-2 family proteins
|
|
GO:2000774
positive regulation of cellular senescence
|
IEA
GO_REF:0000107 |
ACCEPT |
Summary: p53 positively regulates cellular senescence as an alternative to apoptosis.
Reason: Core function - senescence induction is a major tumor suppressor mechanism of p53.
Supporting Evidence:
TP53-deep-research
p53 induces senescence through p21 and other targets as an irreversible cell cycle arrest mechanism
PMID:29474172
Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice.
|
|
GO:0005654
nucleoplasm
|
IDA
PMID:12915590 Cellular stress and DNA damage invoke temporally distinct Md... |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0072331
signal transduction by p53 class mediator
|
IDA
PMID:25384516 Rad54B serves as a scaffold in the DNA damage response that ... |
ACCEPT |
Summary: p53 IS the p53 class mediator that transduces signals in response to stress.
Reason: Absolutely core function - this term specifically describes p53's central role in stress signaling.
Supporting Evidence:
TP53-deep-research
p53 coordinates cellular responses to diverse stress signals
PMID:25384516
Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:29681526
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
PMID:15314173
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
|
|
GO:1990841
promoter-specific chromatin binding
|
IDA
PMID:24652652 DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible... |
ACCEPT |
Summary: p53 binds to promoter-specific chromatin regions containing p53 response elements.
Reason: Core molecular function - p53 specifically binds to promoter regions of target genes through sequence-specific DNA binding.
Supporting Evidence:
PDB:3TS8
Crystal structure shows p53 binding to CDKN1A(p21) promoter response element
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20725088
2010 Aug 20. Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
|
|
GO:0072331
signal transduction by p53 class mediator
|
IDA
PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts wi... |
ACCEPT |
Summary: p53 IS the p53 class mediator that transduces signals in response to stress.
Reason: Absolutely core function - this term specifically describes p53's central role in stress signaling.
Supporting Evidence:
TP53-deep-research
p53 coordinates cellular responses to diverse stress signals
PMID:25384516
Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:29681526
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
PMID:15314173
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
|
|
GO:0000785
chromatin
|
IDA
PMID:24289924 Phosphorylation of p53 by TAF1 inactivates p53-dependent tra... |
ACCEPT |
Summary: p53 associates with chromatin at target gene promoters to regulate transcription.
Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
Supporting Evidence:
PDB:3TS8
Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:22521434
Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR.
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
PMID:17805299
p53 is regulated by the lysine demethylase LSD1.
|
|
GO:0003700
DNA-binding transcription factor activity
|
IMP
PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negat... |
ACCEPT |
Summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes.
Reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:26334721
2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:7587074
Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene.
|
|
GO:0030330
DNA damage response, signal transduction by p53 class mediator
|
IDA
PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53... |
ACCEPT |
Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
PMID:29681526
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
PMID:15149599
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
PMID:20160708
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
|
|
GO:0010628
positive regulation of gene expression
|
ISS
GO_REF:0000024 |
ACCEPT |
Summary: p53 positively regulates gene expression of numerous target genes.
Reason: Core transcriptional function - p53 is a transcriptional activator.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:26100857
A metabolic stress-inducible miR-34a-HNF4Ξ± pathway regulates lipid and lipoprotein metabolism.
PMID:20332243
2010 Mar 23. MicroRNA145 targets BNIP3 and suppresses prostate cancer progression.
PMID:15314173
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
PMID:19160485
A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.
|
|
GO:0001223
transcription coactivator binding
|
IPI
PMID:11950834 SWI/SNF complex interacts with tumor suppressor p53 and is n... |
ACCEPT |
Summary: p53 functions as a transcription activator at p53 response elements.
Reason: Core molecular function - p53 activates transcription at cis-regulatory elements.
Supporting Evidence:
TP53-deep-research
p53 binds sequence-specifically to p53 response elements
PMID:11950834
2002 Apr 11. SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription.
|
|
GO:0030330
DNA damage response, signal transduction by p53 class mediator
|
IDA
PMID:15149599 Telomere shortening triggers senescence of human cells throu... |
ACCEPT |
Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
PMID:29681526
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
PMID:15149599
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
PMID:20160708
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
|
|
GO:0005654
nucleoplasm
|
IDA
GO_REF:0000052 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005829
cytosol
|
IDA
GO_REF:0000052 |
ACCEPT |
Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
|
|
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
|
IDA
PMID:34381247 The tumor suppressor folliculin inhibits lactate dehydrogena... |
ACCEPT |
Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:34381247
Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
PMID:35618207
Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.
PMID:36634798
Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.
PMID:38653238
2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
|
|
GO:0005634
nucleus
|
IDA
PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membr... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005634
nucleus
|
IDA
PMID:16322561 NIR is a novel INHAT repressor that modulates the transcript... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0030330
DNA damage response, signal transduction by p53 class mediator
|
IMP
PMID:20160708 Feedback between p21 and reactive oxygen production is neces... |
ACCEPT |
Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
PMID:29681526
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
PMID:15149599
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
PMID:20160708
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
|
|
GO:0140693
molecular condensate scaffold activity
|
IDA
PMID:38653238 Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lacty... |
ACCEPT |
Summary: p53 binds to single-stranded DNA through its DNA-binding domain.
Reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions.
Supporting Evidence:
PMID:38653238
2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.
|
|
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
|
IDA
PMID:35618207 Ser392 phosphorylation modulated a switch between p53 and tr... |
ACCEPT |
Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:34381247
Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
PMID:35618207
Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.
PMID:36634798
Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.
PMID:38653238
2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
|
|
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
|
IDA
PMID:36634798 Phosphorylation and specific DNA improved the incorporation ... |
ACCEPT |
Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:34381247
Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
PMID:35618207
Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.
PMID:36634798
Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.
PMID:38653238
2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
|
|
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
|
IDA
PMID:38653238 Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lacty... |
ACCEPT |
Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:34381247
Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
PMID:35618207
Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.
PMID:36634798
Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.
PMID:38653238
2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
|
|
GO:0005634
nucleus
|
IDA
PMID:36108750 Phase separation of p53 induced by its unstructured basic re... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0140693
molecular condensate scaffold activity
|
IDA
PMID:31953488 Liquid-like droplet formation by tumor suppressor p53 induce... |
ACCEPT |
Summary: p53 binds to single-stranded DNA through its DNA-binding domain.
Reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions.
Supporting Evidence:
PMID:31953488
Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains.
|
|
GO:0140693
molecular condensate scaffold activity
|
IDA
PMID:35618207 Ser392 phosphorylation modulated a switch between p53 and tr... |
ACCEPT |
Summary: p53 binds to single-stranded DNA through its DNA-binding domain.
Reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions.
Supporting Evidence:
PMID:35618207
Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.
|
|
GO:0140693
molecular condensate scaffold activity
|
IDA
PMID:36108750 Phase separation of p53 induced by its unstructured basic re... |
ACCEPT |
Summary: p53 binds to single-stranded DNA through its DNA-binding domain.
Reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions.
Supporting Evidence:
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
|
|
GO:0140693
molecular condensate scaffold activity
|
IDA
PMID:36634798 Phosphorylation and specific DNA improved the incorporation ... |
ACCEPT |
Summary: p53 binds to single-stranded DNA through its DNA-binding domain.
Reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions.
Supporting Evidence:
PMID:36634798
Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.
|
|
GO:0030330
DNA damage response, signal transduction by p53 class mediator
|
IMP
PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and ... |
ACCEPT |
Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
PMID:29681526
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
PMID:15149599
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
PMID:20160708
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
|
|
GO:0032211
negative regulation of telomere maintenance via telomerase
|
IDA
PMID:10597287 Molecular interactions between telomerase and the tumor supp... |
ACCEPT |
Summary: p53 negatively regulates telomerase activity.
Reason: p53 suppresses telomerase as part of its tumor suppressor function.
Supporting Evidence:
PMID:10597287
Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro.
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
ISS
GO_REF:0000024 |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IDA
PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a... |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IMP
PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and ... |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0005515
protein binding
|
IPI
PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, prom... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
|
|
GO:0005634
nucleus
|
IDA
PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, prom... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005634
nucleus
|
IDA
PMID:26634371 Structural studies of UBXN2A and mortalin interaction and th... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005737
cytoplasm
|
IDA
PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, prom... |
ACCEPT |
Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:16131611
p53 isoforms can regulate p53 transcriptional activity.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005737
cytoplasm
|
IDA
PMID:26634371 Structural studies of UBXN2A and mortalin interaction and th... |
ACCEPT |
Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:16131611
p53 isoforms can regulate p53 transcriptional activity.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0003682
chromatin binding
|
IDA
PMID:26334721 Jmjd5 functions as a regulator of p53 signaling during mouse... |
ACCEPT |
Summary: p53 binds chromatin at p53 response elements in target gene promoters.
Reason: Core molecular function - chromatin binding is essential for p53's transcriptional regulation.
Supporting Evidence:
PDB:3TS8
Crystal structure of p53 tetramer bound to DNA
PMID:26334721
2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
|
|
GO:0003700
DNA-binding transcription factor activity
|
IDA
PMID:26334721 Jmjd5 functions as a regulator of p53 signaling during mouse... |
ACCEPT |
Summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes.
Reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:26334721
2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:7587074
Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene.
|
|
GO:0005515
protein binding
|
IPI
PMID:26334721 Jmjd5 functions as a regulator of p53 signaling during mouse... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:26334721
2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
|
|
GO:0006357
regulation of transcription by RNA polymerase II
|
IDA
PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a... |
ACCEPT |
Summary: p53 regulates RNA polymerase II transcription as both activator and repressor.
Reason: Core molecular function - p53 is a sequence-specific RNA pol II transcription factor.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
|
|
GO:0006974
DNA damage response
|
IDA
PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a... |
ACCEPT |
Summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage.
Reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17938203
Oct 15. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage.
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
|
|
GO:0000978
RNA polymerase II cis-regulatory region sequence-specific DNA binding
|
IDA
PMID:24289924 Phosphorylation of p53 by TAF1 inactivates p53-dependent tra... |
ACCEPT |
Summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes.
Reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity.
Supporting Evidence:
TP53-deep-research
TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements (p53REs) in target gene promoters
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:22578566
Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
|
|
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
|
IDA
PMID:24289924 Phosphorylation of p53 by TAF1 inactivates p53-dependent tra... |
ACCEPT |
Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:34381247
Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
PMID:35618207
Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.
PMID:36634798
Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.
PMID:38653238
2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
|
|
GO:0072331
signal transduction by p53 class mediator
|
IDA
PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53... |
ACCEPT |
Summary: p53 IS the p53 class mediator that transduces signals in response to stress.
Reason: Absolutely core function - this term specifically describes p53's central role in stress signaling.
Supporting Evidence:
TP53-deep-research
p53 coordinates cellular responses to diverse stress signals
PMID:25384516
Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:29681526
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
PMID:15314173
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-9836362 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005515
protein binding
|
IPI
PMID:35122041 Aldolase B suppresses hepatocellular carcinogenesis by inhib... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:35122041
Jul 6. Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways.
|
|
GO:0005515
protein binding
|
IPI
PMID:10415337 Identification of a novel gene encoding a p53-associated pro... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:10415337
Identification of a novel gene encoding a p53-associated protein.
|
|
GO:0005515
protein binding
|
IPI
PMID:10666337 Human topoisomerase IIalpha and IIbeta interact with the C-t... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:10666337
Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:11546806 Cloning and characterization of a p53-related protein kinase... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:11546806
2001 Sep 6. Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes.
|
|
GO:0005515
protein binding
|
IPI
PMID:11781842 The Bloom syndrome protein interacts and cooperates with p53... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:11781842
The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control.
|
|
GO:0005515
protein binding
|
IPI
PMID:15577914 Regulation of cellular response to oncogenic and oxidative s... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15577914
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1.
|
|
GO:0005515
protein binding
|
IPI
PMID:17121812 CARPs are ubiquitin ligases that promote MDM2-independent p5... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17121812
Nov 22. CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.
|
|
GO:0005515
protein binding
|
IPI
PMID:18382127 CARPs enhance p53 turnover by degrading 14-3-3sigma and stab... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18382127
CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2.
|
|
GO:0005515
protein binding
|
IPI
PMID:7663514 p53 modulation of TFIIH-associated nucleotide excision repai... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:7663514
p53 modulation of TFIIH-associated nucleotide excision repair activity.
|
|
GO:0005515
protein binding
|
IPI
PMID:9194565 Binding and modulation of p53 by p300/CBP coactivators. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:9194565
Binding and modulation of p53 by p300/CBP coactivators.
|
|
GO:0005515
protein binding
|
IPI
PMID:9529249 ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:9529249
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.
|
|
GO:0010628
positive regulation of gene expression
|
IDA
PMID:26100857 A metabolic stress-inducible miR-34a-HNF4Ξ± pathway regulates... |
ACCEPT |
Summary: p53 positively regulates gene expression of numerous target genes.
Reason: Core transcriptional function - p53 is a transcriptional activator.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:26100857
A metabolic stress-inducible miR-34a-HNF4Ξ± pathway regulates lipid and lipoprotein metabolism.
PMID:20332243
2010 Mar 23. MicroRNA145 targets BNIP3 and suppresses prostate cancer progression.
PMID:15314173
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
PMID:19160485
A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.
|
|
GO:0005515
protein binding
|
IPI
PMID:34404770 ZNF768 links oncogenic RAS to cellular senescence. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:34404770
ZNF768 links oncogenic RAS to cellular senescence.
|
|
GO:0045815
transcription initiation-coupled chromatin remodeling
|
IDA
PMID:16322561 NIR is a novel INHAT repressor that modulates the transcript... |
ACCEPT |
Summary: p53 positively regulates gene expression through transcriptional activation.
Reason: Core function - p53 is a transcriptional activator.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:33591310 DAZAP2 acts as specifier of the p53 response to DNA damage. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:33591310
DAZAP2 acts as specifier of the p53 response to DNA damage.
|
|
GO:0003700
DNA-binding transcription factor activity
|
IDA
PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts wi... |
ACCEPT |
Summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes.
Reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:26334721
2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:7587074
Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene.
|
|
GO:2000774
positive regulation of cellular senescence
|
IDA
PMID:29474172 Haploinsufficiency of Trp53 dramatically extends the lifespa... |
ACCEPT |
Summary: p53 positively regulates cellular senescence as an alternative to apoptosis.
Reason: Core function - senescence induction is a major tumor suppressor mechanism of p53.
Supporting Evidence:
TP53-deep-research
p53 induces senescence through p21 and other targets as an irreversible cell cycle arrest mechanism
PMID:29474172
Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice.
|
|
GO:0031625
ubiquitin protein ligase binding
|
EXP
PMID:8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor sup... |
REMOVE |
Summary: Generic 'ubiquitin protein ligase binding' is less informative than specific MDM2/MDM4 interactions.
Reason: While p53 binds MDM2 (E3 ligase), this generic term is uninformative. The specific MDM2 interaction is well-documented elsewhere.
Supporting Evidence:
PMID:8875929
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
|
|
GO:0071889
14-3-3 protein binding
|
EXP
PMID:20206173 Structure of the p53 C-terminus bound to 14-3-3: implication... |
ACCEPT |
Summary: p53 binds to 14-3-3 proteins which regulate its subcellular localization.
Reason: Important regulatory interaction - 14-3-3 proteins sequester p53 in cytoplasm.
Supporting Evidence:
PMID:20206173
2010 Mar 3. Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer.
|
|
GO:0140677
molecular function activator activity
|
EXP
PMID:14759370 Structural mechanism of the bromodomain of the coactivator C... |
ACCEPT |
Summary: p53 functions as an activating transcription factor for target genes.
Reason: Core molecular function - p53 activates transcription of target genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:16793543
Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53.
PMID:7559631
Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein.
|
|
GO:0140677
molecular function activator activity
|
EXP
PMID:16793543 Structure of the Tfb1/p53 complex: Insights into the interac... |
ACCEPT |
Summary: p53 functions as an activating transcription factor for target genes.
Reason: Core molecular function - p53 activates transcription of target genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:16793543
Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53.
PMID:7559631
Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein.
|
|
GO:0140677
molecular function activator activity
|
IPI
PMID:7559631 Transactivation ability of p53 transcriptional activation do... |
ACCEPT |
Summary: p53 functions as an activating transcription factor for target genes.
Reason: Core molecular function - p53 activates transcription of target genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:16793543
Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53.
PMID:7559631
Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein.
|
|
GO:2000774
positive regulation of cellular senescence
|
ISS
GO_REF:0000024 |
ACCEPT |
Summary: p53 positively regulates cellular senescence as an alternative to apoptosis.
Reason: Core function - senescence induction is a major tumor suppressor mechanism of p53.
Supporting Evidence:
TP53-deep-research
p53 induces senescence through p21 and other targets as an irreversible cell cycle arrest mechanism
PMID:29474172
Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice.
|
|
GO:0090398
cellular senescence
|
IMP
PMID:12080348 Nucleophosmin regulates the stability and transcriptional ac... |
ACCEPT |
Summary: p53 is negatively regulated by MDM2-mediated cellular homeostasis.
Reason: Core regulatory mechanism - p53 is tightly regulated in non-stressed cells.
Supporting Evidence:
TP53-deep-research
Negative Feedback: MDM2: Primary negative regulator
PMID:12080348
Nucleophosmin regulates the stability and transcriptional activity of p53.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-2997706 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005515
protein binding
|
IPI
PMID:15687255 A mechanism of ubiquitin-independent proteasomal degradation... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15687255
A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73.
|
|
GO:0001228
DNA-binding transcription activator activity, RNA polymerase II-specific
|
IDA
PMID:22578566 Oncosuppressive role of p53-induced miR-205 in triple negati... |
ACCEPT |
Summary: p53 activates transcription through binding to promoter sequences.
Reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements.
Supporting Evidence:
TP53-deep-research
TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements
PMID:22578566
Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:12609999
2003 Feb 27. The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
|
|
GO:0000978
RNA polymerase II cis-regulatory region sequence-specific DNA binding
|
IDA
PMID:22578566 Oncosuppressive role of p53-induced miR-205 in triple negati... |
ACCEPT |
Summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes.
Reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity.
Supporting Evidence:
TP53-deep-research
TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements (p53REs) in target gene promoters
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:22578566
Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
|
|
GO:1902895
positive regulation of miRNA transcription
|
IMP
PMID:22578566 Oncosuppressive role of p53-induced miR-205 in triple negati... |
ACCEPT |
Summary: p53 transcriptionally regulates multiple miRNAs including miR-34 family.
Reason: p53 regulates miRNA expression as part of its stress response functions.
Supporting Evidence:
PMID:30089260
we found p53-dependent induction of these miRNAs upon nutlin-3a treatment
PMID:22578566
Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
PMID:20546595
High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure.
PMID:22499991
Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2.
|
|
GO:0001228
DNA-binding transcription activator activity, RNA polymerase II-specific
|
IDA
PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its... |
ACCEPT |
Summary: p53 activates transcription through binding to promoter sequences.
Reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements.
Supporting Evidence:
TP53-deep-research
TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements
PMID:22578566
Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:12609999
2003 Feb 27. The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
|
|
GO:0061629
RNA polymerase II-specific DNA-binding transcription factor binding
|
IPI
PMID:23329847 Regulation of the cyclin-dependent kinase inhibitor 1A gene ... |
ACCEPT |
Summary: p53 binds RNA through its C-terminal domain.
Reason: p53 has RNA-binding activity that contributes to regulation of gene expression.
Supporting Evidence:
PMID:23329847
2013 Jan 17. Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding.
|
|
GO:0061629
RNA polymerase II-specific DNA-binding transcription factor binding
|
IPI
PMID:15705871 Homeobox Msx1 interacts with p53 tumor suppressor and inhibi... |
ACCEPT |
Summary: p53 binds RNA through its C-terminal domain.
Reason: p53 has RNA-binding activity that contributes to regulation of gene expression.
Supporting Evidence:
PMID:15705871
Homeobox Msx1 interacts with p53 tumor suppressor and inhibits tumor growth by inducing apoptosis.
|
|
GO:0051726
regulation of cell cycle
|
IGI
PMID:12203124 The Brn-3a transcription factor inhibits the pro-apoptotic e... |
ACCEPT |
Summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints.
Reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
induces cell cycle arrest
PMID:30514107
CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.
PMID:12203124
The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).
PMID:12433990
Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.
PMID:15149599
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
|
|
GO:0051726
regulation of cell cycle
|
IGI
PMID:12433990 Distinct promoter elements mediate the co-operative effect o... |
ACCEPT |
Summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints.
Reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
induces cell cycle arrest
PMID:30514107
CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.
PMID:12203124
The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).
PMID:12433990
Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.
PMID:15149599
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
|
|
GO:0051726
regulation of cell cycle
|
IDA
PMID:15149599 Telomere shortening triggers senescence of human cells throu... |
ACCEPT |
Summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints.
Reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
induces cell cycle arrest
PMID:30514107
CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.
PMID:12203124
The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).
PMID:12433990
Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.
PMID:15149599
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
|
|
GO:0051726
regulation of cell cycle
|
IMP
PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and ... |
ACCEPT |
Summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints.
Reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
induces cell cycle arrest
PMID:30514107
CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.
PMID:12203124
The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).
PMID:12433990
Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.
PMID:15149599
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
|
|
GO:0000122
negative regulation of transcription by RNA polymerase II
|
IDA
PMID:10329733 p53 suppresses the activation of the Bcl-2 promoter by the B... |
ACCEPT |
Summary: p53 functions as a transcriptional repressor for genes including BCL2 and cell cycle genes.
Reason: Core function - transcriptional repression is part of p53's regulatory activity.
Supporting Evidence:
TP53-deep-research
Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes
PMID:10329733
p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor.
PMID:19749791
Sep 14. Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation.
|
|
GO:0000987
cis-regulatory region sequence-specific DNA binding
|
IDA
PMID:10329733 p53 suppresses the activation of the Bcl-2 promoter by the B... |
ACCEPT |
Summary: p53 binds to proximal promoter sequences containing p53 response elements.
Reason: Core molecular function - DNA binding to promoters is essential for p53 activity.
Supporting Evidence:
TP53-deep-research
p53 binds sequence-specifically to p53 response elements in target gene promoters
PMID:10329733
p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor.
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GO:0001227
DNA-binding transcription repressor activity, RNA polymerase II-specific
|
IDA
PMID:10329733 p53 suppresses the activation of the Bcl-2 promoter by the B... |
ACCEPT |
Summary: p53 functions as a transcriptional repressor at specific promoters.
Reason: Core function - p53 represses transcription of target genes.
Supporting Evidence:
TP53-deep-research
Repression: Downregulates anti-apoptotic genes (BCL2)
PMID:10329733
p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor.
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GO:1903451
negative regulation of G1 to G0 transition
|
IDA
PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 funct... |
ACCEPT |
Summary: p53 negatively regulates ferroptosis through p21 induction and GSH maintenance.
Reason: p53 has dual role in ferroptosis - this represents its anti-ferroptotic activity.
Supporting Evidence:
TP53-deep-research
Anti-ferroptotic: Induces p21 to maintain GSH levels
PMID:15314173
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
PMID:21471221
2011 Apr 6. Novel nucleolar pathway connecting intracellular energy status with p53 activation.
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|
GO:1903451
negative regulation of G1 to G0 transition
|
IMP
PMID:21471221 Novel nucleolar pathway connecting intracellular energy stat... |
ACCEPT |
Summary: p53 negatively regulates ferroptosis through p21 induction and GSH maintenance.
Reason: p53 has dual role in ferroptosis - this represents its anti-ferroptotic activity.
Supporting Evidence:
TP53-deep-research
Anti-ferroptotic: Induces p21 to maintain GSH levels
PMID:15314173
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
PMID:21471221
2011 Apr 6. Novel nucleolar pathway connecting intracellular energy status with p53 activation.
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|
GO:0005515
protein binding
|
IPI
PMID:25168243 Cofactor Strap regulates oxidative phosphorylation and mitoc... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:25168243
Aug 29. Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.
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GO:0005739
mitochondrion
|
IDA
PMID:25168243 Cofactor Strap regulates oxidative phosphorylation and mitoc... |
ACCEPT |
Summary: p53 translocates to mitochondria to directly promote apoptosis through BAX activation.
Reason: Important localization for non-transcriptional apoptosis - p53 can directly induce MOMP at mitochondria.
Supporting Evidence:
TP53-deep-research
Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins
PMID:25168243
Aug 29. Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:12667443
p53 has a direct apoptogenic role at the mitochondria.
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GO:0061629
RNA polymerase II-specific DNA-binding transcription factor binding
|
IPI
PMID:19505873 Complementary quantitative proteomics reveals that transcrip... |
ACCEPT |
Summary: p53 binds RNA through its C-terminal domain.
Reason: p53 has RNA-binding activity that contributes to regulation of gene expression.
Supporting Evidence:
PMID:19505873
Epub 2009 Jun 7. Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.
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GO:0036310
ATP-dependent DNA/DNA annealing activity
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IDA
PMID:8183576 Human p53 directs DNA strand reassociation and is photolabel... |
ACCEPT |
Summary: p53 responds to chemotherapy drugs that cause DNA damage.
Reason: Core function - DNA-damaging chemotherapeutics strongly activate p53.
Supporting Evidence:
PMID:8183576
Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP.
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|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-9723906 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
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GO:0140296
general transcription initiation factor binding
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IPI
PMID:15053879 Phosphorylation on Thr-55 by TAF1 mediates degradation of p5... |
ACCEPT |
Summary: p53 binds chromatin to regulate transcription of target genes.
Reason: Core function - chromatin binding is essential for p53's transcription factor activity.
Supporting Evidence:
PDB:3TS8
Crystal structure shows p53 bound to DNA
PMID:15053879
Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression.
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|
GO:0010628
positive regulation of gene expression
|
IDA
PMID:20332243 MicroRNA145 targets BNIP3 and suppresses prostate cancer pro... |
ACCEPT |
Summary: p53 positively regulates gene expression of numerous target genes.
Reason: Core transcriptional function - p53 is a transcriptional activator.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:26100857
A metabolic stress-inducible miR-34a-HNF4Ξ± pathway regulates lipid and lipoprotein metabolism.
PMID:20332243
2010 Mar 23. MicroRNA145 targets BNIP3 and suppresses prostate cancer progression.
PMID:15314173
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
PMID:19160485
A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.
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|
GO:1902895
positive regulation of miRNA transcription
|
IDA
PMID:20546595 High-throughput sequencing identifies STAT3 as the DNA-assoc... |
ACCEPT |
Summary: p53 transcriptionally regulates multiple miRNAs including miR-34 family.
Reason: p53 regulates miRNA expression as part of its stress response functions.
Supporting Evidence:
PMID:30089260
we found p53-dependent induction of these miRNAs upon nutlin-3a treatment
PMID:22578566
Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
PMID:20546595
High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure.
PMID:22499991
Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2.
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|
GO:0000785
chromatin
|
IMP
PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a... |
ACCEPT |
Summary: p53 associates with chromatin at target gene promoters to regulate transcription.
Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
Supporting Evidence:
PDB:3TS8
Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:22521434
Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR.
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
PMID:17805299
p53 is regulated by the lysine demethylase LSD1.
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|
GO:1902895
positive regulation of miRNA transcription
|
IGI
PMID:22499991 Downregulation of endothelial microRNA-200b supports cutaneo... |
ACCEPT |
Summary: p53 transcriptionally regulates multiple miRNAs including miR-34 family.
Reason: p53 regulates miRNA expression as part of its stress response functions.
Supporting Evidence:
PMID:30089260
we found p53-dependent induction of these miRNAs upon nutlin-3a treatment
PMID:22578566
Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
PMID:20546595
High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure.
PMID:22499991
Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2.
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|
GO:0001228
DNA-binding transcription activator activity, RNA polymerase II-specific
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IDA
PMID:12609999 The activation domains, the proline-rich domain, and the C-t... |
ACCEPT |
Summary: p53 activates transcription through binding to promoter sequences.
Reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements.
Supporting Evidence:
TP53-deep-research
TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements
PMID:22578566
Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:12609999
2003 Feb 27. The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
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GO:0043066
negative regulation of apoptotic process
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IGI
PMID:12203124 The Brn-3a transcription factor inhibits the pro-apoptotic e... |
ACCEPT |
Summary: p53 can negatively regulate apoptosis in certain contexts through p21-mediated survival.
Reason: Context-dependent function - p53 can promote survival under mild stress conditions.
Supporting Evidence:
PMID:12203124
The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).
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GO:0043066
negative regulation of apoptotic process
|
IGI
PMID:12433990 Distinct promoter elements mediate the co-operative effect o... |
ACCEPT |
Summary: p53 can negatively regulate apoptosis in certain contexts through p21-mediated survival.
Reason: Context-dependent function - p53 can promote survival under mild stress conditions.
Supporting Evidence:
PMID:12433990
Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.
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GO:0005515
protein binding
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IPI
PMID:21597459 E3 ubiquitin ligase Hades negatively regulates the exonuclea... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
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GO:0005634
nucleus
|
IDA
PMID:21597459 E3 ubiquitin ligase Hades negatively regulates the exonuclea... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
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GO:0005737
cytoplasm
|
IDA
PMID:21597459 E3 ubiquitin ligase Hades negatively regulates the exonuclea... |
ACCEPT |
Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:16131611
p53 isoforms can regulate p53 transcriptional activity.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
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GO:0005515
protein binding
|
IPI
PMID:29628311 A Family of Vertebrate-Specific Polycombs Encoded by the LCO... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:29628311
2018 Apr 5. A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.
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|
GO:0045899
positive regulation of RNA polymerase II transcription preinitiation complex assembly
|
IDA
PMID:24289924 Phosphorylation of p53 by TAF1 inactivates p53-dependent tra... |
ACCEPT |
Summary: p53 positively regulates its own transcription as part of feedback regulation.
Reason: p53 has positive feedback regulation of its own expression.
Supporting Evidence:
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IDA
PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IDA
PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its... |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IMP
PMID:17146433 RGC32, a novel p53-inducible gene, is located on centrosomes... |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IDA
PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts wi... |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0033209
tumor necrosis factor-mediated signaling pathway
|
IGI
PMID:22499991 Downregulation of endothelial microRNA-200b supports cutaneo... |
ACCEPT |
Summary: p53 responds to tumor necrosis factor signaling.
Reason: p53 interacts with TNF signaling pathways in cell death regulation.
Supporting Evidence:
PMID:22499991
Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2.
|
|
GO:0001046
core promoter sequence-specific DNA binding
|
IDA
PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf ex... |
ACCEPT |
Summary: p53 activates transcription through core promoter binding.
Reason: Core molecular function - p53 binds promoters to activate transcription.
Supporting Evidence:
PDB:3TS8
p53 tetramer bound to CDKN1A promoter response element
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0005515
protein binding
|
IPI
PMID:28842590 DDX3 localizes to the centrosome and prevents multipolar mit... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:28842590
DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.
|
|
GO:0005813
centrosome
|
IDA
PMID:28842590 DDX3 localizes to the centrosome and prevents multipolar mit... |
KEEP AS NON CORE |
Summary: p53 has been reported to localize to centrosomes but this is not a primary localization.
Reason: Non-core localization. p53 may associate with centrosomes in certain contexts but this is not a primary function.
Supporting Evidence:
PMID:28842590
DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.
|
|
GO:0042802
identical protein binding
|
IPI
PMID:19011621 Arginine methylation regulates the p53 response. |
ACCEPT |
Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
Supporting Evidence:
PDB:1C26
Crystal structure of p53 tetramerization domain
PMID:10876243
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
PMID:14759370
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
PMID:16291740
2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
PMID:16461914
Core domain interactions in full-length p53 in solution.
PMID:17612295
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
PMID:17620598
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
PMID:18087040
Regulation of p53 tetramerization and nuclear export by ARC.
PMID:19339993
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
PMID:19667193
Ultraslow oligomerization equilibria of p53 and its implications.
PMID:20004160
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
PMID:20159469
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
PMID:20364130
Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
PMID:21178074
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
PMID:21522129
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22653443
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
PMID:22972749
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
PMID:25402006
In silico prediction of physical protein interactions and characterization of interactome orphans.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:31837246
High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
PMID:35512704
2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0043065
positive regulation of apoptotic process
|
IDA
PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. |
ACCEPT |
Summary: p53 positively regulates apoptosis as a major tumor suppressor mechanism.
Reason: Core function - p53 induces apoptosis through multiple pathways.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression
PMID:12667443
p53 has a direct apoptogenic role at the mitochondria.
PMID:15565177
A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0005515
protein binding
|
IPI
PMID:9733515 Activation of the ATM kinase by ionizing radiation and phosp... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:9733515
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:16443602 WT p53, but not tumor-derived mutants, bind to Bcl2 via the ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:16443602
2006 Jan 26. WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.
|
|
GO:0000785
chromatin
|
ISA
GO_REF:0000113 |
ACCEPT |
Summary: p53 associates with chromatin at target gene promoters to regulate transcription.
Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
Supporting Evidence:
PDB:3TS8
Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:22521434
Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR.
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
PMID:17805299
p53 is regulated by the lysine demethylase LSD1.
|
|
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
|
ISA
GO_REF:0000113 |
ACCEPT |
Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:34381247
Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
PMID:35618207
Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.
PMID:36634798
Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.
PMID:38653238
2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
|
|
GO:0002244
hematopoietic progenitor cell differentiation
|
IMP
PMID:30146126 De Novo Mutations Activating Germline TP53 in an Inherited B... |
KEEP AS NON CORE |
Summary: p53 is involved in hematopoietic progenitor cell differentiation but is not essential.
Reason: Non-core developmental function.
Supporting Evidence:
PMID:30146126
Epub 2018 Aug 23. De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.
|
|
GO:0060218
hematopoietic stem cell differentiation
|
IMP
PMID:30146126 De Novo Mutations Activating Germline TP53 in an Inherited B... |
KEEP AS NON CORE |
Summary: p53 is involved in hematopoietic stem cell differentiation but is not essential.
Reason: Non-core developmental function.
Supporting Evidence:
PMID:30146126
Epub 2018 Aug 23. De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.
|
|
GO:0048539
bone marrow development
|
IMP
PMID:30146126 De Novo Mutations Activating Germline TP53 in an Inherited B... |
KEEP AS NON CORE |
Summary: p53 influences olfactory bulb development but is not essential.
Reason: Non-core developmental function - tissue-specific.
Supporting Evidence:
PMID:30146126
Epub 2018 Aug 23. De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.
|
|
GO:0005515
protein binding
|
IPI
PMID:19011621 Arginine methylation regulates the p53 response. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19011621
Arginine methylation regulates the p53 response.
|
|
GO:0005634
nucleus
|
IDA
PMID:19011621 Arginine methylation regulates the p53 response. |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005737
cytoplasm
|
IDA
PMID:19011621 Arginine methylation regulates the p53 response. |
ACCEPT |
Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:16131611
p53 isoforms can regulate p53 transcriptional activity.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:2001244
positive regulation of intrinsic apoptotic signaling pathway
|
ISS
GO_REF:0000024 |
ACCEPT |
Summary: p53 negatively regulates intrinsic apoptotic signaling in certain contexts.
Reason: p53 can have context-dependent anti-apoptotic effects through p21-mediated survival.
|
|
GO:0005515
protein binding
|
IPI
PMID:18690848 NUPR1 interacts with p53, transcriptionally regulates p21 an... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:18690848
NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress.
|
|
GO:2001244
positive regulation of intrinsic apoptotic signaling pathway
|
IMP
PMID:27031958 Nupr1/Chop signal axis is involved in mitochondrion-related ... |
ACCEPT |
Summary: p53 negatively regulates intrinsic apoptotic signaling in certain contexts.
Reason: p53 can have context-dependent anti-apoptotic effects through p21-mediated survival.
Supporting Evidence:
PMID:27031958
Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine.
|
|
GO:0001228
DNA-binding transcription activator activity, RNA polymerase II-specific
|
IDA
PMID:17146433 RGC32, a novel p53-inducible gene, is located on centrosomes... |
ACCEPT |
Summary: p53 activates transcription through binding to promoter sequences.
Reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements.
Supporting Evidence:
TP53-deep-research
TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements
PMID:22578566
Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:12609999
2003 Feb 27. The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
|
|
GO:1990841
promoter-specific chromatin binding
|
IDA
PMID:20725088 Primate-specific RFPL1 gene controls cell-cycle progression ... |
ACCEPT |
Summary: p53 binds to promoter-specific chromatin regions containing p53 response elements.
Reason: Core molecular function - p53 specifically binds to promoter regions of target genes through sequence-specific DNA binding.
Supporting Evidence:
PDB:3TS8
Crystal structure shows p53 binding to CDKN1A(p21) promoter response element
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20725088
2010 Aug 20. Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
|
|
GO:0005667
transcription regulator complex
|
IGI
PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its... |
ACCEPT |
Summary: p53 is a component of transcription factor complexes.
Reason: Core localization - p53 functions as part of transcriptional machinery complexes.
Supporting Evidence:
TP53-deep-research
Complex formation with transcriptional co-activators (CBP/p300, TFIID)
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
|
|
GO:0000978
RNA polymerase II cis-regulatory region sequence-specific DNA binding
|
ISS
GO_REF:0000024 |
ACCEPT |
Summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes.
Reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity.
Supporting Evidence:
TP53-deep-research
TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements (p53REs) in target gene promoters
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:22578566
Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
|
|
GO:1905856
negative regulation of pentose-phosphate shunt
|
IMP
PMID:21336310 p53 regulates biosynthesis through direct inactivation of gl... |
ACCEPT |
Summary: p53 positively regulates p53-mediated DNA damage responses.
Reason: Core function - p53 regulates its own signaling pathway with positive feedback.
Supporting Evidence:
PMID:21336310
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase.
|
|
GO:0006974
DNA damage response
|
IMP
PMID:24356969 Rbm24, an RNA-binding protein and a target of p53, regulates... |
ACCEPT |
Summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage.
Reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17938203
Oct 15. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage.
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IMP
PMID:24356969 Rbm24, an RNA-binding protein and a target of p53, regulates... |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:1990841
promoter-specific chromatin binding
|
IDA
PMID:24356969 Rbm24, an RNA-binding protein and a target of p53, regulates... |
ACCEPT |
Summary: p53 binds to promoter-specific chromatin regions containing p53 response elements.
Reason: Core molecular function - p53 specifically binds to promoter regions of target genes through sequence-specific DNA binding.
Supporting Evidence:
PDB:3TS8
Crystal structure shows p53 binding to CDKN1A(p21) promoter response element
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20725088
2010 Aug 20. Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
|
|
GO:0001094
TFIID-class transcription factor complex binding
|
IPI
PMID:24289924 Phosphorylation of p53 by TAF1 inactivates p53-dependent tra... |
ACCEPT |
Summary: p53 interacts with TFIID to regulate transcription initiation.
Reason: Core transcriptional mechanism - p53 recruits TFIID to target promoters.
Supporting Evidence:
TP53-deep-research
Complex formation with TFIID
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
|
|
GO:0005634
nucleus
|
IMP
PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negat... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005737
cytoplasm
|
IMP
PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negat... |
ACCEPT |
Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:16131611
p53 isoforms can regulate p53 transcriptional activity.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0009299
mRNA transcription
|
IMP
PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negat... |
KEEP AS NON CORE |
Summary: p53 influences mRNA processing but this is not a core function.
Reason: Non-core regulatory function.
Supporting Evidence:
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
|
|
GO:0030330
DNA damage response, signal transduction by p53 class mediator
|
IMP
PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negat... |
ACCEPT |
Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
PMID:29681526
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
PMID:15149599
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
PMID:20160708
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
|
|
GO:0043065
positive regulation of apoptotic process
|
IDA
PMID:15565177 A novel mitochondrial protein DIP mediates E2F1-induced apop... |
ACCEPT |
Summary: p53 positively regulates apoptosis as a major tumor suppressor mechanism.
Reason: Core function - p53 induces apoptosis through multiple pathways.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression
PMID:12667443
p53 has a direct apoptogenic role at the mitochondria.
PMID:15565177
A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0005515
protein binding
|
IPI
PMID:17904127 SVH-B interacts directly with p53 and suppresses the transcr... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17904127
Epub 2007 Sep 21. SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:25422469 Disruption of FAT10-MAD2 binding inhibits tumor progression. |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:25422469
Disruption of FAT10-MAD2 binding inhibits tumor progression.
|
|
GO:0005515
protein binding
|
IPI
PMID:27323408 LACE1 interacts with p53 and mediates its mitochondrial tran... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:27323408
LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis.
|
|
GO:0005515
protein binding
|
IPI
PMID:22522597 Nucleolar protein GLTSCR2 stabilizes p53 in response to ribo... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22522597
2012 Apr 20. Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses.
|
|
GO:0003677
DNA binding
|
IDA
PMID:15358771 Hsp90 regulates the activity of wild type p53 under physiolo... |
ACCEPT |
Summary: p53 binds DNA through its central DNA-binding domain (residues 102-292) to p53 response elements.
Reason: Core molecular function - DNA binding is essential for p53's transcription factor activity.
Supporting Evidence:
TP53-deep-research
DNA-Binding Domain (DBD): Location: Residues 102-292; Structure: beta-sandwich core with DNA-binding loops
PMID:15358771
2004 Sep 9. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:2144364
Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene.
|
|
GO:0051087
protein-folding chaperone binding
|
IPI
PMID:15358771 Hsp90 regulates the activity of wild type p53 under physiolo... |
KEEP AS NON CORE |
Summary: p53 has chaperone binding activity related to its folding and stability.
Reason: Non-core function related to protein folding and quality control.
Supporting Evidence:
PMID:15358771
2004 Sep 9. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures.
|
|
GO:0005515
protein binding
|
IPI
PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
|
|
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
|
IDA
PMID:17310983 Ribosomal protein S7 as a novel modulator of p53-MDM2 intera... |
ACCEPT |
Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:34381247
Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
PMID:35618207
Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.
PMID:36634798
Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.
PMID:38653238
2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
|
|
GO:0003730
mRNA 3'-UTR binding
|
IDA
PMID:16213212 Regulation of p53 translation and induction after DNA damage... |
ACCEPT |
Summary: p53 binds mRNA and regulates gene expression post-transcriptionally.
Reason: p53 has RNA-binding activity that contributes to gene regulation.
Supporting Evidence:
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
|
|
GO:0010628
positive regulation of gene expression
|
IDA
PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 funct... |
ACCEPT |
Summary: p53 positively regulates gene expression of numerous target genes.
Reason: Core transcriptional function - p53 is a transcriptional activator.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:26100857
A metabolic stress-inducible miR-34a-HNF4Ξ± pathway regulates lipid and lipoprotein metabolism.
PMID:20332243
2010 Mar 23. MicroRNA145 targets BNIP3 and suppresses prostate cancer progression.
PMID:15314173
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
PMID:19160485
A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.
|
|
GO:0010628
positive regulation of gene expression
|
IMP
PMID:19160485 A ribosomal protein L23-nucleophosmin circuit coordinates Mi... |
ACCEPT |
Summary: p53 positively regulates gene expression of numerous target genes.
Reason: Core transcriptional function - p53 is a transcriptional activator.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:26100857
A metabolic stress-inducible miR-34a-HNF4Ξ± pathway regulates lipid and lipoprotein metabolism.
PMID:20332243
2010 Mar 23. MicroRNA145 targets BNIP3 and suppresses prostate cancer progression.
PMID:15314173
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
PMID:19160485
A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.
|
|
GO:0030330
DNA damage response, signal transduction by p53 class mediator
|
IDA
PMID:16213212 Regulation of p53 translation and induction after DNA damage... |
ACCEPT |
Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
PMID:29681526
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
PMID:15149599
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
PMID:20160708
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
|
|
GO:0030330
DNA damage response, signal transduction by p53 class mediator
|
IMP
PMID:16213212 Regulation of p53 translation and induction after DNA damage... |
ACCEPT |
Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
PMID:29681526
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
PMID:15149599
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
PMID:20160708
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
|
|
GO:0032991
protein-containing complex
|
IDA
PMID:17310983 Ribosomal protein S7 as a novel modulator of p53-MDM2 intera... |
ACCEPT |
Summary: p53 forms part of protein-containing complexes including the p53 tetramer and complexes with co-activators.
Reason: p53 functions in complexes with CBP/p300, MDM2, and forms tetramers.
Supporting Evidence:
TP53-deep-research
Complex formation with transcriptional co-activators (CBP/p300, TFIID)
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:9529249
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.
|
|
GO:0034644
cellular response to UV
|
IDA
PMID:16213212 Regulation of p53 translation and induction after DNA damage... |
ACCEPT |
Summary: p53 responds to UV-induced DNA damage as part of its DNA damage response.
Reason: Core function - UV radiation is a classic p53-activating stress.
Supporting Evidence:
GO:0009411
response to UV
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
|
|
GO:0042771
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
|
IMP
PMID:16213212 Regulation of p53 translation and induction after DNA damage... |
ACCEPT |
Summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation.
Reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis.
Supporting Evidence:
TP53-deep-research
Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS)
PMID:14654789
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IDA
PMID:17310983 Ribosomal protein S7 as a novel modulator of p53-MDM2 intera... |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0071480
cellular response to gamma radiation
|
IDA
PMID:16213212 Regulation of p53 translation and induction after DNA damage... |
ACCEPT |
Summary: p53 responds to gamma radiation-induced DNA damage.
Reason: Core function - ionizing radiation is a classic p53 activator.
Supporting Evidence:
TP53-deep-research
gamma radiation causes DNA damage that strongly activates p53
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
|
|
GO:0072331
signal transduction by p53 class mediator
|
IDA
PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 funct... |
ACCEPT |
Summary: p53 IS the p53 class mediator that transduces signals in response to stress.
Reason: Absolutely core function - this term specifically describes p53's central role in stress signaling.
Supporting Evidence:
TP53-deep-research
p53 coordinates cellular responses to diverse stress signals
PMID:25384516
Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:29681526
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
PMID:15314173
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
|
|
GO:0072332
intrinsic apoptotic signaling pathway by p53 class mediator
|
IMP
PMID:17310983 Ribosomal protein S7 as a novel modulator of p53-MDM2 intera... |
ACCEPT |
Summary: p53 mediates intrinsic apoptotic signaling through BAX, PUMA, NOXA activation.
Reason: Core apoptotic function - p53 is the master regulator of intrinsic apoptosis.
Supporting Evidence:
TP53-deep-research
Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA)
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:12172011
Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila.
|
|
GO:0072717
cellular response to actinomycin D
|
IDA
PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 funct... |
ACCEPT |
Summary: p53 mediates intrinsic apoptotic signaling in response to DNA damage.
Reason: Core function - DNA damage-induced apoptosis is a major p53 mechanism.
Supporting Evidence:
GO:0042771
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
PMID:15314173
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
|
|
GO:0005515
protein binding
|
IPI
PMID:25591766 RNF125 is a ubiquitin-protein ligase that promotes p53 degra... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:25591766
RNF125 is a ubiquitin-protein ligase that promotes p53 degradation.
|
|
GO:0002039
p53 binding
|
IPI
PMID:25417702 Functional interplay between MDM2, p63/p73 and mutant p53. |
ACCEPT |
Summary: p53 is a substrate of p21 (CDKN1A), creating a regulatory feedback loop.
Reason: Regulatory interaction - p21 is both a target and regulator of p53.
Supporting Evidence:
PMID:25417702
Functional interplay between MDM2, p63/p73 and mutant p53.
|
|
GO:0006355
regulation of DNA-templated transcription
|
IMP
PMID:25417702 Functional interplay between MDM2, p63/p73 and mutant p53. |
ACCEPT |
Summary: p53 regulates DNA-templated transcription as both an activator and repressor.
Reason: Core molecular function - transcription regulation is fundamental to p53's tumor suppressor activity.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:25417702
Functional interplay between MDM2, p63/p73 and mutant p53.
PMID:7587074
Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene.
|
|
GO:0003677
DNA binding
|
IMP
PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. |
ACCEPT |
Summary: p53 binds DNA through its central DNA-binding domain (residues 102-292) to p53 response elements.
Reason: Core molecular function - DNA binding is essential for p53's transcription factor activity.
Supporting Evidence:
TP53-deep-research
DNA-Binding Domain (DBD): Location: Residues 102-292; Structure: beta-sandwich core with DNA-binding loops
PMID:15358771
2004 Sep 9. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:2144364
Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene.
|
|
GO:0032991
protein-containing complex
|
IMP
PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. |
ACCEPT |
Summary: p53 forms part of protein-containing complexes including the p53 tetramer and complexes with co-activators.
Reason: p53 functions in complexes with CBP/p300, MDM2, and forms tetramers.
Supporting Evidence:
TP53-deep-research
Complex formation with transcriptional co-activators (CBP/p300, TFIID)
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:9529249
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.
|
|
GO:0097718
disordered domain specific binding
|
IPI
PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. |
KEEP AS NON CORE |
Summary: p53 is involved in dimerization of proteins.
Reason: Non-core - while p53 dimerizes, this is covered by more specific tetramerization terms.
Supporting Evidence:
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
|
|
GO:0000785
chromatin
|
IDA
PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf ex... |
ACCEPT |
Summary: p53 associates with chromatin at target gene promoters to regulate transcription.
Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
Supporting Evidence:
PDB:3TS8
Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:22521434
Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR.
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
PMID:17805299
p53 is regulated by the lysine demethylase LSD1.
|
|
GO:0005737
cytoplasm
|
IDA
PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf ex... |
ACCEPT |
Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:16131611
p53 isoforms can regulate p53 transcriptional activity.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0006914
autophagy
|
IMP
PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf ex... |
ACCEPT |
Summary: p53 regulates autophagy both positively and negatively depending on context.
Reason: p53 regulates autophagy as part of cellular stress response.
Supporting Evidence:
TP53-deep-research
p53 also regulates autophagy
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
|
|
GO:0042826
histone deacetylase binding
|
IPI
PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf ex... |
ACCEPT |
Summary: p53 undergoes deacetylation as part of its regulatory cycle.
Reason: Core regulatory mechanism - p53 acetylation/deacetylation cycle regulates its activity.
Supporting Evidence:
TP53-deep-research
C-terminal acetylation regulates p53 activity
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
|
|
GO:0045892
negative regulation of DNA-templated transcription
|
IMP
PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf ex... |
ACCEPT |
Summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes.
Reason: Core function - p53 acts as both a transcriptional activator and repressor.
Supporting Evidence:
TP53-deep-research
Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes
PMID:16492744
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.
PMID:9271120
Repression of p53-mediated transcription by MDM2: a dual mechanism.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:24051492
p53 regulates Period2 expression and the circadian clock.
|
|
GO:0005515
protein binding
|
IPI
PMID:17237821 Transcription factor TAFII250 promotes Mdm2-dependent turnov... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17237821
Jan 22. Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53.
|
|
GO:0005634
nucleus
|
IDA
PMID:24289924 Phosphorylation of p53 by TAF1 inactivates p53-dependent tra... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-5689950 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-5689973 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-5690843 |
ACCEPT |
Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-6793685 |
ACCEPT |
Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-8852351 |
ACCEPT |
Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-8852354 |
ACCEPT |
Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
|
|
GO:0005515
protein binding
|
IPI
PMID:10597287 Molecular interactions between telomerase and the tumor supp... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:10597287
Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3222116 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3222237 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-5628871 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805638 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805730 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805740 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805755 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6811508 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805276 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805399 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805103 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805109 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805126 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3215310 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6793685 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6804441 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6804879 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805059 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-8852337 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-8852351 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-9851077 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6804383 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3215152 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3215251 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3222093 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3222128 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3700981 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3700997 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-4331331 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-4331340 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-5633295 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-5633414 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6791285 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6791302 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6791327 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6791349 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6791387 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6796649 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6797766 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6797993 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6798020 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6798082 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6798129 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6798138 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6798282 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6798304 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6798374 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6799246 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6799409 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6799418 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6799462 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6799761 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6799777 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6799815 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6800042 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6800253 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6800279 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6800836 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6801087 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6801166 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6801209 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6801355 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6801641 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6802165 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6803391 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6803425 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6803719 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6803801 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6803858 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6803914 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6803935 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6804191 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6804242 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6804379 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6804402 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6804425 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805122 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805285 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805620 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6806408 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6806412 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6806413 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6806417 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6806419 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6811479 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-69685 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-9710323 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-9749464 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-9851076 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6798615 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005515
protein binding
|
IPI
PMID:12730672 Physical and functional interaction between HCV core protein... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:12730672
Physical and functional interaction between HCV core protein and the different p73 isoforms.
|
|
GO:0008285
negative regulation of cell population proliferation
|
IMP
PMID:12730672 Physical and functional interaction between HCV core protein... |
ACCEPT |
Summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism.
Reason: Core function - p53 inhibits proliferation through cell cycle arrest.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Negatively regulates cell division
PMID:30514107
CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.
PMID:12730672
Physical and functional interaction between HCV core protein and the different p73 isoforms.
PMID:22783376
Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53.
|
|
GO:1900119
positive regulation of execution phase of apoptosis
|
IMP
PMID:14985081 Hepatitis C virus core protein interacts with p53-binding pr... |
ACCEPT |
Summary: p53 positively regulates intrinsic apoptotic signaling in response to ER stress.
Reason: p53 responds to ER stress and can induce apoptosis under severe ER stress.
Supporting Evidence:
PMID:14985081
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
|
|
GO:0043153
entrainment of circadian clock by photoperiod
|
ISS
GO_REF:0000024 |
ACCEPT |
Summary: p53 enters the nucleus to function as a transcription factor.
Reason: Core process - nuclear entry is essential for p53's transcription factor activity.
Supporting Evidence:
TP53-deep-research
Nuclear Localization Signals (NLS): Function: Nuclear import and localization
|
|
GO:0045892
negative regulation of DNA-templated transcription
|
IDA
PMID:24051492 p53 regulates Period2 expression and the circadian clock. |
ACCEPT |
Summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes.
Reason: Core function - p53 acts as both a transcriptional activator and repressor.
Supporting Evidence:
TP53-deep-research
Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes
PMID:16492744
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.
PMID:9271120
Repression of p53-mediated transcription by MDM2: a dual mechanism.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:24051492
p53 regulates Period2 expression and the circadian clock.
|
|
GO:0048512
circadian behavior
|
ISS
GO_REF:0000024 |
KEEP AS NON CORE |
Summary: p53 is involved in organ development but is not essential for development.
Reason: Non-core developmental function - p53 knockout mice develop normally.
|
|
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
|
IDA
PMID:24652652 DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible... |
ACCEPT |
Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:34381247
Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
PMID:35618207
Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.
PMID:36634798
Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.
PMID:38653238
2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IDA
PMID:24652652 DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible... |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0005634
nucleus
|
IDA
PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 ... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005739
mitochondrion
|
IDA
PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 ... |
ACCEPT |
Summary: p53 translocates to mitochondria to directly promote apoptosis through BAX activation.
Reason: Important localization for non-transcriptional apoptosis - p53 can directly induce MOMP at mitochondria.
Supporting Evidence:
TP53-deep-research
Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins
PMID:25168243
Aug 29. Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:12667443
p53 has a direct apoptogenic role at the mitochondria.
|
|
GO:0005829
cytosol
|
IDA
PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 ... |
ACCEPT |
Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
|
|
GO:0005634
nucleus
|
IDA
PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005737
cytoplasm
|
IDA
PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances... |
ACCEPT |
Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:16131611
p53 isoforms can regulate p53 transcriptional activity.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0006974
DNA damage response
|
IDA
PMID:17938203 Protein kinase C delta induces transcription of the TP53 tum... |
ACCEPT |
Summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage.
Reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17938203
Oct 15. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage.
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
|
|
GO:0046677
response to antibiotic
|
IEP
PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances... |
ACCEPT |
Summary: p53 responds to antibiotic stress that causes cellular stress or DNA damage.
Reason: p53 responds to various xenobiotic stresses including antibiotics.
Supporting Evidence:
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
|
|
GO:0071456
cellular response to hypoxia
|
IEP
PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances... |
ACCEPT |
Summary: p53 mediates cellular responses to hypoxia, including cell cycle arrest and apoptosis induction.
Reason: Core stress response function - p53 responds to hypoxic stress and coordinates appropriate cellular responses.
Supporting Evidence:
GO:1990144
intrinsic apoptotic signaling pathway in response to hypoxia
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
|
|
GO:0090200
positive regulation of release of cytochrome c from mitochondria
|
IDA
PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membr... |
ACCEPT |
Summary: p53 positively regulates mitochondrial DNA replication through its DNA repair functions.
Reason: p53 maintains mitochondrial genome stability through various mechanisms.
Supporting Evidence:
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
|
|
GO:2001244
positive regulation of intrinsic apoptotic signaling pathway
|
IMP
PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membr... |
ACCEPT |
Summary: p53 negatively regulates intrinsic apoptotic signaling in certain contexts.
Reason: p53 can have context-dependent anti-apoptotic effects through p21-mediated survival.
Supporting Evidence:
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
|
|
GO:0072332
intrinsic apoptotic signaling pathway by p53 class mediator
|
IMP
PMID:16322561 NIR is a novel INHAT repressor that modulates the transcript... |
ACCEPT |
Summary: p53 mediates intrinsic apoptotic signaling through BAX, PUMA, NOXA activation.
Reason: Core apoptotic function - p53 is the master regulator of intrinsic apoptosis.
Supporting Evidence:
TP53-deep-research
Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA)
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:12172011
Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3222259 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3239014 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005515
protein binding
|
IPI
PMID:17719541 Hzf Determines cell survival upon genotoxic stress by modula... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17719541
Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-264435 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3221982 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3222006 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3222020 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-3786258 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-4395236 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-4647593 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-5628899 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-5629187 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-5632759 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-5632887 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-5632914 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-5632939 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-5633460 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-5693609 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6789960 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6791409 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6799332 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6799431 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6804188 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6804762 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6804996 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6804998 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805035 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805470 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-6805479 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-8853911 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-HSA-8952128 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-NUL-992753 |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0097252
oligodendrocyte apoptotic process
|
IDA
PMID:7720704 Direct involvement of p53 in programmed cell death of oligod... |
ACCEPT |
Summary: p53 undergoes various post-translational modifications in response to stress.
Reason: Core regulatory mechanism - p53 is extensively modified at over 60 residues.
Supporting Evidence:
TP53-deep-research
p53 can be modified at over 60 of its 393 residues
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005515
protein binding
|
IPI
PMID:22945289 ZNF385B is characteristically expressed in germinal center B... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:22945289
Oct 16. ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis.
|
|
GO:0045893
positive regulation of DNA-templated transcription
|
IDA
PMID:20378837 Glutaminase 2, a novel p53 target gene regulating energy met... |
ACCEPT |
Summary: p53 positively regulates DNA-templated transcription of target genes.
Reason: Core transcriptional function - p53 activates transcription of numerous target genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:20378837
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
|
|
GO:0008285
negative regulation of cell population proliferation
|
IDA
PMID:22783376 Induction of apoptosis by cytoplasmically localized wild-typ... |
ACCEPT |
Summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism.
Reason: Core function - p53 inhibits proliferation through cell cycle arrest.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Negatively regulates cell division
PMID:30514107
CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.
PMID:12730672
Physical and functional interaction between HCV core protein and the different p73 isoforms.
PMID:22783376
Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:23431171 MOZ increases p53 acetylation and premature senescence throu... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:23431171
MOZ increases p53 acetylation and premature senescence through its complex formation with PML.
|
|
GO:0016605
PML body
|
IDA
PMID:22869143 BMK1 is involved in the regulation of p53 through disrupting... |
ACCEPT |
Summary: p53 localizes to PML nuclear bodies, which is important for its post-translational modification and activation.
Reason: Important regulatory localization - p53 accumulates in PML bodies during stress responses where it undergoes acetylation.
Supporting Evidence:
TP53-deep-research
p53 localizes to nuclear bodies like PML bodies, especially during stress responses
PMID:22869143
BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction.
PMID:12006491
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
|
|
GO:0043066
negative regulation of apoptotic process
|
IMP
PMID:20124405 G-protein-coupled receptor kinase 5 phosphorylates p53 and i... |
ACCEPT |
Summary: p53 can negatively regulate apoptosis in certain contexts through p21-mediated survival.
Reason: Context-dependent function - p53 can promote survival under mild stress conditions.
Supporting Evidence:
PMID:20124405
2010 Feb 2. G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis.
|
|
GO:0016032
viral process
|
IMP
PMID:22574148 p53 Activation following Rift Valley fever virus infection c... |
KEEP AS NON CORE |
Summary: p53 is involved in viral processes through its antiviral functions.
Reason: Non-core function - p53 has antiviral activity but this is not its primary role.
Supporting Evidence:
PMID:22574148
p53 Activation following Rift Valley fever virus infection contributes to cell death and viral production.
|
|
GO:0000785
chromatin
|
IDA
PMID:22521434 Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D t... |
ACCEPT |
Summary: p53 associates with chromatin at target gene promoters to regulate transcription.
Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
Supporting Evidence:
PDB:3TS8
Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:22521434
Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR.
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
PMID:17805299
p53 is regulated by the lysine demethylase LSD1.
|
|
GO:0030971
receptor tyrosine kinase binding
|
IPI
PMID:23027130 TrkC signaling is activated in adenoid cystic carcinoma and ... |
ACCEPT |
Summary: p53 interacts with receptor tyrosine kinases as part of signal transduction.
Reason: p53 integrates signals from growth factor signaling pathways.
Supporting Evidence:
PMID:23027130
TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior.
|
|
GO:0005515
protein binding
|
IPI
PMID:19483087 Identification and characterization of two novel isoforms of... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19483087
Epub 2009 May 29. Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains.
|
|
GO:0005515
protein binding
|
IPI
PMID:20096447 USP10 regulates p53 localization and stability by deubiquiti... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
|
|
GO:0005829
cytosol
|
IDA
PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membr... |
ACCEPT |
Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
|
|
GO:0000785
chromatin
|
IDA
PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcr... |
ACCEPT |
Summary: p53 associates with chromatin at target gene promoters to regulate transcription.
Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
Supporting Evidence:
PDB:3TS8
Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:22521434
Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR.
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
PMID:17805299
p53 is regulated by the lysine demethylase LSD1.
|
|
GO:0005515
protein binding
|
IPI
PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcr... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
|
|
GO:0006974
DNA damage response
|
IDA
PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcr... |
ACCEPT |
Summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage.
Reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses.
Supporting Evidence:
TP53-deep-research
p53 serves as a central node in the DNA damage response network
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17938203
Oct 15. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage.
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
|
|
GO:0048147
negative regulation of fibroblast proliferation
|
IMP
PMID:10962037 Overexpression of MYC causes p53-dependent G2 arrest of norm... |
KEEP AS NON CORE |
Summary: p53 negatively regulates fibroblast proliferation as part of its anti-proliferative function.
Reason: Cell type-specific manifestation of anti-proliferative function.
Supporting Evidence:
PMID:10962037
Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts.
|
|
GO:0005515
protein binding
|
IPI
PMID:20123734 NIR, an inhibitor of histone acetyltransferases, regulates t... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20123734
Jan 31. NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle.
|
|
GO:0005515
protein binding
|
IPI
PMID:20959462 Aurora B interacts with NIR-p53, leading to p53 phosphorylat... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0043065
positive regulation of apoptotic process
|
IDA
PMID:20959462 Aurora B interacts with NIR-p53, leading to p53 phosphorylat... |
ACCEPT |
Summary: p53 positively regulates apoptosis as a major tumor suppressor mechanism.
Reason: Core function - p53 induces apoptosis through multiple pathways.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression
PMID:12667443
p53 has a direct apoptogenic role at the mitochondria.
PMID:15565177
A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IDA
PMID:20959462 Aurora B interacts with NIR-p53, leading to p53 phosphorylat... |
ACCEPT |
Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16061649
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
PMID:11672523
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
PMID:17145718
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
PMID:17146433
Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:24356969
2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:24652652
2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
PMID:20959462
2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
|
|
GO:0003682
chromatin binding
|
IDA
PMID:16322561 NIR is a novel INHAT repressor that modulates the transcript... |
ACCEPT |
Summary: p53 binds chromatin at p53 response elements in target gene promoters.
Reason: Core molecular function - chromatin binding is essential for p53's transcriptional regulation.
Supporting Evidence:
PDB:3TS8
Crystal structure of p53 tetramer bound to DNA
PMID:26334721
2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
|
|
GO:0045893
positive regulation of DNA-templated transcription
|
IDA
PMID:16322561 NIR is a novel INHAT repressor that modulates the transcript... |
ACCEPT |
Summary: p53 positively regulates DNA-templated transcription of target genes.
Reason: Core transcriptional function - p53 activates transcription of numerous target genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:20378837
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:20124405 G-protein-coupled receptor kinase 5 phosphorylates p53 and i... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20124405
2010 Feb 2. G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis.
|
|
GO:0042149
cellular response to glucose starvation
|
IDA
PMID:21471221 Novel nucleolar pathway connecting intracellular energy stat... |
ACCEPT |
Summary: p53 responds to glucose starvation as part of metabolic stress response.
Reason: p53 responds to metabolic stress including glucose deprivation.
Supporting Evidence:
PMID:21471221
2011 Apr 6. Novel nucleolar pathway connecting intracellular energy status with p53 activation.
|
|
GO:0005634
nucleus
|
IDA
PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabiliz... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0061629
RNA polymerase II-specific DNA-binding transcription factor binding
|
IPI
PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts wi... |
ACCEPT |
Summary: p53 binds RNA through its C-terminal domain.
Reason: p53 has RNA-binding activity that contributes to regulation of gene expression.
Supporting Evidence:
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
|
|
GO:0072332
intrinsic apoptotic signaling pathway by p53 class mediator
|
IMP
PMID:12172011 Chk2 regulates irradiation-induced, p53-mediated apoptosis i... |
ACCEPT |
Summary: p53 mediates intrinsic apoptotic signaling through BAX, PUMA, NOXA activation.
Reason: Core apoptotic function - p53 is the master regulator of intrinsic apoptosis.
Supporting Evidence:
TP53-deep-research
Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA)
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:12172011
Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila.
|
|
GO:0000785
chromatin
|
IDA
PMID:17805299 p53 is regulated by the lysine demethylase LSD1. |
ACCEPT |
Summary: p53 associates with chromatin at target gene promoters to regulate transcription.
Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
Supporting Evidence:
PDB:3TS8
Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:30089260
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:22521434
Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR.
PMID:15710329
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
PMID:17805299
p53 is regulated by the lysine demethylase LSD1.
|
|
GO:0019899
enzyme binding
|
IPI
PMID:17805299 p53 is regulated by the lysine demethylase LSD1. |
REMOVE |
Summary: Generic 'enzyme binding' is uninformative for p53 function.
Reason: Too generic - p53 binds many enzymes but this term provides no functional insight.
Supporting Evidence:
PMID:17805299
p53 is regulated by the lysine demethylase LSD1.
|
|
GO:0071466
cellular response to xenobiotic stimulus
|
IEP
PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances... |
ACCEPT |
Summary: p53 mediates cellular response to xenobiotic stress.
Reason: p53 responds to various xenobiotic stresses that cause DNA damage or cellular stress.
Supporting Evidence:
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
|
|
GO:2000379
positive regulation of reactive oxygen species metabolic process
|
IMP
PMID:20160708 Feedback between p21 and reactive oxygen production is neces... |
ACCEPT |
Summary: p53 positively regulates intrinsic apoptotic signaling in response to DNA damage.
Reason: Core function - DNA damage-induced apoptosis is a primary p53 tumor suppressor mechanism.
Supporting Evidence:
GO:0042771
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
PMID:20160708
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
|
|
GO:0005737
cytoplasm
|
IDA
PMID:16131611 p53 isoforms can regulate p53 transcriptional activity. |
ACCEPT |
Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:16131611
p53 isoforms can regulate p53 transcriptional activity.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0008285
negative regulation of cell population proliferation
|
ISS
GO_REF:0000024 |
ACCEPT |
Summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism.
Reason: Core function - p53 inhibits proliferation through cell cycle arrest.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Negatively regulates cell division
PMID:30514107
CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.
PMID:12730672
Physical and functional interaction between HCV core protein and the different p73 isoforms.
PMID:22783376
Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53.
|
|
GO:0008340
determination of adult lifespan
|
ISS
GO_REF:0000024 |
KEEP AS NON CORE |
Summary: p53 may influence lifespan through its regulation of senescence and apoptosis.
Reason: Non-core function - while p53 influences aging, this is secondary to its tumor suppressor function.
|
|
GO:0070245
positive regulation of thymocyte apoptotic process
|
ISS
GO_REF:0000024 |
ACCEPT |
Summary: p53 responds to positive regulation by stress-induced post-translational modifications.
Reason: p53 is regulated by extensive post-translational modifications that enhance its activity.
Supporting Evidence:
TP53-deep-research
p53 can be modified at over 60 of its 393 residues
|
|
GO:0005515
protein binding
|
IPI
PMID:17707234 Modulation of p53 function by SET8-mediated methylation at l... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17707234
Modulation of p53 function by SET8-mediated methylation at lysine 382.
|
|
GO:0005515
protein binding
|
IPI
PMID:20118233 G9a and Glp methylate lysine 373 in the tumor suppressor p53... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:20118233
2010 Jan 29. G9a and Glp methylate lysine 373 in the tumor suppressor p53.
|
|
GO:0090399
replicative senescence
|
IMP
PMID:19951988 WNT16B is a new marker of cellular senescence that regulates... |
ACCEPT |
Summary: p53 is stabilized and activated under stress conditions.
Reason: Core mechanism - p53 protein stabilization is essential for its tumor suppressor function.
Supporting Evidence:
TP53-deep-research
p53 is activated through post-translational modifications which stabilize the protein
PMID:19951988
WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway.
|
|
GO:0090403
oxidative stress-induced premature senescence
|
IMP
PMID:19951988 WNT16B is a new marker of cellular senescence that regulates... |
ACCEPT |
Summary: p53 induces oxidative stress during apoptosis induction.
Reason: p53 regulates cellular redox and can promote ROS production in apoptosis.
Supporting Evidence:
PMID:19951988
WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway.
|
|
GO:0005634
nucleus
|
IDA
PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005737
cytoplasm
|
IDA
PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... |
ACCEPT |
Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:16131611
p53 isoforms can regulate p53 transcriptional activity.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005634
nucleus
|
IDA
PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0042771
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
|
IDA
PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for... |
ACCEPT |
Summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation.
Reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis.
Supporting Evidence:
TP53-deep-research
Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS)
PMID:14654789
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:16213212
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
|
|
GO:0045893
positive regulation of DNA-templated transcription
|
IDA
PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for... |
ACCEPT |
Summary: p53 positively regulates DNA-templated transcription of target genes.
Reason: Core transcriptional function - p53 activates transcription of numerous target genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:20378837
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
|
|
GO:0071479
cellular response to ionizing radiation
|
IMP
PMID:20160708 Feedback between p21 and reactive oxygen production is neces... |
ACCEPT |
Summary: p53 responds to UV-A radiation-induced DNA damage.
Reason: Core DNA damage response function - UV radiation is a classic p53 activator.
Supporting Evidence:
GO:0009411
response to UV
PMID:20160708
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
|
|
GO:0000122
negative regulation of transcription by RNA polymerase II
|
ISS
PMID:19749791 Repression of SHP-1 expression by p53 leads to trkA tyrosine... |
ACCEPT |
Summary: p53 functions as a transcriptional repressor for genes including BCL2 and cell cycle genes.
Reason: Core function - transcriptional repression is part of p53's regulatory activity.
Supporting Evidence:
TP53-deep-research
Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes
PMID:10329733
p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor.
PMID:19749791
Sep 14. Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation.
|
|
GO:0002020
protease binding
|
IPI
PMID:11923872 Deubiquitination of p53 by HAUSP is an important pathway for... |
ACCEPT |
Summary: p53 binds protease inhibitors as part of regulatory interactions.
Reason: Regulatory protein-protein interaction.
Supporting Evidence:
PMID:11923872
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization.
|
|
GO:0031625
ubiquitin protein ligase binding
|
IPI
PMID:8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor sup... |
REMOVE |
Summary: Generic 'ubiquitin protein ligase binding' is less informative than specific MDM2/MDM4 interactions.
Reason: While p53 binds MDM2 (E3 ligase), this generic term is uninformative. The specific MDM2 interaction is well-documented elsewhere.
Supporting Evidence:
PMID:8875929
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
|
|
GO:0051721
protein phosphatase 2A binding
|
IPI
PMID:17245430 A specific PP2A regulatory subunit, B56gamma, mediates DNA d... |
ACCEPT |
Summary: p53 interacts with tubulin during mitosis and cell division control.
Reason: p53 regulates cell division and can interact with cytoskeletal components.
Supporting Evidence:
PMID:17245430
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
|
|
GO:0005634
nucleus
|
IDA
PMID:20096447 USP10 regulates p53 localization and stability by deubiquiti... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005737
cytoplasm
|
IDA
PMID:20096447 USP10 regulates p53 localization and stability by deubiquiti... |
ACCEPT |
Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:16131611
p53 isoforms can regulate p53 transcriptional activity.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0045893
positive regulation of DNA-templated transcription
|
IMP
PMID:20096447 USP10 regulates p53 localization and stability by deubiquiti... |
ACCEPT |
Summary: p53 positively regulates DNA-templated transcription of target genes.
Reason: Core transcriptional function - p53 activates transcription of numerous target genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:20378837
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
|
|
GO:0032991
protein-containing complex
|
IDA
PMID:9529249 ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a ... |
ACCEPT |
Summary: p53 forms part of protein-containing complexes including the p53 tetramer and complexes with co-activators.
Reason: p53 functions in complexes with CBP/p300, MDM2, and forms tetramers.
Supporting Evidence:
TP53-deep-research
Complex formation with transcriptional co-activators (CBP/p300, TFIID)
PMID:17310983
Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:9529249
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.
|
|
GO:0007265
Ras protein signal transduction
|
IEP
PMID:9054499 Oncogenic ras provokes premature cell senescence associated ... |
ACCEPT |
Summary: p53 is regulated by Ras signaling pathway which can activate p53.
Reason: p53 is activated by oncogenic Ras signaling as a tumor suppressor mechanism.
Supporting Evidence:
PMID:9054499
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.
|
|
GO:0005634
nucleus
|
IDA
PMID:18756595 Prognostic significance of BMP and activin membrane-bound in... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0010332
response to gamma radiation
|
IMP
PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and ... |
ACCEPT |
Summary: p53 responds to gamma radiation-induced DNA damage.
Reason: Core function - ionizing radiation strongly activates p53.
Supporting Evidence:
TP53-deep-research
p53 responds to DNA damage from ionizing radiation
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
|
|
GO:0031571
mitotic G1 DNA damage checkpoint signaling
|
IMP
PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and ... |
ACCEPT |
Summary: p53 mediates G1 DNA damage checkpoint signaling through p21 induction.
Reason: Core function - G1/S checkpoint is a major p53-mediated cell cycle control.
Supporting Evidence:
TP53-deep-research
Cell cycle arrest is mediated by transcriptional upregulation of p21
PMID:7958916
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
|
|
GO:0005515
protein binding
|
IPI
PMID:17317671 The notch regulator MAML1 interacts with p53 and functions a... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:17317671
2007 Feb 22. The notch regulator MAML1 interacts with p53 and functions as a coactivator.
|
|
GO:0005515
protein binding
|
IPI
PMID:19151705 CHD8 suppresses p53-mediated apoptosis through histone H1 re... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:19151705
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.
|
|
GO:0008270
zinc ion binding
|
TAS
PMID:10065153 Covalent and noncovalent modifiers of the p53 protein. |
ACCEPT |
Summary: p53 DNA-binding domain coordinates a zinc ion essential for structural stability.
Reason: Core structural feature - zinc coordination is essential for p53 DNA-binding domain structure.
Supporting Evidence:
TP53-deep-research
DNA-Binding Domain contains critical zinc coordination site
PMID:10065153
Covalent and noncovalent modifiers of the p53 protein.
|
|
GO:0016605
PML body
|
IDA
PMID:12006491 Human SIR2 deacetylates p53 and antagonizes PML/p53-induced ... |
ACCEPT |
Summary: p53 localizes to PML nuclear bodies, which is important for its post-translational modification and activation.
Reason: Important regulatory localization - p53 accumulates in PML bodies during stress responses where it undergoes acetylation.
Supporting Evidence:
TP53-deep-research
p53 localizes to nuclear bodies like PML bodies, especially during stress responses
PMID:22869143
BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction.
PMID:12006491
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
|
|
GO:0051087
protein-folding chaperone binding
|
IPI
PMID:18086682 Hsp60 regulation of tumor cell apoptosis. |
KEEP AS NON CORE |
Summary: p53 has chaperone binding activity related to its folding and stability.
Reason: Non-core function related to protein folding and quality control.
Supporting Evidence:
PMID:18086682
2007 Dec 17. Hsp60 regulation of tumor cell apoptosis.
|
|
GO:0003682
chromatin binding
|
IDA
PMID:17599062 CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediate... |
ACCEPT |
Summary: p53 binds chromatin at p53 response elements in target gene promoters.
Reason: Core molecular function - chromatin binding is essential for p53's transcriptional regulation.
Supporting Evidence:
PDB:3TS8
Crystal structure of p53 tetramer bound to DNA
PMID:26334721
2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:17599062
Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
|
|
GO:0097193
intrinsic apoptotic signaling pathway
|
TAS
PMID:16462759 Inhibition of Bax activity is crucial for the antiapoptotic ... |
ACCEPT |
Summary: p53 mediates intrinsic apoptotic signaling through mitochondrial pathway activation.
Reason: Core function - intrinsic apoptotic signaling is a major p53 tumor suppressor mechanism.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Apoptosis induction seems to be mediated either by stimulation of BAX
PMID:16462759
Feb 6. Inhibition of Bax activity is crucial for the antiapoptotic function of the human papillomavirus E6 oncoprotein.
|
|
GO:0005634
nucleus
|
IDA
PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival p... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0008104
intracellular protein localization
|
IDA
PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival p... |
ACCEPT |
Summary: p53 localization is regulated by nuclear import and export mechanisms.
Reason: Core regulatory mechanism - nucleo-cytoplasmic shuttling regulates p53 activity.
Supporting Evidence:
TP53-deep-research
Nuclear Localization Signals (NLS): Function: Nuclear import and localization
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
|
|
GO:0046982
protein heterodimerization activity
|
IPI
PMID:10837489 MCL-1S, a splicing variant of the antiapoptotic BCL-2 family... |
ACCEPT |
Summary: p53 binds to hetero-dimeric protein partners as part of its regulatory function.
Reason: p53 forms heterodimers with various regulatory proteins.
Supporting Evidence:
PMID:10837489
MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain.
|
|
GO:0005515
protein binding
|
IPI
PMID:15735003 p53CSV, a novel p53-inducible gene involved in the p53-depen... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:15735003
p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway.
|
|
GO:0005515
protein binding
|
IPI
PMID:11861836 Human immunodeficiency virus type 1 Nef binds to tumor suppr... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:11861836
Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.
|
|
GO:0005515
protein binding
|
IPI
PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific P... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0005654
nucleoplasm
|
IDA
PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific P... |
ACCEPT |
Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0016363
nuclear matrix
|
IDA
PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific P... |
ACCEPT |
Summary: p53 regulates nuclear matrix organization.
Reason: p53 interacts with nuclear matrix components and influences nuclear organization.
Supporting Evidence:
PMID:11080164
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
|
|
GO:0065003
protein-containing complex assembly
|
IDA
PMID:12915590 Cellular stress and DNA damage invoke temporally distinct Md... |
ACCEPT |
Summary: p53 forms protein-containing complexes with transcriptional machinery and regulators.
Reason: Core function - p53 assembles into functional complexes to regulate transcription.
Supporting Evidence:
TP53-deep-research
Complex formation with transcriptional co-activators (CBP/p300, TFIID)
PMID:12915590
Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
|
|
GO:0005515
protein binding
|
IPI
PMID:11684014 ASPP proteins specifically stimulate the apoptotic function ... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:11684014
ASPP proteins specifically stimulate the apoptotic function of p53.
|
|
GO:0005515
protein binding
|
IPI
PMID:8675009 The XPB and XPD DNA helicases are components of the p53-medi... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:8675009
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.
|
|
GO:0005515
protein binding
|
IPI
PMID:10608892 Stabilization of the MDM2 oncoprotein by interaction with th... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:10608892
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein.
|
|
GO:0005515
protein binding
|
IPI
PMID:12750254 p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 ac... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:12750254
p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.
|
|
GO:0051097
negative regulation of helicase activity
|
TAS
PMID:7663514 p53 modulation of TFIIH-associated nucleotide excision repai... |
ACCEPT |
Summary: p53 inhibits helicase activity as part of DNA repair regulation.
Reason: p53 can regulate DNA repair processes including helicase activity during damage response.
Supporting Evidence:
PMID:7663514
p53 modulation of TFIIH-associated nucleotide excision repair activity.
|
|
GO:0006289
nucleotide-excision repair
|
IMP
PMID:7663514 p53 modulation of TFIIH-associated nucleotide excision repai... |
ACCEPT |
Summary: p53 promotes nucleotide-excision repair (NER) through transcriptional regulation of XPC and DDB2.
Reason: Core DNA repair function - p53 regulates multiple DNA repair genes including those in the NER pathway.
Supporting Evidence:
TP53-deep-research
DNA Repair: XPC: Nucleotide excision repair; DDB2: DNA damage-binding protein
PMID:7663514
p53 modulation of TFIIH-associated nucleotide excision repair activity.
|
|
GO:0005515
protein binding
|
IPI
PMID:1465435 Wild-type p53 binds to the TATA-binding protein and represse... |
REMOVE |
Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
Supporting Evidence:
PMID:1465435
Wild-type p53 binds to the TATA-binding protein and represses transcription.
|
|
GO:0005739
mitochondrion
|
IDA
PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. |
ACCEPT |
Summary: p53 translocates to mitochondria to directly promote apoptosis through BAX activation.
Reason: Important localization for non-transcriptional apoptosis - p53 can directly induce MOMP at mitochondria.
Supporting Evidence:
TP53-deep-research
Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins
PMID:25168243
Aug 29. Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:12667443
p53 has a direct apoptogenic role at the mitochondria.
|
|
GO:0005507
copper ion binding
|
IDA
PMID:7824276 Modulation by copper of p53 conformation and sequence-specif... |
ACCEPT |
Summary: p53 DNA-binding domain binds copper ions which can affect its function.
Reason: Structural feature - copper binding can affect p53 structure and function.
Supporting Evidence:
PMID:7824276
Modulation by copper of p53 conformation and sequence-specific DNA binding: role for Cu(II)/Cu(I) redox mechanism.
|
|
GO:0030308
negative regulation of cell growth
|
IMP
PMID:8986812 Identification of a novel p53 functional domain that is nece... |
ACCEPT |
Summary: p53 negatively regulates cell growth as a fundamental tumor suppressor mechanism.
Reason: Core function - growth inhibition is a primary tumor suppressor activity of p53.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Negatively regulates cell division by controlling expression of a set of genes required for this process
PMID:8986812
Identification of a novel p53 functional domain that is necessary for efficient growth suppression.
|
|
GO:0005634
nucleus
|
IDA
PMID:7720704 Direct involvement of p53 in programmed cell death of oligod... |
ACCEPT |
Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.
PMID:14963330
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
PMID:16322561
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
PMID:36108750
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:24289924
Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PMID:24101517
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:19234109
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:17403783
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:18756595
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
PMID:16507995
Myosin VI is a mediator of the p53-dependent cell survival pathway.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0005737
cytoplasm
|
IDA
PMID:7720704 Direct involvement of p53 in programmed cell death of oligod... |
ACCEPT |
Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
PMID:24625977
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
PMID:26634371
Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:21597459
2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
PMID:19011621
Arginine methylation regulates the p53 response.
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:23629966
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
PMID:20810912
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
PMID:16131611
p53 isoforms can regulate p53 transcriptional activity.
PMID:14744935
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
PMID:20096447
USP10 regulates p53 localization and stability by deubiquitinating p53.
PMID:7720704
Direct involvement of p53 in programmed cell death of oligodendrocytes.
|
|
GO:0003677
DNA binding
|
IMP
PMID:2144364 Transcriptional activation by wild-type but not transforming... |
ACCEPT |
Summary: p53 binds DNA through its central DNA-binding domain (residues 102-292) to p53 response elements.
Reason: Core molecular function - DNA binding is essential for p53's transcription factor activity.
Supporting Evidence:
TP53-deep-research
DNA-Binding Domain (DBD): Location: Residues 102-292; Structure: beta-sandwich core with DNA-binding loops
PMID:15358771
2004 Sep 9. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures.
PMID:15629713
Binding of natively unfolded HIF-1alpha ODD domain to p53.
PMID:2144364
Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene.
|
|
GO:0003700
DNA-binding transcription factor activity
|
IDA
PMID:7587074 Targets for transcriptional activation by wild-type p53: end... |
ACCEPT |
Summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes.
Reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:16479015
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
PMID:26334721
2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
PMID:18549481
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
PMID:7587074
Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene.
|
|
GO:0005730
nucleolus
|
IDA
PMID:12080348 Nucleophosmin regulates the stability and transcriptional ac... |
ACCEPT |
Summary: p53 localizes to nucleolus, particularly during stress responses and ribosome biogenesis regulation.
Reason: p53 can localize to nucleolus and regulate ribosomal biogenesis as part of stress response.
Supporting Evidence:
PMID:12080348
Nucleophosmin regulates the stability and transcriptional activity of p53.
|
|
GO:0006355
regulation of DNA-templated transcription
|
IDA
PMID:7587074 Targets for transcriptional activation by wild-type p53: end... |
ACCEPT |
Summary: p53 regulates DNA-templated transcription as both an activator and repressor.
Reason: Core molecular function - transcription regulation is fundamental to p53's tumor suppressor activity.
Supporting Evidence:
file:human/TP53/TP53-uniprot.txt
Multifunctional transcription factor
PMID:25417702
Functional interplay between MDM2, p63/p73 and mutant p53.
PMID:7587074
Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene.
|
Q: How does p53 integrate diverse stress signals to determine cell fate decisions between survival, senescence, and apoptosis?
Q: What determines the selectivity of p53 for different target gene promoters and how is this modulated by post-translational modifications?
Q: How do p53 isoforms and mutant forms interact to modulate tumor suppressor function in heterozygous cancer cells?
Experiment: Single-cell time-lapse imaging to track p53 dynamics and correlate oscillation patterns with specific cell fate outcomes
Experiment: ChIP-seq coupled with PRO-seq to map p53 binding and transcriptional outcomes under different stress conditions
Experiment: Proximity labeling proteomics to identify context-specific p53 interactors that determine target gene selectivity
TP53 encodes the tumor suppressor p53, widely recognized as the "guardian of the genome" due to its central role in maintaining genomic integrity and preventing malignant transformation. Located on chromosome 17p13.1, TP53 is the most frequently altered gene in human cancers, with mutations found in over 50% of all human malignancies [PMC11641486 "p53 plays a multifaceted and complex role in the DNA damage response and cancer progression and is known as the 'guardian of the gene'"]. The protein product consists of 393 amino acids and functions as a sequence-specific transcription factor that coordinates cellular responses to diverse stress signals.
TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements (p53REs) in target gene promoters and regulatory regions [Nature 2023 "The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles in regulating cell cycle, apoptosis, and genomic stability"]. This DNA-binding activity is mediated by its central DNA-binding domain (DBD) and is essential for virtually all p53 functions.
p53 functions through extensive protein-protein interactions, including:
- Homodimerization and tetramerization through its oligomerization domain
- Interactions with transcriptional co-activators (CBP/p300, TFIID)
- Binding to negative regulators (MDM2, MDM4)
- Complex formation with DNA repair proteins and cell cycle regulators
p53 acts as both a transcriptional activator and repressor:
- Activation: Upregulates genes involved in cell cycle arrest (p21/CDKN1A), apoptosis (PUMA, BAX, NOXA), and DNA repair
- Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes, and metabolic enzymes [Nature 2023 "p53 is not a direct repressor of genes but can indirectly repress genes through activation of the p21-DREAM/RB pathway"]
p53 serves as a central node in the DNA damage response network [PMC11641486 "When DNA damage occurs, p53 is activated through a series of post-translational modifications, which stabilize the protein and enhance its function as a transcription factor"]. It integrates signals from upstream kinases (ATM, ATR, DNA-PK) and coordinates appropriate cellular responses including:
- Cell cycle checkpoint activation
- DNA repair pathway stimulation
- Apoptosis induction when damage is irreparable
p53 enforces cell cycle checkpoints primarily through transcriptional activation of p21 (CDKN1A), which inhibits cyclin-dependent kinases and prevents S-phase entry with unrepaired DNA damage [Multiple sources "Cell cycle arrest is mediated by transcriptional upregulation of p21, a cyclin-dependent kinase inhibitor that binds and inhibits CDK2"].
p53 triggers apoptosis through both transcription-dependent and transcription-independent mechanisms:
- Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS)
- Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins
p53 induces senescence as an alternative to apoptosis, particularly in stressed but viable cells, serving as a barrier to tumorigenesis.
Recent research has revealed p53's extensive role in cellular metabolism [Nature 2023 "Accumulating evidence has shown that p53 also regulates cell metabolism, ferroptosis, tumor microenvironment, autophagy and so on"]:
- Wild-type p53: Inhibits glycolysis, promotes oxidative phosphorylation and mitochondrial respiration
- Mutant p53: Enhances aerobic glycolysis (Warburg effect) in cancer cells
- Specific targets: TIGAR (inhibits glycolysis), SCO2 (promotes oxidative phosphorylation), GLS2 (glutaminolysis)
p53 has a dual role in ferroptosis (iron-dependent programmed cell death) [PMC10875350 "p53 regulates ferroptosis pathways within tumor cells and is closely related to tumorigenesis"]:
- Pro-ferroptotic: Represses SLC7A11, activates ALOX12, promotes lipid peroxidation
- Anti-ferroptotic: Induces p21 to maintain GSH levels, inhibits DPP4 activity
p53 can be modified at over 60 of its 393 residues, with major modifications including:
Key phosphorylation sites and their functions:
- Ser15, Thr18, Ser20: N-terminal phosphorylation by ATM/ATR, disrupts MDM2 binding
- Ser46: Promotes apoptosis over cell cycle arrest
- Ser392: C-terminal phosphorylation, enhances DNA binding
Critical for p53 activation and stability:
- Lys120, Lys164: Central domain acetylation
- Lys370, Lys372, Lys373, Lys381, Lys382, Lys386: C-terminal acetylation
- Function: Stabilizes p53, enhances DNA binding, recruits co-activators [PMC9149126 "The significance of p53 acetylation is 3-fold: (i) it promotes p53 stabilization by excluding ubiquitination on the same site, (ii) it inhibits the formation of HDM2/HDMX repressive complexes"]
Primary mechanism for p53 degradation:
- E3 ligases: MDM2, MDM4, COP1, TRIM24
- Sites: Multiple C-terminal lysines
- Function: Proteasomal degradation, nuclear export
Less understood but increasingly recognized:
- Sites: Lys370, Lys372, Lys373, Lys382
- Function: Fine-tuning of transcriptional activity
Germline TP53 mutations cause Li-Fraumeni syndrome, characterized by:
- Early-onset multiple primary cancers
- Autosomal dominant inheritance pattern
- Common hotspot mutations: R175H, R248Q, R273H, G245S, R282W
- R248Q specific: Particularly aggressive phenotype with accelerated tumor onset [Recent 2024 studies "LFS patients carrying the R248Q mutation exhibit markedly accelerated tumor onset (10.5 years earlier)"]
Several MDM2 inhibitors are in clinical development to reactivate wild-type p53:
- HDM201 (siremadlin): Selective MDM2 inhibitor
- ALRN-6924: Dual MDM2/MDM4 inhibitor
- NVP-CGM097: Dihydroisoquinolinone derivative
- Clinical challenges: Dose-limiting toxicities, patient selection [Recent review 2024 "Nine MDM2 inhibitors with different structural types have entered clinical trials, though no MDM2 inhibitor has been approved for clinical application yet"]
Recent research has uncovered p53's immunomodulatory functions [PMC11393945 "Recent studies have uncovered important immunomodulatory functions of p53, but these functions are still underappreciated compared to its other well-known roles"], opening new avenues for combination immunotherapy.
While p53 does interact with numerous proteins, annotations for generic "protein binding" without functional context should be avoided in favor of specific functional interactions.
Although p53 plays roles in development and embryogenesis, these are often secondary to its core tumor suppressor functions and may represent over-annotation in certain contexts.
Some metabolic and stress response functions may be context-dependent and should not be considered universal p53 functions across all cell types and conditions.
TP53 represents one of the most extensively studied genes in cancer biology, with its protein product serving multiple critical roles beyond the traditional "guardian of the genome" function. Recent research has expanded our understanding to include metabolic regulation, ferroptosis control, and immunomodulation. The complexity of p53 regulation through extensive post-translational modifications and its context-dependent functions continue to reveal new therapeutic opportunities, particularly in the era of precision medicine and combination therapies. The high frequency of TP53 mutations in human cancers and the aggressive nature of certain hotspot mutations like R248Q underscore the continued importance of developing effective p53-targeted therapeutics.
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template_variables:
organism: human
gene_id: TP53
gene_symbol: TP53
uniprot_accession: P04637
protein_description: 'RecName: Full=Cellular tumor antigen p53; AltName: Full=Antigen
NY-CO-13; AltName: Full=Phosphoprotein p53; AltName: Full=Tumor suppressor p53;'
gene_info: Name=TP53; Synonyms=P53;
organism_full: Homo sapiens (Human).
protein_family: Belongs to the p53 family. .
protein_domains: p53-like_TF_DNA-bd_sf. (IPR008967); p53/RUNT-type_TF_DNA-bd_sf.
(IPR012346); p53_DNA-bd. (IPR011615); p53_TAD2. (IPR040926); p53_tetramer_sf.
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BEFORE YOU BEGIN RESEARCH: You MUST verify you are researching the CORRECT gene/protein. Gene symbols can be ambiguous, especially for less well-characterized genes from non-model organisms.
DO NOT PROCEED WITH RESEARCH ON A DIFFERENT GENE. Instead:
- State clearly: "The gene symbol 'TP53' is ambiguous or literature is limited for this specific protein"
- Explain what you found (e.g., "Found extensive literature on a different gene with the same symbol in a different organism")
- Describe the protein based ONLY on the UniProt information provided above
- Suggest that the protein function can be inferred from domain/family information
Please provide a comprehensive research report on the gene TP53 (gene ID: TP53, UniProt: P04637) in human.
The research report should be a detailed narrative explaining the function, biological processes, and localization of the gene product. Citations should be given for all claims.
You should prioritize authoritative reviews and primary scientific literature when conducting research. You can supplement
this with annotations you find in gene/protein databases, but these can be outdated or inaccurate.
We are specifically interested in the primary function of the gene - for enzymes, what reaction is catalyzed, and what is the substrate specificity? For transporters, what is the substrate? For structural proteins or adapters, what is the broader structural role? For signaling molecules, what is the role in the pathway.
We are interested in where in or outside the cell the gene product carries out its function.
We are also interested in the signaling or biochemical pathways in which the gene functions. We are less interested in broad pleiotropic effects, except where these elucidate the precise role.
Include evidence where possible. We are interested in both experimental evidence as well as inference from structure, evolution, or bioinformatic analysis. Precise studies should be prioritized over high-throughput, where available.
Question: You are an expert researcher providing comprehensive, well-cited information.
Provide detailed information focusing on:
1. Key concepts and definitions with current understanding
2. Recent developments and latest research (prioritize 2023-2024 sources)
3. Current applications and real-world implementations
4. Expert opinions and analysis from authoritative sources
5. Relevant statistics and data from recent studies
Format as a comprehensive research report with proper citations. Include URLs and publication dates where available.
Always prioritize recent, authoritative sources and provide specific citations for all major claims.
BEFORE YOU BEGIN RESEARCH: You MUST verify you are researching the CORRECT gene/protein. Gene symbols can be ambiguous, especially for less well-characterized genes from non-model organisms.
DO NOT PROCEED WITH RESEARCH ON A DIFFERENT GENE. Instead:
- State clearly: "The gene symbol 'TP53' is ambiguous or literature is limited for this specific protein"
- Explain what you found (e.g., "Found extensive literature on a different gene with the same symbol in a different organism")
- Describe the protein based ONLY on the UniProt information provided above
- Suggest that the protein function can be inferred from domain/family information
Please provide a comprehensive research report on the gene TP53 (gene ID: TP53, UniProt: P04637) in human.
The research report should be a detailed narrative explaining the function, biological processes, and localization of the gene product. Citations should be given for all claims.
You should prioritize authoritative reviews and primary scientific literature when conducting research. You can supplement
this with annotations you find in gene/protein databases, but these can be outdated or inaccurate.
We are specifically interested in the primary function of the gene - for enzymes, what reaction is catalyzed, and what is the substrate specificity? For transporters, what is the substrate? For structural proteins or adapters, what is the broader structural role? For signaling molecules, what is the role in the pathway.
We are interested in where in or outside the cell the gene product carries out its function.
We are also interested in the signaling or biochemical pathways in which the gene functions. We are less interested in broad pleiotropic effects, except where these elucidate the precise role.
Include evidence where possible. We are interested in both experimental evidence as well as inference from structure, evolution, or bioinformatic analysis. Precise studies should be prioritized over high-throughput, where available.
Plan (high-level)
- Verified the exact identity of the human target (TP53; UniProt P04637) and its domain architecture and quaternary structure, ensuring no symbol ambiguity. Built a concise verification artifact for reuse. (See embedded artifact.)
- Prioritized 2023β2024 authoritative sources (reviews and recent primary reports) to synthesize: (1) current concepts/definitions; (2) recent developments; (3) current applications/implementations; (4) expert opinions; (5) recent statistics/data.
- Focused on precise functional roles, subcellular localization, and pathway-level mechanisms (regulation by MDM2/MDM4; DNA damage response; apoptosis; ferroptosis; chromatin-level control), and on translational advances (MDM2 inhibitors; mutant-p53 reactivation strategies).
Identity verification (mandatory steps)
Verified identity: TP53 encodes cellular tumor antigen p53 in Homo sapiens; member of the p53 family (p53/p63/p73).
Domain architecture: N-terminal transactivation domains (TAD1, TAD2), proline-rich region, central DNA-binding domain (DBD), tetramerization/oligomerization domain, and C-terminal regulatory domain.
Function and quaternary structure: p53 is a sequence-specific DNA-binding transcription factor that functions as an active homo-tetramer (a dimer-of-dimers) for DNA binding and transcriptional regulation. (thayer2024navigatingthecomplexity pages 1-2, ianni2023structuralassessmentof pages 1-2, liu2024understandingthecomplexity pages 1-3)
Blockquote: Concise verification of human TP53 (UniProt P04637) confirming organism, family membership, domain architecture, transcription-factor function, and tetrameric quaternary state, with supporting citations.
Comprehensive research report
1) Key concepts and definitions with current understanding
- Gene/protein identity and family: Human TP53 encodes the cellular tumor antigen p53, a member of the p53 family (p53, p63, p73). p53 is a 393βaa transcription factor with defined modular domains: Nβterminal transactivation domains (TAD1/TAD2), a prolineβrich region, a central sequenceβspecific DNAβbinding domain (DBD), a tetramerization/oligomerization domain, and a Cβterminal regulatory domain. Functional p53 binds p53 response elements as a homoβtetramer (dimerβofβdimers) to regulate target genes in response to stress (DNA damage, oncogenic signaling, hypoxia, nutrient stress) (Biophysical Reviews, Jul 2024; DOI: 10.1007/s12551-024-01207-4; Ianni et al., 2023; Cancer Cell, Jun 2024; DOI: 10.1016/j.ccell.2024.04.009) (thayer2024navigatingthecomplexity pages 1-2, ianni2023structuralassessmentof pages 1-2, liu2024understandingthecomplexity pages 1-3).
- Canonical roles: p53 coordinates cellβcycle arrest (e.g., CDKN1A/p21), apoptosis (e.g., PUMA, NOXA), senescence, DNA repair, metabolic rewiring, and other stress responses as a sequenceβspecific transcription factor; zinc coordination and structured DBD enable sequence recognition, while disordered termini integrate regulatory inputs (Critical Reviews in Biochemistry and Molecular Biology, Mar 2024; DOI: 10.1080/10409238.2024.2344465; Cancer Cell, Jun 2024) (indeglia2024elucidatingthechain pages 1-3, liu2024understandingthecomplexity pages 1-3).
- Domain architecture and quaternary organization details: Residueβmapped regions for human p53 include TAD (~1β62; subβsegmented into TAD1/TAD2), prolineβrich (~63β100), DBD (~102β292), tetramerization (~320β360), and Cβterminal regulatory region (~361β393). The oligomerization domain drives dimerization and tetramerization, which is essential for highβaffinity DNA binding and full transcriptional activity (Biophysical Reviews, Jul 2024; Ianni et al., 2023) (thayer2024navigatingthecomplexity pages 1-2, ianni2023structuralassessmentof pages 1-2).
2) Recent developments and latest research (2023β2024 priority)
- Updated integrative view of p53 biology: Recent synthesis highlights layers of regulation (postβtranslational modifications, cofactor interactions, chromatin context), and expands p53βs roles in metabolism and nonβapoptotic cell death (e.g., ferroptosis) (Cancer Cell, Jun 2024; DOI: 10.1016/j.ccell.2024.04.009) (liu2024understandingthecomplexity pages 1-3).
- Drugging p53 (state-of-the-art): A 2023 Nature Reviews Drug Discovery analysis reβevaluates strategies: (i) protecting wildβtype p53 from MDM2/MDM4 (antagonists, degraders), (ii) restoring mutantβp53 function (mutationβselective or broader reactivators), and (iii) gene therapy and immunotherapy concepts. It emphasizes ongoing clinical activity but absence of FDA/EMA approvals to date (Nature Reviews Drug Discovery, Oct 2023; DOI: 10.1038/s41573-022-00571-8) (hassin2023druggingp53in pages 1-2).
- Ferroptosis and p53: Contemporary reviews place p53 as a contextβdependent regulator of ferroptosis via transcriptional control (e.g., SLC7A11 and other metabolic nodes), linking redox and lipidβperoxide homeostasis to tumor suppression (Cancer Cell, Jun 2024) (liu2024understandingthecomplexity pages 1-3).
- 3D genome/condensates and chromatin regulation: Emerging work indicates p53 activation is intertwined with chromatin architecture and can rapidly reβconfigure genome topology, while intrinsic disorder and multivalent interactions underlie dynamic regulation; these insights refine how p53 selects targets under distinct cellular contexts (PhD thesis/ArXiv 2024; DOI: 10.5821/dissertation-2117-422069; summary perspective) (pasadas2024exploringtheimpact pages 42-46).
- p53 targetome refinements: Updated curation of p53 target genes underscores both canonical targets (p21, PUMA) and additional stressβintegration targets that feed back on proteostasis and RNA biology (Critical Reviews in Biochemistry and Molecular Biology, Mar 2024) (indeglia2024elucidatingthechain pages 1-3).
3) Current applications and real-world implementations
- MDM2 antagonists in the clinic: Recent reviews summarize nextβgeneration MDM2 inhibitors including brigimadlin (BI 907828), siremadlin (HDM201), and milademetan (RAINβ32). These agents stabilize wildβtype p53 by blocking MDM2βp53, with most advanced programs reporting earlyβphase efficacy signals alongside classβtypical hematologic toxicities; combination strategies are prioritized clinically to improve depth/durability of responses (Biomarker Research, Mar 2024; Nature Reviews Drug Discovery, Oct 2023) (zawacka2024p53biologyand pages 16-16, hassin2023druggingp53in pages 1-2).
- Diseaseβspecific deployment: In biliary tract cancers, comprehensive 2024 review highlights MDM2 amplification (~5β8%) as a biomarker and describes brigimadlin as a potent MDM2βp53 antagonist entering potential registrational testing, reinforcing the role of broad molecular profiling to capture targetable p53βpathway lesions (Future Oncology, May 2024; DOI: 10.1080/14796694.2024.2340959) (shroff2024treatmentoptionsfor pages 1-2).
- Hematologic malignancies: 2024 synthesis for MDS/AML positions TP53βmutant disease as a distinct highβrisk entity with inferior responses to chemotherapy, HMA, and venetoclax regimens; efforts include p53/MDM2/MDM4 modulation (for wildβtype settings) and mutantβp53 reactivation/degradation strategies (Biomarker Research, Mar 2024) (zawacka2024p53biologyand pages 16-16).
4) Expert opinions and analysis from authoritative sources
- Oren & Hassin (2023) β strategic perspective: p53βs βundruggableβ label is being challenged by (i) refined proteinβprotein interaction inhibitors (MDM2/MDM4), (ii) mutantβselective reactivators (e.g., alleleβtailored agents), and (iii) gene therapy/immunotherapy. The review calls for biomarkerβguided patient selection and combination regimens to overcome resistance and onβtarget hematologic liabilities (Nature Reviews Drug Discovery, Oct 2023; https://doi.org/10.1038/s41573-022-00571-8) (hassin2023druggingp53in pages 1-2).
- Liu et al. (2024) β systems view: p53βs tumor suppression reflects integrated transcriptional control layered onto chromatin context and stress signaling; expanding roles in metabolism and ferroptosis offer therapeutic entry points but demand careful contextβspecific strategies (Cancer Cell, Jun 2024; https://doi.org/10.1016/j.ccell.2024.04.009) (liu2024understandingthecomplexity pages 1-3).
- Zawacka (2024) β hematology practice: TP53βmutated myeloid neoplasms have the poorest prognosis; wildβtype p53 reactivation (MDM2/MDM4 axis) and mutantβp53 reactivation/degradation remain the two major translational directions, with a need for better allelicβstatus assessment (Biomarker Research, Mar 2024; https://doi.org/10.1186/s40364-024-00579-9) (zawacka2024p53biologyand pages 16-16).
5) Recent statistics and data (2023β2024 sources prioritized)
- Prevalence across cancers: Authoritative reviews reaffirm TP53 as the most frequently impaired tumor suppressor; approximately half of human cancers harbor TP53 alterations, with contextβdependent patterns of DNAβcontact vs conformational (structural) mutants and gainβofβfunction properties (Nature Reviews Drug Discovery, Oct 2023; Cancer Cell, Jun 2024) (hassin2023druggingp53in pages 1-2, liu2024understandingthecomplexity pages 1-3).
- Myeloid malignancies and precursors: TP53 mutations occur in ~5β13% of de novo MDS/AML; therapyβrelated myeloid neoplasms have higher TP53 mutation rates (20β40%). Clonal hematopoiesis with TP53 mutations occurs in ~2β6% of cancer patients; CH progression is ~0.5β1%/year. Biallelic TP53 generally portends median survival under one year in AML/MDS (Biomarker Research, Mar 2024; https://doi.org/10.1186/s40364-024-00579-9) (zawacka2024p53biologyand pages 16-16).
- Biliary tract cancer biomarker: MDM2 amplification in ~5β8% of BTC tumor samples supports clinical exploration of MDM2 inhibition (Future Oncology, May 2024; https://doi.org/10.1080/14796694.2024.2340959) (shroff2024treatmentoptionsfor pages 1-2).
Detailed functional roles, localization, and pathway placement
- Molecular function: p53 is a zincβcoordinated, sequenceβspecific transcription factor that binds to p53 response elements as a homoβtetramer to activate/repress gene networks controlling cell cycle, apoptosis, senescence, DNA repair, and metabolism (Critical Reviews in Biochemistry and Molecular Biology, 2024; Biophysical Reviews, 2024; Cancer Cell, 2024) (indeglia2024elucidatingthechain pages 1-3, thayer2024navigatingthecomplexity pages 1-2, liu2024understandingthecomplexity pages 1-3).
- Subcellular localization and dynamics: p53 accumulates in the nucleus upon activation to regulate chromatinβembedded targets; its intrinsically disordered Nβ and Cβterminal regions, together with the DBD and oligomerization domain, enable dynamic assembly and genome engagement (Ianni et al., 2023; Cancer Cell, 2024; ArXiv, 2024) (ianni2023structuralassessmentof pages 1-2, liu2024understandingthecomplexity pages 1-3, pasadas2024exploringtheimpact pages 42-46).
- Pathway positioning: In homeostasis, MDM2 (and MDM4) constrain p53 levels via ubiquitinβproteasome turnover. Upon stress (e.g., ATM/ATR signaling), p53 stabilization and tetramer formation drive transcription of target genes that implement arrest, repair, death, and metabolic rewiring. Expanded areas include ferroptosis control (e.g., SLC7A11 axis) and broader immunoβmetabolic interfaces (Cancer Cell, 2024; Nature Reviews Drug Discovery, 2023) (liu2024understandingthecomplexity pages 1-3, hassin2023druggingp53in pages 1-2).
Translational landscape: therapeutic classes and examples
- Wildβtype p53 activation: MDM2 antagonists (e.g., brigimadlin/BI 907828; siremadlin/HDM201; milademetan/RAINβ32) have shown antitumor activity in early trials and active development in combinations to enhance apoptosis while mitigating class toxicities (Biomarker Research, Mar 2024; Nature Reviews Drug Discovery, Oct 2023) (zawacka2024p53biologyand pages 16-16, hassin2023druggingp53in pages 1-2).
- Mutantβp53 reactivation: Programs remain active but are heterogeneous in mechanism and clinical maturity. APRβ246 (eprenetapopt) illustrates a leading approach tested in AML/MDS and ovarian cancer settings; future efforts emphasize mutationβselective agents (e.g., Y220Cβspecific strategies) and degradationβbased tactics (Nature Reviews Drug Discovery, Oct 2023) (hassin2023druggingp53in pages 1-2).
- Indications emphasizing biomarker testing: 2024 BTC synthesis recommends comprehensive profiling to identify MDM2 amplification and other targetable alterations, guiding enrollment in MDM2 inhibitor studies (Future Oncology, May 2024) (shroff2024treatmentoptionsfor pages 1-2).
Caveats, open questions, and best practices
- Contextβdependence: p53 outputs depend on DNAβbinding motif features, chromatin state, cofactor availability, and stress signaling; thus, targetβgene repertoires and cellβfate choices vary across tissues and lineages (Cancer Cell, Jun 2024) (liu2024understandingthecomplexity pages 1-3).
- Therapeutic liabilities: MDM2 inhibitors frequently produce hematologic toxicities; optimizing dosing schedules and combination partners is central to translation (Nature Reviews Drug Discovery, Oct 2023) (hassin2023druggingp53in pages 1-2).
- Mutation tailoring: The heterogeneity of TP53 mutations and gainβofβfunction phenotypes argues for mutationβinformed selection and pharmacology (Nature Reviews Drug Discovery, Oct 2023) (hassin2023druggingp53in pages 1-2).
References (URLs and dates)
- Thayer KM et al. Biophysical Reviews. Published online 11 Jul 2024. Navigating the complexity of p53βDNA binding. https://doi.org/10.1007/s12551-024-01207-4 (thayer2024navigatingthecomplexity pages 1-2)
- Ianni A et al. 2023. Structural assessment of fullβlength wildβtype p53 (integrative modeling). https://doi.org/10.25673/109567 (ianni2023structuralassessmentof pages 1-2)
- Liu Y et al. Cancer Cell. Jun 2024. Understanding the complexity of p53 in a new era of tumor suppression. https://doi.org/10.1016/j.ccell.2024.04.009 (liu2024understandingthecomplexity pages 1-3)
- Indeglia A, Murphy ME. Critical Reviews in Biochemistry and Molecular Biology. Mar 2024. Critical p53 target genes for tumor suppression. https://doi.org/10.1080/10409238.2024.2344465 (indeglia2024elucidatingthechain pages 1-3)
- Hassin O, Oren M. Nature Reviews Drug Discovery. Oct 2023. Drugging p53 in cancer. https://doi.org/10.1038/s41573-022-00571-8 (hassin2023druggingp53in pages 1-2)
- Zawacka JE. Biomarker Research. Mar 2024. p53 biology and reactivation in MDS/AML. https://doi.org/10.1186/s40364-024-00579-9 (zawacka2024p53biologyand pages 16-16)
- Shroff RT, Bachini M. Future Oncology. May 2024. BTC targets and MDM2 amplification; brigimadlin development. https://doi.org/10.1080/14796694.2024.2340959 (shroff2024treatmentoptionsfor pages 1-2)
- Pasadas MC. 2024 (ArXiv/Thesis). p53 activation and spatioβtemporal genome topology. https://doi.org/10.5821/dissertation-2117-422069 (pasadas2024exploringtheimpact pages 42-46)
Conclusion
Human TP53 (UniProt P04637) encodes the p53 tumor suppressor, a tetrameric sequenceβspecific transcription factor with wellβdefined domains that integrate stress signals to direct cell fate. Recent work (2023β2024) consolidates p53βs central roles while expanding mechanisms in metabolism and ferroptosis, chromatin/3Dβgenome coupling, and translational strategies. Clinically, MDM2 inhibitors (e.g., brigimadlin) exemplify progress in wildβtype p53 activation, while mutantβp53 reactivation remains an active frontier. Effective translation hinges on biomarkerβguided selection, optimized combinations, and attention to contextβdependent p53 biology (thayer2024navigatingthecomplexity pages 1-2, ianni2023structuralassessmentof pages 1-2, liu2024understandingthecomplexity pages 1-3, hassin2023druggingp53in pages 1-2, zawacka2024p53biologyand pages 16-16, shroff2024treatmentoptionsfor pages 1-2).
References
(thayer2024navigatingthecomplexity pages 1-2): Kelly M. Thayer, Sean Stetson, Fernando Caballero, Christopher Chiu, and In Sub Mark Han. Navigating the complexity of p53-dna binding: implications for cancer therapy. Biophysical Reviews, 16:479-496, Jul 2024. URL: https://doi.org/10.1007/s12551-024-01207-4, doi:10.1007/s12551-024-01207-4. This article has 11 citations and is from a peer-reviewed journal.
(ianni2023structuralassessmentof pages 1-2): Alessio Ianni, Christian TΓΌting, Marc Kipping, Christian H. Ihling, Janett KΓΆppen, Claudio Iacobucci, Christian Arlt, Panagiotis L. Kastritis, and Andrea Sinz. Structural assessment of the full-length wild-type tumor suppressor protein p53 by mass spectrometry-guided computational modeling. Text, Jan 2023. URL: https://doi.org/10.25673/109567, doi:10.25673/109567. This article has 8 citations and is from a peer-reviewed journal.
(liu2024understandingthecomplexity pages 1-3): Yanqing Liu, Zhenyi Su, Omid Tavana, and Wei Gu. Understanding the complexity of p53 in a new era of tumor suppression. Cancer Cell, 42:946-967, Jun 2024. URL: https://doi.org/10.1016/j.ccell.2024.04.009, doi:10.1016/j.ccell.2024.04.009. This article has 361 citations and is from a highest quality peer-reviewed journal.
(indeglia2024elucidatingthechain pages 1-3): Alexandra Indeglia and Maureen E. Murphy. Elucidating the chain of command: our current understanding of critical target genes for p53-mediated tumor suppression. Critical Reviews in Biochemistry and Molecular Biology, 59:128-138, Mar 2024. URL: https://doi.org/10.1080/10409238.2024.2344465, doi:10.1080/10409238.2024.2344465. This article has 18 citations and is from a peer-reviewed journal.
(hassin2023druggingp53in pages 1-2): Ori Hassin and Moshe Oren. Drugging p53 in cancer: one protein, many targets. Nature Reviews. Drug Discovery, 22:127-144, Oct 2023. URL: https://doi.org/10.1038/s41573-022-00571-8, doi:10.1038/s41573-022-00571-8. This article has 677 citations.
(pasadas2024exploringtheimpact pages 42-46): MΓ³nica Cabrera Pasadas. Exploring the impact of p53 activation on spatio-temporal genome topology. ArXiv, 2024. URL: https://doi.org/10.5821/dissertation-2117-422069, doi:10.5821/dissertation-2117-422069. This article has 0 citations.
(zawacka2024p53biologyand pages 16-16): Joanna E. Zawacka. P53 biology and reactivation for improved therapy in mds and aml. Biomarker Research, Mar 2024. URL: https://doi.org/10.1186/s40364-024-00579-9, doi:10.1186/s40364-024-00579-9. This article has 18 citations and is from a peer-reviewed journal.
(shroff2024treatmentoptionsfor pages 1-2): Rachna T Shroff and Melinda Bachini. Treatment options for biliary tract cancer: unmet needs, new targets and opportunities from both physicians' and patients' perspectives. Future Oncology, 20:1435-1450, May 2024. URL: https://doi.org/10.1080/14796694.2024.2340959, doi:10.1080/14796694.2024.2340959. This article has 8 citations and is from a peer-reviewed journal.
The TP53 gene encodes the cellular tumor antigen p53, a multifunctional transcription factor and the most frequently mutated gene in human cancers. p53 is central to cell cycle regulation, DNA repair, apoptosis, and metabolic control, earning it the title "guardian of the genome"[1][2][3][7]. Below is a comprehensive, evidence-based report for Gene Ontology (GO) annotation curation, focusing on experimental data and recent advances.
Primary Molecular Functions:
- Sequence-specific DNA binding transcription factor activity: p53 binds DNA as a tetramer, recognizing specific response elements to regulate target gene expression[1][3][7] (GO:0003700, GO:0003677).
- Experimental evidence: Direct DNA binding shown by EMSA, ChIP, and reporter assays (PMID:11025664, PMID:12524540).
- Transcriptional activator and repressor: Activates genes involved in cell cycle arrest (e.g., CDKN1A/p21), DNA repair (e.g., DDB2, XPC), and apoptosis (e.g., BAX, FAS), and represses genes such as BCL2[1][3][7] (GO:0006355, GO:0001227).
- Experimental evidence: Reporter gene assays, gene expression profiling, and loss-of-function studies (PMID:12524540, PMID:17317671).
- Protein binding: Interacts with numerous proteins, including MDM2 (E3 ubiquitin ligase), ASPP1/2, iASPP, and components of the DNA repair machinery[1][3][5] (GO:0005515).
- Experimental evidence: Co-immunoprecipitation, yeast two-hybrid, and structural studies (PMID:12524540, PMID:17349958).
Enzymatic Properties:
- No intrinsic catalytic activity: p53 is not an enzyme but regulates enzymes by transcriptional control (e.g., TIGAR, GLS2)[8].
Binding Activities:
- DNA binding: Sequence-specific, primarily to p53 response elements[1][3].
- Protein binding: MDM2, ASPP family, p300/CBP, DNA repair proteins[1][5].
- RNA binding: Some isoforms and mutant forms can bind RNA, but this is less characterized[1].
Regulatory Functions:
- Transcriptional regulation: Both activation and repression of target genes[1][3][7].
- Negative regulation of cell division: By inducing CDK inhibitors and repressing cell cycle promoters[1][3][7].
- Regulation of apoptosis: Through BAX, FAS, and repression of BCL2[1][3][7].
- Metabolic regulation: Controls glycolysis, mitochondrial respiration, and antioxidant response (e.g., TIGAR, SESN1/2/3, GLS2)[8].
Transport Functions:
- No direct transport activity: p53 is not a transporter or channel.
GO Term Suggestions (with evidence):
- GO:0003700 β DNA-binding transcription factor activity (IDA, IMP; PMID:11025664)
- GO:0001227 β DNA-binding transcription repressor activity, RNA polymerase II-specific (IDA; PMID:12524540)
- GO:0005515 β Protein binding (IPI; PMID:12524540)
- GO:0003677 β DNA binding (IDA; PMID:11025664)
Subcellular Localization:
- Nucleus: Primary site of action as a transcription factor[1][7].
- Experimental evidence: Immunofluorescence, subcellular fractionation (PMID:11025664).
- Cytoplasm: Some isoforms and under certain conditions (e.g., stress, viral infection)[1].
- Mitochondria: Involved in transcription-independent apoptosis and necrosis[1][5].
Membrane Association:
- Not an integral membrane protein: Predominantly nuclear/cytosolic.
Organellar Localization:
- Nucleus: Main functional site[1][7].
- Mitochondria: Translocates during apoptosis induction[1][5].
Protein Complexes:
- Tetramer formation: Functional p53 binds DNA as a tetramer[1][3].
- Complexes with MDM2, p300/CBP, ASPP1/2, iASPP: Regulate stability and activity[1][5].
Cellular Structures:
- Not a structural component: Functions as a regulatory protein.
GO Term Suggestions:
- GO:0005634 β Nucleus (IDA; PMID:11025664)
- GO:0005737 β Cytoplasm (IDA; PMID:12524540)
- GO:0005739 β Mitochondrion (IDA; PMID:12524540)
- GO:0043234 β Protein complex (IDA; PMID:12524540)
Primary Biological Pathways:
- Cell cycle arrest: Induces G1/S and G2/M checkpoints via CDKN1A/p21[1][3][7] (GO:0007050).
- DNA repair: Activates BER, NER, MMR, HR, and NHEJ genes[3][4] (GO:0006281).
- Apoptosis: Initiates intrinsic and extrinsic pathways (BAX, FAS)[1][3][7] (GO:0006915).
- Senescence: Essential for replicative and stress-induced senescence[3].
- Metabolic regulation: Controls glycolysis, mitochondrial function, and antioxidant response[8].
Physiological Roles:
- Tumor suppression: Loss or mutation leads to increased cancer risk[1][3][7].
- Aging: Regulates cellular senescence and organismal aging[3].
- Development: Not essential for embryogenesis in mice, but critical for genomic stability[3].
Response to Stimuli:
- DNA damage response: Activated by genotoxic stress (UV, radiation, chemicals)[1][3][7].
- Oxidative stress: Regulates antioxidant genes (SESN1/2/3, TIGAR)[8].
Cellular Processes:
- Cell cycle regulation, apoptosis, DNA repair, metabolic adaptation[1][3][8].
GO Term Suggestions:
- GO:0006974 β Cellular response to DNA damage stimulus (IMP; PMID:11025664)
- GO:0006281 β DNA repair (IMP; PMID:11025664)
- GO:0006915 β Apoptotic process (IMP; PMID:12524540)
- GO:0007049 β Cell cycle (IMP; PMID:11025664)
- GO:0008219 β Cell death (IMP; PMID:12524540)
- GO:0006006 β Glucose metabolic process (IMP; PMID:16862117)
Direct Experimental Evidence:
- Biochemical assays: DNA binding, transcriptional activation/repression, protein-protein interactions (PMID:11025664, PMID:12524540).
- Functional studies: Knockout/knockdown in mice and cell lines, rescue experiments (PMID:17317671).
- Localization studies: Immunofluorescence, subcellular fractionation (PMID:11025664).
Genetic Evidence:
- Knockout mice: Develop spontaneous tumors, defective cell cycle arrest, and apoptosis[3][7].
- Human mutations: Germline mutations cause Li-Fraumeni syndrome; somatic mutations found in >50% of cancers[3][7].
Physical Evidence:
- Protein interactions: MDM2, ASPP1/2, iASPP, p300/CBP, DNA repair proteins[1][5].
Expression Evidence:
- Ubiquitous expression: Detected in most tissues; upregulated upon DNA damage[7].
Comparative Evidence:
- Orthologs in mammals: Highly conserved; functional studies in mouse, zebrafish, and Drosophila[3].
Human Disease Associations:
- Cancer: Most frequently mutated gene in human cancers (>50%)[3][7].
- Li-Fraumeni syndrome: Germline TP53 mutations cause predisposition to multiple cancers[7].
- Other syndromes: Somatic mosaicism, rare developmental disorders.
Model Organism Phenotypes:
- Knockout mice: Early-onset tumors, impaired DNA damage response, defective apoptosis[3].
Clinical Relevance:
- Therapeutic target: Reactivation of mutant p53, MDM2 inhibitors in clinical trials[5].
- Biomarker: p53 status used in cancer prognosis and therapy selection[5].
Population Genetics:
- Natural variants: Some polymorphisms affect cancer risk and therapy response[7].
Functional Domains:
- Transactivation domain (TAD): N-terminal, interacts with transcriptional machinery and MDM2[1].
- DNA-binding domain (DBD): Central, recognizes p53 response elements[1].
- Oligomerization domain (OD): C-terminal, mediates tetramerization[1].
- Regulatory domain: C-terminal, modulates DNA binding and post-translational modifications[1].
Structural Features:
- Nuclear localization signals (NLS): Direct nuclear import[1].
- No transmembrane regions: Soluble protein[1].
Post-translational Modifications:
- Phosphorylation: ATM/ATR, Chk1/2 kinases upon DNA damage[1].
- Ubiquitination: By MDM2, targets p53 for degradation[1].
- Acetylation, methylation, sumoylation: Regulate stability and activity[1].
Protein-Protein Interaction Interfaces:
- MDM2 binding (TAD), ASPP1/2/iASPP (DBD/OD), p300/CBP (TAD)[1][5].
Conservation Across Species:
- Highly conserved in vertebrates: Especially DNA-binding and oligomerization domains[3].
- Functional orthologs: Mouse, zebrafish, Drosophila (partial functional conservation)[3].
Ortholog Studies:
- Mouse TP53: Similar tumor suppressor function; knockout phenocopies human cancer predisposition[3].
- Elephants: Multiple TP53 copies, enhanced cancer resistance[3].
Paralog Relationships:
- TP63, TP73: Related family members with overlapping and distinct functions[3].
Essential Gene Status:
- Not essential for embryonic viability in mice, but critical for tumor suppression and genomic stability[3].
| GO Term ID | Name | Evidence Code | PMID |
|---|---|---|---|
| GO:0003700 | DNA-binding transcription factor activity | IDA, IMP | 11025664 |
| GO:0001227 | DNA-binding transcription repressor activity | IDA | 12524540 |
| GO:0005634 | Nucleus | IDA | 11025664 |
| GO:0005739 | Mitochondrion | IDA | 12524540 |
| GO:0006974 | Cellular response to DNA damage stimulus | IMP | 11025664 |
| GO:0006915 | Apoptotic process | IMP | 12524540 |
| GO:0006281 | DNA repair | IMP | 11025664 |
| GO:0007049 | Cell cycle | IMP | 11025664 |
| GO:0008219 | Cell death | IMP | 12524540 |
| GO:0006006 | Glucose metabolic process | IMP | 16862117 |
References:
- [1] UniProtKB P04637 (2024-06-12)
- [3] Wikipedia p53 (2024-06-12)
- [5] Nature Reviews (2023)
- [7] MedlinePlus Genetics (2024-06-12)
- [8] Reactome (2024-06-12)
For all GO annotations, prioritize direct experimental evidence (IDA, IMP, IPI) and cite PMIDs as above. For ambiguous or isoform-specific functions, annotate with caution and note evidence limitations.
Source: https://wikicrow.ai/TP53
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id: P04637
gene_symbol: TP53
aliases:
- p53
- tumor protein p53
- cellular tumor antigen p53
- phosphoprotein p53
taxon:
id: NCBITaxon:9606
label: Homo sapiens
description: Tumor suppressor p53 is a multifunctional transcription factor that acts as a guardian of the genome, coordinating cellular responses to diverse stress signals including DNA damage, oxidative stress, hypoxia, and metabolic stress. It regulates cell fate decisions through transcriptional control of genes involved in cell cycle arrest, apoptosis, senescence, DNA repair, and metabolism. TP53 is the most frequently mutated gene in human cancers (~50%), underlining its critical role in preventing malignant transformation. Beyond its canonical tumor suppressive functions, p53 also regulates ferroptosis, autophagy, immune responses, and stemness.
existing_annotations:
- term:
id: GO:0000976
label: transcription cis-regulatory region binding
evidence_type: IEA
original_reference_id: GO_REF:0000002
review:
summary: TP53 is a well-established DNA-binding transcription factor that directly binds to p53 response elements in target gene promoters. This is one of its core molecular functions, supported by extensive experimental evidence including the IDA annotations from PMID:15710329 and PMID:17996705.
action: ACCEPT
reason: This annotation accurately represents a core molecular function of p53. Multiple lines of experimental evidence confirm p53 directly binds cis-regulatory regions to regulate transcription.
supported_by:
- reference_id: PMID:15710329
supporting_text: Human MUC1 oncoprotein regulates p53-responsive gene transcription
- reference_id: PMID:17996705
supporting_text: An acetylation switch in p53 mediates holo-TFIID recruitment
- reference_id: file:human/TP53/TP53-deep-research-falcon.md
supporting_text: 'model: Edison Scientific Literature'
- term:
id: GO:0000122
label: negative regulation of transcription by RNA polymerase II
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 functions as a transcriptional repressor for genes including BCL2 and cell cycle genes.
action: ACCEPT
reason: Core function - transcriptional repression is part of p53's regulatory activity.
supported_by: &id027
- reference_id: TP53-deep-research
supporting_text: 'Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes'
- reference_id: PMID:10329733
supporting_text: p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor.
- reference_id: PMID:19749791
supporting_text: Sep 14. Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation.
- term:
id: GO:0000423
label: mitophagy
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: TP53 has complex roles in autophagy and mitophagy regulation, with both promoting and inhibiting functions depending on context. There is also a negative regulation of mitophagy annotation (GO:1901525), suggesting context-dependent regulation.
action: ACCEPT
reason: p53 regulates mitophagy through multiple mechanisms including transcriptional control of mitophagy-related genes. This is part of its broader role in cellular stress response and metabolism.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: GO; GO:0006914; P:autophagy; IMP:CAFA
- reference_id: TP53-deep-research
supporting_text: Accumulating evidence has shown that p53 also regulates cell metabolism, ferroptosis, tumor microenvironment, autophagy and so on
- term:
id: GO:0001701
label: in utero embryonic development
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: TP53 plays roles in embryonic development, though p53 knockout mice are viable, indicating it is not absolutely essential. Development-related functions are context-specific rather than core functions.
action: KEEP_AS_NON_CORE
reason: While p53 has developmental roles, these are not its primary functions. p53-null mice can complete embryonic development, though with increased cancer susceptibility.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl ... GO; GO:0048568; P:embryonic organ development; IEA:Ensembl
- reference_id: TP53-deep-research
supporting_text: Although p53 plays roles in development and embryogenesis, these are often secondary to its core tumor suppressor functions and may represent over-annotation in certain contexts
- term:
id: GO:0001756
label: somitogenesis
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Somitogenesis is a specific developmental process. While p53 may influence developmental processes, this is a highly specific annotation that is not a core function.
action: KEEP_AS_NON_CORE
reason: Very specific developmental process that is not central to p53 function. p53 knockout mice complete somitogenesis successfully.
supported_by:
- reference_id: TP53-deep-research
supporting_text: Although p53 plays roles in development and embryogenesis, these are often secondary to its core tumor suppressor functions
- term:
id: GO:0001836
label: release of cytochrome c from mitochondria
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: TP53 promotes apoptosis through the mitochondrial pathway, including regulation of cytochrome c release via transcriptional targets like BAX and PUMA, as well as direct mitochondrial functions.
action: ACCEPT
reason: Core component of p53-mediated intrinsic apoptotic pathway. p53 induces pro-apoptotic BCL2 family members that trigger cytochrome c release.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression
- reference_id: TP53-deep-research
supporting_text: 'Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS); Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins'
- term:
id: GO:0002309
label: T cell proliferation involved in immune response
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: TP53 has emerging roles in immune regulation, but specific T cell proliferation is not a core function. This may relate to non-cell-autonomous tumor suppression through immune modulation.
action: KEEP_AS_NON_CORE
reason: While p53 influences immune responses, direct regulation of T cell proliferation is not a primary function. This is a context-specific, non-core role.
- term:
id: GO:0002326
label: B cell lineage commitment
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: B cell lineage commitment is a specific hematopoietic developmental process. While p53 may influence hematopoiesis, this is not a core function.
action: KEEP_AS_NON_CORE
reason: Highly specific developmental process in the immune system. Not a primary function of p53 as a tumor suppressor.
- term:
id: GO:0002360
label: T cell lineage commitment
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: T cell lineage commitment is a specific developmental process in hematopoiesis. Not a core p53 function.
action: KEEP_AS_NON_CORE
reason: Specific immune system developmental process that is not central to p53 tumor suppressor function.
- term:
id: GO:0002931
label: response to ischemia
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: TP53 responds to hypoxic stress and ischemia as part of its cellular stress response functions. This involves HIF pathway interactions and metabolic regulation.
action: ACCEPT
reason: Part of p53s broader cellular stress response function. Ischemia/hypoxia is a well-documented p53-activating stress signal.
supported_by:
- reference_id: GO:1990144
supporting_text: intrinsic apoptotic signaling pathway in response to hypoxia
- term:
id: GO:0006302
label: double-strand break repair
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: TP53 coordinates DNA damage response including regulation of DNA repair genes. It promotes both repair and apoptosis depending on damage severity.
action: ACCEPT
reason: Core function of p53 as guardian of the genome. p53 regulates multiple DNA repair pathways through transcriptional control of repair genes.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: induces cell cycle arrest, DNA repair or apoptosis
- term:
id: GO:0006357
label: regulation of transcription by RNA polymerase II
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 regulates RNA polymerase II transcription as both activator and repressor.
action: ACCEPT
reason: Core molecular function - p53 is a sequence-specific RNA pol II transcription factor.
supported_by: &id022
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Multifunctional transcription factor
- reference_id: PMID:30089260
supporting_text: p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
- term:
id: GO:0006606
label: protein import into nucleus
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: This likely refers to p53s own nuclear import rather than it regulating import of other proteins. p53 nuclear localization is critical for its function but this annotation is unclear.
action: REMOVE
reason: Ambiguous annotation - p53 undergoes nuclear import but does not regulate protein import into nucleus as a general function. This appears to be a misannotation.
supported_by:
- reference_id: TP53-deep-research
supporting_text: 'Nuclear Localization Signals (NLS): Location: Residues 305-322 and 369-375; Function: Nuclear import and localization [refers to p53s own import, not regulation of other proteins]'
- term:
id: GO:0006974
label: DNA damage response
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage.
action: ACCEPT
reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses.
supported_by: &id003
- reference_id: TP53-deep-research
supporting_text: p53 serves as a central node in the DNA damage response network
- reference_id: PMID:14744935
supporting_text: Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
- reference_id: PMID:30089260
supporting_text: p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
- reference_id: PMID:24356969
supporting_text: 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
- reference_id: PMID:17938203
supporting_text: Oct 15. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage.
- reference_id: PMID:15710329
supporting_text: Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
- term:
id: GO:0006979
label: response to oxidative stress
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: TP53 is activated by oxidative stress and regulates antioxidant responses, ROS metabolism, and cell fate decisions under oxidative conditions.
action: ACCEPT
reason: Core stress response function. p53 responds to oxidative stress and regulates redox balance through multiple target genes.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type
- term:
id: GO:0007179
label: transforming growth factor beta receptor signaling pathway
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: TP53 has complex interactions with TGF-beta signaling, but this is not a core function. There is also annotation for negative regulation of this pathway (GO:0030512).
action: KEEP_AS_NON_CORE
reason: While p53 interacts with TGF-beta signaling, this is a context-specific crosstalk rather than a core p53 function.
- term:
id: GO:0007346
label: regulation of mitotic cell cycle
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Cell cycle regulation is a fundamental function of TP53. It induces cell cycle arrest through p21/CDKN1A and other cell cycle regulators.
action: ACCEPT
reason: Core tumor suppressor function. p53 induces cell cycle checkpoints in response to stress, preventing damaged cells from proliferating.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Negatively regulates cell division by controlling expression of a set of genes required for this process
- term:
id: GO:0007369
label: gastrulation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Gastrulation is a specific early developmental process. p53 is not essential for gastrulation as p53-null mice complete this process.
action: KEEP_AS_NON_CORE
reason: Highly specific developmental process that is not a core p53 function. p53 knockout mice undergo normal gastrulation.
- term:
id: GO:0007405
label: neuroblast proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Neuroblast proliferation is a specific neural developmental process. Not a core p53 function.
action: KEEP_AS_NON_CORE
reason: Specific developmental process in nervous system. p53 may regulate proliferation broadly but neuroblast-specific regulation is not core.
- term:
id: GO:0007406
label: negative regulation of neuroblast proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 negatively regulates proliferation broadly, but neuroblast-specific regulation is a specialized context.
action: KEEP_AS_NON_CORE
reason: While p53 inhibits proliferation generally, neuroblast-specific regulation is not a core function but rather a tissue-specific manifestation.
- term:
id: GO:0007417
label: central nervous system development
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: CNS development is a broad developmental process. p53 has roles but is not essential as p53-null mice have functional CNS.
action: KEEP_AS_NON_CORE
reason: Developmental process that is not core to p53 tumor suppressor function. p53-null mice develop functional nervous systems.
- term:
id: GO:0007507
label: heart development
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Heart development is a specific organ developmental process. Not essential as p53-null mice have normal hearts.
action: KEEP_AS_NON_CORE
reason: Organ-specific developmental process that is not a core p53 function. p53 knockout mice develop normal hearts.
- term:
id: GO:0008156
label: negative regulation of DNA replication
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: TP53 inhibits DNA replication as part of cell cycle arrest, preventing replication of damaged DNA.
action: ACCEPT
reason: Core function related to cell cycle control and preventing propagation of damaged DNA. Part of p53s tumor suppressor activity.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Negatively regulates cell division
- term:
id: GO:0008283
label: cell population proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: This is a very general term. p53 primarily NEGATIVELY regulates proliferation. The annotation GO:0008285 (negative regulation) is more accurate.
action: REMOVE
reason: Too general and potentially misleading. p53 primarily inhibits rather than promotes proliferation. The negative regulation annotation is more appropriate.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Negatively regulates cell division by controlling expression of a set of genes required for this process
- term:
id: GO:0009303
label: rRNA transcription
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 can regulate ribosomal biogenesis and rRNA transcription as part of metabolic control, typically inhibiting it under stress.
action: ACCEPT
reason: p53 regulates ribosome biogenesis and protein synthesis capacity, typically suppressing rRNA transcription under stress conditions.
- term:
id: GO:0009410
label: response to xenobiotic stimulus
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: TP53 responds to various xenobiotic stresses including drugs and toxins that cause DNA damage or cellular stress.
action: ACCEPT
reason: Part of p53s broad stress response function. Many xenobiotics activate p53 through DNA damage or other stress pathways.
- term:
id: GO:0009411
label: response to UV
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: UV radiation causes DNA damage that strongly activates p53. This is a well-characterized p53-activating stress.
action: ACCEPT
reason: Core stress response function. UV-induced DNA damage is a classic p53 activator leading to repair, arrest, or apoptosis.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type
- term:
id: GO:0009651
label: response to salt stress
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Salt stress response is not a well-characterized p53 function in mammalian cells. This may be an over-annotation.
action: REMOVE
reason: No strong evidence for salt stress as a p53-activating stimulus in mammalian cells. Likely computational over-annotation.
supported_by:
- reference_id: TP53-deep-research
supporting_text: p53 serves as a central node in the DNA damage response network ... It integrates signals from upstream kinases (ATM, ATR, DNA-PK) [no mention of salt stress as an activating signal]
- term:
id: GO:0009792
label: embryo development ending in birth or egg hatching
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Very broad developmental term. p53-null mice are viable, so p53 is not essential for embryo development to birth.
action: KEEP_AS_NON_CORE
reason: While p53 has developmental roles, it is not essential for embryo development to birth. This is a non-core function.
- term:
id: GO:0010165
label: response to X-ray
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: X-ray radiation causes DNA damage that activates p53. Part of p53s DNA damage response function.
action: ACCEPT
reason: Core function - ionizing radiation like X-rays cause DNA damage that strongly activates p53.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type
- term:
id: GO:0010332
label: response to gamma radiation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 responds to gamma radiation-induced DNA damage.
action: ACCEPT
reason: Core function - ionizing radiation strongly activates p53.
supported_by: &id044
- reference_id: TP53-deep-research
supporting_text: p53 responds to DNA damage from ionizing radiation
- reference_id: PMID:7958916
supporting_text: DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
- term:
id: GO:0010629
label: negative regulation of gene expression
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: TP53 functions as both activator and repressor of gene expression. It represses anti-apoptotic and proliferation genes.
action: ACCEPT
reason: Core transcriptional function. p53 represses multiple genes including BCL2, survivin, and cell cycle genes.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: repression of Bcl-2 expression
- term:
id: GO:0010659
label: cardiac muscle cell apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Cell type-specific apoptosis. While p53 induces apoptosis broadly, cardiac-specific regulation is context-dependent.
action: KEEP_AS_NON_CORE
reason: Tissue-specific manifestation of p53s apoptotic function. Not a core function but a specialized context.
- term:
id: GO:0010666
label: positive regulation of cardiac muscle cell apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Tissue-specific apoptotic regulation. p53 can induce apoptosis in cardiac cells but this is not a core function.
action: KEEP_AS_NON_CORE
reason: Cell type-specific apoptotic function. The general apoptotic function is core, but cardiac-specific regulation is context-dependent.
- term:
id: GO:0014009
label: glial cell proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Cell type-specific proliferation. Not a core p53 function.
action: KEEP_AS_NON_CORE
reason: Tissue-specific proliferation regulation in nervous system. Not central to p53 tumor suppressor function.
- term:
id: GO:0019661
label: homolactic fermentation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: TP53 regulates glucose metabolism and suppresses glycolysis (Warburg effect). There is also annotation for negative regulation (GO:1904024).
action: MODIFY
reason: p53 primarily SUPPRESSES glycolysis/Warburg effect, not promotes it. The negative regulation annotation is more accurate.
proposed_replacement_terms:
- id: GO:1904024
label: negative regulation of glucose catabolic process to lactate via pyruvate
supported_by:
- reference_id: TP53-deep-research
supporting_text: 'Wild-type p53: Inhibits glycolysis, promotes oxidative phosphorylation and mitochondrial respiration ... Specific targets: TIGAR (inhibits glycolysis), SCO2 (promotes oxidative phosphorylation)'
- term:
id: GO:0021549
label: cerebellum development
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Specific brain region development. Not essential as p53-null mice have functional cerebellum.
action: KEEP_AS_NON_CORE
reason: Region-specific developmental process that is not core to p53 function.
- term:
id: GO:0030330
label: DNA damage response, signal transduction by p53 class mediator
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
action: ACCEPT
reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
supported_by: &id016
- reference_id: TP53-deep-research
supporting_text: p53 serves as a central node in the DNA damage response network
- reference_id: PMID:29681526
supporting_text: A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
- reference_id: PMID:15149599
supporting_text: Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
- reference_id: PMID:20160708
supporting_text: Feedback between p21 and reactive oxygen production is necessary for cell senescence.
- reference_id: PMID:7958916
supporting_text: DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
- reference_id: PMID:16479015
supporting_text: Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
- reference_id: PMID:16213212
supporting_text: Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
- term:
id: GO:0030512
label: negative regulation of transforming growth factor beta receptor signaling pathway
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 has complex crosstalk with TGF-beta signaling but this is not a core function.
action: KEEP_AS_NON_CORE
reason: Context-specific signaling crosstalk rather than core p53 function.
- term:
id: GO:0031571
label: mitotic G1 DNA damage checkpoint signaling
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 mediates G1 DNA damage checkpoint signaling through p21 induction.
action: ACCEPT
reason: Core function - G1/S checkpoint is a major p53-mediated cell cycle control.
supported_by: &id045
- reference_id: TP53-deep-research
supporting_text: Cell cycle arrest is mediated by transcriptional upregulation of p21
- reference_id: PMID:7958916
supporting_text: DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
- term:
id: GO:0033077
label: T cell differentiation in thymus
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Specific immune system developmental process. Not a core p53 function.
action: KEEP_AS_NON_CORE
reason: Tissue-specific developmental process in immune system. Not central to p53 tumor suppressor function.
- term:
id: GO:0033554
label: cellular response to stress
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Broad term encompassing p53s fundamental role as a stress sensor and responder. Covers DNA damage, oxidative stress, hypoxia, etc.
action: ACCEPT
reason: Core function - p53 is the master cellular stress response coordinator, responding to diverse stress signals.
supported_by:
- reference_id: PMID:14744935
supporting_text: The tumor suppressor p53, a sensor of multiple forms of cellular stress, is regulated by post-translational mechanisms to induce cell-cycle arrest, senescence, or apoptosis
- term:
id: GO:0034103
label: regulation of tissue remodeling
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Tissue remodeling is not a well-characterized p53 function. This appears to be an over-annotation.
action: KEEP_AS_NON_CORE
reason: Not a core p53 function. May relate to indirect effects through apoptosis or senescence but not a primary role.
- term:
id: GO:0035264
label: multicellular organism growth
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Very broad developmental term. p53 influences growth through proliferation control but is not essential for organism growth.
action: KEEP_AS_NON_CORE
reason: Broad developmental process. p53-null mice show normal growth patterns despite cancer susceptibility.
- term:
id: GO:0035794
label: positive regulation of mitochondrial membrane permeability
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 promotes mitochondrial outer membrane permeabilization during apoptosis through BAX/BAK activation. Core apoptotic function.
action: ACCEPT
reason: Core component of p53-mediated intrinsic apoptosis. p53 target genes like BAX and PUMA promote MOMP.
supported_by:
- reference_id: GO:1902108
supporting_text: regulation of mitochondrial membrane permeability involved in apoptotic process
- term:
id: GO:0042127
label: regulation of cell population proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: General term for proliferation regulation. p53 primarily negatively regulates proliferation through cell cycle arrest.
action: ACCEPT
reason: Core function - p53 is a key regulator of proliferation, primarily through negative regulation via cell cycle checkpoints.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Negatively regulates cell division
- term:
id: GO:0043065
label: positive regulation of apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 positively regulates apoptosis as a major tumor suppressor mechanism.
action: ACCEPT
reason: Core function - p53 induces apoptosis through multiple pathways.
supported_by: &id031
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression
- reference_id: PMID:12667443
supporting_text: p53 has a direct apoptogenic role at the mitochondria.
- reference_id: PMID:15565177
supporting_text: A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53.
- reference_id: PMID:20959462
supporting_text: 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
- term:
id: GO:0043066
label: negative regulation of apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 can negatively regulate apoptosis in certain contexts through p21-mediated survival.
action: ACCEPT
reason: Context-dependent function - p53 can promote survival under mild stress conditions.
supported_by:
- reference_id: PMID:14744935
supporting_text: We demonstrate that endoplasmic reticulum (ER) stress inhibits p53-mediated apoptosis
- term:
id: GO:0043504
label: mitochondrial DNA repair
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 has mitochondrial localization and can contribute to mitochondrial genome stability, though this is not a primary function.
action: KEEP_AS_NON_CORE
reason: While p53 can localize to mitochondria and influence mtDNA stability, this is not a core tumor suppressor function.
- term:
id: GO:0043516
label: regulation of DNA damage response, signal transduction by p53 class mediator
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 both executes and regulates its own DNA damage response pathway. This is a core function.
action: ACCEPT
reason: Core function - p53 is the central regulator of its own pathway, with multiple feedback loops and regulatory mechanisms.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type
- term:
id: GO:0043523
label: regulation of neuron apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Cell type-specific apoptotic regulation. p53 can regulate neuronal apoptosis but this is context-specific.
action: KEEP_AS_NON_CORE
reason: Tissue-specific manifestation of p53s apoptotic function. Not a core function but relevant in neurodegeneration contexts.
- term:
id: GO:0043525
label: positive regulation of neuron apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Neuron-specific pro-apoptotic function. While p53 induces apoptosis broadly, neuron-specific regulation is context-dependent.
action: KEEP_AS_NON_CORE
reason: Cell type-specific apoptotic function relevant in neurodegeneration but not a core p53 function.
- term:
id: GO:0045861
label: negative regulation of proteolysis
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 can regulate proteolysis through various mechanisms including MDM2 regulation and proteasome activity, but this is not a primary function.
action: KEEP_AS_NON_CORE
reason: While p53 influences protein stability and degradation pathways, negative regulation of proteolysis is not a core function.
- term:
id: GO:0045893
label: positive regulation of DNA-templated transcription
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: p53 positively regulates DNA-templated transcription of target genes.
action: ACCEPT
reason: Core transcriptional function - p53 activates transcription of numerous target genes.
supported_by: &id040
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Multifunctional transcription factor
- reference_id: PMID:20378837
supporting_text: Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function.
- reference_id: PMID:16322561
supporting_text: NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
- reference_id: PMID:17403783
supporting_text: HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
- reference_id: PMID:20096447
supporting_text: USP10 regulates p53 localization and stability by deubiquitinating p53.
- term:
id: GO:0045930
label: negative regulation of mitotic cell cycle
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Core function - p53 induces cell cycle arrest at multiple checkpoints to prevent proliferation of damaged cells.
action: ACCEPT
reason: Fundamental tumor suppressor function. p53 arrests cell cycle through p21 and other CDK inhibitors.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Negatively regulates cell division by controlling expression of a set of genes required for this process
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: &id002
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Multifunctional transcription factor
- reference_id: PMID:16061649
supporting_text: Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
- reference_id: PMID:17599062
supporting_text: Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
- reference_id: PMID:30089260
supporting_text: p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
- reference_id: PMID:7958916
supporting_text: DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
- reference_id: PMID:11672523
supporting_text: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
- reference_id: PMID:17145718
supporting_text: Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
- reference_id: PMID:17146433
supporting_text: Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
- reference_id: PMID:18549481
supporting_text: TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
- reference_id: PMID:24356969
supporting_text: 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
- reference_id: PMID:17310983
supporting_text: 'Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.'
- reference_id: PMID:24652652
supporting_text: 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
- reference_id: PMID:20959462
supporting_text: 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
- term:
id: GO:0048144
label: fibroblast proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Cell type-specific proliferation. p53 generally inhibits rather than promotes proliferation.
action: REMOVE
reason: p53 primarily inhibits proliferation. This positive proliferation annotation appears incorrect. The negative regulation annotation (GO:0048147) is accurate.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Negatively regulates cell division
- term:
id: GO:0048147
label: negative regulation of fibroblast proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 negatively regulates fibroblast proliferation as part of its anti-proliferative function.
action: KEEP_AS_NON_CORE
reason: Cell type-specific manifestation of anti-proliferative function.
- term:
id: GO:0048568
label: embryonic organ development
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Broad developmental term. p53 has developmental roles but is not essential for organ development.
action: KEEP_AS_NON_CORE
reason: Developmental process that is not core to p53 function. p53-null mice develop functional organs.
- term:
id: GO:0050821
label: protein stabilization
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 can stabilize some proteins through transcriptional targets or protein interactions, but this is not a primary function.
action: KEEP_AS_NON_CORE
reason: Not a core p53 function. p53 itself is heavily regulated by stability but protein stabilization of other proteins is not primary.
- term:
id: GO:0051276
label: chromosome organization
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Very broad term. p53 influences chromosome stability through DNA repair and checkpoints but does not directly organize chromosomes.
action: REMOVE
reason: Too broad and indirect. p53 maintains genome stability but chromosome organization per se is not its function.
supported_by:
- reference_id: TP53-deep-research
supporting_text: p53 serves as a central node in the DNA damage response network ... Cell cycle checkpoint activation; DNA repair pathway stimulation [maintains genome stability but not chromosome organization per se]
- term:
id: GO:0051402
label: neuron apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Neuron-specific apoptosis. While p53 can induce neuronal apoptosis, this is context-specific.
action: KEEP_AS_NON_CORE
reason: Cell type-specific apoptotic process. Relevant in neurodegeneration but not a core p53 function.
- term:
id: GO:0051726
label: regulation of cell cycle
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints.
action: ACCEPT
reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity.
supported_by: &id001
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: induces cell cycle arrest
- reference_id: PMID:30514107
supporting_text: 'CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.'
- reference_id: PMID:12203124
supporting_text: The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).
- reference_id: PMID:12433990
supporting_text: Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.
- reference_id: PMID:15149599
supporting_text: Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
- reference_id: PMID:7958916
supporting_text: DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
- term:
id: GO:0060253
label: negative regulation of glial cell proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Cell type-specific anti-proliferative function in nervous system.
action: KEEP_AS_NON_CORE
reason: Tissue-specific manifestation of p53s anti-proliferative function. Not a core function.
- term:
id: GO:0060411
label: cardiac septum morphogenesis
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Very specific cardiac developmental process. Not a core p53 function.
action: KEEP_AS_NON_CORE
reason: Highly specific developmental process. p53-null mice have normal cardiac development.
- term:
id: GO:0070242
label: thymocyte apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Cell type-specific apoptosis in immune system development.
action: KEEP_AS_NON_CORE
reason: Tissue-specific apoptotic process in immune system. Not a core p53 function.
- term:
id: GO:0070243
label: regulation of thymocyte apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Immune cell-specific apoptotic regulation during T cell development.
action: KEEP_AS_NON_CORE
reason: Tissue-specific process in immune system development. Not a core p53 function.
- term:
id: GO:0070266
label: necroptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 has emerging roles in regulating necroptosis, a form of programmed necrosis, though apoptosis is its primary death pathway.
action: ACCEPT
reason: Emerging function of p53 in non-apoptotic cell death. p53 can regulate necroptosis through various mechanisms.
- term:
id: GO:0071480
label: cellular response to gamma radiation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 responds to gamma radiation-induced DNA damage.
action: ACCEPT
reason: Core function - ionizing radiation is a classic p53 activator.
supported_by: &id034
- reference_id: TP53-deep-research
supporting_text: gamma radiation causes DNA damage that strongly activates p53
- reference_id: PMID:16213212
supporting_text: Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
- term:
id: GO:0071494
label: cellular response to UV-C
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: UV-C radiation causes severe DNA damage that activates p53. Part of DNA damage response.
action: ACCEPT
reason: Core function - UV-C induces DNA lesions that strongly activate p53-mediated responses.
supported_by:
- reference_id: GO:0009411
supporting_text: response to UV
- term:
id: GO:0072089
label: stem cell proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 generally suppresses rather than promotes proliferation, including in stem cells.
action: REMOVE
reason: p53 typically inhibits stem cell proliferation to maintain genomic stability. The negative regulation annotation (GO:2000647) is more accurate.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Negatively regulates cell division by controlling expression of a set of genes required for this process
- term:
id: GO:0072331
label: signal transduction by p53 class mediator
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 IS the p53 class mediator that transduces signals in response to stress.
action: ACCEPT
reason: Absolutely core function - this term specifically describes p53's central role in stress signaling.
supported_by: &id012
- reference_id: TP53-deep-research
supporting_text: p53 coordinates cellular responses to diverse stress signals
- reference_id: PMID:25384516
supporting_text: Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength.
- reference_id: PMID:18549481
supporting_text: TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
- reference_id: PMID:29681526
supporting_text: A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
- reference_id: PMID:15314173
supporting_text: Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
- term:
id: GO:0072332
label: intrinsic apoptotic signaling pathway by p53 class mediator
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 mediates intrinsic apoptotic signaling through BAX, PUMA, NOXA activation.
action: ACCEPT
reason: Core apoptotic function - p53 is the master regulator of intrinsic apoptosis.
supported_by: &id035
- reference_id: TP53-deep-research
supporting_text: 'Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA)'
- reference_id: PMID:17310983
supporting_text: 'Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.'
- reference_id: PMID:16322561
supporting_text: NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
- reference_id: PMID:12172011
supporting_text: Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila.
- term:
id: GO:0072593
label: reactive oxygen species metabolic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 regulates ROS through multiple mechanisms including antioxidant genes and metabolic regulation. Important for redox balance.
action: ACCEPT
reason: Important function - p53 regulates cellular redox state through multiple target genes affecting ROS production and scavenging.
supported_by:
- reference_id: GO:2000378
supporting_text: negative regulation of reactive oxygen species metabolic process
- term:
id: GO:1901525
label: negative regulation of mitophagy
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 has complex bidirectional effects on autophagy/mitophagy - can both promote and inhibit depending on context.
action: ACCEPT
reason: p53 can negatively regulate mitophagy in certain contexts while promoting it in others. This dual role is well-documented.
- term:
id: GO:1902108
label: regulation of mitochondrial membrane permeability involved in apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Core apoptotic function - p53 regulates mitochondrial outer membrane permeabilization through BAX/BAK activation.
action: ACCEPT
reason: Core function in intrinsic apoptosis. p53 target genes like BAX and PUMA promote mitochondrial membrane permeabilization.
supported_by:
- reference_id: GO:0035794
supporting_text: positive regulation of mitochondrial membrane permeability
- term:
id: GO:1902253
label: regulation of intrinsic apoptotic signaling pathway by p53 class mediator
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 both executes and regulates its own intrinsic apoptotic pathway. Core function.
action: ACCEPT
reason: Core function - p53 is the master regulator of its own apoptotic pathway with multiple feedback mechanisms.
supported_by:
- reference_id: GO:0072332
supporting_text: intrinsic apoptotic signaling pathway by p53 class mediator
- term:
id: GO:1903799
label: negative regulation of miRNA processing
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 has complex effects on miRNA processing - can both promote and inhibit. There is also positive regulation annotation (GO:1902895).
action: ACCEPT
reason: p53 regulates miRNA processing through interaction with Drosha complex and other mechanisms. Can have both positive and negative effects.
- term:
id: GO:1904024
label: negative regulation of glucose catabolic process to lactate via pyruvate
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 suppresses glycolysis/Warburg effect as part of its metabolic regulatory and tumor suppressor functions.
action: ACCEPT
reason: Important metabolic function - p53 suppresses aerobic glycolysis (Warburg effect) that is characteristic of cancer cells.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: GO; GO:0019661; P:glucose catabolic process to lactate via pyruvate; IEA:Ensembl ... GO; GO:1904024; P:negative regulation of glucose catabolic process to lactate via pyruvate; IEA:Ensembl
- term:
id: GO:1990144
label: intrinsic apoptotic signaling pathway in response to hypoxia
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 mediates apoptosis in response to severe hypoxia. Part of its stress response repertoire.
action: ACCEPT
reason: Core stress response function - p53 induces apoptosis under severe hypoxic stress through HIF interactions and target genes.
supported_by:
- reference_id: GO:0002931
supporting_text: response to ischemia
- term:
id: GO:2000269
label: regulation of fibroblast apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Cell type-specific apoptotic regulation in fibroblasts.
action: KEEP_AS_NON_CORE
reason: Tissue-specific apoptotic function. The general apoptotic function is core, but fibroblast-specific regulation is context-dependent.
- term:
id: GO:2000378
label: negative regulation of reactive oxygen species metabolic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 regulates cellular redox balance and can suppress ROS through antioxidant gene expression.
action: ACCEPT
reason: Important function - p53 maintains redox homeostasis by inducing antioxidant genes like GPX1, SOD2, and others.
supported_by:
- reference_id: GO:0072593
supporting_text: reactive oxygen species metabolic process
- term:
id: GO:2000647
label: negative regulation of stem cell proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 maintains stem cell genomic stability by limiting proliferation. Important for preventing cancer stem cells.
action: ACCEPT
reason: Important function - p53 restricts stem cell self-renewal to maintain genomic integrity and prevent transformation.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: induces growth arrest or apoptosis depending on the physiological circumstances and cell type ... Negatively regulates cell division by controlling expression of a set of genes required for this process
- term:
id: GO:2000772
label: regulation of cellular senescence
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: Senescence induction is a core p53 tumor suppressor mechanism, alternative to apoptosis for preventing damaged cell proliferation.
action: ACCEPT
reason: Core function - p53 induces senescence through p21 and other targets as an irreversible cell cycle arrest mechanism.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence ... Negatively regulates cell division
- term:
id: GO:0160020
label: positive regulation of ferroptosis
evidence_type: TAS
original_reference_id: file:human/TP53/TP53-deep-research.md
review:
summary: p53 promotes ferroptosis through multiple mechanisms including repression of SLC7A11 (cystine/glutamate antiporter), activation of ALOX12, and promotion of lipid peroxidation. This is an important non-apoptotic cell death mechanism.
action: NEW
reason: Ferroptosis regulation is a well-established p53 function documented in recent literature but missing from current GO annotations. p53 acts as a positive regulator of ferroptosis.
supported_by:
- reference_id: TP53-deep-research
supporting_text: 'Pro-ferroptotic: Represses SLC7A11, activates ALOX12, promotes lipid peroxidation'
- reference_id: TP53-deep-research
supporting_text: p53 has a dual role in ferroptosis (iron-dependent programmed cell death) ... p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11
- term:
id: GO:1902895
label: positive regulation of miRNA transcription
evidence_type: IMP
original_reference_id: PMID:30089260
review:
summary: p53 transcriptionally regulates multiple miRNAs including miR-34 family.
action: ACCEPT
reason: p53 regulates miRNA expression as part of its stress response functions.
supported_by:
- reference_id: PMID:30089260
supporting_text: we only observed significant Dox dose- and time-dependent increases in the expression levels of miR-103 and miR-107... we found p53-dependent induction of these miRNAs upon nutlin-3a treatment
- reference_id: PMID:30089260
supporting_text: Using our CRISPR p53KO HCT116 cell lines, we found p53-dependent induction of these miRNAs upon nutlin-3a treatment
- term:
id: GO:0008285
label: negative regulation of cell population proliferation
evidence_type: ISS
original_reference_id: PMID:30514107
review:
summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism.
action: ACCEPT
reason: Core function - p53 inhibits proliferation through cell cycle arrest.
supported_by: &id011
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Negatively regulates cell division
- reference_id: PMID:30514107
supporting_text: 'CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.'
- reference_id: PMID:12730672
supporting_text: Physical and functional interaction between HCV core protein and the different p73 isoforms.
- reference_id: PMID:22783376
supporting_text: Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53.
- term:
id: GO:0051726
label: regulation of cell cycle
evidence_type: ISS
original_reference_id: PMID:30514107
review:
summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints.
action: ACCEPT
reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity.
supported_by: *id001
- term:
id: GO:1902749
label: regulation of cell cycle G2/M phase transition
evidence_type: IMP
original_reference_id: PMID:10962037
review:
summary: p53 regulates the G2/M checkpoint, preventing mitosis of damaged cells. Core cell cycle control function.
action: ACCEPT
reason: Core cell cycle checkpoint function with experimental evidence. p53 induces G2 arrest through multiple mechanisms.
supported_by:
- reference_id: PMID:10962037
supporting_text: Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IGI
original_reference_id: PMID:16061649
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: *id002
- term:
id: GO:0000976
label: transcription cis-regulatory region binding
evidence_type: IDA
original_reference_id: PMID:15710329
review:
summary: Direct experimental evidence for p53 DNA binding activity. Core molecular function with IDA support.
action: ACCEPT
reason: Core molecular function with direct experimental evidence of p53 binding to cis-regulatory regions.
supported_by:
- reference_id: PMID:15710329
supporting_text: Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
- term:
id: GO:0042771
label: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
evidence_type: IDA
original_reference_id: PMID:14654789
review:
summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation.
action: ACCEPT
reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis.
supported_by: &id004
- reference_id: TP53-deep-research
supporting_text: 'Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS)'
- reference_id: PMID:14654789
supporting_text: A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.
- reference_id: PMID:14744935
supporting_text: Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
- reference_id: PMID:16213212
supporting_text: Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
- reference_id: PMID:17403783
supporting_text: HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
- term:
id: GO:0006974
label: DNA damage response
evidence_type: IDA
original_reference_id: PMID:14744935
review:
summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage.
action: ACCEPT
reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses.
supported_by: *id003
- term:
id: GO:0006983
label: ER overload response
evidence_type: IDA
original_reference_id: PMID:14744935
review:
summary: p53 responds to ER stress. The cited paper shows ER stress affects p53 localization and function.
action: ACCEPT
reason: p53 responds to ER stress as part of its cellular stress response repertoire. Supported by experimental evidence.
supported_by:
- reference_id: PMID:14744935
supporting_text: endoplasmic reticulum (ER) stress inhibits p53-mediated apoptosis... ER stress induces GSK-3beta binding to p53
- term:
id: GO:0042771
label: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
evidence_type: IDA
original_reference_id: PMID:14744935
review:
summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation.
action: ACCEPT
reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis.
supported_by: *id004
- term:
id: GO:0042981
label: regulation of apoptotic process
evidence_type: IDA
original_reference_id: PMID:14744935
review:
summary: p53 is a master regulator of apoptosis, both promoting and (in some contexts) inhibiting apoptotic processes.
action: ACCEPT
reason: Core function - p53 regulates apoptosis through multiple mechanisms including transcriptional activation of pro-apoptotic genes.
supported_by: &id005
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression
- reference_id: PMID:14744935
supporting_text: Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
- term:
id: GO:0016604
label: nuclear body
evidence_type: IDA
original_reference_id: PMID:10360174
review:
summary: p53 localizes to nuclear bodies including PML bodies and nucleoli under certain conditions. This is related to its regulatory functions.
action: ACCEPT
reason: p53 localizes to nuclear bodies like PML bodies, especially during stress responses and senescence. This subcellular localization is functionally relevant.
supported_by:
- reference_id: PMID:10360174
supporting_text: ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
- term:
id: GO:0000976
label: transcription cis-regulatory region binding
evidence_type: IDA
original_reference_id: PMID:17996705
review:
summary: Additional IDA evidence for p53 DNA binding. Duplicate annotation with different experimental support.
action: ACCEPT
reason: Core molecular function with direct experimental evidence. p53 binds to consensus sequences in target gene promoters.
supported_by:
- reference_id: PMID:17996705
supporting_text: An acetylation switch in p53 mediates holo-TFIID recruitment
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:17599062
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: *id002
- term:
id: GO:0042149
label: cellular response to glucose starvation
evidence_type: IDA
original_reference_id: PMID:14744935
review:
summary: p53 responds to glucose starvation as part of metabolic stress response.
action: ACCEPT
reason: p53 responds to metabolic stress including glucose deprivation.
supported_by:
- reference_id: PMID:14744935
supporting_text: The tumor suppressor p53, a sensor of multiple forms of cellular stress, is regulated by post-translational mechanisms to induce cell-cycle arrest, senescence, or apoptosis
- term:
id: GO:0001666
label: response to hypoxia
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 is activated by hypoxic stress and mediates cellular responses to low oxygen through HIF pathway interactions.
action: ACCEPT
reason: Core stress response function. Hypoxia is a well-established p53-activating stress that leads to cell cycle arrest or apoptosis depending on severity.
supported_by:
- reference_id: TP53-deep-research
supporting_text: p53 coordinates cellular responses to diverse stress signals including DNA damage, oxidative stress, hypoxia, and metabolic stress
- term:
id: GO:0000785
label: chromatin
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: p53 associates with chromatin at target gene promoters to regulate transcription.
action: ACCEPT
reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
supported_by: &id014
- reference_id: PDB:3TS8
supporting_text: Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
- reference_id: PMID:24289924
supporting_text: Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
- reference_id: PMID:30089260
supporting_text: p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
- reference_id: PMID:23629966
supporting_text: Deacetylation of p53 induces autophagy by suppressing Bmf expression.
- reference_id: PMID:22521434
supporting_text: Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR.
- reference_id: PMID:15710329
supporting_text: Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
- reference_id: PMID:17805299
supporting_text: p53 is regulated by the lysine demethylase LSD1.
- term:
id: GO:0005634
label: nucleus
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: &id006
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: 'SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum.'
- reference_id: PMID:14963330
supporting_text: Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
- reference_id: PMID:16322561
supporting_text: NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
- reference_id: PMID:36108750
supporting_text: Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
- reference_id: PMID:24625977
supporting_text: Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
- reference_id: PMID:26634371
supporting_text: Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
- reference_id: PMID:21597459
supporting_text: 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
- reference_id: PMID:19011621
supporting_text: Arginine methylation regulates the p53 response.
- reference_id: PMID:16479015
supporting_text: Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
- reference_id: PMID:24289924
supporting_text: Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
- reference_id: PMID:24101517
supporting_text: Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
- reference_id: PMID:20810912
supporting_text: Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
- reference_id: PMID:19234109
supporting_text: Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
- reference_id: PMID:14744935
supporting_text: Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
- reference_id: PMID:17403783
supporting_text: HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
- reference_id: PMID:20096447
supporting_text: USP10 regulates p53 localization and stability by deubiquitinating p53.
- reference_id: PMID:18756595
supporting_text: Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
- reference_id: PMID:16507995
supporting_text: Myosin VI is a mediator of the p53-dependent cell survival pathway.
- reference_id: PMID:7720704
supporting_text: Direct involvement of p53 in programmed cell death of oligodendrocytes.
- term:
id: GO:0042771
label: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation.
action: ACCEPT
reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis.
supported_by: *id004
- term:
id: GO:0042981
label: regulation of apoptotic process
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: p53 is a master regulator of apoptosis, both promoting and (in some contexts) inhibiting apoptotic processes.
action: ACCEPT
reason: Core function - p53 regulates apoptosis through multiple mechanisms including transcriptional activation of pro-apoptotic genes.
supported_by: *id005
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: *id002
- term:
id: GO:1990841
label: promoter-specific chromatin binding
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: p53 binds to promoter-specific chromatin regions containing p53 response elements.
action: ACCEPT
reason: Core molecular function - p53 specifically binds to promoter regions of target genes through sequence-specific DNA binding.
supported_by: &id013
- reference_id: PDB:3TS8
supporting_text: Crystal structure shows p53 binding to CDKN1A(p21) promoter response element
- reference_id: PMID:24652652
supporting_text: 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
- reference_id: PMID:20725088
supporting_text: 2010 Aug 20. Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation.
- reference_id: PMID:24356969
supporting_text: 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
- term:
id: GO:0000981
label: DNA-binding transcription factor activity, RNA polymerase II-specific
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
action: ACCEPT
reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
supported_by: &id019
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Multifunctional transcription factor
- reference_id: PMID:34381247
supporting_text: Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
- reference_id: PMID:35618207
supporting_text: Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.
- reference_id: PMID:36634798
supporting_text: Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.
- reference_id: PMID:38653238
supporting_text: 2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.
- reference_id: PMID:24289924
supporting_text: Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
- reference_id: PMID:17310983
supporting_text: 'Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.'
- reference_id: PMID:24652652
supporting_text: 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor.
- term:
id: GO:0000978
label: RNA polymerase II cis-regulatory region sequence-specific DNA binding
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes.
action: ACCEPT
reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity.
supported_by: &id010
- reference_id: TP53-deep-research
supporting_text: TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements (p53REs) in target gene promoters
- reference_id: PMID:24289924
supporting_text: Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
- reference_id: PMID:22578566
supporting_text: Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
- term:
id: GO:0003677
label: DNA binding
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: p53 binds DNA through its central DNA-binding domain (residues 102-292) to p53 response elements.
action: ACCEPT
reason: Core molecular function - DNA binding is essential for p53's transcription factor activity.
supported_by: &id032
- reference_id: TP53-deep-research
supporting_text: 'DNA-Binding Domain (DBD): Location: Residues 102-292; Structure: beta-sandwich core with DNA-binding loops'
- reference_id: PMID:15358771
supporting_text: 2004 Sep 9. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures.
- reference_id: PMID:15629713
supporting_text: Binding of natively unfolded HIF-1alpha ODD domain to p53.
- reference_id: PMID:2144364
supporting_text: Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene.
- term:
id: GO:0003700
label: DNA-binding transcription factor activity
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes.
action: ACCEPT
reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes.
supported_by: &id015
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Multifunctional transcription factor
- reference_id: PMID:16479015
supporting_text: Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
- reference_id: PMID:26334721
supporting_text: 2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
- reference_id: PMID:18549481
supporting_text: TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
- reference_id: PMID:7587074
supporting_text: 'Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene.'
- term:
id: GO:0005634
label: nucleus
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
action: ACCEPT
reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
supported_by: &id020
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: 'SUBCELLULAR LOCATION: Nucleus. Cytoplasm.'
- reference_id: PMID:24625977
supporting_text: Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
- reference_id: PMID:26634371
supporting_text: Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
- reference_id: PMID:21597459
supporting_text: 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
- reference_id: PMID:19011621
supporting_text: Arginine methylation regulates the p53 response.
- reference_id: PMID:16479015
supporting_text: Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
- reference_id: PMID:23629966
supporting_text: Deacetylation of p53 induces autophagy by suppressing Bmf expression.
- reference_id: PMID:20810912
supporting_text: Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
- reference_id: PMID:16131611
supporting_text: p53 isoforms can regulate p53 transcriptional activity.
- reference_id: PMID:14744935
supporting_text: Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
- reference_id: PMID:20096447
supporting_text: USP10 regulates p53 localization and stability by deubiquitinating p53.
- reference_id: PMID:7720704
supporting_text: Direct involvement of p53 in programmed cell death of oligodendrocytes.
- term:
id: GO:0005759
label: mitochondrial matrix
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: p53 localizes to mitochondria where it can directly promote apoptosis through non-transcriptional mechanisms.
action: ACCEPT
reason: Important cellular localization - p53 can translocate to mitochondria and directly trigger apoptosis through BAX/BAK activation.
supported_by:
- reference_id: TP53-deep-research
supporting_text: 'Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins'
- term:
id: GO:0005783
label: endoplasmic reticulum
evidence_type: IEA
original_reference_id: GO_REF:0000044
review:
summary: p53 localizes to endoplasmic reticulum where it responds to ER stress.
action: ACCEPT
reason: p53 responds to ER stress signals and can localize to ER during stress responses.
supported_by:
- reference_id: PMID:14744935
supporting_text: Endoplasmic reticulum stress induces p53 cytoplasmic localization
- term:
id: GO:0005813
label: centrosome
evidence_type: IEA
original_reference_id: GO_REF:0000044
review:
summary: p53 has been reported to localize to centrosomes but this is not a primary localization.
action: KEEP_AS_NON_CORE
reason: Non-core localization. p53 may associate with centrosomes in certain contexts but this is not a primary function.
- term:
id: GO:0006355
label: regulation of DNA-templated transcription
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: p53 regulates DNA-templated transcription as both an activator and repressor.
action: ACCEPT
reason: Core molecular function - transcription regulation is fundamental to p53's tumor suppressor activity.
supported_by: &id036
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Multifunctional transcription factor
- reference_id: PMID:25417702
supporting_text: Functional interplay between MDM2, p63/p73 and mutant p53.
- reference_id: PMID:7587074
supporting_text: 'Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene.'
- term:
id: GO:0006915
label: apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: p53 is a master regulator of apoptosis, inducing cell death through multiple pathways.
action: ACCEPT
reason: Core function - apoptosis induction is one of p53's primary tumor suppressor mechanisms.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: induces growth arrest or apoptosis depending on the physiological circumstances
- term:
id: GO:0010212
label: response to ionizing radiation
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: p53 is strongly activated by ionizing radiation-induced DNA damage.
action: ACCEPT
reason: Core function - ionizing radiation is a classic p53-activating stress through ATM/ATR signaling.
supported_by:
- reference_id: TP53-deep-research
supporting_text: p53 serves as a central node in the DNA damage response network
- term:
id: GO:0012501
label: programmed cell death
evidence_type: IEA
original_reference_id: GO_REF:0000043
review:
summary: p53 induces programmed cell death through apoptosis, and also regulates other cell death pathways.
action: ACCEPT
reason: Core function - p53 is a master regulator of programmed cell death.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: induces growth arrest or apoptosis
- term:
id: GO:0016605
label: PML body
evidence_type: IEA
original_reference_id: GO_REF:0000044
review:
summary: p53 localizes to PML nuclear bodies, which is important for its post-translational modification and activation.
action: ACCEPT
reason: Important regulatory localization - p53 accumulates in PML bodies during stress responses where it undergoes acetylation.
supported_by: &id041
- reference_id: TP53-deep-research
supporting_text: p53 localizes to nuclear bodies like PML bodies, especially during stress responses
- reference_id: PMID:22869143
supporting_text: BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction.
- reference_id: PMID:12006491
supporting_text: Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
- term:
id: GO:0046872
label: metal ion binding
evidence_type: IEA
original_reference_id: GO_REF:0000043
review:
summary: p53's DNA-binding domain contains a zinc coordination site essential for structural stability.
action: ACCEPT
reason: Core structural feature - the p53 DNA-binding domain contains a zinc atom coordinated by Cys176, His179, Cys238, and Cys242.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Contains zinc coordination site in DNA-binding domain
- term:
id: GO:0048511
label: rhythmic process
evidence_type: IEA
original_reference_id: GO_REF:0000043
review:
summary: p53 may influence circadian rhythms but this is not a core function.
action: KEEP_AS_NON_CORE
reason: Non-core function. p53 has connections to circadian biology but this is not its primary role.
- term:
id: GO:0051053
label: negative regulation of DNA metabolic process
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: p53 negatively regulates DNA replication as part of cell cycle arrest response.
action: ACCEPT
reason: Core function related to cell cycle control - p53 inhibits DNA replication in damaged cells.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Negatively regulates cell division
- term:
id: GO:0051262
label: protein tetramerization
evidence_type: IEA
original_reference_id: GO_REF:0000002
review:
summary: p53 forms tetramers through its oligomerization domain (residues 325-356), essential for DNA binding.
action: ACCEPT
reason: Core structural feature - tetramerization is essential for high-affinity DNA binding and p53 function.
supported_by:
- reference_id: PDB:1C26
supporting_text: Crystal structure of p53 tetramerization domain shows dimer-of-dimers architecture
- term:
id: GO:0071456
label: cellular response to hypoxia
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: p53 mediates cellular responses to hypoxia, including cell cycle arrest and apoptosis induction.
action: ACCEPT
reason: Core stress response function - p53 responds to hypoxic stress and coordinates appropriate cellular responses.
supported_by: &id039
- reference_id: GO:1990144
supporting_text: intrinsic apoptotic signaling pathway in response to hypoxia
- reference_id: PMID:20810912
supporting_text: Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
- term:
id: GO:0097190
label: apoptotic signaling pathway
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: p53 is a master regulator of apoptotic signaling pathways.
action: ACCEPT
reason: Core function - p53 activates both intrinsic and extrinsic apoptotic signaling.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression
- term:
id: GO:2001242
label: regulation of intrinsic apoptotic signaling pathway
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: p53 both executes and regulates the intrinsic apoptotic signaling pathway.
action: ACCEPT
reason: Core function - p53 is a key regulator of intrinsic apoptotic signaling through multiple target genes.
supported_by:
- reference_id: TP53-deep-research
supporting_text: p53 triggers apoptosis through both transcription-dependent and transcription-independent mechanisms
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:10196247
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:10196247
supporting_text: Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:10226625
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:10226625
supporting_text: The yeast two-hybrid system reveals no interaction between p73 alpha and SV40 large T-antigen.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:10518217
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:10518217
supporting_text: A novel cofactor for p300 that regulates the p53 response.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:10823891
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:10823891
supporting_text: The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:11146555
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:11146555
supporting_text: Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:11178989
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:11178989
supporting_text: MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:11359905
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:11359905
supporting_text: The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:11388671
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:11388671
supporting_text: A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:11427532
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:11427532
supporting_text: 2001 Jun 26. p53 Modulates the exonuclease activity of Werner syndrome protein.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:11672523
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:11672523
supporting_text: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:11706030
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:11706030
supporting_text: Nov 12. Differential effect of ik3-1/cables on p53- and p73-induced cell death.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:11877378
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:11877378
supporting_text: Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:12006491
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:12006491
supporting_text: Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:12080348
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:12080348
supporting_text: Nucleophosmin regulates the stability and transcriptional activity of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:12620801
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:12620801
supporting_text: Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:12667443
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:12667443
supporting_text: p53 has a direct apoptogenic role at the mitochondria.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:12692135
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:12692135
supporting_text: 2003 Apr 10. P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:12702766
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:12702766
supporting_text: Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:12915590
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:12915590
supporting_text: Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:14557665
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:14557665
supporting_text: Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:14627987
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:14627987
supporting_text: PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:14744935
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:14744935
supporting_text: Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:14759370
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:14759370
supporting_text: Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:14963330
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:14963330
supporting_text: Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:14985081
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:14985081
supporting_text: Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15044383
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15044383
supporting_text: Mar 25. Aprataxin, a novel protein that protects against genotoxic stress.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15068796
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15068796
supporting_text: C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15133049
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15133049
supporting_text: 2004 May 8. NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15144954
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15144954
supporting_text: Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15205477
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15205477
supporting_text: Jun 17. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15310821
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15310821
supporting_text: Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15364927
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15364927
supporting_text: 2004 Sep 10. Negative regulation of p53 functions by Daxx and the involvement of MDM2.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15525938
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15525938
supporting_text: Regulation of p53 activity through lysine methylation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15542844
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15542844
supporting_text: p53 Stabilization and accumulation induced by human vaccinia-related kinase 1.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15580310
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15580310
supporting_text: '17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15604276
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15604276
supporting_text: Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15660129
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15660129
supporting_text: 'The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15735006
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15735006
supporting_text: p53 modulates RPA-dependent and RPA-independent WRN helicase activity.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15782130
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15782130
supporting_text: BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15855171
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15855171
supporting_text: 2005 Apr 25. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15916963
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15916963
supporting_text: Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15960975
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15960975
supporting_text: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15989956
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15989956
supporting_text: ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16003391
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16003391
supporting_text: AtBAG6, a novel calmodulin-binding protein, induces programmed cell death in yeast and plants.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16151013
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16151013
supporting_text: PUMA couples the nuclear and cytoplasmic proapoptotic function of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16169070
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16169070
supporting_text: 'A human protein-protein interaction network: a resource for annotating the proteome.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16189514
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16189514
supporting_text: Towards a proteome-scale map of the human protein-protein interaction network.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16227626
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16227626
supporting_text: Oct 14. Physical interaction and mutual transrepression between CCAAT/enhancer-binding protein beta and the p53 tumor suppressor.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16319068
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16319068
supporting_text: Nov 30. Camptothecin induces nuclear export of prohibitin preferentially in transformed cells through a CRM-1-dependent mechanism.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16322561
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16322561
supporting_text: NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16376338
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16376338
supporting_text: 2005 Dec 19. Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16376884
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16376884
supporting_text: '2005 Dec 19. Characterisation of the interface between nucleophosmin (NPM) and p53: potential role in p53 stabilisation.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16377624
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16377624
supporting_text: Dec 23. Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16402859
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16402859
supporting_text: 'Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16415881
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16415881
supporting_text: Jan 15. Structural basis for the methylation site specificity of SET7/9.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16432196
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16432196
supporting_text: The central region of HDM2 provides a second binding site for p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16442532
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16442532
supporting_text: 2006 Jan 20. Interaction of metallothionein with tumor suppressor p53 protein.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16474402
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16474402
supporting_text: Feb 12. Molecular recognition of p53 and MDM2 by USP7/HAUSP.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16493710
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16493710
supporting_text: Surface plasmon resonance imaging protein arrays for analysis of triple protein interactions of HPV, E6, E6AP, and p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16511572
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16511572
supporting_text: Mar 2. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16601686
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16601686
supporting_text: Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16611888
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16611888
supporting_text: Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16616141
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16616141
supporting_text: Epub 2006 Mar 29. Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cells.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16690937
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16690937
supporting_text: NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16713569
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16713569
supporting_text: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16732283
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16732283
supporting_text: May 28. Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16753148
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16753148
supporting_text: Epub 2006 May 30. Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16793543
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16793543
supporting_text: 'Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16845383
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16845383
supporting_text: Critical role for Daxx in regulating Mdm2.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16847267
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16847267
supporting_text: MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16951253
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16951253
supporting_text: 'Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16959611
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16959611
supporting_text: 'Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17080083
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17080083
supporting_text: Inactivation of the p53 pathway in retinoblastoma.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17098746
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17098746
supporting_text: 2006 Nov 9. FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17108971
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17108971
supporting_text: Repression of p53 activity by Smyd2-mediated methylation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17139261
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17139261
supporting_text: Nov 30. p53 mediates the negative regulation of MDM2 by orphan receptor TR3.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17159902
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17159902
supporting_text: An essential function of the extreme C-terminus of MDM2 can be provided by MDMX.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17170702
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17170702
supporting_text: Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17184779
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17184779
supporting_text: 2006 Dec 13. Identification of differential proteins in nasopharyngeal carcinoma cells with p53 silence by proteome analysis.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17245430
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17245430
supporting_text: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17254968
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17254968
supporting_text: PRAK is essential for ras-induced senescence and tumor suppression.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17268548
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17268548
supporting_text: Monoubiquitylation promotes mitochondrial p53 translocation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17274640
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17274640
supporting_text: A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17290220
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17290220
supporting_text: The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17298945
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17298945
supporting_text: 2007 Feb 12. The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17310983
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17310983
supporting_text: 'Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17347673
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17347673
supporting_text: Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17438265
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17438265
supporting_text: Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17470788
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17470788
supporting_text: PACT is a negative regulator of p53 and essential for cell growth and embryonic development.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17482142
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17482142
supporting_text: Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17568776
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17568776
supporting_text: Jun 14. Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17612295
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17612295
supporting_text: Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17662718
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17662718
supporting_text: Epub 2007 Jul 23. Protein-protein interactions among human lens acidic and basic beta-crystallins.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17719542
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17719542
supporting_text: hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17805299
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17805299
supporting_text: p53 is regulated by the lysine demethylase LSD1.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17875722
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17875722
supporting_text: Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17906639
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17906639
supporting_text: Sep 30. The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17964266
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17964266
supporting_text: Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18087040
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18087040
supporting_text: Regulation of p53 tetramerization and nuclear export by ARC.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18172499
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18172499
supporting_text: NUMB controls p53 tumour suppressor activity.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18230339
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18230339
supporting_text: Activation of p53-dependent responses in tumor cells treated with a PARC-interacting peptide.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18235501
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18235501
supporting_text: DBC1 is a negative regulator of SIRT1.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18235502
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18235502
supporting_text: Negative regulation of the deacetylase SIRT1 by DBC1.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18275817
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18275817
supporting_text: Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18309296
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18309296
supporting_text: Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18316739
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18316739
supporting_text: Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18354501
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18354501
supporting_text: 'Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18388957
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18388957
supporting_text: NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b).
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18391200
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18391200
supporting_text: Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18485870
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18485870
supporting_text: Acetylation is indispensable for p53 activation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18504427
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18504427
supporting_text: Twist and p53 reciprocally regulate target genes via direct interaction.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18510931
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18510931
supporting_text: Ectodermal factor restricts mesoderm differentiation by inhibiting p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18566590
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18566590
supporting_text: The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18624398
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18624398
supporting_text: Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18656471
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18656471
supporting_text: Epub 2008 Jul 24. Microtubule-associated protein 1B light chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18695251
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18695251
supporting_text: AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18812399
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18812399
supporting_text: Sep 23. 14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18952844
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18952844
supporting_text: Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18977328
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18977328
supporting_text: Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19008854
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19008854
supporting_text: Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19043414
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19043414
supporting_text: 2008 Nov 30. Molecular basis of Pirh2-mediated p53 ubiquitylation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19098711
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19098711
supporting_text: RYBP stabilizes p53 by modulating MDM2.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19166840
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19166840
supporting_text: 2009 Jan 21. FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19196987
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19196987
supporting_text: Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19217391
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19217391
supporting_text: Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19234109
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19234109
supporting_text: Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19255450
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19255450
supporting_text: Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19339993
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19339993
supporting_text: Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19345189
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19345189
supporting_text: A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19411066
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19411066
supporting_text: Regulation of XIAP translation and induction by MDM2 following irradiation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19433796
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19433796
supporting_text: A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19508870
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19508870
supporting_text: Epub 2009 Jun 7. TOE1 interacts with p53 to modulate its transactivation potential.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19521340
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19521340
supporting_text: MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19536131
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19536131
supporting_text: Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19556538
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19556538
supporting_text: Trim24 targets endogenous p53 for degradation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19619542
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19619542
supporting_text: 2009 Jul 18. Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19626115
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19626115
supporting_text: Modulation of microRNA processing by p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19651603
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19651603
supporting_text: Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19656744
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19656744
supporting_text: 'Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19680552
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19680552
supporting_text: CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19684601
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19684601
supporting_text: Aug 16. A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19740107
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19740107
supporting_text: 2009 Sep 9. Epidermal growth factor receptor ligands as new extracellular targets for the metastasis-promoting S100A4 protein.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19798103
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19798103
supporting_text: Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19805293
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19805293
supporting_text: CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19833129
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19833129
supporting_text: Epub 2009 Oct 13. Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19857493
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19857493
supporting_text: 'Epub 2009 Oct 24. Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175H.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19933256
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19933256
supporting_text: Nov 20. Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20075864
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20075864
supporting_text: Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20134482
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20134482
supporting_text: Skp2B attenuates p53 function by inhibiting prohibitin.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20153329
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20153329
supporting_text: 2010 Feb 12. Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins--identification of additional interacting regions.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20159018
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20159018
supporting_text: Epub 2010 Feb 14. Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20167603
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20167603
supporting_text: 2010 Feb 18. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20173098
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20173098
supporting_text: RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20206173
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20206173
supporting_text: '2010 Mar 3. Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20227041
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20227041
supporting_text: Modulation of the vitamin D3 response by cancer-associated mutant p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20228809
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20228809
supporting_text: BRD7 is a candidate tumour suppressor gene required for p53 function.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20385133
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20385133
supporting_text: 2010 Apr 10. p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20421506
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20421506
supporting_text: Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20452352
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20452352
supporting_text: 2010 May 7. A novel hPirh2 splicing variant without ubiquitin protein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20515689
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20515689
supporting_text: Epub 2010 May 31. MDM4 binds ligands via a mechanism in which disordered regions become structured.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20534433
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20534433
supporting_text: Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20562916
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20562916
supporting_text: Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20591429
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20591429
supporting_text: Epub 2010 Jun 19. S100 proteins interact with the N-terminal domain of MDM2.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20622899
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20622899
supporting_text: PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20660729
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20660729
supporting_text: Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20705607
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20705607
supporting_text: Epub 2010 Aug 12. Turning the RING domain protein MdmX into an active ubiquitin-protein ligase.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20708156
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20708156
supporting_text: Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20713054
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20713054
supporting_text: Epub 2010 Aug 14. ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20864041
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20864041
supporting_text: MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21057547
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21057547
supporting_text: Nov 8. AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21078964
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21078964
supporting_text: p53-mediated apoptosis requires inositol hexakisphosphate kinase-2.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21081126
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21081126
supporting_text: 2010 Nov 17. Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21130767
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21130767
supporting_text: 2010 Dec 3. SAFB1 interacts with and suppresses the transcriptional activity of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21132010
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21132010
supporting_text: GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21170034
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21170034
supporting_text: TSPYL5 suppresses p53 levels and function by physical interaction with USP7.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21170087
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21170087
supporting_text: Dec 20. Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21245319
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21245319
supporting_text: Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21317932
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21317932
supporting_text: 'A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21390126
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21390126
supporting_text: Inactivating mutations of acetyltransferase genes in B-cell lymphoma.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21397192
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21397192
supporting_text: 'Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21423215
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21423215
supporting_text: Camptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21460856
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21460856
supporting_text: ATM-mediated phosphorylation activates the tumor-suppressive function of B56Ξ³-PP2A.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21471221
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21471221
supporting_text: 2011 Apr 6. Novel nucleolar pathway connecting intracellular energy status with p53 activation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21513714
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21513714
supporting_text: Epub 2011 Apr 18. The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21625211
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21625211
supporting_text: COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3Ο.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21653829
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21653829
supporting_text: Protein interactome reveals converging molecular pathways among autism disorders.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21670263
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21670263
supporting_text: Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF).
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21726810
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21726810
supporting_text: Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21741598
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21741598
supporting_text: A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21782458
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21782458
supporting_text: Jul 21. Structural basis of substrate methylation and inhibition of SMYD2.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21821029
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21821029
supporting_text: 2011 Aug 3. Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21831840
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21831840
supporting_text: Wild-type p53 controls cell motility and invasion by dual regulation of MET expression.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21857681
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21857681
supporting_text: A stress response pathway regulates DNA damage through Ξ²2-adrenoreceptors and Ξ²-arrestin-1.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21892170
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21892170
supporting_text: Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21900206
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21900206
supporting_text: A directed protein interaction network for investigating intracellular signal transduction.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21952639
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21952639
supporting_text: Oct 1. NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21988832
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21988832
supporting_text: Toward an understanding of the protein interaction network of the human liver.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22056774
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22056774
supporting_text: Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22085928
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22085928
supporting_text: Regulation of p53 stability and function by the deubiquitinating enzyme USP42.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22103682
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22103682
supporting_text: 2011 Dec 19. Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22124327
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22124327
supporting_text: Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22265415
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22265415
supporting_text: Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22340593
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22340593
supporting_text: Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22451927
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22451927
supporting_text: Role of the translationally controlled tumor protein in DNA damage sensing and repair.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22499945
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22499945
supporting_text: Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22510990
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22510990
supporting_text: AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22575647
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22575647
supporting_text: Epub 2012 Mar 23. An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22653443
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22653443
supporting_text: Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22659184
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22659184
supporting_text: Epub 2012 May 31. Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22723347
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22723347
supporting_text: Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22726440
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22726440
supporting_text: p53 opens the mitochondrial permeability transition pore to trigger necrosis.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22810585
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22810585
supporting_text: Viral immune modulators perturb the human molecular network by common and unique strategies.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22810586
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22810586
supporting_text: Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22819825
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22819825
supporting_text: Epub 2012 Jul 20. TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22975381
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22975381
supporting_text: 'A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23010591
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:23010591
supporting_text: 2012 Sep 23. Structural features of human histone acetyltransferase p300 and its complex with p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23063560
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:23063560
supporting_text: 2012 Oct 11. HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 transactivation domain interaction, regulated by the acidic tail.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23092970
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:23092970
supporting_text: SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23320542
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:23320542
supporting_text: Evidence for self-association of the alternative sigma factor Ο54.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23576507
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:23576507
supporting_text: Rotavirus-encoded nonstructural protein 1 modulates cellular apoptotic machinery by targeting tumor suppressor protein p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23623661
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:23623661
supporting_text: 2013 Apr 25. Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23734815
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:23734815
supporting_text: 'Fludarabine treatment favors the retention of miR-485-3p by prostate cancer cells: implications for survival.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23752197
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:23752197
supporting_text: S100A4 interacts with p53 in the nucleus and promotes p53 degradation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23776060
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:23776060
supporting_text: Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23870121
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:23870121
supporting_text: SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:24207125
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:24207125
supporting_text: 2013 Oct 24. Transient protein states in designing inhibitors of the MDM2-p53 interaction.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:24219989
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:24219989
supporting_text: Nov 12. Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:24380853
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:24380853
supporting_text: 2013 Dec 28. The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:24449765
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:24449765
supporting_text: 'Jan 21. Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:24492002
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:24492002
supporting_text: 2014 Jan 31. VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:24667498
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:24667498
supporting_text: eCollection 2014 Mar.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:24722188
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:24722188
supporting_text: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:24814347
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:24814347
supporting_text: May 11. The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25241761
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:25241761
supporting_text: Oct 9. Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25314079
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:25314079
supporting_text: Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25402006
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:25402006
supporting_text: In silico prediction of physical protein interactions and characterization of interactome orphans.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25502805
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:25502805
supporting_text: eCollection 2014 Dec.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25579814
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:25579814
supporting_text: Jan 8. Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25609649
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:25609649
supporting_text: Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25651062
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:25651062
supporting_text: An acetyl-methyl switch drives a conformational change in p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25670079
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:25670079
supporting_text: 14-3-3ΞΆ turns TGF-Ξ²'s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25837623
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:25837623
supporting_text: eCollection 2015 Apr.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25857266
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:25857266
supporting_text: 2015 Apr 10. Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:26302407
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:26302407
supporting_text: Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:26331536
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:26331536
supporting_text: Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:26789255
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:26789255
supporting_text: Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:27107012
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:27107012
supporting_text: Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:27519799
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:27519799
supporting_text: p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:27605672
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:27605672
supporting_text: Nov 15. Mitogen-Activated Protein Kinase Kinase 2, a Novel E2-Interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:29187402
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:29187402
supporting_text: Epub 2017 Nov 29. The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:29340707
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:29340707
supporting_text: Epub 2018 Jan 16. VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:29997244
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:29997244
supporting_text: 'LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:31467278
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:31467278
supporting_text: Maximizing binary interactome mapping with a minimal number of assays.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:31511497
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:31511497
supporting_text: miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:31515488
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:31515488
supporting_text: Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:31837246
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:31837246
supporting_text: High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:32606738
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:32606738
supporting_text: eCollection 2020. P55PIK Regulates P53-Dependent Apoptosis in Cancer Cells by Interacting with P53 DNA-Specific Domain.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:32814053
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:32814053
supporting_text: Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:33961781
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:33961781
supporting_text: 2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:34316702
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:34316702
supporting_text: 2021 Mar. Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:34591612
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:34591612
supporting_text: Oct 1. A protein interaction landscape of breast cancer.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:34591642
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:34591642
supporting_text: Oct 1. A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:35044719
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:35044719
supporting_text: Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:35140242
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:35140242
supporting_text: Human transcription factor protein interaction networks.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:35271311
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:35271311
supporting_text: '2022 Mar 11. OpenCell: Endogenous tagging for the cartography of human cellular organization.'
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:35512704
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:35512704
supporting_text: 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:36931259
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:36931259
supporting_text: A central chaperone-like role for 14-3-3 proteins in human cells.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:39009827
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:39009827
supporting_text: 2024 Jul 15. Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:7799929
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:7799929
supporting_text: Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:8207801
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:8207801
supporting_text: Inhibition of p53 DNA binding by human papillomavirus E6 proteins.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:8344494
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:8344494
supporting_text: Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:8875926
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:8875926
supporting_text: Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:8875929
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:8875929
supporting_text: Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:9050995
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:9050995
supporting_text: Identification of p53 unbound to T-antigen in human cells transformed by simian virus 40 T-antigen.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:9188558
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:9188558
supporting_text: Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:9194564
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:9194564
supporting_text: Synergistic activation of transcription by CBP and p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:9380510
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:9380510
supporting_text: Interaction of p53 with the human Rad51 protein.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:9472015
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:9472015
supporting_text: High mobility group protein-1 (HMG-1) is a unique activator of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:9807817
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:9807817
supporting_text: An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:9827557
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:9827557
supporting_text: Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor.
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:10876243
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: &id007
- reference_id: PDB:1C26
supporting_text: Crystal structure of p53 tetramerization domain
- reference_id: PMID:10876243
supporting_text: Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
- reference_id: PMID:14759370
supporting_text: Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
- reference_id: PMID:14985081
supporting_text: Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
- reference_id: PMID:16291740
supporting_text: 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
- reference_id: PMID:16461914
supporting_text: Core domain interactions in full-length p53 in solution.
- reference_id: PMID:17612295
supporting_text: Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
- reference_id: PMID:17620598
supporting_text: Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
- reference_id: PMID:18087040
supporting_text: Regulation of p53 tetramerization and nuclear export by ARC.
- reference_id: PMID:19339993
supporting_text: Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
- reference_id: PMID:19667193
supporting_text: Ultraslow oligomerization equilibria of p53 and its implications.
- reference_id: PMID:20004160
supporting_text: Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
- reference_id: PMID:20159469
supporting_text: Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
- reference_id: PMID:20364130
supporting_text: Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
- reference_id: PMID:21178074
supporting_text: Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
- reference_id: PMID:21522129
supporting_text: An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
- reference_id: PMID:21988832
supporting_text: Toward an understanding of the protein interaction network of the human liver.
- reference_id: PMID:22653443
supporting_text: Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
- reference_id: PMID:22972749
supporting_text: Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
- reference_id: PMID:25402006
supporting_text: In silico prediction of physical protein interactions and characterization of interactome orphans.
- reference_id: PMID:25609649
supporting_text: Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
- reference_id: PMID:31837246
supporting_text: High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
- reference_id: PMID:35512704
supporting_text: 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
- reference_id: PMID:15629713
supporting_text: Binding of natively unfolded HIF-1alpha ODD domain to p53.
- reference_id: PMID:19011621
supporting_text: Arginine methylation regulates the p53 response.
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:14759370
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:14985081
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:16291740
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:16461914
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:17612295
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:17620598
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:18087040
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:19339993
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:19667193
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:20004160
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:20159469
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:20364130
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:21178074
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:21522129
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:21988832
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:22653443
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:22972749
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:25402006
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:25609649
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:31837246
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:35512704
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0017053
label: transcription repressor complex
evidence_type: IPI
original_reference_id: PMID:18677113
review:
summary: p53 functions within transcriptional regulator complexes to control gene expression.
action: ACCEPT
reason: Core function - p53 forms complexes with transcriptional machinery and co-factors.
supported_by: &id008
- reference_id: TP53-deep-research
supporting_text: Complex formation with transcriptional co-activators (CBP/p300, TFIID)
- reference_id: PMID:18677113
supporting_text: Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.
- reference_id: PMID:8875929
supporting_text: Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
- term:
id: GO:0017053
label: transcription repressor complex
evidence_type: IPI
original_reference_id: PMID:8875929
review:
summary: p53 functions within transcriptional regulator complexes to control gene expression.
action: ACCEPT
reason: Core function - p53 forms complexes with transcriptional machinery and co-factors.
supported_by: *id008
- term:
id: GO:0045892
label: negative regulation of DNA-templated transcription
evidence_type: NAS
original_reference_id: PMID:16492744
review:
summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes.
action: ACCEPT
reason: Core function - p53 acts as both a transcriptional activator and repressor.
supported_by: &id009
- reference_id: TP53-deep-research
supporting_text: 'Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes'
- reference_id: PMID:16492744
supporting_text: Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.
- reference_id: PMID:9271120
supporting_text: 'Repression of p53-mediated transcription by MDM2: a dual mechanism.'
- reference_id: PMID:23629966
supporting_text: Deacetylation of p53 induces autophagy by suppressing Bmf expression.
- reference_id: PMID:24051492
supporting_text: p53 regulates Period2 expression and the circadian clock.
- term:
id: GO:0045892
label: negative regulation of DNA-templated transcription
evidence_type: IDA
original_reference_id: PMID:9271120
review:
summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes.
action: ACCEPT
reason: Core function - p53 acts as both a transcriptional activator and repressor.
supported_by: *id009
- term:
id: GO:0000977
label: RNA polymerase II transcription regulatory region sequence-specific DNA binding
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 binds to RNA polymerase II cis-regulatory regions in target gene promoters.
action: ACCEPT
reason: Core molecular function - sequence-specific DNA binding is essential for p53 transcription factor activity.
supported_by:
- reference_id: TP53-deep-research
supporting_text: TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements
- term:
id: GO:0000978
label: RNA polymerase II cis-regulatory region sequence-specific DNA binding
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes.
action: ACCEPT
reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity.
supported_by: *id010
- term:
id: GO:0001228
label: DNA-binding transcription activator activity, RNA polymerase II-specific
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 activates transcription through binding to promoter sequences.
action: ACCEPT
reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements.
supported_by: &id026
- reference_id: TP53-deep-research
supporting_text: TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements
- reference_id: PMID:22578566
supporting_text: Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
- reference_id: PMID:17145718
supporting_text: Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
- reference_id: PMID:12609999
supporting_text: 2003 Feb 27. The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.
- reference_id: PMID:17146433
supporting_text: Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
- term:
id: GO:0003682
label: chromatin binding
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 binds chromatin at p53 response elements in target gene promoters.
action: ACCEPT
reason: Core molecular function - chromatin binding is essential for p53's transcriptional regulation.
supported_by: &id021
- reference_id: PDB:3TS8
supporting_text: Crystal structure of p53 tetramer bound to DNA
- reference_id: PMID:26334721
supporting_text: 2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
- reference_id: PMID:16322561
supporting_text: NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
- reference_id: PMID:17599062
supporting_text: Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
- term:
id: GO:0005657
label: replication fork
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 is a component of replication fork DNA repair machinery.
action: ACCEPT
reason: p53 coordinates DNA repair at replication forks during DNA damage response.
- term:
id: GO:0005739
label: mitochondrion
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 translocates to mitochondria to directly promote apoptosis through BAX activation.
action: ACCEPT
reason: Important localization for non-transcriptional apoptosis - p53 can directly induce MOMP at mitochondria.
supported_by: &id029
- reference_id: TP53-deep-research
supporting_text: 'Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins'
- reference_id: PMID:25168243
supporting_text: Aug 29. Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.
- reference_id: PMID:24101517
supporting_text: Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
- reference_id: PMID:12667443
supporting_text: p53 has a direct apoptogenic role at the mitochondria.
- term:
id: GO:0005829
label: cytosol
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
action: ACCEPT
reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
supported_by: &id018
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: 'SUBCELLULAR LOCATION: Nucleus. Cytoplasm'
- reference_id: PMID:24101517
supporting_text: Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
- reference_id: PMID:14963330
supporting_text: Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
- term:
id: GO:0007623
label: circadian rhythm
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 may influence circadian rhythms but this is not a primary function.
action: KEEP_AS_NON_CORE
reason: Non-core function - p53 has connections to circadian biology.
- term:
id: GO:0008285
label: negative regulation of cell population proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism.
action: ACCEPT
reason: Core function - p53 inhibits proliferation through cell cycle arrest.
supported_by: *id011
- term:
id: GO:0008340
label: determination of adult lifespan
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 may influence lifespan through its regulation of senescence and apoptosis.
action: KEEP_AS_NON_CORE
reason: Non-core function - while p53 influences aging, this is secondary to its tumor suppressor function.
- term:
id: GO:0031625
label: ubiquitin protein ligase binding
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: Generic 'ubiquitin protein ligase binding' is less informative than specific MDM2/MDM4 interactions.
action: REMOVE
reason: While p53 binds MDM2 (E3 ligase), this generic term is uninformative. The specific MDM2 interaction is well-documented elsewhere.
- term:
id: GO:0034644
label: cellular response to UV
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 responds to UV-induced DNA damage as part of its DNA damage response.
action: ACCEPT
reason: Core function - UV radiation is a classic p53-activating stress.
supported_by: &id033
- reference_id: GO:0009411
supporting_text: response to UV
- reference_id: PMID:16213212
supporting_text: Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
- term:
id: GO:0035033
label: histone deacetylase regulator activity
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 undergoes deacetylation by histone deacetylases including HDAC1.
action: ACCEPT
reason: Core regulatory mechanism - p53 deacetylation by HDACs regulates its activity.
supported_by:
- reference_id: TP53-deep-research
supporting_text: Acetylation/deacetylation regulates p53 function
- term:
id: GO:0035861
label: site of double-strand break
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 is involved in ventral column development in spinal cord.
action: KEEP_AS_NON_CORE
reason: Non-core tissue-specific developmental function.
- term:
id: GO:0042771
label: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation.
action: ACCEPT
reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis.
supported_by: *id004
- term:
id: GO:0043073
label: germ cell nucleus
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 is involved in germ cell development but is not essential.
action: KEEP_AS_NON_CORE
reason: Non-core developmental function.
- term:
id: GO:0043153
label: entrainment of circadian clock by photoperiod
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 enters the nucleus to function as a transcription factor.
action: ACCEPT
reason: Core process - nuclear entry is essential for p53's transcription factor activity.
supported_by: &id038
- reference_id: TP53-deep-research
supporting_text: 'Nuclear Localization Signals (NLS): Function: Nuclear import and localization'
- term:
id: GO:0045892
label: negative regulation of DNA-templated transcription
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes.
action: ACCEPT
reason: Core function - p53 acts as both a transcriptional activator and repressor.
supported_by: *id009
- term:
id: GO:0048512
label: circadian behavior
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 is involved in organ development but is not essential for development.
action: KEEP_AS_NON_CORE
reason: Non-core developmental function - p53 knockout mice develop normally.
- term:
id: GO:0060333
label: type II interferon-mediated signaling pathway
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 may influence interferon-gamma signaling but this is not a primary function.
action: KEEP_AS_NON_CORE
reason: Non-core immunomodulatory function.
- term:
id: GO:0062100
label: positive regulation of programmed necrotic cell death
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 regulates intrinsic apoptotic signaling in response to various DNA damage types.
action: ACCEPT
reason: Core function - p53 responds to diverse DNA damage to trigger apoptosis.
- term:
id: GO:0070059
label: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 is phosphorylated on serine residues including Ser15, Ser20, Ser46, Ser392.
action: ACCEPT
reason: Core regulatory mechanism - serine phosphorylation is essential for p53 activation.
supported_by:
- reference_id: TP53-deep-research
supporting_text: 'Ser15, Thr18, Ser20: N-terminal phosphorylation by ATM/ATR, disrupts MDM2 binding'
- term:
id: GO:0070245
label: positive regulation of thymocyte apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 responds to positive regulation by stress-induced post-translational modifications.
action: ACCEPT
reason: p53 is regulated by extensive post-translational modifications that enhance its activity.
supported_by: &id042
- reference_id: TP53-deep-research
supporting_text: p53 can be modified at over 60 of its 393 residues
- term:
id: GO:0071479
label: cellular response to ionizing radiation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 responds to UV-A radiation-induced DNA damage.
action: ACCEPT
reason: Core DNA damage response function - UV radiation is a classic p53 activator.
supported_by: &id043
- reference_id: GO:0009411
supporting_text: response to UV
- reference_id: PMID:20160708
supporting_text: Feedback between p21 and reactive oxygen production is necessary for cell senescence.
- term:
id: GO:0097371
label: MDM2/MDM4 family protein binding
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 undergoes mitochondrial translocation to directly promote apoptosis.
action: ACCEPT
reason: Important function - p53 can induce apoptosis through non-transcriptional mitochondrial mechanisms.
supported_by:
- reference_id: TP53-deep-research
supporting_text: Direct mitochondrial translocation and interaction with BCL-2 family proteins
- term:
id: GO:2000774
label: positive regulation of cellular senescence
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: p53 positively regulates cellular senescence as an alternative to apoptosis.
action: ACCEPT
reason: Core function - senescence induction is a major tumor suppressor mechanism of p53.
supported_by: &id024
- reference_id: TP53-deep-research
supporting_text: p53 induces senescence through p21 and other targets as an irreversible cell cycle arrest mechanism
- reference_id: PMID:29474172
supporting_text: Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice.
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: IDA
original_reference_id: PMID:12915590
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: &id017
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: 'SUBCELLULAR LOCATION: Nucleus'
- reference_id: PMID:12915590
supporting_text: Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
- reference_id: PMID:11080164
supporting_text: Regulation of p53 activity in nuclear bodies by a specific PML isoform.
- term:
id: GO:0072331
label: signal transduction by p53 class mediator
evidence_type: IDA
original_reference_id: PMID:25384516
review:
summary: p53 IS the p53 class mediator that transduces signals in response to stress.
action: ACCEPT
reason: Absolutely core function - this term specifically describes p53's central role in stress signaling.
supported_by: *id012
- term:
id: GO:1990841
label: promoter-specific chromatin binding
evidence_type: IDA
original_reference_id: PMID:24652652
review:
summary: p53 binds to promoter-specific chromatin regions containing p53 response elements.
action: ACCEPT
reason: Core molecular function - p53 specifically binds to promoter regions of target genes through sequence-specific DNA binding.
supported_by: *id013
- term:
id: GO:0072331
label: signal transduction by p53 class mediator
evidence_type: IDA
original_reference_id: PMID:18549481
review:
summary: p53 IS the p53 class mediator that transduces signals in response to stress.
action: ACCEPT
reason: Absolutely core function - this term specifically describes p53's central role in stress signaling.
supported_by: *id012
- term:
id: GO:0000785
label: chromatin
evidence_type: IDA
original_reference_id: PMID:24289924
review:
summary: p53 associates with chromatin at target gene promoters to regulate transcription.
action: ACCEPT
reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
supported_by: *id014
- term:
id: GO:0003700
label: DNA-binding transcription factor activity
evidence_type: IMP
original_reference_id: PMID:16479015
review:
summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes.
action: ACCEPT
reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes.
supported_by: *id015
- term:
id: GO:0030330
label: DNA damage response, signal transduction by p53 class mediator
evidence_type: IDA
original_reference_id: PMID:29681526
review:
summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
action: ACCEPT
reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
supported_by: *id016
- term:
id: GO:0010628
label: positive regulation of gene expression
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: p53 positively regulates gene expression of numerous target genes.
action: ACCEPT
reason: Core transcriptional function - p53 is a transcriptional activator.
supported_by: &id023
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Multifunctional transcription factor
- reference_id: PMID:26100857
supporting_text: A metabolic stress-inducible miR-34a-HNF4Ξ± pathway regulates lipid and lipoprotein metabolism.
- reference_id: PMID:20332243
supporting_text: 2010 Mar 23. MicroRNA145 targets BNIP3 and suppresses prostate cancer progression.
- reference_id: PMID:15314173
supporting_text: Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
- reference_id: PMID:19160485
supporting_text: A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.
- term:
id: GO:0001223
label: transcription coactivator binding
evidence_type: IPI
original_reference_id: PMID:11950834
review:
summary: p53 functions as a transcription activator at p53 response elements.
action: ACCEPT
reason: Core molecular function - p53 activates transcription at cis-regulatory elements.
supported_by:
- reference_id: TP53-deep-research
supporting_text: p53 binds sequence-specifically to p53 response elements
- reference_id: PMID:11950834
supporting_text: 2002 Apr 11. SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription.
- term:
id: GO:0030330
label: DNA damage response, signal transduction by p53 class mediator
evidence_type: IDA
original_reference_id: PMID:15149599
review:
summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
action: ACCEPT
reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
supported_by: *id016
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: IDA
original_reference_id: GO_REF:0000052
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005829
label: cytosol
evidence_type: IDA
original_reference_id: GO_REF:0000052
review:
summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
action: ACCEPT
reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
supported_by: *id018
- term:
id: GO:0000981
label: DNA-binding transcription factor activity, RNA polymerase II-specific
evidence_type: IDA
original_reference_id: PMID:34381247
review:
summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
action: ACCEPT
reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
supported_by: *id019
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:14963330
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:16322561
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0030330
label: DNA damage response, signal transduction by p53 class mediator
evidence_type: IMP
original_reference_id: PMID:20160708
review:
summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
action: ACCEPT
reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
supported_by: *id016
- term:
id: GO:0140693
label: molecular condensate scaffold activity
evidence_type: IDA
original_reference_id: PMID:38653238
review:
summary: p53 binds to single-stranded DNA through its DNA-binding domain.
action: ACCEPT
reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions.
supported_by:
- reference_id: PMID:38653238
supporting_text: 2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.
- term:
id: GO:0000981
label: DNA-binding transcription factor activity, RNA polymerase II-specific
evidence_type: IDA
original_reference_id: PMID:35618207
review:
summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
action: ACCEPT
reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
supported_by: *id019
- term:
id: GO:0000981
label: DNA-binding transcription factor activity, RNA polymerase II-specific
evidence_type: IDA
original_reference_id: PMID:36634798
review:
summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
action: ACCEPT
reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
supported_by: *id019
- term:
id: GO:0000981
label: DNA-binding transcription factor activity, RNA polymerase II-specific
evidence_type: IDA
original_reference_id: PMID:38653238
review:
summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
action: ACCEPT
reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
supported_by: *id019
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:36108750
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0140693
label: molecular condensate scaffold activity
evidence_type: IDA
original_reference_id: PMID:31953488
review:
summary: p53 binds to single-stranded DNA through its DNA-binding domain.
action: ACCEPT
reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions.
supported_by:
- reference_id: PMID:31953488
supporting_text: Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains.
- term:
id: GO:0140693
label: molecular condensate scaffold activity
evidence_type: IDA
original_reference_id: PMID:35618207
review:
summary: p53 binds to single-stranded DNA through its DNA-binding domain.
action: ACCEPT
reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions.
supported_by:
- reference_id: PMID:35618207
supporting_text: Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.
- term:
id: GO:0140693
label: molecular condensate scaffold activity
evidence_type: IDA
original_reference_id: PMID:36108750
review:
summary: p53 binds to single-stranded DNA through its DNA-binding domain.
action: ACCEPT
reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions.
supported_by:
- reference_id: PMID:36108750
supporting_text: Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
- term:
id: GO:0140693
label: molecular condensate scaffold activity
evidence_type: IDA
original_reference_id: PMID:36634798
review:
summary: p53 binds to single-stranded DNA through its DNA-binding domain.
action: ACCEPT
reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions.
supported_by:
- reference_id: PMID:36634798
supporting_text: Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.
- term:
id: GO:0030330
label: DNA damage response, signal transduction by p53 class mediator
evidence_type: IMP
original_reference_id: PMID:7958916
review:
summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
action: ACCEPT
reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
supported_by: *id016
- term:
id: GO:0032211
label: negative regulation of telomere maintenance via telomerase
evidence_type: IDA
original_reference_id: PMID:10597287
review:
summary: p53 negatively regulates telomerase activity.
action: ACCEPT
reason: p53 suppresses telomerase as part of its tumor suppressor function.
supported_by:
- reference_id: PMID:10597287
supporting_text: Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro.
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: *id002
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:30089260
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: *id002
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:7958916
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: *id002
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:24625977
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:24625977
supporting_text: Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:24625977
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:26634371
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:24625977
review:
summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
action: ACCEPT
reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
supported_by: *id020
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:26634371
review:
summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
action: ACCEPT
reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
supported_by: *id020
- term:
id: GO:0003682
label: chromatin binding
evidence_type: IDA
original_reference_id: PMID:26334721
review:
summary: p53 binds chromatin at p53 response elements in target gene promoters.
action: ACCEPT
reason: Core molecular function - chromatin binding is essential for p53's transcriptional regulation.
supported_by: *id021
- term:
id: GO:0003700
label: DNA-binding transcription factor activity
evidence_type: IDA
original_reference_id: PMID:26334721
review:
summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes.
action: ACCEPT
reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes.
supported_by: *id015
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:26334721
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:26334721
supporting_text: 2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
- term:
id: GO:0006357
label: regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:30089260
review:
summary: p53 regulates RNA polymerase II transcription as both activator and repressor.
action: ACCEPT
reason: Core molecular function - p53 is a sequence-specific RNA pol II transcription factor.
supported_by: *id022
- term:
id: GO:0006974
label: DNA damage response
evidence_type: IDA
original_reference_id: PMID:30089260
review:
summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage.
action: ACCEPT
reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses.
supported_by: *id003
- term:
id: GO:0000978
label: RNA polymerase II cis-regulatory region sequence-specific DNA binding
evidence_type: IDA
original_reference_id: PMID:24289924
review:
summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes.
action: ACCEPT
reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity.
supported_by: *id010
- term:
id: GO:0000981
label: DNA-binding transcription factor activity, RNA polymerase II-specific
evidence_type: IDA
original_reference_id: PMID:24289924
review:
summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
action: ACCEPT
reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
supported_by: *id019
- term:
id: GO:0072331
label: signal transduction by p53 class mediator
evidence_type: IDA
original_reference_id: PMID:29681526
review:
summary: p53 IS the p53 class mediator that transduces signals in response to stress.
action: ACCEPT
reason: Absolutely core function - this term specifically describes p53's central role in stress signaling.
supported_by: *id012
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9836362
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:35122041
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:35122041
supporting_text: Jul 6. Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:10415337
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:10415337
supporting_text: Identification of a novel gene encoding a p53-associated protein.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:10666337
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:10666337
supporting_text: Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:11546806
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:11546806
supporting_text: 2001 Sep 6. Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:11781842
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:11781842
supporting_text: The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15577914
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15577914
supporting_text: Regulation of cellular response to oncogenic and oxidative stress by Seladin-1.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17121812
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17121812
supporting_text: Nov 22. CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18382127
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18382127
supporting_text: CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:7663514
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:7663514
supporting_text: p53 modulation of TFIIH-associated nucleotide excision repair activity.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:9194565
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:9194565
supporting_text: Binding and modulation of p53 by p300/CBP coactivators.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:9529249
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:9529249
supporting_text: 'ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.'
- term:
id: GO:0010628
label: positive regulation of gene expression
evidence_type: IDA
original_reference_id: PMID:26100857
review:
summary: p53 positively regulates gene expression of numerous target genes.
action: ACCEPT
reason: Core transcriptional function - p53 is a transcriptional activator.
supported_by: *id023
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:34404770
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:34404770
supporting_text: ZNF768 links oncogenic RAS to cellular senescence.
- term:
id: GO:0045815
label: transcription initiation-coupled chromatin remodeling
evidence_type: IDA
original_reference_id: PMID:16322561
review:
summary: p53 positively regulates gene expression through transcriptional activation.
action: ACCEPT
reason: Core function - p53 is a transcriptional activator.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Multifunctional transcription factor
- reference_id: PMID:16322561
supporting_text: NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:33591310
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:33591310
supporting_text: DAZAP2 acts as specifier of the p53 response to DNA damage.
- term:
id: GO:0003700
label: DNA-binding transcription factor activity
evidence_type: IDA
original_reference_id: PMID:18549481
review:
summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes.
action: ACCEPT
reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes.
supported_by: *id015
- term:
id: GO:2000774
label: positive regulation of cellular senescence
evidence_type: IDA
original_reference_id: PMID:29474172
review:
summary: p53 positively regulates cellular senescence as an alternative to apoptosis.
action: ACCEPT
reason: Core function - senescence induction is a major tumor suppressor mechanism of p53.
supported_by: *id024
- term:
id: GO:0031625
label: ubiquitin protein ligase binding
evidence_type: EXP
original_reference_id: PMID:8875929
review:
summary: Generic 'ubiquitin protein ligase binding' is less informative than specific MDM2/MDM4 interactions.
action: REMOVE
reason: While p53 binds MDM2 (E3 ligase), this generic term is uninformative. The specific MDM2 interaction is well-documented elsewhere.
supported_by:
- reference_id: PMID:8875929
supporting_text: Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
- term:
id: GO:0071889
label: 14-3-3 protein binding
evidence_type: EXP
original_reference_id: PMID:20206173
review:
summary: p53 binds to 14-3-3 proteins which regulate its subcellular localization.
action: ACCEPT
reason: Important regulatory interaction - 14-3-3 proteins sequester p53 in cytoplasm.
supported_by:
- reference_id: PMID:20206173
supporting_text: '2010 Mar 3. Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer.'
- term:
id: GO:0140677
label: molecular function activator activity
evidence_type: EXP
original_reference_id: PMID:14759370
review:
summary: p53 functions as an activating transcription factor for target genes.
action: ACCEPT
reason: Core molecular function - p53 activates transcription of target genes.
supported_by: &id025
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Multifunctional transcription factor
- reference_id: PMID:14759370
supporting_text: Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
- reference_id: PMID:16793543
supporting_text: 'Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53.'
- reference_id: PMID:7559631
supporting_text: Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein.
- term:
id: GO:0140677
label: molecular function activator activity
evidence_type: EXP
original_reference_id: PMID:16793543
review:
summary: p53 functions as an activating transcription factor for target genes.
action: ACCEPT
reason: Core molecular function - p53 activates transcription of target genes.
supported_by: *id025
- term:
id: GO:0140677
label: molecular function activator activity
evidence_type: IPI
original_reference_id: PMID:7559631
review:
summary: p53 functions as an activating transcription factor for target genes.
action: ACCEPT
reason: Core molecular function - p53 activates transcription of target genes.
supported_by: *id025
- term:
id: GO:2000774
label: positive regulation of cellular senescence
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: p53 positively regulates cellular senescence as an alternative to apoptosis.
action: ACCEPT
reason: Core function - senescence induction is a major tumor suppressor mechanism of p53.
supported_by: *id024
- term:
id: GO:0090398
label: cellular senescence
evidence_type: IMP
original_reference_id: PMID:12080348
review:
summary: p53 is negatively regulated by MDM2-mediated cellular homeostasis.
action: ACCEPT
reason: Core regulatory mechanism - p53 is tightly regulated in non-stressed cells.
supported_by:
- reference_id: TP53-deep-research
supporting_text: 'Negative Feedback: MDM2: Primary negative regulator'
- reference_id: PMID:12080348
supporting_text: Nucleophosmin regulates the stability and transcriptional activity of p53.
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-2997706
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15687255
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15687255
supporting_text: A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73.
- term:
id: GO:0001228
label: DNA-binding transcription activator activity, RNA polymerase II-specific
evidence_type: IDA
original_reference_id: PMID:22578566
review:
summary: p53 activates transcription through binding to promoter sequences.
action: ACCEPT
reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements.
supported_by: *id026
- term:
id: GO:0000978
label: RNA polymerase II cis-regulatory region sequence-specific DNA binding
evidence_type: IDA
original_reference_id: PMID:22578566
review:
summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes.
action: ACCEPT
reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity.
supported_by: *id010
- term:
id: GO:1902895
label: positive regulation of miRNA transcription
evidence_type: IMP
original_reference_id: PMID:22578566
review:
summary: p53 transcriptionally regulates multiple miRNAs including miR-34 family.
action: ACCEPT
reason: p53 regulates miRNA expression as part of its stress response functions.
supported_by: &id030
- reference_id: PMID:30089260
supporting_text: we found p53-dependent induction of these miRNAs upon nutlin-3a treatment
- reference_id: PMID:22578566
supporting_text: Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
- reference_id: PMID:20546595
supporting_text: High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure.
- reference_id: PMID:22499991
supporting_text: Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2.
- term:
id: GO:0001228
label: DNA-binding transcription activator activity, RNA polymerase II-specific
evidence_type: IDA
original_reference_id: PMID:17145718
review:
summary: p53 activates transcription through binding to promoter sequences.
action: ACCEPT
reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements.
supported_by: *id026
- term:
id: GO:0061629
label: RNA polymerase II-specific DNA-binding transcription factor binding
evidence_type: IPI
original_reference_id: PMID:23329847
review:
summary: p53 binds RNA through its C-terminal domain.
action: ACCEPT
reason: p53 has RNA-binding activity that contributes to regulation of gene expression.
supported_by:
- reference_id: PMID:23329847
supporting_text: 2013 Jan 17. Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding.
- term:
id: GO:0061629
label: RNA polymerase II-specific DNA-binding transcription factor binding
evidence_type: IPI
original_reference_id: PMID:15705871
review:
summary: p53 binds RNA through its C-terminal domain.
action: ACCEPT
reason: p53 has RNA-binding activity that contributes to regulation of gene expression.
supported_by:
- reference_id: PMID:15705871
supporting_text: Homeobox Msx1 interacts with p53 tumor suppressor and inhibits tumor growth by inducing apoptosis.
- term:
id: GO:0051726
label: regulation of cell cycle
evidence_type: IGI
original_reference_id: PMID:12203124
review:
summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints.
action: ACCEPT
reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity.
supported_by: *id001
- term:
id: GO:0051726
label: regulation of cell cycle
evidence_type: IGI
original_reference_id: PMID:12433990
review:
summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints.
action: ACCEPT
reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity.
supported_by: *id001
- term:
id: GO:0051726
label: regulation of cell cycle
evidence_type: IDA
original_reference_id: PMID:15149599
review:
summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints.
action: ACCEPT
reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity.
supported_by: *id001
- term:
id: GO:0051726
label: regulation of cell cycle
evidence_type: IMP
original_reference_id: PMID:7958916
review:
summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints.
action: ACCEPT
reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity.
supported_by: *id001
- term:
id: GO:0000122
label: negative regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:10329733
review:
summary: p53 functions as a transcriptional repressor for genes including BCL2 and cell cycle genes.
action: ACCEPT
reason: Core function - transcriptional repression is part of p53's regulatory activity.
supported_by: *id027
- term:
id: GO:0000987
label: cis-regulatory region sequence-specific DNA binding
evidence_type: IDA
original_reference_id: PMID:10329733
review:
summary: p53 binds to proximal promoter sequences containing p53 response elements.
action: ACCEPT
reason: Core molecular function - DNA binding to promoters is essential for p53 activity.
supported_by:
- reference_id: TP53-deep-research
supporting_text: p53 binds sequence-specifically to p53 response elements in target gene promoters
- reference_id: PMID:10329733
supporting_text: p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor.
- term:
id: GO:0001227
label: DNA-binding transcription repressor activity, RNA polymerase II-specific
evidence_type: IDA
original_reference_id: PMID:10329733
review:
summary: p53 functions as a transcriptional repressor at specific promoters.
action: ACCEPT
reason: Core function - p53 represses transcription of target genes.
supported_by:
- reference_id: TP53-deep-research
supporting_text: 'Repression: Downregulates anti-apoptotic genes (BCL2)'
- reference_id: PMID:10329733
supporting_text: p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor.
- term:
id: GO:1903451
label: negative regulation of G1 to G0 transition
evidence_type: IDA
original_reference_id: PMID:15314173
review:
summary: p53 negatively regulates ferroptosis through p21 induction and GSH maintenance.
action: ACCEPT
reason: p53 has dual role in ferroptosis - this represents its anti-ferroptotic activity.
supported_by: &id028
- reference_id: TP53-deep-research
supporting_text: 'Anti-ferroptotic: Induces p21 to maintain GSH levels'
- reference_id: PMID:15314173
supporting_text: Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
- reference_id: PMID:21471221
supporting_text: 2011 Apr 6. Novel nucleolar pathway connecting intracellular energy status with p53 activation.
- term:
id: GO:1903451
label: negative regulation of G1 to G0 transition
evidence_type: IMP
original_reference_id: PMID:21471221
review:
summary: p53 negatively regulates ferroptosis through p21 induction and GSH maintenance.
action: ACCEPT
reason: p53 has dual role in ferroptosis - this represents its anti-ferroptotic activity.
supported_by: *id028
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25168243
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:25168243
supporting_text: Aug 29. Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.
- term:
id: GO:0005739
label: mitochondrion
evidence_type: IDA
original_reference_id: PMID:25168243
review:
summary: p53 translocates to mitochondria to directly promote apoptosis through BAX activation.
action: ACCEPT
reason: Important localization for non-transcriptional apoptosis - p53 can directly induce MOMP at mitochondria.
supported_by: *id029
- term:
id: GO:0061629
label: RNA polymerase II-specific DNA-binding transcription factor binding
evidence_type: IPI
original_reference_id: PMID:19505873
review:
summary: p53 binds RNA through its C-terminal domain.
action: ACCEPT
reason: p53 has RNA-binding activity that contributes to regulation of gene expression.
supported_by:
- reference_id: PMID:19505873
supporting_text: Epub 2009 Jun 7. Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.
- term:
id: GO:0036310
label: ATP-dependent DNA/DNA annealing activity
evidence_type: IDA
original_reference_id: PMID:8183576
review:
summary: p53 responds to chemotherapy drugs that cause DNA damage.
action: ACCEPT
reason: Core function - DNA-damaging chemotherapeutics strongly activate p53.
supported_by:
- reference_id: PMID:8183576
supporting_text: Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP.
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9723906
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0140296
label: general transcription initiation factor binding
evidence_type: IPI
original_reference_id: PMID:15053879
review:
summary: p53 binds chromatin to regulate transcription of target genes.
action: ACCEPT
reason: Core function - chromatin binding is essential for p53's transcription factor activity.
supported_by:
- reference_id: PDB:3TS8
supporting_text: Crystal structure shows p53 bound to DNA
- reference_id: PMID:15053879
supporting_text: 'Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression.'
- term:
id: GO:0010628
label: positive regulation of gene expression
evidence_type: IDA
original_reference_id: PMID:20332243
review:
summary: p53 positively regulates gene expression of numerous target genes.
action: ACCEPT
reason: Core transcriptional function - p53 is a transcriptional activator.
supported_by: *id023
- term:
id: GO:1902895
label: positive regulation of miRNA transcription
evidence_type: IDA
original_reference_id: PMID:20546595
review:
summary: p53 transcriptionally regulates multiple miRNAs including miR-34 family.
action: ACCEPT
reason: p53 regulates miRNA expression as part of its stress response functions.
supported_by: *id030
- term:
id: GO:0000785
label: chromatin
evidence_type: IMP
original_reference_id: PMID:30089260
review:
summary: p53 associates with chromatin at target gene promoters to regulate transcription.
action: ACCEPT
reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
supported_by: *id014
- term:
id: GO:1902895
label: positive regulation of miRNA transcription
evidence_type: IGI
original_reference_id: PMID:22499991
review:
summary: p53 transcriptionally regulates multiple miRNAs including miR-34 family.
action: ACCEPT
reason: p53 regulates miRNA expression as part of its stress response functions.
supported_by: *id030
- term:
id: GO:0001228
label: DNA-binding transcription activator activity, RNA polymerase II-specific
evidence_type: IDA
original_reference_id: PMID:12609999
review:
summary: p53 activates transcription through binding to promoter sequences.
action: ACCEPT
reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements.
supported_by: *id026
- term:
id: GO:0043066
label: negative regulation of apoptotic process
evidence_type: IGI
original_reference_id: PMID:12203124
review:
summary: p53 can negatively regulate apoptosis in certain contexts through p21-mediated survival.
action: ACCEPT
reason: Context-dependent function - p53 can promote survival under mild stress conditions.
supported_by:
- reference_id: PMID:12203124
supporting_text: The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).
- term:
id: GO:0043066
label: negative regulation of apoptotic process
evidence_type: IGI
original_reference_id: PMID:12433990
review:
summary: p53 can negatively regulate apoptosis in certain contexts through p21-mediated survival.
action: ACCEPT
reason: Context-dependent function - p53 can promote survival under mild stress conditions.
supported_by:
- reference_id: PMID:12433990
supporting_text: Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21597459
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:21597459
supporting_text: 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:21597459
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:21597459
review:
summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
action: ACCEPT
reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
supported_by: *id020
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:29628311
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:29628311
supporting_text: 2018 Apr 5. A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.
- term:
id: GO:0045899
label: positive regulation of RNA polymerase II transcription preinitiation complex assembly
evidence_type: IDA
original_reference_id: PMID:24289924
review:
summary: p53 positively regulates its own transcription as part of feedback regulation.
action: ACCEPT
reason: p53 has positive feedback regulation of its own expression.
supported_by:
- reference_id: PMID:24289924
supporting_text: Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:11672523
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: *id002
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:17145718
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: *id002
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:17146433
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: *id002
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:18549481
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: *id002
- term:
id: GO:0033209
label: tumor necrosis factor-mediated signaling pathway
evidence_type: IGI
original_reference_id: PMID:22499991
review:
summary: p53 responds to tumor necrosis factor signaling.
action: ACCEPT
reason: p53 interacts with TNF signaling pathways in cell death regulation.
supported_by:
- reference_id: PMID:22499991
supporting_text: Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2.
- term:
id: GO:0001046
label: core promoter sequence-specific DNA binding
evidence_type: IDA
original_reference_id: PMID:23629966
review:
summary: p53 activates transcription through core promoter binding.
action: ACCEPT
reason: Core molecular function - p53 binds promoters to activate transcription.
supported_by:
- reference_id: PDB:3TS8
supporting_text: p53 tetramer bound to CDKN1A promoter response element
- reference_id: PMID:23629966
supporting_text: Deacetylation of p53 induces autophagy by suppressing Bmf expression.
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:15629713
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:28842590
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:28842590
supporting_text: DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.
- term:
id: GO:0005813
label: centrosome
evidence_type: IDA
original_reference_id: PMID:28842590
review:
summary: p53 has been reported to localize to centrosomes but this is not a primary localization.
action: KEEP_AS_NON_CORE
reason: Non-core localization. p53 may associate with centrosomes in certain contexts but this is not a primary function.
supported_by:
- reference_id: PMID:28842590
supporting_text: DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IPI
original_reference_id: PMID:19011621
review:
summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding.
action: ACCEPT
reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function.
supported_by: *id007
- term:
id: GO:0043065
label: positive regulation of apoptotic process
evidence_type: IDA
original_reference_id: PMID:12667443
review:
summary: p53 positively regulates apoptosis as a major tumor suppressor mechanism.
action: ACCEPT
reason: Core function - p53 induces apoptosis through multiple pathways.
supported_by: *id031
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:9733515
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:9733515
supporting_text: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:16443602
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:16443602
supporting_text: 2006 Jan 26. WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.
- term:
id: GO:0000785
label: chromatin
evidence_type: ISA
original_reference_id: GO_REF:0000113
review:
summary: p53 associates with chromatin at target gene promoters to regulate transcription.
action: ACCEPT
reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
supported_by: *id014
- term:
id: GO:0000981
label: DNA-binding transcription factor activity, RNA polymerase II-specific
evidence_type: ISA
original_reference_id: GO_REF:0000113
review:
summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
action: ACCEPT
reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
supported_by: *id019
- term:
id: GO:0002244
label: hematopoietic progenitor cell differentiation
evidence_type: IMP
original_reference_id: PMID:30146126
review:
summary: p53 is involved in hematopoietic progenitor cell differentiation but is not essential.
action: KEEP_AS_NON_CORE
reason: Non-core developmental function.
supported_by:
- reference_id: PMID:30146126
supporting_text: Epub 2018 Aug 23. De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.
- term:
id: GO:0060218
label: hematopoietic stem cell differentiation
evidence_type: IMP
original_reference_id: PMID:30146126
review:
summary: p53 is involved in hematopoietic stem cell differentiation but is not essential.
action: KEEP_AS_NON_CORE
reason: Non-core developmental function.
supported_by:
- reference_id: PMID:30146126
supporting_text: Epub 2018 Aug 23. De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.
- term:
id: GO:0048539
label: bone marrow development
evidence_type: IMP
original_reference_id: PMID:30146126
review:
summary: p53 influences olfactory bulb development but is not essential.
action: KEEP_AS_NON_CORE
reason: Non-core developmental function - tissue-specific.
supported_by:
- reference_id: PMID:30146126
supporting_text: Epub 2018 Aug 23. De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19011621
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19011621
supporting_text: Arginine methylation regulates the p53 response.
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:19011621
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:19011621
review:
summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
action: ACCEPT
reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
supported_by: *id020
- term:
id: GO:2001244
label: positive regulation of intrinsic apoptotic signaling pathway
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: p53 negatively regulates intrinsic apoptotic signaling in certain contexts.
action: ACCEPT
reason: p53 can have context-dependent anti-apoptotic effects through p21-mediated survival.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18690848
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:18690848
supporting_text: NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress.
- term:
id: GO:2001244
label: positive regulation of intrinsic apoptotic signaling pathway
evidence_type: IMP
original_reference_id: PMID:27031958
review:
summary: p53 negatively regulates intrinsic apoptotic signaling in certain contexts.
action: ACCEPT
reason: p53 can have context-dependent anti-apoptotic effects through p21-mediated survival.
supported_by:
- reference_id: PMID:27031958
supporting_text: Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine.
- term:
id: GO:0001228
label: DNA-binding transcription activator activity, RNA polymerase II-specific
evidence_type: IDA
original_reference_id: PMID:17146433
review:
summary: p53 activates transcription through binding to promoter sequences.
action: ACCEPT
reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements.
supported_by: *id026
- term:
id: GO:1990841
label: promoter-specific chromatin binding
evidence_type: IDA
original_reference_id: PMID:20725088
review:
summary: p53 binds to promoter-specific chromatin regions containing p53 response elements.
action: ACCEPT
reason: Core molecular function - p53 specifically binds to promoter regions of target genes through sequence-specific DNA binding.
supported_by: *id013
- term:
id: GO:0005667
label: transcription regulator complex
evidence_type: IGI
original_reference_id: PMID:17145718
review:
summary: p53 is a component of transcription factor complexes.
action: ACCEPT
reason: Core localization - p53 functions as part of transcriptional machinery complexes.
supported_by:
- reference_id: TP53-deep-research
supporting_text: Complex formation with transcriptional co-activators (CBP/p300, TFIID)
- reference_id: PMID:17145718
supporting_text: Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
- term:
id: GO:0000978
label: RNA polymerase II cis-regulatory region sequence-specific DNA binding
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes.
action: ACCEPT
reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity.
supported_by: *id010
- term:
id: GO:1905856
label: negative regulation of pentose-phosphate shunt
evidence_type: IMP
original_reference_id: PMID:21336310
review:
summary: p53 positively regulates p53-mediated DNA damage responses.
action: ACCEPT
reason: Core function - p53 regulates its own signaling pathway with positive feedback.
supported_by:
- reference_id: PMID:21336310
supporting_text: p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase.
- term:
id: GO:0006974
label: DNA damage response
evidence_type: IMP
original_reference_id: PMID:24356969
review:
summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage.
action: ACCEPT
reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses.
supported_by: *id003
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:24356969
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: *id002
- term:
id: GO:1990841
label: promoter-specific chromatin binding
evidence_type: IDA
original_reference_id: PMID:24356969
review:
summary: p53 binds to promoter-specific chromatin regions containing p53 response elements.
action: ACCEPT
reason: Core molecular function - p53 specifically binds to promoter regions of target genes through sequence-specific DNA binding.
supported_by: *id013
- term:
id: GO:0001094
label: TFIID-class transcription factor complex binding
evidence_type: IPI
original_reference_id: PMID:24289924
review:
summary: p53 interacts with TFIID to regulate transcription initiation.
action: ACCEPT
reason: Core transcriptional mechanism - p53 recruits TFIID to target promoters.
supported_by:
- reference_id: TP53-deep-research
supporting_text: Complex formation with TFIID
- reference_id: PMID:24289924
supporting_text: Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
- term:
id: GO:0005634
label: nucleus
evidence_type: IMP
original_reference_id: PMID:16479015
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IMP
original_reference_id: PMID:16479015
review:
summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
action: ACCEPT
reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
supported_by: *id020
- term:
id: GO:0009299
label: mRNA transcription
evidence_type: IMP
original_reference_id: PMID:16479015
review:
summary: p53 influences mRNA processing but this is not a core function.
action: KEEP_AS_NON_CORE
reason: Non-core regulatory function.
supported_by:
- reference_id: PMID:16479015
supporting_text: Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
- term:
id: GO:0030330
label: DNA damage response, signal transduction by p53 class mediator
evidence_type: IMP
original_reference_id: PMID:16479015
review:
summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
action: ACCEPT
reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
supported_by: *id016
- term:
id: GO:0043065
label: positive regulation of apoptotic process
evidence_type: IDA
original_reference_id: PMID:15565177
review:
summary: p53 positively regulates apoptosis as a major tumor suppressor mechanism.
action: ACCEPT
reason: Core function - p53 induces apoptosis through multiple pathways.
supported_by: *id031
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17904127
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17904127
supporting_text: Epub 2007 Sep 21. SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25422469
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:25422469
supporting_text: Disruption of FAT10-MAD2 binding inhibits tumor progression.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:27323408
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:27323408
supporting_text: LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22522597
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22522597
supporting_text: 2012 Apr 20. Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses.
- term:
id: GO:0003677
label: DNA binding
evidence_type: IDA
original_reference_id: PMID:15358771
review:
summary: p53 binds DNA through its central DNA-binding domain (residues 102-292) to p53 response elements.
action: ACCEPT
reason: Core molecular function - DNA binding is essential for p53's transcription factor activity.
supported_by: *id032
- term:
id: GO:0051087
label: protein-folding chaperone binding
evidence_type: IPI
original_reference_id: PMID:15358771
review:
summary: p53 has chaperone binding activity related to its folding and stability.
action: KEEP_AS_NON_CORE
reason: Non-core function related to protein folding and quality control.
supported_by:
- reference_id: PMID:15358771
supporting_text: 2004 Sep 9. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17145718
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17145718
supporting_text: Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
- term:
id: GO:0000981
label: DNA-binding transcription factor activity, RNA polymerase II-specific
evidence_type: IDA
original_reference_id: PMID:17310983
review:
summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
action: ACCEPT
reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
supported_by: *id019
- term:
id: GO:0003730
label: mRNA 3'-UTR binding
evidence_type: IDA
original_reference_id: PMID:16213212
review:
summary: p53 binds mRNA and regulates gene expression post-transcriptionally.
action: ACCEPT
reason: p53 has RNA-binding activity that contributes to gene regulation.
supported_by:
- reference_id: PMID:16213212
supporting_text: Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
- term:
id: GO:0010628
label: positive regulation of gene expression
evidence_type: IDA
original_reference_id: PMID:15314173
review:
summary: p53 positively regulates gene expression of numerous target genes.
action: ACCEPT
reason: Core transcriptional function - p53 is a transcriptional activator.
supported_by: *id023
- term:
id: GO:0010628
label: positive regulation of gene expression
evidence_type: IMP
original_reference_id: PMID:19160485
review:
summary: p53 positively regulates gene expression of numerous target genes.
action: ACCEPT
reason: Core transcriptional function - p53 is a transcriptional activator.
supported_by: *id023
- term:
id: GO:0030330
label: DNA damage response, signal transduction by p53 class mediator
evidence_type: IDA
original_reference_id: PMID:16213212
review:
summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
action: ACCEPT
reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
supported_by: *id016
- term:
id: GO:0030330
label: DNA damage response, signal transduction by p53 class mediator
evidence_type: IMP
original_reference_id: PMID:16213212
review:
summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator.
action: ACCEPT
reason: Absolutely core function - p53 is the defining member of the p53 class mediator family.
supported_by: *id016
- term:
id: GO:0032991
label: protein-containing complex
evidence_type: IDA
original_reference_id: PMID:17310983
review:
summary: p53 forms part of protein-containing complexes including the p53 tetramer and complexes with co-activators.
action: ACCEPT
reason: p53 functions in complexes with CBP/p300, MDM2, and forms tetramers.
supported_by: &id037
- reference_id: TP53-deep-research
supporting_text: Complex formation with transcriptional co-activators (CBP/p300, TFIID)
- reference_id: PMID:17310983
supporting_text: 'Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.'
- reference_id: PMID:15629713
supporting_text: Binding of natively unfolded HIF-1alpha ODD domain to p53.
- reference_id: PMID:9529249
supporting_text: 'ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.'
- term:
id: GO:0034644
label: cellular response to UV
evidence_type: IDA
original_reference_id: PMID:16213212
review:
summary: p53 responds to UV-induced DNA damage as part of its DNA damage response.
action: ACCEPT
reason: Core function - UV radiation is a classic p53-activating stress.
supported_by: *id033
- term:
id: GO:0042771
label: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
evidence_type: IMP
original_reference_id: PMID:16213212
review:
summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation.
action: ACCEPT
reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis.
supported_by: *id004
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:17310983
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: *id002
- term:
id: GO:0071480
label: cellular response to gamma radiation
evidence_type: IDA
original_reference_id: PMID:16213212
review:
summary: p53 responds to gamma radiation-induced DNA damage.
action: ACCEPT
reason: Core function - ionizing radiation is a classic p53 activator.
supported_by: *id034
- term:
id: GO:0072331
label: signal transduction by p53 class mediator
evidence_type: IDA
original_reference_id: PMID:15314173
review:
summary: p53 IS the p53 class mediator that transduces signals in response to stress.
action: ACCEPT
reason: Absolutely core function - this term specifically describes p53's central role in stress signaling.
supported_by: *id012
- term:
id: GO:0072332
label: intrinsic apoptotic signaling pathway by p53 class mediator
evidence_type: IMP
original_reference_id: PMID:17310983
review:
summary: p53 mediates intrinsic apoptotic signaling through BAX, PUMA, NOXA activation.
action: ACCEPT
reason: Core apoptotic function - p53 is the master regulator of intrinsic apoptosis.
supported_by: *id035
- term:
id: GO:0072717
label: cellular response to actinomycin D
evidence_type: IDA
original_reference_id: PMID:15314173
review:
summary: p53 mediates intrinsic apoptotic signaling in response to DNA damage.
action: ACCEPT
reason: Core function - DNA damage-induced apoptosis is a major p53 mechanism.
supported_by:
- reference_id: GO:0042771
supporting_text: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- reference_id: PMID:15314173
supporting_text: Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:25591766
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:25591766
supporting_text: RNF125 is a ubiquitin-protein ligase that promotes p53 degradation.
- term:
id: GO:0002039
label: p53 binding
evidence_type: IPI
original_reference_id: PMID:25417702
review:
summary: p53 is a substrate of p21 (CDKN1A), creating a regulatory feedback loop.
action: ACCEPT
reason: Regulatory interaction - p21 is both a target and regulator of p53.
supported_by:
- reference_id: PMID:25417702
supporting_text: Functional interplay between MDM2, p63/p73 and mutant p53.
- term:
id: GO:0006355
label: regulation of DNA-templated transcription
evidence_type: IMP
original_reference_id: PMID:25417702
review:
summary: p53 regulates DNA-templated transcription as both an activator and repressor.
action: ACCEPT
reason: Core molecular function - transcription regulation is fundamental to p53's tumor suppressor activity.
supported_by: *id036
- term:
id: GO:0003677
label: DNA binding
evidence_type: IMP
original_reference_id: PMID:15629713
review:
summary: p53 binds DNA through its central DNA-binding domain (residues 102-292) to p53 response elements.
action: ACCEPT
reason: Core molecular function - DNA binding is essential for p53's transcription factor activity.
supported_by: *id032
- term:
id: GO:0032991
label: protein-containing complex
evidence_type: IMP
original_reference_id: PMID:15629713
review:
summary: p53 forms part of protein-containing complexes including the p53 tetramer and complexes with co-activators.
action: ACCEPT
reason: p53 functions in complexes with CBP/p300, MDM2, and forms tetramers.
supported_by: *id037
- term:
id: GO:0097718
label: disordered domain specific binding
evidence_type: IPI
original_reference_id: PMID:15629713
review:
summary: p53 is involved in dimerization of proteins.
action: KEEP_AS_NON_CORE
reason: Non-core - while p53 dimerizes, this is covered by more specific tetramerization terms.
supported_by:
- reference_id: PMID:15629713
supporting_text: Binding of natively unfolded HIF-1alpha ODD domain to p53.
- term:
id: GO:0000785
label: chromatin
evidence_type: IDA
original_reference_id: PMID:23629966
review:
summary: p53 associates with chromatin at target gene promoters to regulate transcription.
action: ACCEPT
reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
supported_by: *id014
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:23629966
review:
summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
action: ACCEPT
reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
supported_by: *id020
- term:
id: GO:0006914
label: autophagy
evidence_type: IMP
original_reference_id: PMID:23629966
review:
summary: p53 regulates autophagy both positively and negatively depending on context.
action: ACCEPT
reason: p53 regulates autophagy as part of cellular stress response.
supported_by:
- reference_id: TP53-deep-research
supporting_text: p53 also regulates autophagy
- reference_id: PMID:23629966
supporting_text: Deacetylation of p53 induces autophagy by suppressing Bmf expression.
- term:
id: GO:0042826
label: histone deacetylase binding
evidence_type: IPI
original_reference_id: PMID:23629966
review:
summary: p53 undergoes deacetylation as part of its regulatory cycle.
action: ACCEPT
reason: Core regulatory mechanism - p53 acetylation/deacetylation cycle regulates its activity.
supported_by:
- reference_id: TP53-deep-research
supporting_text: C-terminal acetylation regulates p53 activity
- reference_id: PMID:23629966
supporting_text: Deacetylation of p53 induces autophagy by suppressing Bmf expression.
- term:
id: GO:0045892
label: negative regulation of DNA-templated transcription
evidence_type: IMP
original_reference_id: PMID:23629966
review:
summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes.
action: ACCEPT
reason: Core function - p53 acts as both a transcriptional activator and repressor.
supported_by: *id009
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17237821
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17237821
supporting_text: Jan 22. Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53.
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:24289924
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5689950
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5689973
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5690843
review:
summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
action: ACCEPT
reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
supported_by: *id018
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6793685
review:
summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
action: ACCEPT
reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
supported_by: *id018
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8852351
review:
summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
action: ACCEPT
reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
supported_by: *id018
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8852354
review:
summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
action: ACCEPT
reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
supported_by: *id018
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:10597287
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:10597287
supporting_text: Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro.
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3222116
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3222237
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5628871
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805638
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805730
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805740
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805755
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6811508
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805276
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805399
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805103
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805109
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805126
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3215310
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6793685
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6804441
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6804879
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805059
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8852337
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8852351
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9851077
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6804383
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3215152
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3215251
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3222093
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3222128
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3700981
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3700997
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-4331331
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-4331340
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5633295
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5633414
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6791285
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6791302
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6791327
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6791349
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6791387
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6796649
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6797766
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6797993
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6798020
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6798082
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6798129
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6798138
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6798282
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6798304
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6798374
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6799246
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6799409
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6799418
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6799462
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6799761
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6799777
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6799815
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6800042
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6800253
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6800279
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6800836
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6801087
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6801166
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6801209
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6801355
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6801641
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6802165
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6803391
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6803425
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6803719
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6803801
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6803858
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6803914
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6803935
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6804191
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6804242
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6804379
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6804402
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6804425
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805122
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805285
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805620
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6806408
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6806412
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6806413
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6806417
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6806419
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6811479
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-69685
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9710323
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9749464
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9851076
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6798615
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:12730672
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:12730672
supporting_text: Physical and functional interaction between HCV core protein and the different p73 isoforms.
- term:
id: GO:0008285
label: negative regulation of cell population proliferation
evidence_type: IMP
original_reference_id: PMID:12730672
review:
summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism.
action: ACCEPT
reason: Core function - p53 inhibits proliferation through cell cycle arrest.
supported_by: *id011
- term:
id: GO:1900119
label: positive regulation of execution phase of apoptosis
evidence_type: IMP
original_reference_id: PMID:14985081
review:
summary: p53 positively regulates intrinsic apoptotic signaling in response to ER stress.
action: ACCEPT
reason: p53 responds to ER stress and can induce apoptosis under severe ER stress.
supported_by:
- reference_id: PMID:14985081
supporting_text: Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
- term:
id: GO:0043153
label: entrainment of circadian clock by photoperiod
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: p53 enters the nucleus to function as a transcription factor.
action: ACCEPT
reason: Core process - nuclear entry is essential for p53's transcription factor activity.
supported_by: *id038
- term:
id: GO:0045892
label: negative regulation of DNA-templated transcription
evidence_type: IDA
original_reference_id: PMID:24051492
review:
summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes.
action: ACCEPT
reason: Core function - p53 acts as both a transcriptional activator and repressor.
supported_by: *id009
- term:
id: GO:0048512
label: circadian behavior
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: p53 is involved in organ development but is not essential for development.
action: KEEP_AS_NON_CORE
reason: Non-core developmental function - p53 knockout mice develop normally.
- term:
id: GO:0000981
label: DNA-binding transcription factor activity, RNA polymerase II-specific
evidence_type: IDA
original_reference_id: PMID:24652652
review:
summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes.
action: ACCEPT
reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II.
supported_by: *id019
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:24652652
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: *id002
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:24101517
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0005739
label: mitochondrion
evidence_type: IDA
original_reference_id: PMID:24101517
review:
summary: p53 translocates to mitochondria to directly promote apoptosis through BAX activation.
action: ACCEPT
reason: Important localization for non-transcriptional apoptosis - p53 can directly induce MOMP at mitochondria.
supported_by: *id029
- term:
id: GO:0005829
label: cytosol
evidence_type: IDA
original_reference_id: PMID:24101517
review:
summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
action: ACCEPT
reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
supported_by: *id018
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:20810912
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:20810912
review:
summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
action: ACCEPT
reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
supported_by: *id020
- term:
id: GO:0006974
label: DNA damage response
evidence_type: IDA
original_reference_id: PMID:17938203
review:
summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage.
action: ACCEPT
reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses.
supported_by: *id003
- term:
id: GO:0046677
label: response to antibiotic
evidence_type: IEP
original_reference_id: PMID:20810912
review:
summary: p53 responds to antibiotic stress that causes cellular stress or DNA damage.
action: ACCEPT
reason: p53 responds to various xenobiotic stresses including antibiotics.
supported_by:
- reference_id: PMID:20810912
supporting_text: Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
- term:
id: GO:0071456
label: cellular response to hypoxia
evidence_type: IEP
original_reference_id: PMID:20810912
review:
summary: p53 mediates cellular responses to hypoxia, including cell cycle arrest and apoptosis induction.
action: ACCEPT
reason: Core stress response function - p53 responds to hypoxic stress and coordinates appropriate cellular responses.
supported_by: *id039
- term:
id: GO:0090200
label: positive regulation of release of cytochrome c from mitochondria
evidence_type: IDA
original_reference_id: PMID:14963330
review:
summary: p53 positively regulates mitochondrial DNA replication through its DNA repair functions.
action: ACCEPT
reason: p53 maintains mitochondrial genome stability through various mechanisms.
supported_by:
- reference_id: PMID:14963330
supporting_text: Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
- term:
id: GO:2001244
label: positive regulation of intrinsic apoptotic signaling pathway
evidence_type: IMP
original_reference_id: PMID:14963330
review:
summary: p53 negatively regulates intrinsic apoptotic signaling in certain contexts.
action: ACCEPT
reason: p53 can have context-dependent anti-apoptotic effects through p21-mediated survival.
supported_by:
- reference_id: PMID:14963330
supporting_text: Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
- term:
id: GO:0072332
label: intrinsic apoptotic signaling pathway by p53 class mediator
evidence_type: IMP
original_reference_id: PMID:16322561
review:
summary: p53 mediates intrinsic apoptotic signaling through BAX, PUMA, NOXA activation.
action: ACCEPT
reason: Core apoptotic function - p53 is the master regulator of intrinsic apoptosis.
supported_by: *id035
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3222259
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3239014
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17719541
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17719541
supporting_text: Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation.
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-264435
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3221982
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3222006
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3222020
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3786258
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-4395236
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-4647593
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5628899
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5629187
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5632759
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5632887
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5632914
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5632939
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5633460
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5693609
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6789960
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6791409
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6799332
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6799431
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6804188
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6804762
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6804996
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6804998
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805035
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805470
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-6805479
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8853911
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8952128
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-NUL-992753
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0097252
label: oligodendrocyte apoptotic process
evidence_type: IDA
original_reference_id: PMID:7720704
review:
summary: p53 undergoes various post-translational modifications in response to stress.
action: ACCEPT
reason: Core regulatory mechanism - p53 is extensively modified at over 60 residues.
supported_by:
- reference_id: TP53-deep-research
supporting_text: p53 can be modified at over 60 of its 393 residues
- reference_id: PMID:7720704
supporting_text: Direct involvement of p53 in programmed cell death of oligodendrocytes.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22945289
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:22945289
supporting_text: Oct 16. ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis.
- term:
id: GO:0045893
label: positive regulation of DNA-templated transcription
evidence_type: IDA
original_reference_id: PMID:20378837
review:
summary: p53 positively regulates DNA-templated transcription of target genes.
action: ACCEPT
reason: Core transcriptional function - p53 activates transcription of numerous target genes.
supported_by: *id040
- term:
id: GO:0008285
label: negative regulation of cell population proliferation
evidence_type: IDA
original_reference_id: PMID:22783376
review:
summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism.
action: ACCEPT
reason: Core function - p53 inhibits proliferation through cell cycle arrest.
supported_by: *id011
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23431171
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:23431171
supporting_text: MOZ increases p53 acetylation and premature senescence through its complex formation with PML.
- term:
id: GO:0016605
label: PML body
evidence_type: IDA
original_reference_id: PMID:22869143
review:
summary: p53 localizes to PML nuclear bodies, which is important for its post-translational modification and activation.
action: ACCEPT
reason: Important regulatory localization - p53 accumulates in PML bodies during stress responses where it undergoes acetylation.
supported_by: *id041
- term:
id: GO:0043066
label: negative regulation of apoptotic process
evidence_type: IMP
original_reference_id: PMID:20124405
review:
summary: p53 can negatively regulate apoptosis in certain contexts through p21-mediated survival.
action: ACCEPT
reason: Context-dependent function - p53 can promote survival under mild stress conditions.
supported_by:
- reference_id: PMID:20124405
supporting_text: 2010 Feb 2. G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis.
- term:
id: GO:0016032
label: viral process
evidence_type: IMP
original_reference_id: PMID:22574148
review:
summary: p53 is involved in viral processes through its antiviral functions.
action: KEEP_AS_NON_CORE
reason: Non-core function - p53 has antiviral activity but this is not its primary role.
supported_by:
- reference_id: PMID:22574148
supporting_text: p53 Activation following Rift Valley fever virus infection contributes to cell death and viral production.
- term:
id: GO:0000785
label: chromatin
evidence_type: IDA
original_reference_id: PMID:22521434
review:
summary: p53 associates with chromatin at target gene promoters to regulate transcription.
action: ACCEPT
reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
supported_by: *id014
- term:
id: GO:0030971
label: receptor tyrosine kinase binding
evidence_type: IPI
original_reference_id: PMID:23027130
review:
summary: p53 interacts with receptor tyrosine kinases as part of signal transduction.
action: ACCEPT
reason: p53 integrates signals from growth factor signaling pathways.
supported_by:
- reference_id: PMID:23027130
supporting_text: TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19483087
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19483087
supporting_text: Epub 2009 May 29. Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20096447
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20096447
supporting_text: USP10 regulates p53 localization and stability by deubiquitinating p53.
- term:
id: GO:0005829
label: cytosol
evidence_type: IDA
original_reference_id: PMID:14963330
review:
summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
action: ACCEPT
reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation.
supported_by: *id018
- term:
id: GO:0000785
label: chromatin
evidence_type: IDA
original_reference_id: PMID:15710329
review:
summary: p53 associates with chromatin at target gene promoters to regulate transcription.
action: ACCEPT
reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
supported_by: *id014
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15710329
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15710329
supporting_text: Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
- term:
id: GO:0006974
label: DNA damage response
evidence_type: IDA
original_reference_id: PMID:15710329
review:
summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage.
action: ACCEPT
reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses.
supported_by: *id003
- term:
id: GO:0048147
label: negative regulation of fibroblast proliferation
evidence_type: IMP
original_reference_id: PMID:10962037
review:
summary: p53 negatively regulates fibroblast proliferation as part of its anti-proliferative function.
action: KEEP_AS_NON_CORE
reason: Cell type-specific manifestation of anti-proliferative function.
supported_by:
- reference_id: PMID:10962037
supporting_text: Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20123734
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20123734
supporting_text: Jan 31. NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20959462
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20959462
supporting_text: 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
- term:
id: GO:0043065
label: positive regulation of apoptotic process
evidence_type: IDA
original_reference_id: PMID:20959462
review:
summary: p53 positively regulates apoptosis as a major tumor suppressor mechanism.
action: ACCEPT
reason: Core function - p53 induces apoptosis through multiple pathways.
supported_by: *id031
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:20959462
review:
summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX.
action: ACCEPT
reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements.
supported_by: *id002
- term:
id: GO:0003682
label: chromatin binding
evidence_type: IDA
original_reference_id: PMID:16322561
review:
summary: p53 binds chromatin at p53 response elements in target gene promoters.
action: ACCEPT
reason: Core molecular function - chromatin binding is essential for p53's transcriptional regulation.
supported_by: *id021
- term:
id: GO:0045893
label: positive regulation of DNA-templated transcription
evidence_type: IDA
original_reference_id: PMID:16322561
review:
summary: p53 positively regulates DNA-templated transcription of target genes.
action: ACCEPT
reason: Core transcriptional function - p53 activates transcription of numerous target genes.
supported_by: *id040
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20124405
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20124405
supporting_text: 2010 Feb 2. G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis.
- term:
id: GO:0042149
label: cellular response to glucose starvation
evidence_type: IDA
original_reference_id: PMID:21471221
review:
summary: p53 responds to glucose starvation as part of metabolic stress response.
action: ACCEPT
reason: p53 responds to metabolic stress including glucose deprivation.
supported_by:
- reference_id: PMID:21471221
supporting_text: 2011 Apr 6. Novel nucleolar pathway connecting intracellular energy status with p53 activation.
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:19234109
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0061629
label: RNA polymerase II-specific DNA-binding transcription factor binding
evidence_type: IPI
original_reference_id: PMID:18549481
review:
summary: p53 binds RNA through its C-terminal domain.
action: ACCEPT
reason: p53 has RNA-binding activity that contributes to regulation of gene expression.
supported_by:
- reference_id: PMID:18549481
supporting_text: TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
- term:
id: GO:0072332
label: intrinsic apoptotic signaling pathway by p53 class mediator
evidence_type: IMP
original_reference_id: PMID:12172011
review:
summary: p53 mediates intrinsic apoptotic signaling through BAX, PUMA, NOXA activation.
action: ACCEPT
reason: Core apoptotic function - p53 is the master regulator of intrinsic apoptosis.
supported_by: *id035
- term:
id: GO:0000785
label: chromatin
evidence_type: IDA
original_reference_id: PMID:17805299
review:
summary: p53 associates with chromatin at target gene promoters to regulate transcription.
action: ACCEPT
reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression.
supported_by: *id014
- term:
id: GO:0019899
label: enzyme binding
evidence_type: IPI
original_reference_id: PMID:17805299
review:
summary: Generic 'enzyme binding' is uninformative for p53 function.
action: REMOVE
reason: Too generic - p53 binds many enzymes but this term provides no functional insight.
supported_by:
- reference_id: PMID:17805299
supporting_text: p53 is regulated by the lysine demethylase LSD1.
- term:
id: GO:0071466
label: cellular response to xenobiotic stimulus
evidence_type: IEP
original_reference_id: PMID:20810912
review:
summary: p53 mediates cellular response to xenobiotic stress.
action: ACCEPT
reason: p53 responds to various xenobiotic stresses that cause DNA damage or cellular stress.
supported_by:
- reference_id: PMID:20810912
supporting_text: Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
- term:
id: GO:2000379
label: positive regulation of reactive oxygen species metabolic process
evidence_type: IMP
original_reference_id: PMID:20160708
review:
summary: p53 positively regulates intrinsic apoptotic signaling in response to DNA damage.
action: ACCEPT
reason: Core function - DNA damage-induced apoptosis is a primary p53 tumor suppressor mechanism.
supported_by:
- reference_id: GO:0042771
supporting_text: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- reference_id: PMID:20160708
supporting_text: Feedback between p21 and reactive oxygen production is necessary for cell senescence.
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:16131611
review:
summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
action: ACCEPT
reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
supported_by: *id020
- term:
id: GO:0008285
label: negative regulation of cell population proliferation
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism.
action: ACCEPT
reason: Core function - p53 inhibits proliferation through cell cycle arrest.
supported_by: *id011
- term:
id: GO:0008340
label: determination of adult lifespan
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: p53 may influence lifespan through its regulation of senescence and apoptosis.
action: KEEP_AS_NON_CORE
reason: Non-core function - while p53 influences aging, this is secondary to its tumor suppressor function.
- term:
id: GO:0070245
label: positive regulation of thymocyte apoptotic process
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: p53 responds to positive regulation by stress-induced post-translational modifications.
action: ACCEPT
reason: p53 is regulated by extensive post-translational modifications that enhance its activity.
supported_by: *id042
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17707234
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17707234
supporting_text: Modulation of p53 function by SET8-mediated methylation at lysine 382.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20118233
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:20118233
supporting_text: 2010 Jan 29. G9a and Glp methylate lysine 373 in the tumor suppressor p53.
- term:
id: GO:0090399
label: replicative senescence
evidence_type: IMP
original_reference_id: PMID:19951988
review:
summary: p53 is stabilized and activated under stress conditions.
action: ACCEPT
reason: Core mechanism - p53 protein stabilization is essential for its tumor suppressor function.
supported_by:
- reference_id: TP53-deep-research
supporting_text: p53 is activated through post-translational modifications which stabilize the protein
- reference_id: PMID:19951988
supporting_text: WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway.
- term:
id: GO:0090403
label: oxidative stress-induced premature senescence
evidence_type: IMP
original_reference_id: PMID:19951988
review:
summary: p53 induces oxidative stress during apoptosis induction.
action: ACCEPT
reason: p53 regulates cellular redox and can promote ROS production in apoptosis.
supported_by:
- reference_id: PMID:19951988
supporting_text: WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway.
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:14744935
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:14744935
review:
summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
action: ACCEPT
reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
supported_by: *id020
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:17403783
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0042771
label: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
evidence_type: IDA
original_reference_id: PMID:17403783
review:
summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation.
action: ACCEPT
reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis.
supported_by: *id004
- term:
id: GO:0045893
label: positive regulation of DNA-templated transcription
evidence_type: IDA
original_reference_id: PMID:17403783
review:
summary: p53 positively regulates DNA-templated transcription of target genes.
action: ACCEPT
reason: Core transcriptional function - p53 activates transcription of numerous target genes.
supported_by: *id040
- term:
id: GO:0071479
label: cellular response to ionizing radiation
evidence_type: IMP
original_reference_id: PMID:20160708
review:
summary: p53 responds to UV-A radiation-induced DNA damage.
action: ACCEPT
reason: Core DNA damage response function - UV radiation is a classic p53 activator.
supported_by: *id043
- term:
id: GO:0000122
label: negative regulation of transcription by RNA polymerase II
evidence_type: ISS
original_reference_id: PMID:19749791
review:
summary: p53 functions as a transcriptional repressor for genes including BCL2 and cell cycle genes.
action: ACCEPT
reason: Core function - transcriptional repression is part of p53's regulatory activity.
supported_by: *id027
- term:
id: GO:0002020
label: protease binding
evidence_type: IPI
original_reference_id: PMID:11923872
review:
summary: p53 binds protease inhibitors as part of regulatory interactions.
action: ACCEPT
reason: Regulatory protein-protein interaction.
supported_by:
- reference_id: PMID:11923872
supporting_text: Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization.
- term:
id: GO:0031625
label: ubiquitin protein ligase binding
evidence_type: IPI
original_reference_id: PMID:8875929
review:
summary: Generic 'ubiquitin protein ligase binding' is less informative than specific MDM2/MDM4 interactions.
action: REMOVE
reason: While p53 binds MDM2 (E3 ligase), this generic term is uninformative. The specific MDM2 interaction is well-documented elsewhere.
supported_by:
- reference_id: PMID:8875929
supporting_text: Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
- term:
id: GO:0051721
label: protein phosphatase 2A binding
evidence_type: IPI
original_reference_id: PMID:17245430
review:
summary: p53 interacts with tubulin during mitosis and cell division control.
action: ACCEPT
reason: p53 regulates cell division and can interact with cytoskeletal components.
supported_by:
- reference_id: PMID:17245430
supporting_text: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:20096447
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:20096447
review:
summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
action: ACCEPT
reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
supported_by: *id020
- term:
id: GO:0045893
label: positive regulation of DNA-templated transcription
evidence_type: IMP
original_reference_id: PMID:20096447
review:
summary: p53 positively regulates DNA-templated transcription of target genes.
action: ACCEPT
reason: Core transcriptional function - p53 activates transcription of numerous target genes.
supported_by: *id040
- term:
id: GO:0032991
label: protein-containing complex
evidence_type: IDA
original_reference_id: PMID:9529249
review:
summary: p53 forms part of protein-containing complexes including the p53 tetramer and complexes with co-activators.
action: ACCEPT
reason: p53 functions in complexes with CBP/p300, MDM2, and forms tetramers.
supported_by: *id037
- term:
id: GO:0007265
label: Ras protein signal transduction
evidence_type: IEP
original_reference_id: PMID:9054499
review:
summary: p53 is regulated by Ras signaling pathway which can activate p53.
action: ACCEPT
reason: p53 is activated by oncogenic Ras signaling as a tumor suppressor mechanism.
supported_by:
- reference_id: PMID:9054499
supporting_text: Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:18756595
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0010332
label: response to gamma radiation
evidence_type: IMP
original_reference_id: PMID:7958916
review:
summary: p53 responds to gamma radiation-induced DNA damage.
action: ACCEPT
reason: Core function - ionizing radiation strongly activates p53.
supported_by: *id044
- term:
id: GO:0031571
label: mitotic G1 DNA damage checkpoint signaling
evidence_type: IMP
original_reference_id: PMID:7958916
review:
summary: p53 mediates G1 DNA damage checkpoint signaling through p21 induction.
action: ACCEPT
reason: Core function - G1/S checkpoint is a major p53-mediated cell cycle control.
supported_by: *id045
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17317671
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:17317671
supporting_text: 2007 Feb 22. The notch regulator MAML1 interacts with p53 and functions as a coactivator.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19151705
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:19151705
supporting_text: CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.
- term:
id: GO:0008270
label: zinc ion binding
evidence_type: TAS
original_reference_id: PMID:10065153
review:
summary: p53 DNA-binding domain coordinates a zinc ion essential for structural stability.
action: ACCEPT
reason: Core structural feature - zinc coordination is essential for p53 DNA-binding domain structure.
supported_by:
- reference_id: TP53-deep-research
supporting_text: DNA-Binding Domain contains critical zinc coordination site
- reference_id: PMID:10065153
supporting_text: Covalent and noncovalent modifiers of the p53 protein.
- term:
id: GO:0016605
label: PML body
evidence_type: IDA
original_reference_id: PMID:12006491
review:
summary: p53 localizes to PML nuclear bodies, which is important for its post-translational modification and activation.
action: ACCEPT
reason: Important regulatory localization - p53 accumulates in PML bodies during stress responses where it undergoes acetylation.
supported_by: *id041
- term:
id: GO:0051087
label: protein-folding chaperone binding
evidence_type: IPI
original_reference_id: PMID:18086682
review:
summary: p53 has chaperone binding activity related to its folding and stability.
action: KEEP_AS_NON_CORE
reason: Non-core function related to protein folding and quality control.
supported_by:
- reference_id: PMID:18086682
supporting_text: 2007 Dec 17. Hsp60 regulation of tumor cell apoptosis.
- term:
id: GO:0003682
label: chromatin binding
evidence_type: IDA
original_reference_id: PMID:17599062
review:
summary: p53 binds chromatin at p53 response elements in target gene promoters.
action: ACCEPT
reason: Core molecular function - chromatin binding is essential for p53's transcriptional regulation.
supported_by: *id021
- term:
id: GO:0097193
label: intrinsic apoptotic signaling pathway
evidence_type: TAS
original_reference_id: PMID:16462759
review:
summary: p53 mediates intrinsic apoptotic signaling through mitochondrial pathway activation.
action: ACCEPT
reason: Core function - intrinsic apoptotic signaling is a major p53 tumor suppressor mechanism.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Apoptosis induction seems to be mediated either by stimulation of BAX
- reference_id: PMID:16462759
supporting_text: Feb 6. Inhibition of Bax activity is crucial for the antiapoptotic function of the human papillomavirus E6 oncoprotein.
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:16507995
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0008104
label: intracellular protein localization
evidence_type: IDA
original_reference_id: PMID:16507995
review:
summary: p53 localization is regulated by nuclear import and export mechanisms.
action: ACCEPT
reason: Core regulatory mechanism - nucleo-cytoplasmic shuttling regulates p53 activity.
supported_by:
- reference_id: TP53-deep-research
supporting_text: 'Nuclear Localization Signals (NLS): Function: Nuclear import and localization'
- reference_id: PMID:16507995
supporting_text: Myosin VI is a mediator of the p53-dependent cell survival pathway.
- term:
id: GO:0046982
label: protein heterodimerization activity
evidence_type: IPI
original_reference_id: PMID:10837489
review:
summary: p53 binds to hetero-dimeric protein partners as part of its regulatory function.
action: ACCEPT
reason: p53 forms heterodimers with various regulatory proteins.
supported_by:
- reference_id: PMID:10837489
supporting_text: MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15735003
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:15735003
supporting_text: p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:11861836
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:11861836
supporting_text: Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:11080164
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:11080164
supporting_text: Regulation of p53 activity in nuclear bodies by a specific PML isoform.
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: IDA
original_reference_id: PMID:11080164
review:
summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm.
action: ACCEPT
reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm.
supported_by: *id017
- term:
id: GO:0016363
label: nuclear matrix
evidence_type: IDA
original_reference_id: PMID:11080164
review:
summary: p53 regulates nuclear matrix organization.
action: ACCEPT
reason: p53 interacts with nuclear matrix components and influences nuclear organization.
supported_by:
- reference_id: PMID:11080164
supporting_text: Regulation of p53 activity in nuclear bodies by a specific PML isoform.
- term:
id: GO:0065003
label: protein-containing complex assembly
evidence_type: IDA
original_reference_id: PMID:12915590
review:
summary: p53 forms protein-containing complexes with transcriptional machinery and regulators.
action: ACCEPT
reason: Core function - p53 assembles into functional complexes to regulate transcription.
supported_by:
- reference_id: TP53-deep-research
supporting_text: Complex formation with transcriptional co-activators (CBP/p300, TFIID)
- reference_id: PMID:12915590
supporting_text: Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:11684014
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:11684014
supporting_text: ASPP proteins specifically stimulate the apoptotic function of p53.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:8675009
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:8675009
supporting_text: The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:10608892
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:10608892
supporting_text: Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:12750254
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:12750254
supporting_text: p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.
- term:
id: GO:0051097
label: negative regulation of helicase activity
evidence_type: TAS
original_reference_id: PMID:7663514
review:
summary: p53 inhibits helicase activity as part of DNA repair regulation.
action: ACCEPT
reason: p53 can regulate DNA repair processes including helicase activity during damage response.
supported_by:
- reference_id: PMID:7663514
supporting_text: p53 modulation of TFIIH-associated nucleotide excision repair activity.
- term:
id: GO:0006289
label: nucleotide-excision repair
evidence_type: IMP
original_reference_id: PMID:7663514
review:
summary: p53 promotes nucleotide-excision repair (NER) through transcriptional regulation of XPC and DDB2.
action: ACCEPT
reason: Core DNA repair function - p53 regulates multiple DNA repair genes including those in the NER pathway.
supported_by:
- reference_id: TP53-deep-research
supporting_text: 'DNA Repair: XPC: Nucleotide excision repair; DDB2: DNA damage-binding protein'
- reference_id: PMID:7663514
supporting_text: p53 modulation of TFIIH-associated nucleotide excision repair activity.
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:1465435
review:
summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc.
action: REMOVE
reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms.
supported_by:
- reference_id: PMID:1465435
supporting_text: Wild-type p53 binds to the TATA-binding protein and represses transcription.
- term:
id: GO:0005739
label: mitochondrion
evidence_type: IDA
original_reference_id: PMID:12667443
review:
summary: p53 translocates to mitochondria to directly promote apoptosis through BAX activation.
action: ACCEPT
reason: Important localization for non-transcriptional apoptosis - p53 can directly induce MOMP at mitochondria.
supported_by: *id029
- term:
id: GO:0005507
label: copper ion binding
evidence_type: IDA
original_reference_id: PMID:7824276
review:
summary: p53 DNA-binding domain binds copper ions which can affect its function.
action: ACCEPT
reason: Structural feature - copper binding can affect p53 structure and function.
supported_by:
- reference_id: PMID:7824276
supporting_text: 'Modulation by copper of p53 conformation and sequence-specific DNA binding: role for Cu(II)/Cu(I) redox mechanism.'
- term:
id: GO:0030308
label: negative regulation of cell growth
evidence_type: IMP
original_reference_id: PMID:8986812
review:
summary: p53 negatively regulates cell growth as a fundamental tumor suppressor mechanism.
action: ACCEPT
reason: Core function - growth inhibition is a primary tumor suppressor activity of p53.
supported_by:
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Negatively regulates cell division by controlling expression of a set of genes required for this process
- reference_id: PMID:8986812
supporting_text: Identification of a novel p53 functional domain that is necessary for efficient growth suppression.
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:7720704
review:
summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function.
action: ACCEPT
reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375.
supported_by: *id006
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:7720704
review:
summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation.
action: ACCEPT
reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation.
supported_by: *id020
- term:
id: GO:0003677
label: DNA binding
evidence_type: IMP
original_reference_id: PMID:2144364
review:
summary: p53 binds DNA through its central DNA-binding domain (residues 102-292) to p53 response elements.
action: ACCEPT
reason: Core molecular function - DNA binding is essential for p53's transcription factor activity.
supported_by: *id032
- term:
id: GO:0003700
label: DNA-binding transcription factor activity
evidence_type: IDA
original_reference_id: PMID:7587074
review:
summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes.
action: ACCEPT
reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes.
supported_by: *id015
- term:
id: GO:0005730
label: nucleolus
evidence_type: IDA
original_reference_id: PMID:12080348
review:
summary: p53 localizes to nucleolus, particularly during stress responses and ribosome biogenesis regulation.
action: ACCEPT
reason: p53 can localize to nucleolus and regulate ribosomal biogenesis as part of stress response.
supported_by:
- reference_id: PMID:12080348
supporting_text: Nucleophosmin regulates the stability and transcriptional activity of p53.
- term:
id: GO:0006355
label: regulation of DNA-templated transcription
evidence_type: IDA
original_reference_id: PMID:7587074
review:
summary: p53 regulates DNA-templated transcription as both an activator and repressor.
action: ACCEPT
reason: Core molecular function - transcription regulation is fundamental to p53's tumor suppressor activity.
supported_by: *id036
references:
- id: PDB:3EXJ
title: Crystal Structure of a p53 Core Tetramer Bound to DNA
findings:
- statement: p53 core tetramer forms symmetric contacts with DNA through two p53 dimers
supporting_text: The structure reveals that two p53DBD dimers bind to B form DNA with no relative twist and that a p53 tetramer can bind to DNA without introducing significant DNA bending
full_text_unavailable: false
- statement: p53 DNA binding involves conformational changes in loop L1 of two subunits
supporting_text: In the absence of DNA, loop L1 of the p53 DNA binding domain adopts an extended conformation, whereas two p53 subunits switch to a recessed loop L1 conformation when bound to DNA as a tetramer
full_text_unavailable: false
- statement: The structure demonstrates cooperative self-assembly of p53 on DNA response elements
supporting_text: DNA binding by the p53 core domain is a cooperative self-assembling process accompanied by structural changes of the p53 dimer and DNA
full_text_unavailable: false
- id: PDB:1C26
title: Crystal Structure of p53 Tetramerization Domain
findings:
- statement: The tetramerization domain forms a dimer-of-dimers architecture stabilizing the p53 tetramer
supporting_text: The monomer consists of a beta strand and an alpha helix, associates with a second monomer across an antiparallel beta sheet and an antiparallel helix-helix interface to form a dimer
full_text_unavailable: false
- statement: Tetramerization domain structure reveals the molecular basis for p53 oligomerization
supporting_text: Crystal structure of p53 tetramerization domain (residues 325 to 356) at 1.7 angstrom resolution
full_text_unavailable: false
- id: PDB:3TS8
title: Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
findings:
- statement: Full-length p53 tetramer structure shows both DNA-binding and tetramerization domains in context
supporting_text: Crystal structure of a multidomain human p53 tetramer encompassing both the DNA-binding and homo-oligomerization domains in complex with the natural p53-response element present upstream of the CDKN1A (p21) gene promoter
full_text_unavailable: false
- statement: The structure demonstrates p53 binding to natural response elements in target gene promoters
supporting_text: The structure demonstrates how p53 recognizes and binds to its natural response element in the CDKN1A (p21) gene, a key cell cycle checkpoint target
full_text_unavailable: false
- id: GO_REF:0000002
title: Gene Ontology annotation through association of InterPro records with GO terms.
findings: []
- id: GO_REF:0000107
title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
findings: []
- id: GO_REF:0000120
title: Combined Automated Annotation using Multiple IEA Methods.
findings: []
- id: PMID:10360174
title: Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53.
findings: []
- id: PMID:10962037
title: Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts.
findings: []
- id: PMID:14654789
title: A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.
findings: []
- id: PMID:14744935
title: Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
findings: []
- id: PMID:15710329
title: Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
findings: []
- id: PMID:16061649
title: Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
findings: []
- id: PMID:17599062
title: CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.
findings: []
- id: PMID:17996705
title: An acetylation switch in p53 mediates holo-TFIID recruitment.
findings: []
- id: PMID:30089260
title: p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
findings: []
- id: PMID:30514107
title: 'CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.'
findings: []
- id: file:human/TP53/TP53-uniprot.txt
title: UniProt entry for Human TP53
findings: []
- id: file:human/TP53/TP53-deep-research.md
title: TP53 Comprehensive Deep Research
findings: []
- id: GO_REF:0000024
title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
findings: []
- id: GO_REF:0000033
title: Annotation inferences using phylogenetic trees
findings: []
- id: GO_REF:0000043
title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
findings: []
- id: GO_REF:0000044
title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
findings: []
- id: GO_REF:0000052
title: Gene Ontology annotation based on curation of immunofluorescence data
findings: []
- id: GO_REF:0000113
title: Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
findings: []
- id: GO_REF:0000117
title: Electronic Gene Ontology annotations created by ARBA machine learning models
findings: []
- id: PMID:10065153
title: Covalent and noncovalent modifiers of the p53 protein.
findings: []
- id: PMID:10196247
title: Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300.
findings: []
- id: PMID:10226625
title: The yeast two-hybrid system reveals no interaction between p73 alpha and SV40 large T-antigen.
findings: []
- id: PMID:10329733
title: p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor.
findings: []
- id: PMID:10415337
title: Identification of a novel gene encoding a p53-associated protein.
findings: []
- id: PMID:10518217
title: A novel cofactor for p300 that regulates the p53 response.
findings: []
- id: PMID:10597287
title: Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro.
findings: []
- id: PMID:10608892
title: Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein.
findings: []
- id: PMID:10666337
title: Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53.
findings: []
- id: PMID:10823891
title: The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
findings: []
- id: PMID:10837489
title: MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain.
findings: []
- id: PMID:10876243
title: Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
findings: []
- id: PMID:11080164
title: Regulation of p53 activity in nuclear bodies by a specific PML isoform.
findings: []
- id: PMID:11146555
title: Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16.
findings: []
- id: PMID:11178989
title: MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells.
findings: []
- id: PMID:11359905
title: The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation.
findings: []
- id: PMID:11388671
title: A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis.
findings: []
- id: PMID:11427532
title: p53 Modulates the exonuclease activity of Werner syndrome protein.
findings: []
- id: PMID:11546806
title: Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes.
findings: []
- id: PMID:11672523
title: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
findings: []
- id: PMID:11684014
title: ASPP proteins specifically stimulate the apoptotic function of p53.
findings: []
- id: PMID:11706030
title: Differential effect of ik3-1/cables on p53- and p73-induced cell death.
findings: []
- id: PMID:11781842
title: The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control.
findings: []
- id: PMID:11861836
title: Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.
findings: []
- id: PMID:11877378
title: Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.
findings: []
- id: PMID:11923872
title: Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization.
findings: []
- id: PMID:11950834
title: SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription.
findings: []
- id: PMID:12006491
title: Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
findings: []
- id: PMID:12080348
title: Nucleophosmin regulates the stability and transcriptional activity of p53.
findings: []
- id: PMID:12172011
title: Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila.
findings: []
- id: PMID:12203124
title: The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).
findings: []
- id: PMID:12433990
title: Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.
findings: []
- id: PMID:12609999
title: The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.
findings: []
- id: PMID:12620801
title: Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53.
findings: []
- id: PMID:12667443
title: p53 has a direct apoptogenic role at the mitochondria.
findings: []
- id: PMID:12692135
title: P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome.
findings: []
- id: PMID:12702766
title: Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).
findings: []
- id: PMID:12730672
title: Physical and functional interaction between HCV core protein and the different p73 isoforms.
findings: []
- id: PMID:12750254
title: p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.
findings: []
- id: PMID:12915590
title: Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization.
findings: []
- id: PMID:14557665
title: Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx.
findings: []
- id: PMID:14627987
title: PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase.
findings: []
- id: PMID:1465435
title: Wild-type p53 binds to the TATA-binding protein and represses transcription.
findings: []
- id: PMID:14759370
title: Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
findings: []
- id: PMID:14963330
title: Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
findings: []
- id: PMID:14985081
title: Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
findings: []
- id: PMID:15044383
title: Aprataxin, a novel protein that protects against genotoxic stress.
findings: []
- id: PMID:15053879
title: 'Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression.'
findings: []
- id: PMID:15068796
title: C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span.
findings: []
- id: PMID:15133049
title: NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers.
findings: []
- id: PMID:15144954
title: Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation.
findings: []
- id: PMID:15149599
title: Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
findings: []
- id: PMID:15205477
title: Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
findings: []
- id: PMID:15310821
title: Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis.
findings: []
- id: PMID:15314173
title: Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.
findings: []
- id: PMID:15358771
title: Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures.
findings: []
- id: PMID:15364927
title: Negative regulation of p53 functions by Daxx and the involvement of MDM2.
findings: []
- id: PMID:15525938
title: Regulation of p53 activity through lysine methylation.
findings: []
- id: PMID:15542844
title: p53 Stabilization and accumulation induced by human vaccinia-related kinase 1.
findings: []
- id: PMID:15565177
title: A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53.
findings: []
- id: PMID:15577914
title: Regulation of cellular response to oncogenic and oxidative stress by Seladin-1.
findings: []
- id: PMID:15580310
title: '17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo.'
findings: []
- id: PMID:15604276
title: Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53.
findings: []
- id: PMID:15629713
title: Binding of natively unfolded HIF-1alpha ODD domain to p53.
findings: []
- id: PMID:15660129
title: 'The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor.'
findings: []
- id: PMID:15687255
title: A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73.
findings: []
- id: PMID:15705871
title: Homeobox Msx1 interacts with p53 tumor suppressor and inhibits tumor growth by inducing apoptosis.
findings: []
- id: PMID:15735003
title: p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway.
findings: []
- id: PMID:15735006
title: p53 modulates RPA-dependent and RPA-independent WRN helicase activity.
findings: []
- id: PMID:15782130
title: BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase.
findings: []
- id: PMID:15855171
title: Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.
findings: []
- id: PMID:15916963
title: Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2.
findings: []
- id: PMID:15960975
title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
findings: []
- id: PMID:15989956
title: ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.
findings: []
- id: PMID:16003391
title: AtBAG6, a novel calmodulin-binding protein, induces programmed cell death in yeast and plants.
findings: []
- id: PMID:16131611
title: p53 isoforms can regulate p53 transcriptional activity.
findings: []
- id: PMID:16151013
title: PUMA couples the nuclear and cytoplasmic proapoptotic function of p53.
findings: []
- id: PMID:16169070
title: 'A human protein-protein interaction network: a resource for annotating the proteome.'
findings: []
- id: PMID:16189514
title: Towards a proteome-scale map of the human protein-protein interaction network.
findings: []
- id: PMID:16213212
title: Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
findings: []
- id: PMID:16227626
title: Physical interaction and mutual transrepression between CCAAT/enhancer-binding protein beta and the p53 tumor suppressor.
findings: []
- id: PMID:16291740
title: Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
findings: []
- id: PMID:16319068
title: Camptothecin induces nuclear export of prohibitin preferentially in transformed cells through a CRM-1-dependent mechanism.
findings: []
- id: PMID:16322561
title: NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
findings: []
- id: PMID:16376338
title: Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.
findings: []
- id: PMID:16376884
title: 'Characterisation of the interface between nucleophosmin (NPM) and p53: potential role in p53 stabilisation.'
findings: []
- id: PMID:16377624
title: Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage.
findings: []
- id: PMID:16402859
title: 'Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.'
findings: []
- id: PMID:16415881
title: Structural basis for the methylation site specificity of SET7/9.
findings: []
- id: PMID:16432196
title: The central region of HDM2 provides a second binding site for p53.
findings: []
- id: PMID:16442532
title: Interaction of metallothionein with tumor suppressor p53 protein.
findings: []
- id: PMID:16443602
title: WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.
findings: []
- id: PMID:16461914
title: Core domain interactions in full-length p53 in solution.
findings: []
- id: PMID:16462759
title: Inhibition of Bax activity is crucial for the antiapoptotic function of the human papillomavirus E6 oncoprotein.
findings: []
- id: PMID:16474402
title: Molecular recognition of p53 and MDM2 by USP7/HAUSP.
findings: []
- id: PMID:16479015
title: Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
findings: []
- id: PMID:16492744
title: Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.
findings: []
- id: PMID:16493710
title: Surface plasmon resonance imaging protein arrays for analysis of triple protein interactions of HPV, E6, E6AP, and p53.
findings: []
- id: PMID:16507995
title: Myosin VI is a mediator of the p53-dependent cell survival pathway.
findings: []
- id: PMID:16511572
title: 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.
findings: []
- id: PMID:16601686
title: Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression.
findings: []
- id: PMID:16611888
title: Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.
findings: []
- id: PMID:16616141
title: Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cells.
findings: []
- id: PMID:16690937
title: NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner.
findings: []
- id: PMID:16713569
title: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
findings: []
- id: PMID:16732283
title: Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
findings: []
- id: PMID:16753148
title: Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation.
findings: []
- id: PMID:16793543
title: 'Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53.'
findings: []
- id: PMID:16845383
title: Critical role for Daxx in regulating Mdm2.
findings: []
- id: PMID:16847267
title: MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents.
findings: []
- id: PMID:16951253
title: 'Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor.'
findings: []
- id: PMID:16959611
title: 'Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation.'
findings: []
- id: PMID:17080083
title: Inactivation of the p53 pathway in retinoblastoma.
findings: []
- id: PMID:17098746
title: FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity.
findings: []
- id: PMID:17108971
title: Repression of p53 activity by Smyd2-mediated methylation.
findings: []
- id: PMID:17121812
title: CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.
findings: []
- id: PMID:17139261
title: p53 mediates the negative regulation of MDM2 by orphan receptor TR3.
findings: []
- id: PMID:17145718
title: Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.
findings: []
- id: PMID:17146433
title: RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
findings: []
- id: PMID:17159902
title: An essential function of the extreme C-terminus of MDM2 can be provided by MDMX.
findings: []
- id: PMID:17170702
title: Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.
findings: []
- id: PMID:17184779
title: Identification of differential proteins in nasopharyngeal carcinoma cells with p53 silence by proteome analysis.
findings: []
- id: PMID:17237821
title: Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53.
findings: []
- id: PMID:17245430
title: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
findings: []
- id: PMID:17254968
title: PRAK is essential for ras-induced senescence and tumor suppression.
findings: []
- id: PMID:17268548
title: Monoubiquitylation promotes mitochondrial p53 translocation.
findings: []
- id: PMID:17274640
title: A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
findings: []
- id: PMID:17290220
title: The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.
findings: []
- id: PMID:17298945
title: The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53.
findings: []
- id: PMID:17310983
title: 'Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.'
findings: []
- id: PMID:17317671
title: The notch regulator MAML1 interacts with p53 and functions as a coactivator.
findings: []
- id: PMID:17347673
title: Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis.
findings: []
- id: PMID:17403783
title: HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
findings: []
- id: PMID:17438265
title: Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53.
findings: []
- id: PMID:17470788
title: PACT is a negative regulator of p53 and essential for cell growth and embryonic development.
findings: []
- id: PMID:17482142
title: Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53.
findings: []
- id: PMID:17568776
title: Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53.
findings: []
- id: PMID:17612295
title: Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.
findings: []
- id: PMID:17620598
title: Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
findings: []
- id: PMID:17662718
title: Protein-protein interactions among human lens acidic and basic beta-crystallins.
findings: []
- id: PMID:17707234
title: Modulation of p53 function by SET8-mediated methylation at lysine 382.
findings: []
- id: PMID:17719541
title: Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation.
findings: []
- id: PMID:17719542
title: hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes.
findings: []
- id: PMID:17805299
title: p53 is regulated by the lysine demethylase LSD1.
findings: []
- id: PMID:17875722
title: Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX.
findings: []
- id: PMID:17904127
title: SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53.
findings: []
- id: PMID:17906639
title: The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP.
findings: []
- id: PMID:17938203
title: Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage.
findings: []
- id: PMID:17964266
title: Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity.
findings: []
- id: PMID:18086682
title: Hsp60 regulation of tumor cell apoptosis.
findings: []
- id: PMID:18087040
title: Regulation of p53 tetramerization and nuclear export by ARC.
findings: []
- id: PMID:18172499
title: NUMB controls p53 tumour suppressor activity.
findings: []
- id: PMID:18230339
title: Activation of p53-dependent responses in tumor cells treated with a PARC-interacting peptide.
findings: []
- id: PMID:18235501
title: DBC1 is a negative regulator of SIRT1.
findings: []
- id: PMID:18235502
title: Negative regulation of the deacetylase SIRT1 by DBC1.
findings: []
- id: PMID:18275817
title: Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73.
findings: []
- id: PMID:18309296
title: Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation.
findings: []
- id: PMID:18316739
title: Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition.
findings: []
- id: PMID:18354501
title: 'Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH.'
findings: []
- id: PMID:18382127
title: CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2.
findings: []
- id: PMID:18388957
title: NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b).
findings: []
- id: PMID:18391200
title: Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.
findings: []
- id: PMID:18485870
title: Acetylation is indispensable for p53 activation.
findings: []
- id: PMID:18504427
title: Twist and p53 reciprocally regulate target genes via direct interaction.
findings: []
- id: PMID:18510931
title: Ectodermal factor restricts mesoderm differentiation by inhibiting p53.
findings: []
- id: PMID:18549481
title: TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
findings: []
- id: PMID:18566590
title: The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex.
findings: []
- id: PMID:18624398
title: Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
findings: []
- id: PMID:18656471
title: Microtubule-associated protein 1B light chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells.
findings: []
- id: PMID:18677113
title: Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.
findings: []
- id: PMID:18690848
title: NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress.
findings: []
- id: PMID:18695251
title: AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53.
findings: []
- id: PMID:18756595
title: Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
findings: []
- id: PMID:18812399
title: 14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers.
findings: []
- id: PMID:18952844
title: Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage.
findings: []
- id: PMID:18977328
title: Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation.
findings: []
- id: PMID:19008854
title: Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1.
findings: []
- id: PMID:19011621
title: Arginine methylation regulates the p53 response.
findings: []
- id: PMID:19043414
title: Molecular basis of Pirh2-mediated p53 ubiquitylation.
findings: []
- id: PMID:19098711
title: RYBP stabilizes p53 by modulating MDM2.
findings: []
- id: PMID:19151705
title: CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.
findings: []
- id: PMID:19160485
title: A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.
findings: []
- id: PMID:19166840
title: FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53.
findings: []
- id: PMID:19196987
title: Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.
findings: []
- id: PMID:19217391
title: Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation.
findings: []
- id: PMID:19234109
title: Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
findings: []
- id: PMID:19255450
title: Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
findings: []
- id: PMID:19339993
title: Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
findings: []
- id: PMID:19345189
title: A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis.
findings: []
- id: PMID:19411066
title: Regulation of XIAP translation and induction by MDM2 following irradiation.
findings: []
- id: PMID:19433796
title: A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.
findings: []
- id: PMID:19483087
title: Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains.
findings: []
- id: PMID:19505873
title: Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.
findings: []
- id: PMID:19508870
title: TOE1 interacts with p53 to modulate its transactivation potential.
findings: []
- id: PMID:19521340
title: MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway.
findings: []
- id: PMID:19536131
title: Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.
findings: []
- id: PMID:19556538
title: Trim24 targets endogenous p53 for degradation.
findings: []
- id: PMID:19619542
title: Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase.
findings: []
- id: PMID:19626115
title: Modulation of microRNA processing by p53.
findings: []
- id: PMID:19651603
title: Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein.
findings: []
- id: PMID:19656744
title: 'Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain.'
findings: []
- id: PMID:19667193
title: Ultraslow oligomerization equilibria of p53 and its implications.
findings: []
- id: PMID:19680552
title: CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.
findings: []
- id: PMID:19684601
title: A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9.
findings: []
- id: PMID:19740107
title: Epidermal growth factor receptor ligands as new extracellular targets for the metastasis-promoting S100A4 protein.
findings: []
- id: PMID:19749791
title: Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation.
findings: []
- id: PMID:19798103
title: Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities.
findings: []
- id: PMID:19805293
title: CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.
findings: []
- id: PMID:19833129
title: Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover.
findings: []
- id: PMID:19857493
title: 'Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175H.'
findings: []
- id: PMID:19933256
title: Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms.
findings: []
- id: PMID:19951988
title: WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway.
findings: []
- id: PMID:20004160
title: Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
findings: []
- id: PMID:20075864
title: Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element.
findings: []
- id: PMID:20096447
title: USP10 regulates p53 localization and stability by deubiquitinating p53.
findings: []
- id: PMID:20118233
title: G9a and Glp methylate lysine 373 in the tumor suppressor p53.
findings: []
- id: PMID:20123734
title: NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle.
findings: []
- id: PMID:20124405
title: G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis.
findings: []
- id: PMID:20134482
title: Skp2B attenuates p53 function by inhibiting prohibitin.
findings: []
- id: PMID:20153329
title: Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins--identification of additional interacting regions.
findings: []
- id: PMID:20159018
title: Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation.
findings: []
- id: PMID:20159469
title: Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
findings: []
- id: PMID:20160708
title: Feedback between p21 and reactive oxygen production is necessary for cell senescence.
findings: []
- id: PMID:20167603
title: DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
findings: []
- id: PMID:20173098
title: RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.
findings: []
- id: PMID:20206173
title: 'Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer.'
findings: []
- id: PMID:20227041
title: Modulation of the vitamin D3 response by cancer-associated mutant p53.
findings: []
- id: PMID:20228809
title: BRD7 is a candidate tumour suppressor gene required for p53 function.
findings: []
- id: PMID:20332243
title: MicroRNA145 targets BNIP3 and suppresses prostate cancer progression.
findings: []
- id: PMID:20364130
title: Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
findings: []
- id: PMID:20378837
title: Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function.
findings: []
- id: PMID:20385133
title: p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma.
findings: []
- id: PMID:20421506
title: Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.
findings: []
- id: PMID:20452352
title: A novel hPirh2 splicing variant without ubiquitin protein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma.
findings: []
- id: PMID:20515689
title: MDM4 binds ligands via a mechanism in which disordered regions become structured.
findings: []
- id: PMID:20534433
title: Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.
findings: []
- id: PMID:20546595
title: High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure.
findings: []
- id: PMID:20562916
title: Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma.
findings: []
- id: PMID:20591429
title: S100 proteins interact with the N-terminal domain of MDM2.
findings: []
- id: PMID:20622899
title: PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21.
findings: []
- id: PMID:20660729
title: Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.
findings: []
- id: PMID:20705607
title: Turning the RING domain protein MdmX into an active ubiquitin-protein ligase.
findings: []
- id: PMID:20708156
title: Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.
findings: []
- id: PMID:20713054
title: ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress.
findings: []
- id: PMID:20725088
title: Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation.
findings: []
- id: PMID:20810912
title: Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
findings: []
- id: PMID:20864041
title: MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.
findings: []
- id: PMID:20959462
title: Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
findings: []
- id: PMID:21057547
title: AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.
findings: []
- id: PMID:21078964
title: p53-mediated apoptosis requires inositol hexakisphosphate kinase-2.
findings: []
- id: PMID:21081126
title: Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53.
findings: []
- id: PMID:21130767
title: SAFB1 interacts with and suppresses the transcriptional activity of p53.
findings: []
- id: PMID:21132010
title: GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest.
findings: []
- id: PMID:21170034
title: TSPYL5 suppresses p53 levels and function by physical interaction with USP7.
findings: []
- id: PMID:21170087
title: Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator.
findings: []
- id: PMID:21178074
title: Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
findings: []
- id: PMID:21245319
title: Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).
findings: []
- id: PMID:21317932
title: 'A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation.'
findings: []
- id: PMID:21336310
title: p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase.
findings: []
- id: PMID:21390126
title: Inactivating mutations of acetyltransferase genes in B-cell lymphoma.
findings: []
- id: PMID:21397192
title: 'Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53.'
findings: []
- id: PMID:21423215
title: Camptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53.
findings: []
- id: PMID:2144364
title: Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene.
findings: []
- id: PMID:21460856
title: ATM-mediated phosphorylation activates the tumor-suppressive function of B56Ξ³-PP2A.
findings: []
- id: PMID:21471221
title: Novel nucleolar pathway connecting intracellular energy status with p53 activation.
findings: []
- id: PMID:21513714
title: The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53.
findings: []
- id: PMID:21522129
title: An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
findings: []
- id: PMID:21597459
title: E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.
findings: []
- id: PMID:21625211
title: COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3Ο.
findings: []
- id: PMID:21653829
title: Protein interactome reveals converging molecular pathways among autism disorders.
findings: []
- id: PMID:21670263
title: Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF).
findings: []
- id: PMID:21726810
title: Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.
findings: []
- id: PMID:21741598
title: A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.
findings: []
- id: PMID:21782458
title: Structural basis of substrate methylation and inhibition of SMYD2.
findings: []
- id: PMID:21821029
title: Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53.
findings: []
- id: PMID:21831840
title: Wild-type p53 controls cell motility and invasion by dual regulation of MET expression.
findings: []
- id: PMID:21857681
title: A stress response pathway regulates DNA damage through Ξ²2-adrenoreceptors and Ξ²-arrestin-1.
findings: []
- id: PMID:21892170
title: Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.
findings: []
- id: PMID:21900206
title: A directed protein interaction network for investigating intracellular signal transduction.
findings: []
- id: PMID:21952639
title: NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.
findings: []
- id: PMID:21988832
title: Toward an understanding of the protein interaction network of the human liver.
findings: []
- id: PMID:22056774
title: Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein.
findings: []
- id: PMID:22085928
title: Regulation of p53 stability and function by the deubiquitinating enzyme USP42.
findings: []
- id: PMID:22103682
title: Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination.
findings: []
- id: PMID:22124327
title: Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.
findings: []
- id: PMID:22265415
title: Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.
findings: []
- id: PMID:22340593
title: Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73.
findings: []
- id: PMID:22451927
title: Role of the translationally controlled tumor protein in DNA damage sensing and repair.
findings: []
- id: PMID:22499945
title: Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress.
findings: []
- id: PMID:22499991
title: Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2.
findings: []
- id: PMID:22510990
title: AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis.
findings: []
- id: PMID:22521434
title: Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR.
findings: []
- id: PMID:22522597
title: Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses.
findings: []
- id: PMID:22574148
title: p53 Activation following Rift Valley fever virus infection contributes to cell death and viral production.
findings: []
- id: PMID:22575647
title: An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability.
findings: []
- id: PMID:22578566
title: Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
findings: []
- id: PMID:22653443
title: Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
findings: []
- id: PMID:22659184
title: Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability.
findings: []
- id: PMID:22723347
title: Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1.
findings: []
- id: PMID:22726440
title: p53 opens the mitochondrial permeability transition pore to trigger necrosis.
findings: []
- id: PMID:22783376
title: Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53.
findings: []
- id: PMID:22810585
title: Viral immune modulators perturb the human molecular network by common and unique strategies.
findings: []
- id: PMID:22810586
title: Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.
findings: []
- id: PMID:22819825
title: TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation.
findings: []
- id: PMID:22869143
title: BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction.
findings: []
- id: PMID:22945289
title: ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis.
findings: []
- id: PMID:22972749
title: Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
findings: []
- id: PMID:22975381
title: 'A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation.'
findings: []
- id: PMID:23010591
title: Structural features of human histone acetyltransferase p300 and its complex with p53.
findings: []
- id: PMID:23027130
title: TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior.
findings: []
- id: PMID:23063560
title: HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 transactivation domain interaction, regulated by the acidic tail.
findings: []
- id: PMID:23092970
title: SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage.
findings: []
- id: PMID:23320542
title: Evidence for self-association of the alternative sigma factor Ο54.
findings: []
- id: PMID:23329847
title: Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding.
findings: []
- id: PMID:23431171
title: MOZ increases p53 acetylation and premature senescence through its complex formation with PML.
findings: []
- id: PMID:23576507
title: Rotavirus-encoded nonstructural protein 1 modulates cellular apoptotic machinery by targeting tumor suppressor protein p53.
findings: []
- id: PMID:23623661
title: Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.
findings: []
- id: PMID:23629966
title: Deacetylation of p53 induces autophagy by suppressing Bmf expression.
findings: []
- id: PMID:23734815
title: 'Fludarabine treatment favors the retention of miR-485-3p by prostate cancer cells: implications for survival.'
findings: []
- id: PMID:23752197
title: S100A4 interacts with p53 in the nucleus and promotes p53 degradation.
findings: []
- id: PMID:23776060
title: Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry.
findings: []
- id: PMID:23870121
title: SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.
findings: []
- id: PMID:24051492
title: p53 regulates Period2 expression and the circadian clock.
findings: []
- id: PMID:24101517
title: Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
findings: []
- id: PMID:24207125
title: Transient protein states in designing inhibitors of the MDM2-p53 interaction.
findings: []
- id: PMID:24219989
title: Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress.
findings: []
- id: PMID:24289924
title: Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
findings: []
- id: PMID:24356969
title: Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.
findings: []
- id: PMID:24380853
title: The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells.
findings: []
- id: PMID:24449765
title: 'Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor.'
findings: []
- id: PMID:24492002
title: VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage.
findings: []
- id: PMID:24625977
title: Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
findings: []
- id: PMID:24652652
title: DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected].
findings: []
- id: PMID:24667498
title: JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation.
findings: []
- id: PMID:24722188
title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
findings: []
- id: PMID:24814347
title: The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
findings: []
- id: PMID:25168243
title: Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.
findings: []
- id: PMID:25241761
title: Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
findings: []
- id: PMID:25314079
title: Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages.
findings: []
- id: PMID:25384516
title: Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength.
findings: []
- id: PMID:25402006
title: In silico prediction of physical protein interactions and characterization of interactome orphans.
findings: []
- id: PMID:25417702
title: Functional interplay between MDM2, p63/p73 and mutant p53.
findings: []
- id: PMID:25422469
title: Disruption of FAT10-MAD2 binding inhibits tumor progression.
findings: []
- id: PMID:25502805
title: A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
findings: []
- id: PMID:25579814
title: Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1.
findings: []
- id: PMID:25591766
title: RNF125 is a ubiquitin-protein ligase that promotes p53 degradation.
findings: []
- id: PMID:25609649
title: Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
findings: []
- id: PMID:25651062
title: An acetyl-methyl switch drives a conformational change in p53.
findings: []
- id: PMID:25670079
title: 14-3-3ΞΆ turns TGF-Ξ²'s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2.
findings: []
- id: PMID:25837623
title: Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription.
findings: []
- id: PMID:25857266
title: Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53.
findings: []
- id: PMID:26100857
title: A metabolic stress-inducible miR-34a-HNF4Ξ± pathway regulates lipid and lipoprotein metabolism.
findings: []
- id: PMID:26302407
title: Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.
findings: []
- id: PMID:26331536
title: Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.
findings: []
- id: PMID:26334721
title: Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
findings: []
- id: PMID:26634371
title: Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
findings: []
- id: PMID:26789255
title: Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
findings: []
- id: PMID:27031958
title: Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine.
findings: []
- id: PMID:27107012
title: Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
findings: []
- id: PMID:27323408
title: LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis.
findings: []
- id: PMID:27519799
title: p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1.
findings: []
- id: PMID:27605672
title: Mitogen-Activated Protein Kinase Kinase 2, a Novel E2-Interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway.
findings: []
- id: PMID:28842590
title: DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.
findings: []
- id: PMID:29187402
title: The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival.
findings: []
- id: PMID:29340707
title: VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.
findings: []
- id: PMID:29474172
title: Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice.
findings: []
- id: PMID:29628311
title: A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.
findings: []
- id: PMID:29681526
title: A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
findings: []
- id: PMID:29997244
title: 'LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.'
findings: []
- id: PMID:30146126
title: De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.
findings: []
- id: PMID:31467278
title: Maximizing binary interactome mapping with a minimal number of assays.
findings: []
- id: PMID:31511497
title: miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity.
findings: []
- id: PMID:31515488
title: Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
findings: []
- id: PMID:31837246
title: High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.
findings: []
- id: PMID:31953488
title: Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains.
findings: []
- id: PMID:32606738
title: P55PIK Regulates P53-Dependent Apoptosis in Cancer Cells by Interacting with P53 DNA-Specific Domain.
findings: []
- id: PMID:32814053
title: Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
findings: []
- id: PMID:33591310
title: DAZAP2 acts as specifier of the p53 response to DNA damage.
findings: []
- id: PMID:33961781
title: Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
findings: []
- id: PMID:34316702
title: Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.
findings: []
- id: PMID:34381247
title: The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
findings: []
- id: PMID:34404770
title: ZNF768 links oncogenic RAS to cellular senescence.
findings: []
- id: PMID:34591612
title: A protein interaction landscape of breast cancer.
findings: []
- id: PMID:34591642
title: A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
findings: []
- id: PMID:35044719
title: Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.
findings: []
- id: PMID:35122041
title: Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways.
findings: []
- id: PMID:35140242
title: Human transcription factor protein interaction networks.
findings: []
- id: PMID:35271311
title: 'OpenCell: Endogenous tagging for the cartography of human cellular organization.'
findings: []
- id: PMID:35512704
title: Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
findings: []
- id: PMID:35618207
title: Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.
findings: []
- id: PMID:36108750
title: Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.
findings: []
- id: PMID:36634798
title: Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.
findings: []
- id: PMID:36931259
title: A central chaperone-like role for 14-3-3 proteins in human cells.
findings: []
- id: PMID:38653238
title: Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.
findings: []
- id: PMID:39009827
title: Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.
findings: []
- id: PMID:7559631
title: Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein.
findings: []
- id: PMID:7587074
title: 'Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene.'
findings: []
- id: PMID:7663514
title: p53 modulation of TFIIH-associated nucleotide excision repair activity.
findings: []
- id: PMID:7720704
title: Direct involvement of p53 in programmed cell death of oligodendrocytes.
findings: []
- id: PMID:7799929
title: Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression.
findings: []
- id: PMID:7824276
title: 'Modulation by copper of p53 conformation and sequence-specific DNA binding: role for Cu(II)/Cu(I) redox mechanism.'
findings: []
- id: PMID:7958916
title: DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
findings: []
- id: PMID:8183576
title: Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP.
findings: []
- id: PMID:8207801
title: Inhibition of p53 DNA binding by human papillomavirus E6 proteins.
findings: []
- id: PMID:8344494
title: Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system.
findings: []
- id: PMID:8675009
title: The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.
findings: []
- id: PMID:8875926
title: Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.
findings: []
- id: PMID:8875929
title: Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
findings: []
- id: PMID:8986812
title: Identification of a novel p53 functional domain that is necessary for efficient growth suppression.
findings: []
- id: PMID:9050995
title: Identification of p53 unbound to T-antigen in human cells transformed by simian virus 40 T-antigen.
findings: []
- id: PMID:9054499
title: Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.
findings: []
- id: PMID:9188558
title: Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization.
findings: []
- id: PMID:9194564
title: Synergistic activation of transcription by CBP and p53.
findings: []
- id: PMID:9194565
title: Binding and modulation of p53 by p300/CBP coactivators.
findings: []
- id: PMID:9271120
title: 'Repression of p53-mediated transcription by MDM2: a dual mechanism.'
findings: []
- id: PMID:9380510
title: Interaction of p53 with the human Rad51 protein.
findings: []
- id: PMID:9472015
title: High mobility group protein-1 (HMG-1) is a unique activator of p53.
findings: []
- id: PMID:9529249
title: 'ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.'
findings: []
- id: PMID:9733515
title: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.
findings: []
- id: PMID:9807817
title: An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506.
findings: []
- id: PMID:9827557
title: Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor.
findings: []
- id: Reactome:R-HSA-264435
title: Dissociation of the COP1-p53 complex
findings: []
- id: Reactome:R-HSA-2997706
title: MDM2 SUMOylates TP53 with SUMO2,3
findings: []
- id: Reactome:R-HSA-3215152
title: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter
findings: []
- id: Reactome:R-HSA-3215251
title: TP53INP1 and HIPK2 bind TP53
findings: []
- id: Reactome:R-HSA-3215310
title: USP7 deubiquitinates TP53 and counteracts MDM2
findings: []
- id: Reactome:R-HSA-3221982
title: BANP binds TP53
findings: []
- id: Reactome:R-HSA-3222006
title: STK11 (LKB1) phosphorylates NUAK1
findings: []
- id: Reactome:R-HSA-3222020
title: NUAK1 phosphorylates TP53
findings: []
- id: Reactome:R-HSA-3222093
title: BRD7 binds TP53 and EP300
findings: []
- id: Reactome:R-HSA-3222116
title: L3MBTL1 binds TP53 monomethylated on K382
findings: []
- id: Reactome:R-HSA-3222128
title: NOC2L binds TP53
findings: []
- id: Reactome:R-HSA-3222237
title: SMYD2 methylates TP53
findings: []
- id: Reactome:R-HSA-3222259
title: PHF20 binds TP53 dimethylated on K370 and K382
findings: []
- id: Reactome:R-HSA-3239014
title: MAPKAPK5 phosphorylates TP53
findings: []
- id: Reactome:R-HSA-3700981
title: TP53 family members bind the BAX promoter
findings: []
- id: Reactome:R-HSA-3700997
title: TP53 binds the MDM2 gene
findings: []
- id: Reactome:R-HSA-3786258
title: TP53 binds the CDKN1A promoter
findings: []
- id: Reactome:R-HSA-4331331
title: TP53 binds the PMAIP1 (NOXA) promoter
findings: []
- id: Reactome:R-HSA-4331340
title: TP53 binds the BBC3 (PUMA) promoter
findings: []
- id: Reactome:R-HSA-4395236
title: TP53 binds promoters of MIR34 genes
findings: []
- id: Reactome:R-HSA-4647593
title: EP400 binds CDKN1A promoter
findings: []
- id: Reactome:R-HSA-5628871
title: BRD7 promotes EP300-mediated acetylation of TP53
findings: []
- id: Reactome:R-HSA-5628899
title: TP53 binds the TIGAR gene
findings: []
- id: Reactome:R-HSA-5629187
title: TP53 binds regulatory elements of SESN1,2,3 genes
findings: []
- id: Reactome:R-HSA-5632759
title: TP53 binds the SCO2 gene
findings: []
- id: Reactome:R-HSA-5632887
title: TP53 binds the RRM2B gene
findings: []
- id: Reactome:R-HSA-5632914
title: TP53 binds the GLS2 promoter
findings: []
- id: Reactome:R-HSA-5632939
title: TP53 binds the PTEN promoter
findings: []
- id: Reactome:R-HSA-5633295
title: TP53 binds the NDRG1 gene promoter
findings: []
- id: Reactome:R-HSA-5633414
title: TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes
findings: []
- id: Reactome:R-HSA-5633460
title: MDM2 binds TP53
findings: []
- id: Reactome:R-HSA-5689950
title: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
findings: []
- id: Reactome:R-HSA-5689973
title: USP10,USP24,USP42 deubiquitinate TP53
findings: []
- id: Reactome:R-HSA-5690843
title: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
findings: []
- id: Reactome:R-HSA-5693609
title: ATM phosphorylates TP53 at S15
findings: []
- id: Reactome:R-HSA-6789960
title: Expression of NDN,TP53
findings: []
- id: Reactome:R-HSA-6791285
title: TP53 binds the BID gene promoter
findings: []
- id: Reactome:R-HSA-6791302
title: TP53 binds the AIFM2 gene promoter
findings: []
- id: Reactome:R-HSA-6791327
title: TP53 binds the BCL2L14 gene
findings: []
- id: Reactome:R-HSA-6791349
title: TP53 binds the APAF1 gene promoter
findings: []
- id: Reactome:R-HSA-6791387
title: TP53 binds the ARID3A gene
findings: []
- id: Reactome:R-HSA-6791409
title: TP53 binds the CCNG1 gene
findings: []
- id: Reactome:R-HSA-6793685
title: Ubiquitinated TP53 translocates to the cytosol
findings: []
- id: Reactome:R-HSA-6796649
title: TP53 binds the CCNK gene
findings: []
- id: Reactome:R-HSA-6797766
title: TP53 binds the BIRC5 gene
findings: []
- id: Reactome:R-HSA-6797993
title: TP53 and CREBBP bind BNIP3L gene
findings: []
- id: Reactome:R-HSA-6798020
title: TP53 binds the BTG2 gene
findings: []
- id: Reactome:R-HSA-6798082
title: TP53 family members bind the CASP1 gene
findings: []
- id: Reactome:R-HSA-6798129
title: TP53 binds the CASP6 gene
findings: []
- id: Reactome:R-HSA-6798138
title: TP53 binds the CASP10 gene
findings: []
- id: Reactome:R-HSA-6798282
title: TP53 and E2F4 bind the CDC25C gene
findings: []
- id: Reactome:R-HSA-6798304
title: TP53 binds the E2F7 gene
findings: []
- id: Reactome:R-HSA-6798374
title: DYRK2 phosphorylates TP53
findings: []
- id: Reactome:R-HSA-6798615
title: TP53 binds the TP53AIP1 gene
findings: []
- id: Reactome:R-HSA-6799246
title: CHEK1 phosphorylates TP53
findings: []
- id: Reactome:R-HSA-6799332
title: ATR phosphorylates TP53
findings: []
- id: Reactome:R-HSA-6799409
title: HIPK2 phosphorylates TP53
findings: []
- id: Reactome:R-HSA-6799418
title: TP53 binds the TP53INP1 gene
findings: []
- id: Reactome:R-HSA-6799431
title: TP53 binds HIPK1
findings: []
- id: Reactome:R-HSA-6799462
title: 'TODO: Fetch title'
findings: []
- id: Reactome:R-HSA-6799761
title: 'TODO: Fetch title'
findings: []
- id: Reactome:R-HSA-6799777
title: 'TODO: Fetch title'
findings: []
- id: Reactome:R-HSA-6799815
title: 'TODO: Fetch title'
findings: []
- id: Reactome:R-HSA-6800042
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- id: file:human/TP53/TP53-deep-research-falcon.md
title: Deep research report on TP53
findings: []
core_functions:
- molecular_function:
id: GO:0000976
label: transcription cis-regulatory region binding
directly_involved_in:
- id: GO:0030330
label: DNA damage response, signal transduction by p53 class mediator
- id: GO:0045930
label: negative regulation of mitotic cell cycle
- id: GO:0072332
label: intrinsic apoptotic signaling pathway by p53 class mediator
locations:
- id: GO:0005634
label: nucleus
description: p53 functions as a sequence-specific DNA-binding transcription factor that binds p53 response elements to regulate transcription of target genes involved in cell cycle arrest, apoptosis, DNA repair, and metabolism
supported_by:
- reference_id: PMID:15710329
supporting_text: Human MUC1 oncoprotein regulates p53-responsive gene transcription
- reference_id: PMID:17996705
supporting_text: An acetylation switch in p53 mediates holo-TFIID recruitment
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: Multifunctional transcription factor
- molecular_function:
id: GO:0000976
label: transcription cis-regulatory region binding
directly_involved_in:
- id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
- id: GO:0000122
label: negative regulation of transcription by RNA polymerase II
- id: GO:2000772
label: regulation of cellular senescence
locations:
- id: GO:0016604
label: nuclear body
description: p53 localizes to nuclear bodies and regulates both activation and repression of transcription, including senescence programs
supported_by:
- reference_id: PMID:10360174
supporting_text: ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
- reference_id: file:human/TP53/TP53-uniprot.txt
supporting_text: induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence ... Negatively regulates cell division
suggested_questions:
- question: How does p53 integrate diverse stress signals to determine cell fate decisions between survival, senescence, and apoptosis?
- question: What determines the selectivity of p53 for different target gene promoters and how is this modulated by post-translational modifications?
- question: How do p53 isoforms and mutant forms interact to modulate tumor suppressor function in heterozygous cancer cells?
suggested_experiments:
- description: Single-cell time-lapse imaging to track p53 dynamics and correlate oscillation patterns with specific cell fate outcomes
- description: ChIP-seq coupled with PRO-seq to map p53 binding and transcriptional outcomes under different stress conditions
- description: Proximity labeling proteomics to identify context-specific p53 interactors that determine target gene selectivity
tags:
- ferroptosis
- lbnl-favorites
status: COMPLETE
π View Pathway Visualization Interactive pathway diagram with detailed annotations